ES301736A1 - Procedure for the preparation of new derivatives of tetrahidroisoquinolina. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new derivatives of tetrahidroisoquinolina. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES301736A1 ES301736A1 ES0301736A ES301736A ES301736A1 ES 301736 A1 ES301736 A1 ES 301736A1 ES 0301736 A ES0301736 A ES 0301736A ES 301736 A ES301736 A ES 301736A ES 301736 A1 ES301736 A1 ES 301736A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- translation
- procedure
- preparation
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedure for the preparation of new tetrahydroisoquinoline derivatives of the formulas **(See formula)** wherein A represents a lower alkylene, lower hydroxy-alkylene, or lower oxo-alkylene radical, R1 represents a lower alkyl radical, R2 represents a hydrogen atom or a lower alkyl radical, and R3 represents a halogen atom, and its non-toxic addition salts and quaternary ammonium compounds, characterized in that a compound of the formula is reacted under the Mannich reaction conditions: **(See formula)** (where R1 and R2 are as defined herein above) with formaldehyde and a ketone of the formula: **(See formula)** (where R4 represents a hydrogen atom or an alkyl group having no more than 3 carbon atoms, and R3 is as defined herein above), to form a compound of the formula: **(See formula)** (in which the various symbols are as defined herein above) and optionally reducing the carbonyl group in the product obtained to the group -CH2- or -CHOH- by known methods for such reactions. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2702263 | 1963-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES301736A1 true ES301736A1 (en) | 1965-01-16 |
Family
ID=10252896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0301736A Expired ES301736A1 (en) | 1963-07-08 | 1964-07-06 | Procedure for the preparation of new derivatives of tetrahidroisoquinolina. (Machine-translation by Google Translate, not legally binding) |
Country Status (5)
| Country | Link |
|---|---|
| AT (4) | AT250964B (en) |
| BE (1) | BE649952A (en) |
| ES (1) | ES301736A1 (en) |
| FR (1) | FR4637M (en) |
| NL (1) | NL6407478A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108484574B (en) * | 2018-04-12 | 2020-06-19 | 广东医科大学 | Preparation and Application of Tetrahydroisoquinoline Derivatives |
-
1964
- 1964-07-01 BE BE649952D patent/BE649952A/xx unknown
- 1964-07-01 NL NL6407478A patent/NL6407478A/xx unknown
- 1964-07-06 ES ES0301736A patent/ES301736A1/en not_active Expired
- 1964-07-08 AT AT837065A patent/AT250964B/en active
- 1964-07-08 AT AT836965A patent/AT250963B/en active
- 1964-07-08 AT AT836865A patent/AT250962B/en active
- 1964-07-08 AT AT589164A patent/AT250961B/en active
- 1964-10-06 FR FR990446A patent/FR4637M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL6407478A (en) | 1965-01-11 |
| AT250961B (en) | 1966-12-12 |
| AT250963B (en) | 1966-12-12 |
| FR4637M (en) | 1966-12-05 |
| AT250962B (en) | 1966-12-12 |
| BE649952A (en) | 1965-01-04 |
| AT250964B (en) | 1966-12-12 |
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