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ES272931A1 - A PROCEDURE FOR THE PREPARATION OF 17-ALPHA-ETHINYL 18-NOR 13-BETA-N-PROPIL ESTRADIOL AND ITS ESTERS AND ETHERS (Machine-translation by Google Translate, not legally binding) - Google Patents

A PROCEDURE FOR THE PREPARATION OF 17-ALPHA-ETHINYL 18-NOR 13-BETA-N-PROPIL ESTRADIOL AND ITS ESTERS AND ETHERS (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES272931A1
ES272931A1 ES0272931A ES272931A ES272931A1 ES 272931 A1 ES272931 A1 ES 272931A1 ES 0272931 A ES0272931 A ES 0272931A ES 272931 A ES272931 A ES 272931A ES 272931 A1 ES272931 A1 ES 272931A1
Authority
ES
Spain
Prior art keywords
estradiol
preparation
propil
ethinyl
ethers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0272931A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Francais de Chimiotherapie SA
Laboratoires Francaise de Chimiotherapie
Original Assignee
Laboratoires Francais de Chimiotherapie SA
Laboratoires Francaise de Chimiotherapie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR846887A external-priority patent/FR1366722A/en
Priority claimed from FR862521A external-priority patent/FR83552E/en
Application filed by Laboratoires Francais de Chimiotherapie SA, Laboratoires Francaise de Chimiotherapie filed Critical Laboratoires Francais de Chimiotherapie SA
Publication of ES272931A1 publication Critical patent/ES272931A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises compounds having the formulae <FORM:1005726/C2/1> wherein R represents H or an acyl radical or alkyl radical and processes for the preparation of a 17a -ethynyl-13b -n-alkyl-18-nor-estradiol by selectively oxidizing 13b -n-alkyl 18-nor-estradiol at the 17-position so as to form the corresponding estrone which after preliminary etherification at the 3-position is then ethynylated by reaction with ethynyl magnesium halide. Selective oxidation may be effected with aluminium isopropylate in the presence of cyclohexanone and etherification may be effected with a -tetrahydropyranyl ether. Specifications 979,891 and 1,005,727 are referred to.
ES0272931A 1960-12-14 1961-12-13 A PROCEDURE FOR THE PREPARATION OF 17-ALPHA-ETHINYL 18-NOR 13-BETA-N-PROPIL ESTRADIOL AND ITS ESTERS AND ETHERS (Machine-translation by Google Translate, not legally binding) Expired ES272931A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR846887A FR1366722A (en) 1960-12-14 1960-12-14 Novel ethynyl analogue of estradiol, its functional derivatives and method of preparation
FR862521A FR83552E (en) 1961-05-23 1961-05-23 Novel ethynyl analogue of estradiol, its functional derivatives and method of preparation

Publications (1)

Publication Number Publication Date
ES272931A1 true ES272931A1 (en) 1962-02-16

Family

ID=26188552

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0272931A Expired ES272931A1 (en) 1960-12-14 1961-12-13 A PROCEDURE FOR THE PREPARATION OF 17-ALPHA-ETHINYL 18-NOR 13-BETA-N-PROPIL ESTRADIOL AND ITS ESTERS AND ETHERS (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
BE (1) BE611478A (en)
CH (1) CH405293A (en)
ES (1) ES272931A1 (en)
GB (2) GB1005727A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115353541B (en) * 2022-09-01 2024-06-18 英科新创（苏州）生物科技有限公司 Process for the preparation of estradiol derivatives, intermediates, process for the preparation thereof and use thereof
CN115417908B (en) * 2022-09-01 2024-06-18 英科新创（苏州）生物科技有限公司 Estradiol derivative, preparation method thereof, detection kit and estradiol quantitative detection method

Also Published As

Publication number Publication date
GB1005726A (en) 1965-09-29
BE611478A (en) 1962-06-13
CH405293A (en) 1966-01-15
GB1005727A (en) 1965-09-29

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