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GB931784A - New steroid compounds and processes for their preparation - Google Patents

New steroid compounds and processes for their preparation

Info

Publication number
GB931784A
GB931784A GB2024062A GB2024062A GB931784A GB 931784 A GB931784 A GB 931784A GB 2024062 A GB2024062 A GB 2024062A GB 2024062 A GB2024062 A GB 2024062A GB 931784 A GB931784 A GB 931784A
Authority
GB
United Kingdom
Prior art keywords
diene
group
processes
preparation
androsta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2024062A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB931784A publication Critical patent/GB931784A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0007—Androstane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises androsta-3,5-diene derivatives having the formula: <FORM:0931784/IV(a)/1> in which R represents a lower alkyl group having 1-6 carbon atoms, and where R3 may be a ketone group in which case R1 will also represent a ketone group, but R2 a p-toluene-sulphonyloxy-substituent, or alternatively R3 is an hydroxyl group in which case the R substituent is as before but R1 is either a hydroxyl or ketone group, and R2 either a p-toluenesulphonyloxy group or a hydrogen atom, and processes for the preparation thereof by enolising 17-p-toluenesulphonyloxy-androst-4-ene-3,11,16-trione, e.g. with an alkyl orthoformate, to form a 3-alkoxy-17-p-toluenesulphonyloxyandrosta- 3,5- diene-11, 16-dione, reducing this enol ether to form 3-alkoxy- 11b ,16-dihydroxy- 17-p-toluenesulphonyloxy-androsta-3, 5-diene, which is saponified at 17-position to obtain 3-alkoxy-11b -hydroxy-androsta-3,5-diene-16-one.
GB2024062A 1959-06-04 1960-06-01 New steroid compounds and processes for their preparation Expired GB931784A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR796581A FR1344159A (en) 1959-06-04 1959-06-04 16-ethynyl teroid compounds of the androstane series and their production process

Publications (1)

Publication Number Publication Date
GB931784A true GB931784A (en) 1963-07-17

Family

ID=8715622

Family Applications (3)

Application Number Title Priority Date Filing Date
GB1934460A Expired GB931783A (en) 1959-06-04 1960-06-01 New steroid compounds, and processes for their preparation
GB2024062A Expired GB931784A (en) 1959-06-04 1960-06-01 New steroid compounds and processes for their preparation
GB2024162A Expired GB931785A (en) 1959-06-04 1960-06-01 New steroid compounds, and processes for their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1934460A Expired GB931783A (en) 1959-06-04 1960-06-01 New steroid compounds, and processes for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB2024162A Expired GB931785A (en) 1959-06-04 1960-06-01 New steroid compounds, and processes for their preparation

Country Status (5)

Country Link
BE (1) BE591544A (en)
CH (1) CH421095A (en)
ES (1) ES258549A1 (en)
FR (1) FR1344159A (en)
GB (3) GB931783A (en)

Also Published As

Publication number Publication date
BE591544A (en) 1960-12-05
CH421095A (en) 1966-09-30
GB931783A (en) 1963-07-17
ES258549A1 (en) 1960-11-16
FR1344159A (en) 1963-11-29
GB931785A (en) 1963-07-17

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