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ES2634763T3 - Enzimas para la transformación de ergopeptinas así como un procedimiento para ello - Google Patents

Enzimas para la transformación de ergopeptinas así como un procedimiento para ello Download PDF

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Publication number
ES2634763T3
ES2634763T3 ES13791893.4T ES13791893T ES2634763T3 ES 2634763 T3 ES2634763 T3 ES 2634763T3 ES 13791893 T ES13791893 T ES 13791893T ES 2634763 T3 ES2634763 T3 ES 2634763T3
Authority
ES
Spain
Prior art keywords
enzymes
transformation
ergopeptinas
procedure
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13791893.4T
Other languages
English (en)
Inventor
Gerd Schatzmayr
Eva-Maria Binder
Michaela THAMHESL
Dieter Moll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Austria GmbH
Original Assignee
Erber AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erber AG filed Critical Erber AG
Application granted granted Critical
Publication of ES2634763T3 publication Critical patent/ES2634763T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/14—Pretreatment of feeding-stuffs with enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/183—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing an indolo[4,3-F,G]quinoleine nucleus, e.g. compound containing the lysergic acid nucleus as well as the dimeric ergot nucleus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Enzimas para la transformación de ergopeptinas, especialmente para la escisión hidrolítica en el átomo C3' del anillo ciclol, caracterizadas porque las enzimas son α/ß-hidrolasas que tienen al menos un 96% de identidad de secuencia con la secuencia con nº de ID 1.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6

Claims (1)

  1. imagen1
ES13791893.4T 2012-10-09 2013-10-04 Enzimas para la transformación de ergopeptinas así como un procedimiento para ello Active ES2634763T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT10912012 2012-10-09
ATA1091/2012A AT513473B1 (de) 2012-10-09 2012-10-09 Enzyme zur Transformation von Ergopeptinen sowie Verfahren hierfür
PCT/AT2013/000161 WO2014056006A1 (de) 2012-10-09 2013-10-04 Enzyme zur transformation von ergopeptinen sowie verfahren hierfür

Publications (1)

Publication Number Publication Date
ES2634763T3 true ES2634763T3 (es) 2017-09-28

Family

ID=49585222

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13791893.4T Active ES2634763T3 (es) 2012-10-09 2013-10-04 Enzimas para la transformación de ergopeptinas así como un procedimiento para ello

Country Status (11)

Country Link
US (1) US9586990B2 (es)
EP (1) EP2906709B8 (es)
CN (1) CN104769124A (es)
AT (1) AT513473B1 (es)
AU (1) AU2013330204B2 (es)
CA (1) CA2885760C (es)
DK (1) DK2906709T3 (es)
ES (1) ES2634763T3 (es)
HU (1) HUE036358T2 (es)
PL (1) PL2906709T3 (es)
WO (1) WO2014056006A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023003959A (es) 2020-10-08 2023-05-25 DSM Austria GmbH Variantes de hidrolasa alfa/beta tetramerica con estabilidad a la temperatura incrementada y metodos de uso y produccion de las mismas.
EP4263826A2 (en) 2020-12-18 2023-10-25 DSM Austria GmbH Means and methods for detoxifying ochratoxin a
EP4392552A1 (en) 2021-08-27 2024-07-03 DSM Austria GmbH Means and methods for detoxifying ochratoxin a
WO2025036933A1 (en) 2023-08-17 2025-02-20 Dsm Ip Assets B.V. Means and methods for reducing estrogenic effect of xenoestrogen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1362876A (fr) * 1963-07-08 1964-06-05 Farmaceutici Italia Nouveau procédé de préparation de l'acide lysergique
WO2002029042A2 (en) * 2000-10-05 2002-04-11 Millennium Pharmaceuticals, Inc. 48120, 23479, and 46689, novel human hydrolases and uses thereof

Also Published As

Publication number Publication date
CN104769124A (zh) 2015-07-08
US9586990B2 (en) 2017-03-07
EP2906709B1 (de) 2017-06-21
AT513473A1 (de) 2014-04-15
CA2885760A1 (en) 2014-04-17
AU2013330204B2 (en) 2017-06-01
CA2885760C (en) 2018-04-17
AT513473B1 (de) 2016-01-15
HUE036358T2 (hu) 2018-07-30
EP2906709B8 (de) 2017-08-02
PL2906709T3 (pl) 2017-12-29
AU2013330204A1 (en) 2015-04-02
EP2906709A1 (de) 2015-08-19
US20150274775A1 (en) 2015-10-01
WO2014056006A1 (de) 2014-04-17
DK2906709T3 (en) 2017-09-18

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ES2634763T3 (es) Enzimas para la transformación de ergopeptinas así como un procedimiento para ello