ES2571127T3 - Método para la separación de moléculas o partículas objetivo a partir de muestras que contienen fibrinógeno, incluyendo componentes sanguíneos - Google Patents
Método para la separación de moléculas o partículas objetivo a partir de muestras que contienen fibrinógeno, incluyendo componentes sanguíneosInfo
- Publication number
- ES2571127T3 ES2571127T3 ES11788227T ES11788227T ES2571127T3 ES 2571127 T3 ES2571127 T3 ES 2571127T3 ES 11788227 T ES11788227 T ES 11788227T ES 11788227 T ES11788227 T ES 11788227T ES 2571127 T3 ES2571127 T3 ES 2571127T3
- Authority
- ES
- Spain
- Prior art keywords
- particles
- target molecules
- separation
- samples containing
- fibrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108010049003 Fibrinogen Proteins 0.000 title abstract 3
- 102000008946 Fibrinogen Human genes 0.000 title abstract 3
- 229940012952 fibrinogen Drugs 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title abstract 2
- 239000012503 blood component Substances 0.000 title 1
- 102000009123 Fibrin Human genes 0.000 abstract 6
- 108010073385 Fibrin Proteins 0.000 abstract 6
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 6
- 229950003499 fibrin Drugs 0.000 abstract 6
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
- 230000002345 thrombinlike Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56938—Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/14—Streptococcus; Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/75—Fibrin; Fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Método para el procesamiento de una muestra líquida que comprende fibrinógeno, para la separación y concentración de moléculas o partículas objetivo de la muestra, que comprende: a. Atrapar dichas moléculas o partículas objetivo en una red de fibrina sometiendo la muestra a trombina o enzimas de tipo trombina para convertir, como mínimo, parcialmente el fibrinógeno contenido en la dicha muestra en fibrina para formar la red de fibrina b. Retraer dicha red de fibrina para formar un coágulo de fibrina c. Separar de dicho coágulo de fibrina del medio de muestra circundante.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH14782010 | 2010-09-15 | ||
| CH20412010 | 2010-12-07 | ||
| CH12072011 | 2011-07-20 | ||
| PCT/IB2011/054035 WO2012035508A2 (en) | 2010-09-15 | 2011-09-15 | Method for separating target molecules or particles from fibrinogen-containing samples including blood components |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2571127T3 true ES2571127T3 (es) | 2016-05-24 |
Family
ID=45044632
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11788227T Active ES2571127T3 (es) | 2010-09-15 | 2011-09-15 | Método para la separación de moléculas o partículas objetivo a partir de muestras que contienen fibrinógeno, incluyendo componentes sanguíneos |
| ES16154770T Active ES2751660T3 (es) | 2010-09-15 | 2011-09-15 | Dispositivo que incluye componentes sanguíneos para separar moléculas o partículas diana de muestras |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16154770T Active ES2751660T3 (es) | 2010-09-15 | 2011-09-15 | Dispositivo que incluye componentes sanguíneos para separar moléculas o partículas diana de muestras |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9689881B2 (es) |
| EP (2) | EP2616550B1 (es) |
| JP (1) | JP5999776B2 (es) |
| KR (1) | KR101948944B1 (es) |
| CN (2) | CN103108959B (es) |
| AU (2) | AU2011303467C1 (es) |
| CA (1) | CA2811493C (es) |
| CY (1) | CY1122166T1 (es) |
| DK (2) | DK2616550T3 (es) |
| ES (2) | ES2571127T3 (es) |
| HR (1) | HRP20191785T1 (es) |
| HU (2) | HUE045771T2 (es) |
| LT (1) | LT3067431T (es) |
| PL (2) | PL3067431T3 (es) |
| PT (1) | PT3067431T (es) |
| SI (1) | SI3067431T1 (es) |
| WO (1) | WO2012035508A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2571127T3 (es) | 2010-09-15 | 2016-05-24 | Debiopharm Int Sa | Método para la separación de moléculas o partículas objetivo a partir de muestras que contienen fibrinógeno, incluyendo componentes sanguíneos |
| US9688959B2 (en) | 2011-06-27 | 2017-06-27 | Emory University | Compositions, uses, and preparation of platelet lysates |
| US10444240B2 (en) * | 2013-03-29 | 2019-10-15 | Siemens Healthcare Diagnostics, Inc. | Rare cell concentration |
| PL3148698T3 (pl) | 2014-06-01 | 2020-03-31 | Debiopharm International Sa | Urządzenie do pobierania i przetwarzania próbek |
| JP7085476B2 (ja) | 2015-11-30 | 2022-06-16 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 流体を処理するための電磁アセンブリ |
| US10596236B2 (en) | 2016-03-10 | 2020-03-24 | Arthrex, Inc. | Systems and methods for preparing a thrombin serum |
| CA3013659C (en) | 2016-03-10 | 2023-11-14 | Arthrex, Inc. | Systems and methods for preparing protein enhanced serums |
| AU2019329686A1 (en) | 2018-08-27 | 2020-12-03 | Regeneron Pharmaceuticals, Inc. | Use of raman spectroscopy in downstream purification |
| JP7298449B2 (ja) * | 2019-11-14 | 2023-06-27 | 株式会社島津製作所 | 血液凝固分析装置、及び分注ノズルの洗浄方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1035260A (en) * | 1974-08-12 | 1978-07-25 | Baxter Travenol Laboratories | Collection and processing tube |
| FR2625321B1 (fr) * | 1987-12-24 | 1992-10-02 | Pasteur Institut | Reactif pour le diagnostic de staphylococcus aureus par agglutination |
| DE3803463A1 (de) * | 1988-02-05 | 1989-08-17 | Linhart Axel | Semiquantitativer kalzium-schnelltest |
| DE58902472D1 (de) * | 1988-01-05 | 1992-11-26 | Linhart Axel | Verfahren und test-kit zur semiquantitativen bestimmung des kalziumgehaltes im blut. |
| US5691160A (en) * | 1992-08-14 | 1997-11-25 | Biogen, Inc. | Effects of actin filaments of fibrin clot structure and lysis |
| EP0587398B1 (en) * | 1992-09-09 | 1998-01-14 | Tokuyama Corporation | Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof |
| JP3292760B2 (ja) * | 1993-04-22 | 2002-06-17 | テルモ株式会社 | 採血管およびその製造方法 |
| US5670329A (en) * | 1993-05-28 | 1997-09-23 | Cardiovascular Diagnostics, Inc. | Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field |
| WO1995015397A1 (en) | 1993-12-03 | 1995-06-08 | Dorn Gordon L | Method for improving quantitative recovery of microorganisms fro m specimens containing blood components |
| DE19602673A1 (de) * | 1996-01-25 | 1997-08-07 | Pereg Gmbh | Synthetische Testanschmutzung |
| US6121232A (en) * | 1997-01-31 | 2000-09-19 | Omrix Biopharmaceuticals Sa | Stabilized mixture comprising fibrinogen |
| US6680195B1 (en) * | 1997-11-26 | 2004-01-20 | Inhibitex, Inc. | Extracellular matrix-binding proteins from staphylococcus aureus |
| JP2000262499A (ja) * | 2000-01-01 | 2000-09-26 | Terumo Corp | 採血管 |
| US6686204B2 (en) * | 2001-08-27 | 2004-02-03 | Becton, Dickinson & Company | Collection device |
| CN1606447A (zh) * | 2001-10-03 | 2005-04-13 | 克里斯托弗·J·伍尔弗顿 | 保存稳定的纤维蛋白原溶液 |
| DK1504269T3 (da) * | 2002-05-01 | 2007-12-03 | Synapse Bv | Diagnostisk test til bestemmelse af koncentrationen af forbigående proteolytisk aktivitet i sammensatte biologiske medier |
| ES2266374T3 (es) | 2002-09-18 | 2007-03-01 | Sirs-Lab Gmbh | Procedimiento para la deteccion de adn procariotico. |
| SI1654387T1 (sl) * | 2003-08-15 | 2009-10-31 | Univ South Florida | Materiali in postopki za ujetje patogenov in odstranitev avrintrikarboksilne kisline iz vzorca |
| US20050065454A1 (en) * | 2003-09-22 | 2005-03-24 | Becton, Dickinson And Company | Non-evacuated blood collection tube |
| US7399609B2 (en) * | 2003-12-30 | 2008-07-15 | 3M Innovative Properties Company | Staphylococcus detection |
| US8419722B2 (en) * | 2004-10-29 | 2013-04-16 | Spinal Restoration, Inc. | Apparatus and method for injection of fibrin sealant in spinal applications |
| DE102005009479A1 (de) | 2005-03-02 | 2006-09-07 | Molzym Gmbh & Co. Kg | Verwendung von Nukleasen zum Abbau von Nukleinsäure in Gegenwart von chaotropen Agenzien und/oder Tensiden |
| WO2007015782A1 (en) * | 2005-07-29 | 2007-02-08 | Ecole Polytechnique Federale De Lausanne | Molecular variant fibrinogen fusion proteins |
| KR20100017576A (ko) * | 2007-05-03 | 2010-02-16 | 아큐메트릭스, 인크. | 트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법 |
| ES2531455T3 (es) | 2007-08-02 | 2015-03-16 | UNIVERSITé LAVAL | Concentración y enriquecimiento de células microbianas y ácidos nucleicos microbianos a partir de fluidos corporales |
| JP5029217B2 (ja) * | 2007-08-27 | 2012-09-19 | 東レ株式会社 | シート状物の製造方法 |
| PL2310411T3 (pl) * | 2008-07-09 | 2017-02-28 | Profibrix Bv | Rekombinowany fibrynogen |
| US9353160B2 (en) | 2009-07-16 | 2016-05-31 | Glaxosmithkline Biologicals S.A. | Method of prophlactically treating infection using a recombinant fibrinogen binding protein clumping factor A (ClfA) or fragment thereof |
| ES2571127T3 (es) | 2010-09-15 | 2016-05-24 | Debiopharm Int Sa | Método para la separación de moléculas o partículas objetivo a partir de muestras que contienen fibrinógeno, incluyendo componentes sanguíneos |
-
2011
- 2011-09-15 ES ES11788227T patent/ES2571127T3/es active Active
- 2011-09-15 CN CN201180044211.XA patent/CN103108959B/zh active Active
- 2011-09-15 JP JP2013528815A patent/JP5999776B2/ja active Active
- 2011-09-15 AU AU2011303467A patent/AU2011303467C1/en active Active
- 2011-09-15 DK DK11788227.4T patent/DK2616550T3/en active
- 2011-09-15 US US13/822,209 patent/US9689881B2/en active Active
- 2011-09-15 KR KR1020137009329A patent/KR101948944B1/ko active Active
- 2011-09-15 EP EP11788227.4A patent/EP2616550B1/en active Active
- 2011-09-15 ES ES16154770T patent/ES2751660T3/es active Active
- 2011-09-15 LT LT16154770T patent/LT3067431T/lt unknown
- 2011-09-15 DK DK16154770.8T patent/DK3067431T3/da active
- 2011-09-15 WO PCT/IB2011/054035 patent/WO2012035508A2/en not_active Ceased
- 2011-09-15 CA CA2811493A patent/CA2811493C/en active Active
- 2011-09-15 PT PT161547708T patent/PT3067431T/pt unknown
- 2011-09-15 CN CN201710338814.XA patent/CN107389932B/zh active Active
- 2011-09-15 SI SI201131797T patent/SI3067431T1/sl unknown
- 2011-09-15 PL PL16154770T patent/PL3067431T3/pl unknown
- 2011-09-15 HU HUE16154770A patent/HUE045771T2/hu unknown
- 2011-09-15 HU HUE11788227A patent/HUE028915T2/en unknown
- 2011-09-15 PL PL11788227T patent/PL2616550T3/pl unknown
- 2011-09-15 EP EP16154770.8A patent/EP3067431B1/en active Active
-
2016
- 2016-12-02 AU AU2016266066A patent/AU2016266066B2/en active Active
-
2017
- 2017-05-22 US US15/601,677 patent/US20170336424A1/en not_active Abandoned
-
2019
- 2019-10-02 HR HRP20191785TT patent/HRP20191785T1/hr unknown
- 2019-10-11 CY CY20191101074T patent/CY1122166T1/el unknown
-
2021
- 2021-01-28 US US17/160,814 patent/US20210148940A1/en not_active Abandoned
-
2023
- 2023-08-09 US US18/231,880 patent/US20240280593A1/en not_active Abandoned
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