ES2570665T3 - Factor de permisividad celular para virus, y usos del mismo - Google Patents
Factor de permisividad celular para virus, y usos del mismoInfo
- Publication number
- ES2570665T3 ES2570665T3 ES12178283T ES12178283T ES2570665T3 ES 2570665 T3 ES2570665 T3 ES 2570665T3 ES 12178283 T ES12178283 T ES 12178283T ES 12178283 T ES12178283 T ES 12178283T ES 2570665 T3 ES2570665 T3 ES 2570665T3
- Authority
- ES
- Spain
- Prior art keywords
- viruses
- factor
- polypeptide
- permissiveness
- cellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700605 Viruses Species 0.000 title 1
- 230000001413 cellular effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0688—Cells from the lungs or the respiratory tract
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/12011—Asfarviridae
- C12N2710/12051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un procedimiento in vitro para facilitar la infección de una célula de vertebrado por el VSRRP que comprende la etapa de (a) dirigir la expresión aumentada de un polipéptido de CD163 por dicha célula de vertebrado en el que dicho polipéptido de CD163 comprende un dominio transmembrana y dicho polipéptido de CD163 tiene (i) una identidad de al menos el 70 % con la SEQ ID NO: 2 o (ii) una identidad de al menos el 99 % con un polipéptido expuesto en la SEQ ID NO: 14 y en el que dicha expresión aumentada se logra mediante la introducción de ácido nucleico exógeno.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56521404P | 2004-04-23 | 2004-04-23 | |
| US63473604P | 2004-12-09 | 2004-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2570665T3 true ES2570665T3 (es) | 2016-05-19 |
Family
ID=35320736
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05736317T Expired - Lifetime ES2530694T3 (es) | 2004-04-23 | 2005-04-05 | Factor de permisividad celular para virus, y usos del mismo |
| ES12178283T Expired - Lifetime ES2570665T3 (es) | 2004-04-23 | 2005-04-05 | Factor de permisividad celular para virus, y usos del mismo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05736317T Expired - Lifetime ES2530694T3 (es) | 2004-04-23 | 2005-04-05 | Factor de permisividad celular para virus, y usos del mismo |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US7754464B2 (es) |
| EP (2) | EP2520310B1 (es) |
| JP (2) | JP5273642B2 (es) |
| CN (1) | CN102220289B (es) |
| AR (3) | AR049033A1 (es) |
| AU (2) | AU2005240002B2 (es) |
| BR (1) | BRPI0508928B1 (es) |
| CA (1) | CA2564769C (es) |
| CL (1) | CL2008002323A1 (es) |
| DK (1) | DK1742658T3 (es) |
| EA (1) | EA013071B1 (es) |
| ES (2) | ES2530694T3 (es) |
| HK (1) | HK1109065A1 (es) |
| IL (1) | IL178160A0 (es) |
| MA (1) | MA28544B1 (es) |
| MX (1) | MXPA06012216A (es) |
| NO (1) | NO341211B1 (es) |
| NZ (1) | NZ550145A (es) |
| PL (1) | PL1742658T3 (es) |
| TW (2) | TWI354025B (es) |
| UY (1) | UY28867A1 (es) |
| WO (1) | WO2005107796A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1742658T3 (pl) * | 2004-04-23 | 2015-05-29 | Zoetis Services Llc | Czynnik permisywności komórkowej wobec wirusów i jego zastosowania |
| DK2106440T3 (en) | 2007-01-12 | 2015-12-14 | Univ Illinois | NON-SIMIANCES FOR CULTIVATING PORCINT REPRODUCTION AND RESPIRATION SYNDROME (PRRS) VIRUS |
| US8420373B2 (en) * | 2007-07-27 | 2013-04-16 | Universiteit Gent | Permissive cells and uses thereof |
| UA108902C2 (uk) * | 2010-11-10 | 2015-06-25 | Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування | |
| MX2014013964A (es) | 2012-05-17 | 2015-03-04 | Zoetis Llc | Vacunacion eficaz contral el virus del sindrome reproductivo y respiratorio porcino (prrs) antes del destete. |
| CN103525766B (zh) * | 2013-03-24 | 2015-06-17 | 西北农林科技大学 | 一种猪肾细胞系及其应用 |
| GB201313235D0 (en) | 2013-07-24 | 2013-09-04 | Univ Edinburgh | Antiviral Compositions Methods and Animals |
| CN104459160A (zh) * | 2014-12-30 | 2015-03-25 | 洛阳普莱柯万泰生物技术有限公司 | 试剂盒及其制备方法和使用方法 |
| GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| UA124976C2 (uk) * | 2016-12-14 | 2021-12-22 | Зоетіс Сервісіз Ллс | Вакцина для захисту тварини свині від зараження вірусом prrs |
| CN108103099B (zh) * | 2017-12-18 | 2022-03-04 | 中山大学 | 一种抗蓝耳病Marc-145细胞系及其制备方法和应用 |
| CN108893450B (zh) * | 2018-08-13 | 2022-04-19 | 江苏省农业科学院 | 先天性免疫系统重构的bhk21细胞群及其细胞克隆增毒应用 |
| CN111996213A (zh) * | 2020-02-06 | 2020-11-27 | 广西大学 | 猪繁殖与呼吸综合征病毒双荧光标记基因重组毒株的构建方法 |
| KR102254246B1 (ko) * | 2020-03-23 | 2021-05-20 | 큐벳 주식회사 | 항-cd163 항체 또는 이의 항원 결합 단편을 인코딩하는 핵산 분자 및 이를 포함하는 아데노바이러스 벡터, 및 이의 아프리카 돼지열병의 예방 또는 치료용도 |
| US11796548B2 (en) * | 2020-04-22 | 2023-10-24 | The United States Of America, As Represented By The Secretary Of Agriculture | Continuous stable cell line for identification of infectious African swine fever virus in clinical samples |
| WO2024123640A1 (en) | 2022-12-06 | 2024-06-13 | Zoetis Services Llc | Methods and compositions for vaccinating piglets against prrs-1 virus |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622871A (en) | 1987-04-27 | 1997-04-22 | Unilever Patent Holdings B.V. | Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| CA1303983C (en) | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| US5118937A (en) | 1989-08-22 | 1992-06-02 | Finnigan Mat Gmbh | Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules |
| RU2128227C1 (ru) | 1989-12-22 | 1999-03-27 | Апплайд Резеч Системз АРС Холдинг Н.В. (NL) (Антильские острова) | Способ активации транскрипционно-молчащего гена |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| AU664847B2 (en) | 1991-05-15 | 1995-12-07 | Cell Genesys, Inc. | Genomic modifications with homologous DNA targeting |
| US5846805A (en) | 1991-08-26 | 1998-12-08 | Boehringer Ingelheim Animal Health, Inc. | Culture of swine infertility and respiratory syndrome virus in simian cells |
| US5514545A (en) | 1992-06-11 | 1996-05-07 | Trustees Of The University Of Pennsylvania | Method for characterizing single cells based on RNA amplification for diagnostics and therapeutics |
| TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| WO1994028418A1 (en) | 1993-05-28 | 1994-12-08 | Baylor College Of Medicine | Method and apparatus for desorption and ionization of analytes |
| DK0676467T3 (da) * | 1994-04-11 | 2002-01-21 | Akzo Nobel Nv | Europæiske vaccinestammer af det porcine reproduktive respiratoriske syndromvirus (PRRSV) |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| WO1998035023A1 (en) * | 1997-02-07 | 1998-08-13 | Origen, Inc. | Method for growing porcine reproductive and respiratory syndrome virus for use as vaccines and diagnostic assays |
| US6740490B2 (en) | 2001-01-29 | 2004-05-25 | Kansas State University Research Foundation | Identification and applications of porcine reproductive and respiratory syndrome virus host susceptibility factor(s) for improved swine breeding |
| EP1414984B1 (en) | 2001-07-24 | 2018-07-04 | Universiteit Gent | Nucleic acid encoding polypeptide involved in cellular entrance of the prrs virus |
| AU2003243058A1 (en) * | 2002-05-27 | 2003-12-12 | Bioceros B.V. | Methods for using the cd163 pathway for modulating an immune response |
| PL1742658T3 (pl) * | 2004-04-23 | 2015-05-29 | Zoetis Services Llc | Czynnik permisywności komórkowej wobec wirusów i jego zastosowania |
-
2005
- 2005-04-05 PL PL05736317T patent/PL1742658T3/pl unknown
- 2005-04-05 BR BRPI0508928A patent/BRPI0508928B1/pt active IP Right Grant
- 2005-04-05 ES ES05736317T patent/ES2530694T3/es not_active Expired - Lifetime
- 2005-04-05 AU AU2005240002A patent/AU2005240002B2/en active Active
- 2005-04-05 CA CA2564769A patent/CA2564769C/en not_active Expired - Lifetime
- 2005-04-05 NZ NZ550145A patent/NZ550145A/en unknown
- 2005-04-05 EP EP12178283.3A patent/EP2520310B1/en not_active Expired - Lifetime
- 2005-04-05 EA EA200601677A patent/EA013071B1/ru not_active IP Right Cessation
- 2005-04-05 WO PCT/US2005/011502 patent/WO2005107796A2/en active Application Filing
- 2005-04-05 DK DK05736317T patent/DK1742658T3/en active
- 2005-04-05 CN CN201110127305.5A patent/CN102220289B/zh not_active Expired - Lifetime
- 2005-04-05 ES ES12178283T patent/ES2570665T3/es not_active Expired - Lifetime
- 2005-04-05 EP EP05736317.8A patent/EP1742658B1/en not_active Expired - Lifetime
- 2005-04-05 JP JP2007509491A patent/JP5273642B2/ja not_active Expired - Lifetime
- 2005-04-05 MX MXPA06012216A patent/MXPA06012216A/es active IP Right Grant
- 2005-04-20 TW TW94112572A patent/TWI354025B/zh active
- 2005-04-20 TW TW100121989A patent/TWI438278B/zh active
- 2005-04-22 AR ARP050101615 patent/AR049033A1/es active IP Right Grant
- 2005-04-22 UY UY28867A patent/UY28867A1/es not_active Application Discontinuation
- 2005-04-25 US US11/113,751 patent/US7754464B2/en active Active
-
2006
- 2006-09-18 IL IL178160A patent/IL178160A0/en unknown
- 2006-10-20 MA MA29400A patent/MA28544B1/fr unknown
- 2006-11-06 NO NO20065115A patent/NO341211B1/no unknown
-
2007
- 2007-12-31 HK HK07114307A patent/HK1109065A1/xx unknown
-
2008
- 2008-08-07 CL CL2008002323A patent/CL2008002323A1/es unknown
-
2009
- 2009-06-16 AU AU2009202410A patent/AU2009202410A1/en not_active Abandoned
-
2010
- 2010-05-06 US US12/775,283 patent/US8058050B2/en active Active
-
2011
- 2011-09-29 US US13/248,537 patent/US8486685B2/en active Active
- 2011-12-21 AR ARP110104870 patent/AR084529A2/es unknown
- 2011-12-21 AR ARP110104871 patent/AR084530A2/es unknown
-
2012
- 2012-11-22 JP JP2012256338A patent/JP5600340B2/ja not_active Expired - Lifetime
-
2013
- 2013-07-12 US US13/940,317 patent/US9102912B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2570665T3 (es) | Factor de permisividad celular para virus, y usos del mismo | |
| BRPI0516221A (pt) | método de produção de vìrus de uma cultura de células, composição, e, método de produção de reovìrus infeccioso | |
| CL2008003794A1 (es) | Virus de la estomatitis vesicular geneticamente modificado (vsv) que comprende por lo menos una mutacion de aminoacido en una region de alguna de las proteinas m, g y l del virus; metodo para producirlo; composicion inmunogenica que lo comprende; metodo para adaptar un virus en un cultivo celular. | |
| PL1685243T3 (pl) | Unieśmiertelnione ptasie linie komórkowe do wytwarzania wirusów | |
| PE20091218A1 (es) | Anticuerpo anti-glipicano 3 con cinetica en plasma mejorada | |
| ES2622087T3 (es) | Vacuna recombinante contra paramyxovirus aviar y procedimiento de fabricación y utilización de la misma | |
| ES2692918T3 (es) | Métodos y composiciones para producir aldehídos grasos | |
| EA200801756A1 (ru) | Противогриппозные вакцины, содержащие гемагглютинин и белки матрикса | |
| BR0309659A (pt) | Método para produzir vìrus de uma cultura de células, composição, e, método para produzir reovìrus infeccioso | |
| CO6141479A2 (es) | Proceso para producir poxvirus y composiciones de poxvirus | |
| DE50214416D1 (de) | Vermehrung von viren in zellkultur | |
| ATE407138T1 (de) | Verfahren zur herstellung interferierender rna- moleküle in säugetierzellen und therapeutische anwendungen solcher moleküle | |
| AR039465A1 (es) | Sistema multi plasmid para la produccion de virus influenza | |
| PE20110310A1 (es) | Axmi-115, axmi-113, axmi-005, axmi-163 y axmi-184: proteinas insecticidas | |
| PA8813901A1 (es) | Paramixovirus oncolíticos atenuados que codifican citoquinas de aves | |
| DE502006008908D1 (de) | Verwendung von genaktivitäts-klassifikatoren für die in vitro klassifizierung von genexpressionsprofilen von patienten mit infektiösem/nichtinfektiösem multiorganversagen | |
| AR085167A1 (es) | Polipeptidos de porphyromonas gingivalis, metodo de tratamiento, uso, anticuerpo y kit | |
| BRPI0313559B8 (pt) | método para o cultivo de células primárias e para a amplificação de vírus sob condições isentas de soro | |
| AR060827A1 (es) | Metodo para bloquear la infeccion por flavivirus, moleculas y usos | |
| ES2531115T3 (es) | Combinaciones de clados de RrgB neumocócicos | |
| CL2008003821A1 (es) | Metodo para producir el virus de la estomatitis vesicular (vsv) atenuado en celulas, que comprende: a) proporcionar una celula que comprende un gen g vsv optimizado e inducible, b) inducir la celula a expresar dicho gen, c) infectar la celula con un vsv atenuado, d) hacer crecer dichas celulas, y e) recuperar el vsv atenuado | |
| BRPI0511802A (pt) | processo para criação de meios para uso em separadores de ar/óleo | |
| BRPI0914805B8 (pt) | método para replicar vírus em uma cultura de células scldk, processo para adaptar células cldk dependentes do substrato para desenvolvimento em suspensão, método para propagar continuamente células scldk em suspensão, e, composição | |
| EP4410970A3 (en) | Efficient cell culture system for hepatitis c virus genotype 6a | |
| ES2673972T3 (es) | Formas solubles de la glicoproteína G de los virus hendra y nipah |