ES255872A1 - Method and composition for coating tablets - Google Patents

Abstract

A coated solid medicament has the coating material in the form of a film of a physiologically acceptable composition consisting essentially of the water permeable combination of a water-soluble or water-dispersible wax (A) and a cellulose ester of a 2 to 4 carbon aliphatic monocarboxylic acid (B). Typical cellulose esters are cellulose acetate, cellulose propionate and cellulose butyrate. The waxes are polyethylene glycols of melting point of at least 50 DEG C., glyceryl monostearate and diglycol stearate. Optional ingredients are (a) dyes, lakes and pigments, (b) water-insoluble glossing and polishing agents such as beeswax, lanolin, stearic acid, cocoa butter and cetyl alcohol (C), (c) plasticizers such as castor oil, mineral oil, corn oil, sesame oil and propylene glycol, alone or in admixture with a drying oil such as soybeam oil (D), (d) surface-active agents such as polyoxyethylene sorbitan derivatives and sulphated fatty alcohols. The compositions contain 14 to 20 grms. of (A), 2 to 10 grms. of (B), not more than 1 grm. of (C), and not more than 2 grms. of (D) per 100 ml. of the fluid composition, which is prepared by dissolving the components in a non-aqueous solvent such as acetone, ethanol, a mixture thereof, or methyl ethyl ketone. The finished coat comprises 60 to 91% of (A) and 9 to 40% of (B) with the rest not exceeding 5%. Specification 764,342 is referred to.