GB760403A - Improvements in or relating to enteric coatings - Google Patents
Improvements in or relating to enteric coatingsInfo
- Publication number
- GB760403A GB760403A GB28392/53A GB2839253A GB760403A GB 760403 A GB760403 A GB 760403A GB 28392/53 A GB28392/53 A GB 28392/53A GB 2839253 A GB2839253 A GB 2839253A GB 760403 A GB760403 A GB 760403A
- Authority
- GB
- United Kingdom
- Prior art keywords
- film
- forming substance
- cellulose
- phthalate
- propylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002702 enteric coating Substances 0.000 title abstract 2
- 238000009505 enteric coating Methods 0.000 title abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 12
- 239000000126 substance Substances 0.000 abstract 8
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 6
- -1 dicarboxylic acid ester Chemical class 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 5
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 abstract 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 4
- 229920000623 Cellulose acetate phthalate Polymers 0.000 abstract 4
- 229940081734 cellulose acetate phthalate Drugs 0.000 abstract 4
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 4
- 239000011707 mineral Substances 0.000 abstract 4
- 235000010755 mineral Nutrition 0.000 abstract 4
- 239000007787 solid Substances 0.000 abstract 4
- 239000001593 sorbitan monooleate Substances 0.000 abstract 4
- 229940035049 sorbitan monooleate Drugs 0.000 abstract 4
- 235000011069 sorbitan monooleate Nutrition 0.000 abstract 4
- 239000000454 talc Substances 0.000 abstract 4
- 229910052623 talc Inorganic materials 0.000 abstract 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 abstract 4
- 229960003276 erythromycin Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 2
- DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000005909 Kieselgur Substances 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 abstract 2
- 230000032683 aging Effects 0.000 abstract 2
- 239000000440 bentonite Substances 0.000 abstract 2
- 229910000278 bentonite Inorganic materials 0.000 abstract 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 abstract 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 229940105847 calamine Drugs 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229920002678 cellulose Polymers 0.000 abstract 2
- 239000001913 cellulose Substances 0.000 abstract 2
- 229920003086 cellulose ether Polymers 0.000 abstract 2
- 229920006218 cellulose propionate Polymers 0.000 abstract 2
- 238000005336 cracking Methods 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 239000001087 glyceryl triacetate Substances 0.000 abstract 2
- 235000013773 glyceryl triacetate Nutrition 0.000 abstract 2
- 229910052864 hemimorphite Inorganic materials 0.000 abstract 2
- 239000000787 lecithin Substances 0.000 abstract 2
- 229940067606 lecithin Drugs 0.000 abstract 2
- 235000010445 lecithin Nutrition 0.000 abstract 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 abstract 2
- 239000004014 plasticizer Substances 0.000 abstract 2
- 239000008262 pumice Substances 0.000 abstract 2
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 229960002622 triacetin Drugs 0.000 abstract 2
- YZWRNSARCRTXDS-UHFFFAOYSA-N tripropionin Chemical compound CCC(=O)OCC(OC(=O)CC)COC(=O)CC YZWRNSARCRTXDS-UHFFFAOYSA-N 0.000 abstract 2
- 239000011787 zinc oxide Substances 0.000 abstract 2
- 235000014692 zinc oxide Nutrition 0.000 abstract 2
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 abstract 2
- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 abstract 1
- 235000007173 Abies balsamea Nutrition 0.000 abstract 1
- 239000004857 Balsam Substances 0.000 abstract 1
- 244000018716 Impatiens biflora Species 0.000 abstract 1
- 229920001800 Shellac Polymers 0.000 abstract 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 abstract 1
- 229920002494 Zein Polymers 0.000 abstract 1
- 229940023020 acriflavine Drugs 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 235000019270 ammonium chloride Nutrition 0.000 abstract 1
- 229960001040 ammonium chloride Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000003556 anti-epileptic effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 229940125717 barbiturate Drugs 0.000 abstract 1
- 239000008199 coating composition Substances 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 239000011790 ferrous sulphate Substances 0.000 abstract 1
- 235000003891 ferrous sulphate Nutrition 0.000 abstract 1
- 229960001235 gentian violet Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920002689 polyvinyl acetate Polymers 0.000 abstract 1
- 239000011118 polyvinyl acetate Substances 0.000 abstract 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 abstract 1
- 239000004208 shellac Substances 0.000 abstract 1
- 229940113147 shellac Drugs 0.000 abstract 1
- 235000013874 shellac Nutrition 0.000 abstract 1
- 229960004025 sodium salicylate Drugs 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
- 239000005019 zein Substances 0.000 abstract 1
- 229940093612 zein Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A coating composition for medicaments (see Group VI) comprises a film-forming substance having uniformly dispersed therein a finely-divided mineral solid which is inert to the film-forming substance and which is present in amount sufficient to prevent the film from cracking and crazing upon ageing, i.e. 10-150 per cent by weight based on the weight of the film-forming substance. The film-forming substance may be a dicarboxylic acid ester of cellulose containing free carboxyl groups such as cellulose acetate phthalate and cellulose propionate phthalate, or a cellulose ether. Specified mineral solids include talc, fuller's earth, diatomaceous earth, calamine, bentonite, pumice and insoluble sodium metaphosphate. Plasticizers, such as propylene glycol, triacetin, tripropionin, ethyl acid adipate and butyl acid phthalate, and edible surface-active agents, such as lecithin and sorbitan monooleate, may also be present. In an example erythromycin tablets are coated with a composition comprising cellulose acetate phthalate. talc, anhydrous alcohol, anhydrous acetone, propylene glycol and sorbitan monooleate, Specification 526,276,[Group IV], is referred to.ALSO:An enteric coating composition comprises an enteric film-forming substance having uniformly dispersed therein a finely divided mineral solid which is inert to the film-forming substance and which is present in an amount sufficient to prevent the film from cracking and crazing upon ageing, i.e. 10-150 per cent by weight based on the weight of the film-forming substance. The film-forming substance may be a dicarboxylic acid ester of cellulose containing free carboxyl groups such as cellulose acetate phthalate and cellulose propionate phthalate, polyvinyl acetate, polyvinylphthalate, a cellulose ether, a copolymer of an aliphatic dibasic unsaturated acid and a vinyl compound, shellac, zein, balsam tolu or a higher fatty acid. Specified mineral solids include talc, fuller's earth, diatomaceous earth, calamine, bentonite, pumice and insoluble sodium metaphosphate. Plasticizers, such as propylene glycol, triacetin, tripropionin, ethyl acid adipate and butyl acid phthalate and edible surface active agents such as lecithin and sorbitan monooleate may also be present. Medicaments which may be coated include antibiotics such as erythromycin, ammonium chloride, sodium salicylate, diethylstilboestrol, gentian violet, barbiturates; anti-epileptics, acriflavine and ferrous sulphate. These materials may be coated by known methods. In an example erythromycin tablets are coated with a composition comprising cellulose acetate phthalate, talc, anhydrous alcohol anhydrous acetone, propylene glycol and sorbitan mono-oleate. Specification 526,276 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US760403XA | 1952-10-16 | 1952-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB760403A true GB760403A (en) | 1956-10-31 |
Family
ID=22129569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28392/53A Expired GB760403A (en) | 1952-10-16 | 1953-10-14 | Improvements in or relating to enteric coatings |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1043588B (en) |
| GB (1) | GB760403A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2992166A (en) * | 1957-11-05 | 1961-07-11 | Cilag Chemie | Diagnostic composition |
| US3080251A (en) * | 1958-03-13 | 1963-03-05 | Xerox Corp | Method of xerographic development |
| US3080250A (en) * | 1958-03-13 | 1963-03-05 | Xerox Corp | Self-tackifying xerographic toner |
| US3080318A (en) * | 1958-03-13 | 1963-03-05 | Xerox Corp | Three-component xerographic toner |
| US3265630A (en) * | 1958-12-22 | 1966-08-09 | Ncr Co | Encapsulating lipophilic material by coacervation |
| US3317394A (en) * | 1955-12-22 | 1967-05-02 | Haessle Ab | Medicinal tablet and a method for its preparation |
| EP0247983A3 (en) * | 1986-04-30 | 1988-10-19 | Aktiebolaget Hassle | New pharmaceutical preparation for oral use |
| EP0244380A3 (en) * | 1986-04-30 | 1988-10-19 | Aktiebolaget Hassle | Pharmaceutical formulations of acid labile substances for oral use |
| DE4100920A1 (en) * | 1991-01-15 | 1992-07-16 | Degussa | ACTIVE SUBSTANCE PREPARATION FOR ORAL ADMINISTRATION TO Ruminants |
| US5599556A (en) * | 1991-12-31 | 1997-02-04 | Abbott Laboratories | Prolamine coatings for taste masking |
| CN116570572A (en) * | 2023-05-23 | 2023-08-11 | 曲阜贝斯迪生物医药有限公司 | Gastric-soluble film coating premix and preparation method thereof |
-
1953
- 1953-10-14 GB GB28392/53A patent/GB760403A/en not_active Expired
- 1953-10-15 DE DEA18984A patent/DE1043588B/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3317394A (en) * | 1955-12-22 | 1967-05-02 | Haessle Ab | Medicinal tablet and a method for its preparation |
| US2992166A (en) * | 1957-11-05 | 1961-07-11 | Cilag Chemie | Diagnostic composition |
| US3080251A (en) * | 1958-03-13 | 1963-03-05 | Xerox Corp | Method of xerographic development |
| US3080250A (en) * | 1958-03-13 | 1963-03-05 | Xerox Corp | Self-tackifying xerographic toner |
| US3080318A (en) * | 1958-03-13 | 1963-03-05 | Xerox Corp | Three-component xerographic toner |
| US3265630A (en) * | 1958-12-22 | 1966-08-09 | Ncr Co | Encapsulating lipophilic material by coacervation |
| EP0567201A3 (en) * | 1986-04-30 | 1995-06-07 | Haessle Ab | Vehicle for oral administration of acid labile pharmaceuticals. |
| EP0244380A3 (en) * | 1986-04-30 | 1988-10-19 | Aktiebolaget Hassle | Pharmaceutical formulations of acid labile substances for oral use |
| EP0496437A3 (en) * | 1986-04-30 | 1992-09-02 | Aktiebolaget Haessle | Use of specific core material and layers to obtain pharmaceutical formulations stable to discolouration of omeprazole |
| EP0502556A1 (en) * | 1986-04-30 | 1992-09-09 | Aktiebolaget Hässle | Use of specific core material and layers to obtain pharmaceutical formulations stable to discolouration of acid labile compounds |
| EP0247983A3 (en) * | 1986-04-30 | 1988-10-19 | Aktiebolaget Hassle | New pharmaceutical preparation for oral use |
| EP0565210A3 (en) * | 1986-04-30 | 1995-06-07 | Haessle Ab | |
| DE4100920A1 (en) * | 1991-01-15 | 1992-07-16 | Degussa | ACTIVE SUBSTANCE PREPARATION FOR ORAL ADMINISTRATION TO Ruminants |
| US5279832A (en) * | 1991-01-15 | 1994-01-18 | Degussa Ag | Active-substance preparation for oral administration, especially to ruminants |
| US5599556A (en) * | 1991-12-31 | 1997-02-04 | Abbott Laboratories | Prolamine coatings for taste masking |
| US5609909A (en) * | 1991-12-31 | 1997-03-11 | Abbott Laboratories | Prolamine coatings for taste masking |
| CN116570572A (en) * | 2023-05-23 | 2023-08-11 | 曲阜贝斯迪生物医药有限公司 | Gastric-soluble film coating premix and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1043588B (en) | 1958-11-13 |
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