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ES2536198T3 - Sustancia proteínica que tiene estructura de hélice triple y método de producción de la misma - Google Patents

Sustancia proteínica que tiene estructura de hélice triple y método de producción de la misma Download PDF

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Publication number
ES2536198T3
ES2536198T3 ES09834882.4T ES09834882T ES2536198T3 ES 2536198 T3 ES2536198 T3 ES 2536198T3 ES 09834882 T ES09834882 T ES 09834882T ES 2536198 T3 ES2536198 T3 ES 2536198T3
Authority
ES
Spain
Prior art keywords
human
triple helix
helix structure
domain gene
production method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09834882.4T
Other languages
English (en)
Inventor
Yusuke Suzuki
Hiroshi Tahara
Keiichi Yamamoto
Yuzuru Kitahara
Yasuhiko Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
Fuso Pharmaceutical Industries Ltd
Original Assignee
Hokkaido University NUC
Fuso Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokkaido University NUC, Fuso Pharmaceutical Industries Ltd filed Critical Hokkaido University NUC
Application granted granted Critical
Publication of ES2536198T3 publication Critical patent/ES2536198T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Una proteína recombinante que tiene una estructura de hélice triple, que comprende una proteína codificada por un polinucleótido que comprende (i) a (v) a continuación en orden desde el terminal amino: (i) un gen de dominio de péptido de señalización de colectina humana; (ii) un gen de domino rico en cisteína de colectina humana; (iii) un gen de dominio de colágeno de colágeno humano; (iv) un gen de dominio de cuello de colectina humana; y (v) un gen de dominio de reconocimiento de carbohidratos de colectina humana.

Description

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Claims (1)

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ES09834882.4T 2008-12-22 2009-12-22 Sustancia proteínica que tiene estructura de hélice triple y método de producción de la misma Active ES2536198T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008325691 2008-12-22
JP2008325691 2008-12-22
PCT/JP2009/071327 WO2010074081A1 (ja) 2008-12-22 2009-12-22 三重螺旋構造を有するタンパク質、およびその製造方法

Publications (1)

Publication Number Publication Date
ES2536198T3 true ES2536198T3 (es) 2015-05-21

Family

ID=42287689

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09834882.4T Active ES2536198T3 (es) 2008-12-22 2009-12-22 Sustancia proteínica que tiene estructura de hélice triple y método de producción de la misma

Country Status (12)

Country Link
US (1) US8470555B2 (es)
EP (1) EP2380979B1 (es)
JP (1) JP5645187B2 (es)
KR (1) KR101686688B1 (es)
CN (2) CN106243229B (es)
AU (1) AU2009331327B2 (es)
CA (1) CA2748015C (es)
DK (1) DK2380979T3 (es)
ES (1) ES2536198T3 (es)
HK (1) HK1163153A1 (es)
PT (1) PT2380979E (es)
WO (1) WO2010074081A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102325881B (zh) 2008-12-22 2014-08-20 国立大学法人北海道大学 用于用动物细胞大量生产源自外源基因的蛋白质的表达载体及其应用
ES2678143T3 (es) 2010-01-19 2018-08-09 President And Fellows Of Harvard College Opsonina obtenida por ingeniería genética para la detección y el tratamiento de microorganismos patógenos
JP2014523914A (ja) 2011-07-18 2014-09-18 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 操作された微生物標的化分子およびその使用
CN102351954B (zh) * 2011-10-26 2013-12-18 陕西巨子生物技术有限公司 重组胶原蛋白
AU2014268603B2 (en) 2013-05-21 2018-03-22 President And Fellows Of Harvard College Engineered heme-binding compositions and uses thereof
CN108289928B (zh) * 2015-08-06 2024-09-17 哈佛大学校长及研究员协会 改进的微生物-结合分子和其用途
CA3012006A1 (en) * 2017-07-31 2019-01-31 Modern Meadow, Inc. Yeast strains and methods for controlling hydroxylation of recombinant collagen
KR20230104164A (ko) * 2020-10-08 2023-07-07 젤라텍, 인크. 동물 세포주 및/또는 조직 외식편으로부터 콜라겐 및/또는 젤라틴 생산, 단리 및/또는 추출
WO2025038705A1 (en) * 2023-08-14 2025-02-20 The Regents Of The University Of California Surfaces incorporating treated leaves for physical capture of arthropods

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8708009D0 (en) 1987-04-03 1987-05-07 Clayton Found Res Injectable soft tissue augmentation materials
WO1993007889A1 (en) 1991-10-23 1993-04-29 Thomas Jefferson University Synthesis of human procollagens and collagens in recombinant dna systems
US5428022A (en) 1992-07-29 1995-06-27 Collagen Corporation Composition of low type III content human placental collagen
GB9409768D0 (en) * 1994-05-16 1994-07-06 Medical Res Council Trimerising polypeptides
JPH0823979A (ja) 1994-07-15 1996-01-30 Terumo Corp ヒト・コラーゲン発現ベクターおよびヒト・コラーゲンの製造方法
CA2400143C (en) 1995-08-17 2009-05-12 Fuso Pharmaceutical Industries, Ltd. Recombinant conglutinin and producing method thereof
AU751173B2 (en) 1998-08-24 2002-08-08 Fuso Pharmaceutical Industries, Ltd. Novel collectin
JP2001316282A (ja) 2000-05-11 2001-11-13 Yoshihiko Shimizu 生理活性ペプチド含有コラーゲン成形体及びその製法
JP3603103B2 (ja) 2000-11-15 2004-12-22 独立行政法人農業・生物系特定産業技術研究機構 動物（但し、ヒトを除く。）の受精卵の共培養担体及びこの担体を用いる動物（但し、ヒトを除く。）の受精卵の培養方法
AU2002218154A1 (en) * 2000-11-27 2002-06-03 Jens Christian Jensenius Collectins as adjuvants
JP2002325584A (ja) 2000-11-30 2002-11-12 Japan Science & Technology Corp 組換えヒトｉｖ型コラーゲンペプチドとその製造方法
JP4701336B2 (ja) 2001-04-18 2011-06-15 独立行政法人農業生物資源研究所 ヒト・コラーゲンを産生する形質転換カイコ
CN1694961A (zh) 2002-09-10 2005-11-09 内蒂穆恩公司 胶原凝集素－补体激活蛋白嵌合体
JP4681214B2 (ja) 2003-06-10 2011-05-11 グンゼ株式会社 コラーゲンスポンジの製造方法及び人工皮膚の製造方法
JP2005014774A (ja) 2003-06-26 2005-01-20 Kubota Corp 作業車の車軸ケース支持構造
ES2387467T3 (es) * 2005-03-31 2012-09-24 Fuso Pharmaceutical Industries, Ltd. Procedimientos de producción de proteínas que tienen estructura helicoidal triple
GB2433029A (en) 2005-12-09 2007-06-13 Ethicon Inc Wound dressings comprising oxidized cellulose and human recombinant collagen
JP4677559B2 (ja) 2006-02-02 2011-04-27 財団法人ヒューマンサイエンス振興財団 任意の形状のビトリゲルと、当該ビトリゲルの製造方法
WO2007102200A1 (ja) 2006-03-07 2007-09-13 Osaka University 抗ｃｄ２０モノクローナル抗体
PT2258843T (pt) 2008-02-27 2017-02-07 Nat Univ Corp Hokkaido Univ Vetor de expressão para a produção em massa de uma proteína derivada de um gene estranho utilizando uma célula animal e sua utilização

Also Published As

Publication number Publication date
CN102325882A (zh) 2012-01-18
EP2380979A4 (en) 2012-07-25
EP2380979A1 (en) 2011-10-26
KR20110119650A (ko) 2011-11-02
PT2380979E (pt) 2015-06-26
DK2380979T3 (da) 2015-06-22
JP5645187B2 (ja) 2014-12-24
JPWO2010074081A1 (ja) 2012-06-21
AU2009331327A1 (en) 2011-07-14
AU2009331327B2 (en) 2014-04-24
CN106243229A (zh) 2016-12-21
CA2748015C (en) 2017-02-28
CA2748015A1 (en) 2010-07-01
CN106243229B (zh) 2019-09-06
HK1163153A1 (en) 2012-09-07
KR101686688B1 (ko) 2016-12-14
US8470555B2 (en) 2013-06-25
WO2010074081A1 (ja) 2010-07-01
EP2380979B1 (en) 2015-04-15
AU2009331327A8 (en) 2011-07-28
US20120059152A1 (en) 2012-03-08

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