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ES2499067T3 - Preparación transdérmica de nicotina y método de producción de la misma - Google Patents

Preparación transdérmica de nicotina y método de producción de la misma Download PDF

Info

Publication number
ES2499067T3
ES2499067T3 ES06255234.4T ES06255234T ES2499067T3 ES 2499067 T3 ES2499067 T3 ES 2499067T3 ES 06255234 T ES06255234 T ES 06255234T ES 2499067 T3 ES2499067 T3 ES 2499067T3
Authority
ES
Spain
Prior art keywords
adhesive layer
nicotine
monomer
monomers containing
main component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06255234.4T
Other languages
English (en)
Inventor
Shiro Satoda
Kazuhisa Ninomiya
Junichi Saito
Kensuke Matsuoka
Shunetsu Kikuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Corp
Original Assignee
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko Corp filed Critical Nitto Denko Corp
Application granted granted Critical
Publication of ES2499067T3 publication Critical patent/ES2499067T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una preparación transdérmica de nicotina que comprende un soporte y una capa adhesiva formada sobre él, cuya capa adhesiva comprende nicotina y un ingrediente líquido compatible con el adhesivo, en donde un ángulo de contacto de nicotina con la capa adhesiva antes de que contenga la nicotina es 20-60°, la capa adhesiva es una capa adhesiva de tipo acrílico que comprende un componente principal que es éster alquílico del ácido (met)acrílico y que comprende un monómero secundario y un monómero terciario ambos copolimerizados con dicho componente principal, siendo dicho monómero secundario un monómero capaz de estar involucrado en una reacción de reticulación, comprendiendo dicho monómero terciario uno o más tipos de componentes monómeros seleccionados del grupo constituido por ésteres vinílicos, éteres vinílicos, amidas vinílicas, monómeros que contienen grupos hidroxi, monómeros que contienen grupos amido, monómeros que contienen grupos alcoxi, y monómeros vinílicos, y siendo dicho ingrediente líquido palmitato de isopropilo contenido en una proporción de 30-60 % en peso respecto al peso total de la capa adhesiva antes de que contenga nicotina, en donde la capa adhesiva tiene un espesor de 80- 120 μm.
ES06255234.4T 2005-10-13 2006-10-11 Preparación transdérmica de nicotina y método de producción de la misma Active ES2499067T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005299203 2005-10-13
JP2005299203 2005-10-13

Publications (1)

Publication Number Publication Date
ES2499067T3 true ES2499067T3 (es) 2014-09-26

Family

ID=37708220

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06255234.4T Active ES2499067T3 (es) 2005-10-13 2006-10-11 Preparación transdérmica de nicotina y método de producción de la misma

Country Status (9)

Country Link
US (1) US8506991B2 (es)
EP (1) EP1774964B1 (es)
KR (1) KR101317053B1 (es)
CN (1) CN1951375B (es)
CA (1) CA2563496C (es)
ES (1) ES2499067T3 (es)
IL (1) IL178537A0 (es)
RU (1) RU2407516C2 (es)
TW (1) TWI383794B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL177071A0 (en) * 2005-08-01 2006-12-10 Nitto Denko Corp Method of preparing a nicotine transdermal preparation
JP4327841B2 (ja) 2006-12-20 2009-09-09 日東電工株式会社 経皮吸収製剤の製造装置および製造方法
JP5725940B2 (ja) * 2011-04-01 2015-05-27 日東電工株式会社 ニコチン含有貼付製剤
KR101883410B1 (ko) * 2011-04-22 2018-07-30 아이큐어 주식회사 경피 흡수 제제 및 그 제조방법
RU2572720C1 (ru) * 2014-07-29 2016-01-20 Дмитрий Евгеньевич Денисов Комплексное антиникотиновое средство
CN112618617A (zh) * 2021-01-05 2021-04-09 鹤壁市星银凯丰科技有限公司 一种含咖啡粉贴剂及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687481A (en) 1984-10-01 1987-08-18 Biotek, Inc. Transdermal drug delivery system
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US6139868A (en) 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
DE3629304A1 (de) 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
IL86170A (en) 1987-05-01 1992-12-01 Elan Transdermal Ltd Preparations and compositions comprising nicotine for percutaneous administration
US4915950A (en) 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US5474783A (en) 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5508038A (en) 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
US5202125A (en) * 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
TW221970B (es) * 1991-06-26 1994-04-01 Tbs Lab Inc
JPH08502727A (ja) 1992-08-25 1996-03-26 シグナス セラピューティック システムズ プリントされた経皮薬剤送達デバイス
CA2183083C (en) 1994-03-07 2006-01-03 Charles D. Ebert Drug-containing adhesive composite transdermal delivery device
DE69517816T2 (de) 1994-09-14 2000-12-28 Minnesota Mining & Mfg Matrix für transdermale wirkstofffreisetzung
KR0159145B1 (ko) 1995-02-24 1998-12-01 강박광 피부 약물 전달 체계용 에멀젼 네트웍의 제조방법
US5688523A (en) * 1995-03-31 1997-11-18 Minnesota Mining And Manufacturing Company Method of making a pressure sensitive skin adhesive sheet material
US7150881B2 (en) * 1997-06-26 2006-12-19 Mylan Technologies, Inc. Adhesive mixture for transdermal delivery of highly plasticizing drugs
NZ525878A (en) 1998-12-07 2004-12-24 Elan Pharma Int Ltd A method of treating nicotine dependance with mecamylamine
BR9916214A (pt) 1998-12-18 2001-09-11 Alza Corp Dispositivos de distribuição de nicotina transdérmicos transparentes
NZ513808A (en) 1999-01-29 2001-09-28 Strakan Ltd Adhesives
DE19913732A1 (de) 1999-03-26 2000-09-28 Lohmann Therapie Syst Lts Nikotin-TTS mit einem Zusatz von Monoterpenketonen
DE10110391A1 (de) 2001-03-03 2002-09-26 Lohmann Therapie Syst Lts Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff
DE10121471A1 (de) * 2001-05-02 2002-11-07 Beiersdorf Ag Oberflächendotierte wirkstoffhaltige Pflaster
JP4777542B2 (ja) * 2001-06-19 2011-09-21 日東電工株式会社 貼付剤および貼付製剤、ならびにそれらの製造方法
EP1740162A4 (en) * 2004-04-29 2009-11-18 Caldwell Galer Inc TOPICAL METHADONE COMPOSITION AND METHOD FOR THEIR USE
JP5000932B2 (ja) 2005-06-21 2012-08-15 日東電工株式会社 ニコチン含有経皮吸収製剤
IL177071A0 (en) * 2005-08-01 2006-12-10 Nitto Denko Corp Method of preparing a nicotine transdermal preparation

Also Published As

Publication number Publication date
TWI383794B (zh) 2013-02-01
EP1774964B1 (en) 2014-08-06
RU2006136140A (ru) 2008-04-20
IL178537A0 (en) 2007-02-11
EP1774964A1 (en) 2007-04-18
US8506991B2 (en) 2013-08-13
KR20070041390A (ko) 2007-04-18
KR101317053B1 (ko) 2013-10-11
TW200800190A (en) 2008-01-01
CA2563496A1 (en) 2007-04-13
RU2407516C2 (ru) 2010-12-27
US20070087043A1 (en) 2007-04-19
CN1951375B (zh) 2010-11-03
CA2563496C (en) 2013-12-31
CN1951375A (zh) 2007-04-25

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