ES2340842T3 - Anticuerpos anti-apc no neutralizantes. - Google Patents
Anticuerpos anti-apc no neutralizantes. Download PDFInfo
- Publication number
- ES2340842T3 ES2340842T3 ES03741459T ES03741459T ES2340842T3 ES 2340842 T3 ES2340842 T3 ES 2340842T3 ES 03741459 T ES03741459 T ES 03741459T ES 03741459 T ES03741459 T ES 03741459T ES 2340842 T3 ES2340842 T3 ES 2340842T3
- Authority
- ES
- Spain
- Prior art keywords
- apc
- present
- antibodies
- activity
- inactivation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000694 effects Effects 0.000 abstract 3
- 230000002779 inactivation Effects 0.000 abstract 3
- 206010040047 Sepsis Diseases 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 2
- 101800004937 Protein C Proteins 0.000 abstract 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 1
- 101800001700 Saposin-D Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un anticuerpo contra la proteína C o la proteína C activada, que comprende regiones determinantes de la complementariedad que comprenden las secuencias de aminoácidos de: (a) SEQ ID NOs: 9, 10, 11 (VH), y SEQ ID NOs: 21, 22, 23 (VL), (b) SEQ ID NOs: 31, 32, 33 (VH), y SEQ ID NOs: 24, 25, 34 (VL), o (c) SEQ ID NOs: 15, 16, 17 (VH), y SEQ ID NOs: 27, 28, 29 (VL); en donde el anticuerpo comprende la actividad de (i) potenciar una actividad de la proteína C activada in vivo; (ii) suprimir la inactivación de la proteína C activada in vivo; o (iii) suprimir la inactivación de la proteína C activada, causada por (1) sangre; (2) un inhibidor fisiológico de la proteína C activada; o (3) tanto (1) como (2).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002212582 | 2002-07-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2340842T3 true ES2340842T3 (es) | 2010-06-10 |
Family
ID=30767813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03741459T Expired - Lifetime ES2340842T3 (es) | 2002-07-22 | 2003-07-17 | Anticuerpos anti-apc no neutralizantes. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7517965B2 (es) |
| EP (1) | EP1544214B1 (es) |
| JP (1) | JP4398369B2 (es) |
| AT (1) | ATE460431T1 (es) |
| AU (1) | AU2003281619A1 (es) |
| DE (1) | DE60331665D1 (es) |
| ES (1) | ES2340842T3 (es) |
| TW (1) | TW200407335A (es) |
| WO (1) | WO2004009641A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007101362A (ja) * | 2005-10-04 | 2007-04-19 | Hamamatsu Univ School Of Medicine | Ｅｉａプレート及びその利用方法 |
| EP3056568B1 (en) * | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| EP2047863B1 (en) | 2006-06-08 | 2013-07-31 | Chugai Seiyaku Kabushiki Kaisha | Preventive or remedy for inflammatory disease |
| JP5334319B2 (ja) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Ｃｄｒのアミノ酸置換により抗体の等電点を改変する方法 |
| KR102339457B1 (ko) * | 2007-09-26 | 2021-12-14 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
| US8716218B2 (en) | 2007-11-06 | 2014-05-06 | Oklahoma Medical Research Foundation | Extracellular histones as biomarkers for prognosis and molecular targets for therapy |
| KR101840994B1 (ko) | 2007-12-05 | 2018-03-21 | 추가이 세이야쿠 가부시키가이샤 | 항ｎｒ１０ 항체 및 그의 이용 |
| WO2010107109A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2409991B1 (en) | 2009-03-19 | 2017-05-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| EP2421900A1 (en) | 2009-04-24 | 2012-02-29 | Alper Biotech, Llc | Monoclonal antibodies against pcbp-1 antigens, and uses therefor |
| WO2012009577A2 (en) * | 2010-07-14 | 2012-01-19 | Alper Biotech, Llc | Monoclonal antibodies against pcbp-1 antigens, and uses therefor |
| MX2015006738A (es) | 2012-11-29 | 2015-08-05 | Bayer Healthcare Llc | Anticuerpos monoclonales humanizados contra la proteina c activada y sus usos. |
| JP6445440B2 (ja) * | 2013-09-20 | 2018-12-26 | 中外製薬株式会社 | 抗プロテインｃ抗体による出血性疾患の治療 |
| WO2016167263A1 (ja) | 2015-04-14 | 2016-10-20 | 中外製薬株式会社 | Ｉｌ－３１アンタゴニストを有効成分として含有する、アトピー性皮膚炎の予防用及び／又は治療用医薬組成物 |
| US11077187B2 (en) | 2015-11-17 | 2021-08-03 | Oklahoma Medical Research Foundation | Epitope of optimized humanized monoclonal antibodies against activated protein C and uses thereof |
| JP6845973B1 (ja) | 2019-11-20 | 2021-03-24 | 中外製薬株式会社 | 抗体含有製剤 |
| CN118370814A (zh) * | 2023-01-20 | 2024-07-23 | 上海莱士血液制品股份有限公司 | 一种抗aPC单克隆抗体的制剂及其应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11A (es) * | 1836-08-10 | |||
| US1222929A (en) * | 1916-08-22 | 1917-04-17 | Brewster & Co | Brake mechanism for motor-cars. |
| US4208479A (en) * | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| GB8327860D0 (en) * | 1983-10-18 | 1983-11-16 | Fujisawa Pharmaceutical Co | Monoclonal antiprotein c antibody |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| DE3882411T2 (de) * | 1987-04-17 | 1993-12-16 | Teijin Ltd | Verfahren zur Trennung von aktiviertem menschlichem Protein C. |
| CA2006684C (en) | 1988-12-30 | 1996-12-17 | Charles T. Esmon | Monoclonal antibody against protein c |
| JP2749619B2 (ja) | 1989-03-10 | 1998-05-13 | エーザイ株式会社 | 活性化ヒトプロテインｃとヒトプロテインｃインヒビターの複合体の測定方法および測定試薬 |
| JPH03200066A (ja) | 1989-12-28 | 1991-09-02 | Tosoh Corp | 活性化ヒトプロテインｃの測定方法 |
| US5279956A (en) * | 1991-06-24 | 1994-01-18 | The Scripps Research Institute | Activated protein C polypeptides and anti-peptide antibodies, diagnostic methods and systems for inhibiting activated protein C |
| WO1993009807A1 (en) | 1991-11-18 | 1993-05-27 | The Scripps Research Institute | Methods of inhibiting thrombosis via elevation of circulating endogenous activated protein c levels |
| DK0584348T3 (da) | 1992-03-11 | 2005-09-19 | Powderject Vaccines Inc | Genetisk vaccine mod immundefektvirusser |
| ATE410514T1 (de) | 1994-06-10 | 2008-10-15 | Oklahoma Med Res Found | Calciumbindende rekombinante antikörper gegen protein c |
| JPH1160500A (ja) * | 1997-08-11 | 1999-03-02 | Nippon Chem Res Kk | 血液凝固異常亢進抑制剤 |
| HUP0001237A3 (en) * | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| JPH11124399A (ja) | 1997-10-21 | 1999-05-11 | Eisai Co Ltd | プロテインｃインヒビターとプロテアーゼの複合体測定用モノクローナル抗体 |
| SE9900431D0 (sv) * | 1999-02-09 | 1999-02-09 | Johan Stenflo | Monoklonal antikropp |
| DE60236386D1 (de) | 2001-01-11 | 2010-07-01 | D Collen Res Foundation Vzw | Verfahren und pharmazeutische Zusammensetzung zur Vorbeugung und/oder Behandlung des Syndroms der systemischen entzündlichen Reaktion |
| US20060167230A1 (en) * | 2003-01-20 | 2006-07-27 | Takaki Koga | Anti-pci neutralizing antibody |
-
2003
- 2003-07-16 TW TW092119361A patent/TW200407335A/zh not_active IP Right Cessation
- 2003-07-17 DE DE60331665T patent/DE60331665D1/de not_active Expired - Lifetime
- 2003-07-17 ES ES03741459T patent/ES2340842T3/es not_active Expired - Lifetime
- 2003-07-17 JP JP2004522748A patent/JP4398369B2/ja not_active Expired - Lifetime
- 2003-07-17 US US10/522,086 patent/US7517965B2/en not_active Expired - Lifetime
- 2003-07-17 EP EP03741459A patent/EP1544214B1/en not_active Expired - Lifetime
- 2003-07-17 AU AU2003281619A patent/AU2003281619A1/en not_active Abandoned
- 2003-07-17 AT AT03741459T patent/ATE460431T1/de not_active IP Right Cessation
- 2003-07-17 WO PCT/JP2003/009087 patent/WO2004009641A1/ja active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| DE60331665D1 (de) | 2010-04-22 |
| US7517965B2 (en) | 2009-04-14 |
| US20060121022A1 (en) | 2006-06-08 |
| AU2003281619A1 (en) | 2004-02-09 |
| EP1544214B1 (en) | 2010-03-10 |
| TW200407335A (en) | 2004-05-16 |
| EP1544214A4 (en) | 2007-03-28 |
| JP4398369B2 (ja) | 2010-01-13 |
| WO2004009641A1 (ja) | 2004-01-29 |
| TWI322814B (es) | 2010-04-01 |
| EP1544214A1 (en) | 2005-06-22 |
| ATE460431T1 (de) | 2010-03-15 |
| JPWO2004009641A1 (ja) | 2005-11-17 |
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