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ES2260244T3 - Compuesto de succinamida heterociclicos condensados y analogos de los mismos, moduladores de la funcion del receptor nuclear de hormona. - Google Patents

Compuesto de succinamida heterociclicos condensados y analogos de los mismos, moduladores de la funcion del receptor nuclear de hormona.

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Publication number
ES2260244T3
ES2260244T3 ES01948503T ES01948503T ES2260244T3 ES 2260244 T3 ES2260244 T3 ES 2260244T3 ES 01948503 T ES01948503 T ES 01948503T ES 01948503 T ES01948503 T ES 01948503T ES 2260244 T3 ES2260244 T3 ES 2260244T3
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Spain
Prior art keywords
substituted
aryl
alkyl
arylalkyl
heterocycle
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ES01948503T
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Inventor
Mark E. Salvati
James Aaron Balog
Dacia A. Pickering
Soren Giese
Aberra Fura
Wenying Li
Ramesh N. Patel
Ronald L. Hanson
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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Abstract

Un compuesto de la siguiente fórmula (I) o una sal o hidrato del mismo: (Ver fórmula) en la que los símbolos tienen los siguientes significados y, para cada aparición, se seleccionan independientemente entre: G es un grupo arilo o heterociclo, siendo dicho grupo mono- o policíclico, y está opcionalmente sustituido en una o más posiciones; L es un enlace, (CR7R7")n (donde n es 1 y cada uno de R7 y R7'' es independientemente H, alquilo o alquilo sustituido), o -CH2-NH-; cada uno de A1 y A2 es independientemente CR7 donde R7 (i) es hidrógeno, alquilo o alquilo sustituido, arilalquilo o arilalquilo sustituido, alquenilo o alquenilo sustituido, arilo o arilo sustituido, heterociclo o heterociclo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, donde, para cada uno los sustituyentes son uno o más grupos seleccionados entre V1, o (ii) forma, junto con R7 de un grupo W, un anillo heterocíclico; V1 es OH, CN, halo, -O-arilo, -O-arilo sustituido, -O-heterociclo, -O-heterociclo sustituido, -O-CO-alquilo, -OCO-alquilo sustituido, -O-(alquilsililo), -O-arilalquilo, -O-arilalquilo sustituido, -O-CO-arilalquilo, -O-CO-arilalquilo sustituido, -O-CO-arilo, -O-CO-arilo sustituido, -O-CO-heterociclo, -O-CO-heterociclo sustituido, S-(aril opcionalmente sustituido)-NH-CO-(alquilo opcionalmente sustituido), -SO-(aril opcionalmente sustituido)-NH-CO-(alquilo opcionalmente sustituido), -SO2-(aril opcionalmente sustituido)-NH-CO-(alquilo opcionalmente sustituido), -NHSO2-arilo, -NH-SO2-arilo sustituido, -NH-CO-O-(arilalquil opcionalmente sustituido), -NH-CO-O-alquilo, -NH-COO-alquilo sustituido, -NH-CO-alquilo, -NH-CO-alquilo sustituido, -NH-CO-arilo, -NH-CO-arilo sustituido, -NH-CO(arilalquilo opcionalmente sustituido), -NH-CO-(alquil opcionalmente sustituido)-O-(arilo opcionalmente sustituido), -N(alquil opcionalmente sustituido)(arilo opcionalmente sustituido), -N(alquil opcionalmente sustituido)(arilalquilo opcionalmente sustituido), -COH, -COOH, -CO-O-alquilo, -CO-O-alquilo sustituido, -CO-O-arilalquilo opcionalmente sustituido, -CO-arilo, -CO-arilo sustituido, -O-CO-NH-arilo, -O-CO-NH-arilo sustituido, -CO-NH-arilo, -CONH-arilo sustituido, -CO-NH-arilaquilo, -CO-NH-arilalquilo sustituido, u-O-(aril opcionalmente sustituido)-NH-CO(alquilo opcionalmente sustituido); Y es -O-, -SO-, -N(V2), -CH2-N(V2)-, -CO-N(alquil)-, -CH2-S-, o -CH2-SO2; V2 es hidrógeno, alquilo, arilalquilo, -CO-alquilo, -CO-O-arilo, o -CO-O-arilalquilo; Z1 y Z2 son O; Q1 y Q2 son H; W es CR7R7''-CR7R7'', CR7R7''-C=O, NR9-CR7R7'', N=CR8, N=N, NR9-NR9'', cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, o arilo o arilo sustituido, donde, cuando W no es NR9-CR7R7'', N=CR8, N=N, NR9-NR9'', o heterociclo o heterociclo sustituido, entonces Y debe ser -O-, -CH2S-, -SO-, -CH2-SO2-, N(V2)- o -CH2-N(V2), cada uno de R1 y R1" es independientemente H, alquilo o alquilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido.
ES01948503T 2000-09-19 2001-06-20 Compuesto de succinamida heterociclicos condensados y analogos de los mismos, moduladores de la funcion del receptor nuclear de hormona. Expired - Lifetime ES2260244T3 (es)

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US23351900P 2000-09-19 2000-09-19
US233519P 2000-09-19
US28443801P 2001-04-18 2001-04-18
US28473001P 2001-04-18 2001-04-18
US284438P 2001-04-18
US284730P 2001-04-18

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US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
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