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ES2196824T3 - Derivado de triazolo-piridazina sustituido y composiciones farmaceuticas fabricadas con el mismo. - Google Patents

Derivado de triazolo-piridazina sustituido y composiciones farmaceuticas fabricadas con el mismo.

Info

Publication number
ES2196824T3
ES2196824T3 ES99929508T ES99929508T ES2196824T3 ES 2196824 T3 ES2196824 T3 ES 2196824T3 ES 99929508 T ES99929508 T ES 99929508T ES 99929508 T ES99929508 T ES 99929508T ES 2196824 T3 ES2196824 T3 ES 2196824T3
Authority
ES
Spain
Prior art keywords
triazolo
piridazina
derived
replaced
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99929508T
Other languages
English (en)
Inventor
William Robert Carling
Pineiro Jose Luis Castro
Cameron John Cowden
Antony John Davies
Andrew Madin
James Francis Mccabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2196824T3 publication Critical patent/ES2196824T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

7 - (1, 1 - Dimetiletil) - 6 - (2 - etil - 2H - 1, 2, 4 - triazol - 3 - ilmetoxi) - 3 - (2 - fluorofenil) - 1, 2, 4 triazolo[4, 3 - b]piridazina.
ES99929508T 1998-06-24 1999-06-15 Derivado de triazolo-piridazina sustituido y composiciones farmaceuticas fabricadas con el mismo. Expired - Lifetime ES2196824T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9813576.7A GB9813576D0 (en) 1998-06-24 1998-06-24 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2196824T3 true ES2196824T3 (es) 2003-12-16

Family

ID=10834265

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99929508T Expired - Lifetime ES2196824T3 (es) 1998-06-24 1999-06-15 Derivado de triazolo-piridazina sustituido y composiciones farmaceuticas fabricadas con el mismo.

Country Status (35)

Country Link
US (1) US6630471B1 (es)
EP (1) EP1090004B1 (es)
JP (1) JP4749545B2 (es)
KR (1) KR100604108B1 (es)
CN (1) CN1138779C (es)
AR (1) AR018925A1 (es)
AT (1) ATE239730T1 (es)
AU (1) AU757315B2 (es)
BG (1) BG64989B1 (es)
BR (1) BR9911563A (es)
CA (1) CA2335328C (es)
CO (1) CO5031239A1 (es)
CZ (1) CZ291409B6 (es)
DE (1) DE69907675T2 (es)
EA (1) EA003332B1 (es)
EE (1) EE200000767A (es)
ES (1) ES2196824T3 (es)
GB (1) GB9813576D0 (es)
GE (1) GEP20033143B (es)
HR (1) HRP20000879A2 (es)
HU (1) HUP0102894A3 (es)
ID (1) ID27771A (es)
IL (2) IL139775A0 (es)
IS (1) IS2258B (es)
MY (1) MY124341A (es)
NO (1) NO317992B1 (es)
NZ (1) NZ508290A (es)
PE (1) PE20000710A1 (es)
PL (1) PL204650B1 (es)
RS (1) RS49746B (es)
SK (1) SK285307B6 (es)
TR (1) TR200003789T2 (es)
TW (1) TWI222449B (es)
WO (1) WO1999067245A1 (es)
ZA (1) ZA200007485B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2345443A (en) * 1999-01-08 2000-07-12 Merck Sharp & Dohme Use of triazolo-pyridazines for treating premenstrual syndrome
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
GB0111191D0 (en) * 2001-05-08 2001-06-27 Merck Sharp & Dohme Therapeutic agents
CA2510534C (en) 2002-12-18 2011-09-20 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
EP2454259A1 (en) 2009-06-23 2012-05-23 Concert Pharmaceuticals Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
EP2456311A4 (en) * 2009-07-24 2013-01-23 Concert Pharmaceuticals Inc SUBSTITUTED IMIDASOTRIAZINES
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) * 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
EP2760866B1 (en) 2011-09-27 2017-12-13 Genfit Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
CN108697694B (zh) 2016-01-27 2022-12-09 苏黎世大学 Gabaa受体调节剂用于治疗发痒的用途
JP7449272B2 (ja) * 2018-04-18 2024-03-13 ニューロサイクル・セラピューティクス・インコーポレイテッド Ｇａｂａａ陽性アロステリックモジュレーター化合物、その作製の方法および使用
KR102712565B1 (ko) 2018-09-13 2024-10-02 사니오나 에이/에스 Gabaa 수용체 리간드
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
WO2021191837A1 (en) 2020-03-26 2021-09-30 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators
WO2025141131A1 (en) 2023-12-27 2025-07-03 Saniona A/S A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127911A0 (en) * 1996-07-25 1999-11-30 Merck Sharp & Dohme Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Also Published As

Publication number Publication date
ATE239730T1 (de) 2003-05-15
AU757315B2 (en) 2003-02-13
ID27771A (id) 2001-04-26
KR20010053136A (ko) 2001-06-25
PL204650B1 (pl) 2010-01-29
JP2002518501A (ja) 2002-06-25
SK285307B6 (sk) 2006-10-05
CZ291409B6 (cs) 2003-03-12
CN1307579A (zh) 2001-08-08
CA2335328C (en) 2007-11-27
PL345332A1 (en) 2001-12-17
IL139775A0 (en) 2002-02-10
BG105152A (en) 2001-10-31
MY124341A (en) 2006-06-30
BR9911563A (pt) 2001-03-20
CN1138779C (zh) 2004-02-18
EA003332B1 (ru) 2003-04-24
BG64989B1 (bg) 2006-11-30
YU77800A (sh) 2003-10-31
NO20006576L (no) 2001-02-14
JP4749545B2 (ja) 2011-08-17
EA200100071A1 (ru) 2001-06-25
TWI222449B (en) 2004-10-21
TR200003789T2 (tr) 2001-04-20
HUP0102894A3 (en) 2003-03-28
AR018925A1 (es) 2001-12-12
NO20006576D0 (no) 2000-12-21
DE69907675D1 (de) 2003-06-12
HRP20000879A2 (en) 2001-06-30
RS49746B (sr) 2008-04-04
CZ20004872A3 (cs) 2001-07-11
WO1999067245A1 (en) 1999-12-29
KR100604108B1 (ko) 2006-07-26
IS5730A (is) 2000-11-24
IL139775A (en) 2007-02-11
EE200000767A (et) 2002-06-17
DE69907675T2 (de) 2004-03-04
HUP0102894A2 (hu) 2001-11-28
GEP20033143B (en) 2003-12-25
ZA200007485B (en) 2002-01-07
AU4630199A (en) 2000-01-10
EP1090004A1 (en) 2001-04-11
CO5031239A1 (es) 2001-04-27
NO317992B1 (no) 2005-01-17
SK19552000A3 (sk) 2001-08-06
NZ508290A (en) 2003-09-26
IS2258B (is) 2007-06-15
US6630471B1 (en) 2003-10-07
PE20000710A1 (es) 2000-08-14
GB9813576D0 (en) 1998-08-19
CA2335328A1 (en) 1999-12-29
EP1090004B1 (en) 2003-05-07

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