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ES2184096T3 - Metodo para producir peptidos. - Google Patents

Metodo para producir peptidos.

Info

Publication number
ES2184096T3
ES2184096T3 ES97927386T ES97927386T ES2184096T3 ES 2184096 T3 ES2184096 T3 ES 2184096T3 ES 97927386 T ES97927386 T ES 97927386T ES 97927386 T ES97927386 T ES 97927386T ES 2184096 T3 ES2184096 T3 ES 2184096T3
Authority
ES
Spain
Prior art keywords
peptide
formula
defined above
optionally
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97927386T
Other languages
English (en)
Inventor
Chitoshi Hatanaka
Yasuaki Abe
Mitsuhisa Yamano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2184096T3 publication Critical patent/ES2184096T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

SE DESCRIBE UN PEPTIDO DE FORMULA (I): 5 - OXO - PRO - R SUP,1 - TRP - SER - R 2 - R 3 - R 4 - ARG - PRO R 6 , DONDE R 1 REPRESENTA HIS, TYR, TRP O P - NH SUB,2 - PHE; R 2 REPRESENTA TYR O PHE; R 3 REPRESENTA GLY OPCIONALMENTE SUSTITUIDO O UN RESIDUO DE AL - D - AMINOACIDO OPCIONALMENTE SUSTITUIDO; R 4 REPRESENTA LEU, ILE O NLE; R 6 REPRESENTA (1) GLY - NH - R 7 , DONDE, R SUP,7 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO QUE PUEDE ESTAR OPCIONALMENTE SUSTITUIDO POR UN GRUPO HIDROXILO, O (2) NH R 8 , DONDE, R 8 REPRESENTA UN ATOMO DE HIDROGE NO, UN GRUPO ALQUILO QUE PUEDE ESTAR OPCIONALMENTE SUSTITUIDO POR UN GRUPO HIDROXILO O UN GRUPO UREIDO (- NH - CO - NH 2). DICHO PEPTIDO SE PRODUCE VENTAJOSAMENTE A ESCALA INDUSTRIAL MEDIANTE LA REACCION DE UN PEPTIDO DE FORMULA (II): 5 - OXO PRO - R 1 TRP - SER - R 2 - R 3 - OH, DONDE, R SUP,1 , R 2 Y R 3 TIENEN EL MISMO SIGNIFICADO CITADO ANTERIORMENTE O SUS SALES, CON UN PEPTIDO DE FORMULA (III): H - R 4 - R 5 PRO - R 6 , DONDE, R 4 Y R 6 TIENEN EL MISMO SIGNIFICADO QUE LOS CITADOS ANTERIORMENTE Y R 5 REPRESENTA ARG PROTEGIDA, O SUS SALES. DICHA REACCION PRODUCE UN PEPTIDO DE FORMULA (I''): 5 - OXO - PRO - R 1 TRP - SER - R 2 R 3 - R 4 - R 5 - PRO - R SUP,6 , DONDE R 1 , R 2 , R 2 , R 3 , R 4 , R 5 Y R 6 TIENEN EL MISMO SIGNIFICADO QUE EL DEFINIDO ANTERIORMENTE, O SUS SALES. LUEGO SE SOMETE EL PEPTIDO (I'') ASI OBTENIDO A UNA REACCION CON UN GRUPO DE DESPROTECCION.
ES97927386T 1996-06-21 1997-06-19 Metodo para producir peptidos. Expired - Lifetime ES2184096T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16179196 1996-06-21

Publications (1)

Publication Number Publication Date
ES2184096T3 true ES2184096T3 (es) 2003-04-01

Family

ID=15741986

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97927386T Expired - Lifetime ES2184096T3 (es) 1996-06-21 1997-06-19 Metodo para producir peptidos.

Country Status (13)

Country Link
US (1) US6211333B1 (es)
EP (1) EP0910575B1 (es)
KR (1) KR100459978B1 (es)
CN (1) CN1129607C (es)
AT (1) ATE224912T1 (es)
AU (1) AU3189997A (es)
CA (1) CA2257381C (es)
DE (1) DE69715860T2 (es)
DK (1) DK0910575T3 (es)
ES (1) ES2184096T3 (es)
IL (3) IL163521A0 (es)
PT (1) PT910575E (es)
WO (1) WO1997048726A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6939855B2 (en) 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
IL143929A0 (en) 1999-01-22 2002-04-21 Elan Pharm Inc Acyl derivatives which treat vla-4 related disorders
DE60027268T2 (de) * 1999-01-26 2007-03-15 Elan Pharmaceuticals, Inc., San Francisco Pyroglutaminsäurederivate und damit verwandte verbindungen, die die durch vla-4 vermittelte leukozytenadhäsion verringern
US6407066B1 (en) 1999-01-26 2002-06-18 Elan Pharmaceuticals, Inc. Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4
EP1207167B1 (en) * 1999-06-30 2006-10-04 Takeda Pharmaceutical Company Limited Process for the preparation of lh-rh derivatives
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
US20050244567A1 (en) * 2002-07-29 2005-11-03 Aminotech As Method for production of peptides/amino acids produced by said method and use of the same
JP2008534628A (ja) * 2005-05-03 2008-08-28 ノベタイド，リミティド ペプチド誘導体の製造のための方法
ATE493405T1 (de) 2005-09-29 2011-01-15 Elan Pharm Inc Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren
JP5081828B2 (ja) 2005-09-29 2012-11-28 エラン ファーマシューティカルズ，インコーポレイテッド Ｖｌａ−４によって媒介される白血球粘着を阻害するカルバメート化合物
BRPI0708331A2 (pt) 2006-02-27 2011-05-24 Elan Pharm Inc compostos de pirimidinil sulfonamida que inibem a adesão leucocitária mediada por vla-4
US8367836B2 (en) 2009-04-27 2013-02-05 Elan Pharmaceuticals, Inc. Pyridinone antagonists of alpha-4 integrins
JP6564539B1 (ja) 2018-09-14 2019-08-21 長瀬産業株式会社 スルホン酸化合物によるペプチド精製方法
CN113527438A (zh) * 2021-08-30 2021-10-22 湖南三太药业有限公司 一种全液相合成丙氨瑞林的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947569A (en) * 1972-04-12 1976-03-30 American Home Products Corporation Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor
US3855198A (en) 1972-09-29 1974-12-17 American Home Prod Novel intermediates for synthesis of l-(5-oxoprolyl)-l-histidy-l-tryptophyl-l-seryl-l-tyrosyl-l-glycyl-l-leucyl-l-arginyl-l-prolyl-glycine amide
JPS49100081A (es) 1973-01-30 1974-09-20
CA1023350A (en) 1974-01-21 1977-12-27 Manfred K. Gotz Derivatives of the lh- and fsh-releasing hormone
US3997516A (en) * 1974-07-04 1976-12-14 Takeda Chemical Industries, Ltd. Method for protecting guanidino group and restoring the same
HU185238B (en) 1980-02-12 1984-12-28 Takeda Chemical Industries Ltd Process for preparing peptides containing guanidino-group
IT1178775B (it) * 1983-12-23 1987-09-16 Konzponti Valto Es Hitelbank R Derivati della gonadoliberina e procedimento per la loro preparazione
EP0328090A3 (en) * 1988-02-10 1990-08-16 Abbott Laboratories Lhrh analogs

Also Published As

Publication number Publication date
DE69715860D1 (de) 2002-10-31
DE69715860T2 (de) 2003-08-07
DK0910575T3 (da) 2003-02-03
PT910575E (pt) 2003-02-28
CA2257381A1 (en) 1997-12-24
US6211333B1 (en) 2001-04-03
KR20000016798A (ko) 2000-03-25
AU3189997A (en) 1998-01-07
CA2257381C (en) 2007-08-21
EP0910575A1 (en) 1999-04-28
IL163521A (en) 2007-07-04
IL127312A0 (en) 1999-09-22
CN1129607C (zh) 2003-12-03
ATE224912T1 (de) 2002-10-15
KR100459978B1 (ko) 2005-01-15
CN1222916A (zh) 1999-07-14
WO1997048726A1 (en) 1997-12-24
EP0910575B1 (en) 2002-09-25
IL163521A0 (en) 2005-12-18

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