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ES2169816T3 - Alcoholes lipidicos como nuevos medicamentos supresores de inmunidad y anti-viricos. - Google Patents

Alcoholes lipidicos como nuevos medicamentos supresores de inmunidad y anti-viricos.

Info

Publication number
ES2169816T3
ES2169816T3 ES96934651T ES96934651T ES2169816T3 ES 2169816 T3 ES2169816 T3 ES 2169816T3 ES 96934651 T ES96934651 T ES 96934651T ES 96934651 T ES96934651 T ES 96934651T ES 2169816 T3 ES2169816 T3 ES 2169816T3
Authority
ES
Spain
Prior art keywords
sulfonyl
alcoxi
viric
carbonylamide
amidocarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96934651T
Other languages
English (en)
Inventor
Harald Zilch
Dieter Herrmann
Hans-Georg Opitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heidelberg Pharma Holding GmbH
Original Assignee
Heidelberg Pharma Holding GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Holding GmbH filed Critical Heidelberg Pharma Holding GmbH
Application granted granted Critical
Publication of ES2169816T3 publication Critical patent/ES2169816T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SON OBJETO DE LA PRESENTE INVENCION NUEVOS MEDICAMENTOS INMUNOSUPRESORES Y ANTIVIRALES UTILIZANDO ALCOHOLES LIPIDICOS DE FORMULAS GENERALES (I) Y (II), EN LOS QUE R 1 ES UNA CADENA DE ALQUILO LINEAL O RAMIFICADA, SATURADA O INSATURADA CON ENTRE 1 Y 30 ATOMOS DE CARBONO, QUE EVENTUALMENTE PUEDE ESTAR SUSTITUIDA UNA O VARIAS VECES CON HALOGENO, GRUPOS ALCOXI C SUB,1 - C 6 , MERCAPTOALQUILO C 1 - C 6 , ALCOXI C 1 - C 6 CARBONILO, CARBOXI, ALQUILO C 1 C 6 SULFINILO O ALQUIL C 1 - C 6 SULFONILO, R 2 ES HIDROGENO, UNA CADENA DE 1 A 20 ATOMOS DE CARBONO, QUE EVENTUALMENTE PUEDE ESTAR SUSTITUIDA UNA O VARIAS VECES CON HALOGENO, GRUPOS ALCOXI C 1 - C 6 , MERCAPTO ALQUILO C 1 - C 6 , ALCOXI C 1 - C 6 CARBONILO O ALQUIL C1 - C 6 SULFONILO, X ES EL ENLACE DE LA VALENCIA, O XICARBONILO, CARBONILOXI, AMIDOCARBONILO, CARBONILAMIDO, OXIGENO, AZUFRE, EL GRUPO SULFINILO O SULFONILO, Y ES EL ENLACE DE LA VALENCIA, OXICARBONILO, CARBONILOXI, AMIDOCARBONILO, CARBONILAMIDO, OXIGENO, AZUFRE, EL GRUPO SULFINILO OSULFONILO, N PUEDE SER UN NUMERO ENTERO ENTRE 1 Y 5, ASI COMO SUS TAUTOMEROS Y LAS COMBINACIONES QUE COMPRENDEN ESTOS COMPUESTOS JUNTO CON OTRAS SUSTANCIAS ACTIVAS.
ES96934651T 1995-10-14 1996-10-11 Alcoholes lipidicos como nuevos medicamentos supresores de inmunidad y anti-viricos. Expired - Lifetime ES2169816T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19538402A DE19538402A1 (de) 1995-10-14 1995-10-14 Lipidalkohole als neue immunsuppressive und antivirale Arzneimittel

Publications (1)

Publication Number Publication Date
ES2169816T3 true ES2169816T3 (es) 2002-07-16

Family

ID=7774931

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96934651T Expired - Lifetime ES2169816T3 (es) 1995-10-14 1996-10-11 Alcoholes lipidicos como nuevos medicamentos supresores de inmunidad y anti-viricos.

Country Status (18)

Country Link
US (1) US6177469B1 (es)
EP (1) EP0854708B1 (es)
JP (1) JPH11513677A (es)
KR (1) KR19990064240A (es)
AT (1) ATE210434T1 (es)
AU (1) AU722835B2 (es)
CA (1) CA2234244A1 (es)
DE (2) DE19538402A1 (es)
DK (1) DK0854708T3 (es)
ES (1) ES2169816T3 (es)
HU (1) HUP9900725A3 (es)
IL (1) IL123915A (es)
NO (1) NO981629L (es)
NZ (1) NZ320211A (es)
PT (1) PT854708E (es)
TW (1) TW426513B (es)
WO (1) WO1997014410A1 (es)
ZA (1) ZA968597B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293795B1 (it) * 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
US6406722B1 (en) 1999-02-18 2002-06-18 Robert G. Gallaher Method of treating viral infections and lesions with taxane compounds
BR0114713A (pt) * 2000-10-16 2004-01-13 Neopharm Inc Formulação lipossÈmica de mitoxantrona
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US7341985B2 (en) * 2004-10-08 2008-03-11 Air Products And Chemicals, Inc. 2-Hydroxy-3-alkoxypropyl sulfides, sulfones, and sulfoxides: new surface active agents
WO2009129395A1 (en) * 2008-04-16 2009-10-22 Abbott Laboratories Cationic lipids and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857511A (en) * 1985-09-17 1989-08-15 Burroughs Wellcome Co. Treatment of human viral infections
DE3638126A1 (de) * 1986-11-08 1988-05-11 Nattermann A & Cie Mercaptoalkanolphospholipide und deren derivate, verfahren zu ihrer herstellung und ihre verwendung als wirkstoffe in arzneimitteln
US4997851A (en) * 1987-12-31 1991-03-05 Isaacs Charles E Antiviral and antibacterial activity of fatty acids and monoglycerides
DE3929217A1 (de) * 1989-09-02 1991-03-07 Boehringer Mannheim Gmbh Verwendung von phospholipid-derivaten als antivirale arzneimittel und neue phospholipide
DE3934820A1 (de) * 1989-10-19 1991-04-25 Boehringer Mannheim Gmbh Verwendung von lecithin-analoga als antivirale arzneimittel und neue derivate

Also Published As

Publication number Publication date
WO1997014410A1 (de) 1997-04-24
CA2234244A1 (en) 1997-04-24
AU722835B2 (en) 2000-08-10
HUP9900725A3 (en) 2001-08-28
TW426513B (en) 2001-03-21
NZ320211A (en) 2000-01-28
EP0854708A1 (de) 1998-07-29
US6177469B1 (en) 2001-01-23
DE19538402A1 (de) 1997-04-17
AU7291296A (en) 1997-05-07
EP0854708B1 (de) 2001-12-12
KR19990064240A (ko) 1999-07-26
DE59608464D1 (de) 2002-01-24
HUP9900725A2 (hu) 1999-06-28
JPH11513677A (ja) 1999-11-24
NO981629L (no) 1998-06-12
ATE210434T1 (de) 2001-12-15
DK0854708T3 (da) 2002-04-08
NO981629D0 (no) 1998-04-08
IL123915A (en) 2003-01-12
PT854708E (pt) 2002-06-28
ZA968597B (en) 1998-04-14

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