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ES2166352T3 - Dominio externo de c-erbb-2:gp75. - Google Patents

Dominio externo de c-erbb-2:gp75.

Info

Publication number
ES2166352T3
ES2166352T3 ES90914094T ES90914094T ES2166352T3 ES 2166352 T3 ES2166352 T3 ES 2166352T3 ES 90914094 T ES90914094 T ES 90914094T ES 90914094 T ES90914094 T ES 90914094T ES 2166352 T3 ES2166352 T3 ES 2166352T3
Authority
ES
Spain
Prior art keywords
erbb
polypeptides
exposed
useful
external domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90914094T
Other languages
English (en)
Inventor
Susan G Stuart
John J Monahan
Beatrice Claudia Langton
Miriam E C Hancock
Lorrine A Chao
Peter Bluford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23540312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2166352(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2166352T3 publication Critical patent/ES2166352T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE EXPONEN METODOS Y COMPUESTOS PARA IDENTIFICAR TUMORES MALIGNOS QUE SOBREEXPRESAN EL ONCOGENE C-ERBB-2. SE INCORPORAN ENSAYOS UTILES PARA LA DIAGNOSIS Y PROGNOSIS DE ENFERMEDADES NEOPLASTICAS QUE DETECTAN EL DOMINIO EXTERNO DE C-ERBB-2, LA GLICOPROTEINA GP75 Y CUANTIFICAN EL NIVEL DE GP75 EN LOS FLUIDOS BIOLOGICOS DE MAMIFEROS QUE LLEVAN UNA CARGA TUMORAL. ADEMAS SE EXPONEN PROTEINAS Y POLIPEPTIDOS NUEVAS RECOMBINANTES, PRODUCIDAS SINTETICAMENTE Y, EN OTROS CASOS, BIOLOGICAMENTE, QUE SE CODIFICAN MEDIANTE LA SECUENCIA DE ADN DE DOMINIO EXTERNO DEL ONCOGENE C-ERBB-2 (EL GEN GP75) O FRAGMENTOS DEL MISMO. DICHAS PROTEINAS Y POLIPEPTIDOS DEL GP75 SON UTILES COMO VACUNAS, DE FORMA TERAPEUTICA EN EL TRATAMIENTO DEL CANCER, SOLOS O EN COMBINACION CON AGENTES QUIMIOTERAPEUTICOS. TAMBIEN SE EXPONEN ANTICUERPOS PARA TALES PROTEINAS Y POLIPEPTIDOS DEL GP75 QUE SON UTILES EN SENTIDO TERAPEUTICO Y DE DIAGNOSIS. TAMBIEN SE EXPONEN EQUIPOS DE PRUEBA QUE REPRESENTAN LOS ENSAYOS DE ESTA INVENCION.
ES90914094T 1989-08-04 1990-08-02 Dominio externo de c-erbb-2:gp75. Expired - Lifetime ES2166352T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38992089A 1989-08-04 1989-08-04

Publications (1)

Publication Number Publication Date
ES2166352T3 true ES2166352T3 (es) 2002-04-16

Family

ID=23540312

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90914094T Expired - Lifetime ES2166352T3 (es) 1989-08-04 1990-08-02 Dominio externo de c-erbb-2:gp75.

Country Status (10)

Country Link
US (2) US20020155527A1 (es)
EP (2) EP1006194A3 (es)
JP (2) JP3859695B2 (es)
AT (1) ATE207958T1 (es)
AU (1) AU645760B2 (es)
CA (1) CA2042064C (es)
DE (1) DE69033842T2 (es)
DK (1) DK0444181T3 (es)
ES (1) ES2166352T3 (es)
WO (1) WO1991002062A2 (es)

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DE69031120T2 (de) * 1989-05-19 1998-01-15 Genentech, Inc., South San Francisco, Calif. Her2 extrazellulare domäne
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Also Published As

Publication number Publication date
DK0444181T3 (da) 2002-02-25
DE69033842T2 (de) 2002-06-20
AU6413590A (en) 1991-03-11
ATE207958T1 (de) 2001-11-15
JP3859695B2 (ja) 2006-12-20
EP1006194A2 (en) 2000-06-07
JPH04503012A (ja) 1992-06-04
AU645760B2 (en) 1994-01-27
EP0444181B1 (en) 2001-10-31
DE69033842D1 (de) 2001-12-06
CA2042064A1 (en) 1991-02-05
US20020155527A1 (en) 2002-10-24
EP0444181A1 (en) 1991-09-04
EP1006194A3 (en) 2008-07-02
US20060019344A1 (en) 2006-01-26
JP2006304807A (ja) 2006-11-09
WO1991002062A2 (en) 1991-02-21
WO1991002062A3 (en) 1991-06-13
EP0444181B2 (en) 2010-11-24
CA2042064C (en) 2008-10-21

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