[go: up one dir, main page]

ES2165430T3 - Analogos fluorados del 2-nitroimidazol para detectar celulas tumorales hipoxicas. - Google Patents

Analogos fluorados del 2-nitroimidazol para detectar celulas tumorales hipoxicas.

Info

Publication number
ES2165430T3
ES2165430T3 ES95927535T ES95927535T ES2165430T3 ES 2165430 T3 ES2165430 T3 ES 2165430T3 ES 95927535 T ES95927535 T ES 95927535T ES 95927535 T ES95927535 T ES 95927535T ES 2165430 T3 ES2165430 T3 ES 2165430T3
Authority
ES
Spain
Prior art keywords
tumor cells
hypoxic tumor
nitroimidazol
fluorated
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95927535T
Other languages
English (en)
Inventor
Michael Tracy
Andrew B Kelson
Paul Workman
Alexander D Lewis
Eric O Aboagye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Campaign Technology Ltd
University of Glasgow
SRI International Inc
Original Assignee
Cancer Research Campaign Technology Ltd
University of Glasgow
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Campaign Technology Ltd, University of Glasgow, SRI International Inc, Stanford Research Institute filed Critical Cancer Research Campaign Technology Ltd
Application granted granted Critical
Publication of ES2165430T3 publication Critical patent/ES2165430T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PROPORCIONAN NUEVOS AGENTES UTILES PARA LA DETECCION DE CELULAS TUMORALES HIPOXICAS. DICHOS COMPUESTOS TIENEN LA FORMULA ESTRUCTURAL (I), DONDE R{SUP,1} Y R{SUP,2} SON TAL Y COMO SE LOS DEFINE MAS ABAJO. ASIMISMO, SE PROPORCIONAN METODOS DE UTILIZACION DE DICHOS COMPUESTOS PARA DETECTAR CELULAS TUMORALES HIPOXICAS, ASI COMO COMPOSICIONES FARMACEUTICAS QUE INCLUYEN EN SU FORMULACION LOS NUEVOS COMPUESTOS.
ES95927535T 1994-08-05 1995-07-31 Analogos fluorados del 2-nitroimidazol para detectar celulas tumorales hipoxicas. Expired - Lifetime ES2165430T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28647794A 1994-08-05 1994-08-05
US08/458,178 US5721265A (en) 1994-08-05 1995-06-02 Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells

Publications (1)

Publication Number Publication Date
ES2165430T3 true ES2165430T3 (es) 2002-03-16

Family

ID=26963851

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95927535T Expired - Lifetime ES2165430T3 (es) 1994-08-05 1995-07-31 Analogos fluorados del 2-nitroimidazol para detectar celulas tumorales hipoxicas.

Country Status (10)

Country Link
US (1) US5721265A (es)
EP (1) EP0775117B1 (es)
JP (1) JP3872511B2 (es)
AT (1) ATE209187T1 (es)
CA (1) CA2196900C (es)
DE (1) DE69524103T2 (es)
DK (1) DK0775117T3 (es)
ES (1) ES2165430T3 (es)
PT (1) PT775117E (es)
WO (1) WO1996004249A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
US6252087B1 (en) * 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
US20050026974A1 (en) * 1996-02-08 2005-02-03 Trustees Of The University Of Pennsylvania Detection of hypoxia
ES2123449B1 (es) * 1997-03-06 1999-09-16 Univ Madrid Nac Educacion Procedimiento para la obtencion de imagenes y espectros del ph extracelular por resonancia magnetica con indicadores extrinsecos conteniendo 1h o 19f.
ATE293633T1 (de) * 1997-08-21 2005-05-15 Quark Biotech Inc Hypoxie-regulierte gene
WO2000018723A1 (en) * 1998-09-25 2000-04-06 Monsanto Company Substituted n-aliphatic-n-aromatic tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US7230115B1 (en) 1999-07-21 2007-06-12 The Trustees Of The University Of Pennsylvania Preparation of compounds useful for the detection of hypoxia
DE60043616D1 (de) * 1999-07-21 2010-02-11 Univ Pennsylvania Herstellung von verbindungen zur bestimmung der hypoxie
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
CA2400092A1 (en) * 2000-02-14 2001-08-16 Virexx Research, Inc. Diagnostic and therapeutic compositions and methods for affecting tumor growth using oxygen mimetic agents
DE102005063244A1 (de) * 2005-12-21 2007-06-28 Eberhard-Karls-Universität Tübingen Modifiziertes 2-Nitroimidazol-Derivat
US9056136B2 (en) * 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
CA2683433C (en) * 2007-04-05 2016-10-11 Siemens Medical Solutions Usa, Inc. Nitro-imidazole hypoxia imaging agents
EP2123620A1 (en) * 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft {F-19}-labeled L-Glutamic acid and L-Glutamine derivative (III), use thereof and method for obtaining them
WO2010073126A2 (en) * 2008-12-22 2010-07-01 The Governors Of The University Of Alberta Compounds useful in delivering anti-neoplastic therapy and diagnostic imaging to hypoxic cells and methods of use thereof
CN101624392B (zh) * 2009-08-10 2014-07-09 北京师范大学 F-三唑环-聚乙二醇-2-硝基咪唑化合物及其制备方法
US9074129B2 (en) 2009-12-01 2015-07-07 University Of Virginia Patent Foundation Mechanochromic luminescent difluoroboron beta-diketonates
CN113501789B (zh) * 2021-06-16 2023-03-31 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) 一种硝基咪唑类衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505349A (en) * 1966-04-18 1970-04-07 Hoffmann La Roche 2-nitro-imidazolyl-1-acetamides
US5304654A (en) * 1987-06-10 1994-04-19 Yasunori Nishijima Fluorine-containing nitroimidazole compounds
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
IL92597A0 (en) * 1988-12-14 1990-08-31 Yasunori Nishijima President K Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same
WO1994011348A1 (en) * 1992-11-19 1994-05-26 The Trustees Of The University Of Pennsylvania Detection of hypoxia

Also Published As

Publication number Publication date
DK0775117T3 (da) 2002-05-21
DE69524103D1 (de) 2002-01-03
WO1996004249A1 (en) 1996-02-15
EP0775117A1 (en) 1997-05-28
ATE209187T1 (de) 2001-12-15
CA2196900C (en) 2009-02-24
JP3872511B2 (ja) 2007-01-24
CA2196900A1 (en) 1996-02-15
EP0775117B1 (en) 2001-11-21
JPH10506104A (ja) 1998-06-16
DE69524103T2 (de) 2002-07-18
PT775117E (pt) 2002-05-31
US5721265A (en) 1998-02-24

Similar Documents

Publication Publication Date Title
ES2165430T3 (es) Analogos fluorados del 2-nitroimidazol para detectar celulas tumorales hipoxicas.
EA200200360A1 (ru) Производные пурина
TR200102800T2 (tr) Yeni bileşikler.
EA200201291A1 (ru) Производные пурина
ES478052A1 (es) Procedimiento para la preparacion de nuevos nitroimidazoles.
SE7906533L (sv) Pyrrolidinderivat
ES8106696A1 (es) Procedimiento para la preparacion de bis-(hidroxialcohilami-das)de acidos 5-(n-alcohil-a-hidroxiacil-amino)-2,4,6-triyo-do-isoftalicos
EA200101107A1 (ru) Пуриновые производные
EA200200770A1 (ru) Производные пурина
DK92781A (da) Fremgangsmaade til fremstilling af indanderivater eller syreadditionssalte deraf
ES431307A1 (es) Procedimiento para la preparacion de nuevos derivados de quinoleina.
IL47529A (en) Substituted (1-(-4,4-bisphenylbutyl)-4-piperidyl-)1,3-dihydro-2h-benzimidazol-2-one derivatives and certain intermediates for obtaining such compounds,their preparation and pharmaceutical compositions containing them
DK148183A (da) Fremgangsmaade til fremstilling af imidazolylphenyl-tetrahydropyridaziner
ES434533A1 (es) Un procedimiento para la preparacion de compuestos tetraci-clicos.
ATE48835T1 (de) Chinolylglycinamidderivate, verfahren zu ihrer herstellung und therapeutische verwendung als psychotrope.
ES459283A1 (es) Procedimiento para preparar 1,1-1-triaril-alquilaminas.
ES466851A1 (es) Procedimiento para la preparacion de 2-bromo-6-fluor-n-2- imidazolidinilidenbenzamina.
ES448175A1 (es) Procedimiento para la preparacion de propargil-2-fenilamino-imidazolinas-(2).
TR200504091T2 (tr) (7alfa,17alfa)-17-hidroksi-7-metil-19-nor-17-pregn-5(10)-en 20-in-3-on içeren yüksek saflıkta bileşim.
ATE153657T1 (de) Cyclische benzylamino-, benzylamido- und benzylimido derivate als antipsychotische wirkstoffe
FI872719A0 (fi) Nya tetrahydro-benzotiazoler, deras framstaellning och anvaendning.
BG50160A3 (en) Method for preparing of alcandiol dicarboxilates
ES516158A0 (es) Procedimiento de preparacion de nuevos derivados del adamantano.
ES2098370T3 (es) Derivado del acido epoxisuccinamico.
ES2120483T3 (es) Alcoholes benzilo y benzhidrilo.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 775117

Country of ref document: ES