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ES2164653T3 - Procedimiento para producir heterociclos polihidroxilicos que contienen nitrogeno n-sustituidos. - Google Patents

Procedimiento para producir heterociclos polihidroxilicos que contienen nitrogeno n-sustituidos.

Info

Publication number
ES2164653T3
ES2164653T3 ES93870047T ES93870047T ES2164653T3 ES 2164653 T3 ES2164653 T3 ES 2164653T3 ES 93870047 T ES93870047 T ES 93870047T ES 93870047 T ES93870047 T ES 93870047T ES 2164653 T3 ES2164653 T3 ES 2164653T3
Authority
ES
Spain
Prior art keywords
produce
polyhydroxy
heterocicles
polyhydroxyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93870047T
Other languages
English (en)
Inventor
Roy Walter Grabner
Bryan Hayden Landis
Richard Joe Rutter
Mike Gust Scaros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
GD Searle LLC
Original Assignee
Monsanto Co
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co, GD Searle LLC filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2164653T3 publication Critical patent/ES2164653T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE DESCUBRE UN PROCESO PARA PRODUCIR COMPUESTOS AMINO N-SUSTITUIDOS, UN PROCESO PARA OXIDAR UN COMPUESTO AMINO N-SUSTITUIDO CON UN MICROBIO, O FRAGMENTO CELULAR O CELULA LIBRE EXTRAIDA DE EL, Y UN PROCESO PARA OXIDAR UN COMPUESTO AMINO N TITUIDO CON UN MICROBIO, O FRAGMENTO DE CELULA O CELULA LIBRE EXTRAIDA DE EL Y REDUCIR EL COMPUESTO AMINO N DADO A PIPERIDINAS POLIHIDROXI SAMINAS, ALOSAMINAS Y ALTROSAMINAS N AS POLIHIDROXI NSUSTITUIDAS, Y AZETIDINAS POLIHIDROXI N ITUIDAS. EN ADICION, UN UNICO PROCESO DE CRISOL PARA PRODUCIR PIPERIDINAS POLIHIDROXI N IDROXI N AS A PARTIR DEL AZUCAR RESPECTIVO. UNA SEGUNDA FORMA DE REALIZACION PRACTICA COMPRENDE NUEVAS COMPOSICIONES DE N AMINO AS Y 4
ES93870047T 1992-03-16 1993-03-15 Procedimiento para producir heterociclos polihidroxilicos que contienen nitrogeno n-sustituidos. Expired - Lifetime ES2164653T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/851,818 US5401645A (en) 1992-03-16 1992-03-16 Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium

Publications (1)

Publication Number Publication Date
ES2164653T3 true ES2164653T3 (es) 2002-03-01

Family

ID=25311760

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93870047T Expired - Lifetime ES2164653T3 (es) 1992-03-16 1993-03-15 Procedimiento para producir heterociclos polihidroxilicos que contienen nitrogeno n-sustituidos.

Country Status (9)

Country Link
US (2) US5401645A (es)
EP (2) EP0624652B1 (es)
JP (1) JPH0638780A (es)
AT (1) ATE206763T1 (es)
CA (1) CA2091668C (es)
DE (1) DE69330905T2 (es)
DK (1) DK0624652T3 (es)
ES (1) ES2164653T3 (es)
PT (1) PT624652E (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009040A1 (en) 1995-09-08 1997-03-13 Novo Nordisk A/S 2-alkylpyrrolidines
ATE382351T1 (de) 1999-08-10 2008-01-15 Univ Oxford Langkettige n-alkyl verbindungen und deren oxa- derivate zur verwendung als anitvirale mittel
EP1181277A4 (en) 2000-03-31 2005-08-10 Univ Michigan State PROCESS FOR THE PREPARATION OF 1,5-DIDESOXY-1,5-IMINO HEXITOLS FROM OXIMES OR IMINES
WO2002074737A2 (en) * 2001-03-19 2002-09-26 Lonza Ag Process for the preparation of 2-hydroxymethyl-pyrolidine-3,4-diols
US6479713B1 (en) 2001-10-23 2002-11-12 Battelle Memorial Institute Hydrogenolysis of 5-carbon sugars, sugar alcohols, and other methods and compositions for reactions involving hydrogen
AT502145B1 (de) * 2005-03-24 2012-01-15 Univ Graz Tech Glycosidase-hemmendes iminoalditol
AU2006247065B8 (en) 2005-05-17 2012-07-12 Amicus Therapeutics, Inc. A method for the treatment of Pompe disease using 1-deoxynojirimycin derivatives
DE102005058542A1 (de) * 2005-12-08 2007-06-14 Merck Patent Gmbh Erythruloseester als UV Filter
GB0614947D0 (en) * 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
CN102727437A (zh) 2006-08-02 2012-10-17 牛津大学院长校长专家委员会 病毒感染的脂质体治疗
CA2666814A1 (en) * 2006-08-21 2008-05-29 United Therapeutics Corporation Combination therapy for treatment of viral infections
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
KR20100127842A (ko) * 2008-03-26 2010-12-06 유니버시티 오브 옥스퍼드 소포체 표적화 리포좀
EP2410989A2 (en) * 2009-03-27 2012-02-01 The Chancellor, Masters and Scholars of the University of Oxford Cholesterol level lowering liposomes
ES2374352B1 (es) * 2010-08-03 2013-01-24 Consejo Superior De Investigaciones Científicas (Csic) Proceso de obtención de derivados de azetidinas.
CN102399228B (zh) * 2010-09-08 2013-10-16 中国科学院成都生物研究所 N-烷基多羟基哌啶衍生物的制备方法
US20210047609A1 (en) 2018-01-26 2021-02-18 Zhejiang University Of Technology Method For Promoting Synthesis Of Sorbitol Dehydrogenase And Coenzyme Pyrroloquinoline Quinone From Gluconobacter Oxydans

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5317677B2 (es) * 1973-09-25 1978-06-09
DE2834122A1 (de) * 1978-08-03 1980-02-14 Bayer Ag Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose
DE2853573A1 (de) * 1978-12-12 1980-07-03 Bayer Ag Herstellung von n-substituierten derivaten des l-desoxynojirimycins
DE3038901A1 (de) * 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
DE3049446A1 (de) * 1980-12-30 1982-07-29 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 1,5-didesoxy-1,5-imino-d-glucitol und dessen n-derivaten
JPS5911188A (ja) * 1982-07-12 1984-01-20 Mitsubishi Gas Chem Co Inc Ｄ−グルコサミン酸の製造法
JPS5914785A (ja) * 1982-07-19 1984-01-25 Mitsubishi Gas Chem Co Inc 新規微生物
JPS5914786A (ja) * 1982-07-19 1984-01-25 Mitsubishi Gas Chem Co Inc 新規微生物
JPS5914787A (ja) * 1982-07-19 1984-01-25 Mitsubishi Gas Chem Co Inc 新規微生物
DE3611841A1 (de) * 1986-04-09 1987-10-15 Bayer Ag Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten
DE3814549A1 (de) * 1987-10-30 1989-05-18 Bayer Ag N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln
ATE137266T1 (de) * 1990-09-20 1996-05-15 Monsanto Co Verfahren zur herstellung von n-substituiertem 1- deoxynojirimycin

Also Published As

Publication number Publication date
CA2091668C (en) 2003-05-20
JPH0638780A (ja) 1994-02-15
EP1132370A3 (en) 2004-03-10
EP1132370A2 (en) 2001-09-12
DK0624652T3 (da) 2001-11-12
EP0624652A1 (en) 1994-11-17
DE69330905T2 (de) 2002-08-08
ATE206763T1 (de) 2001-10-15
US5695969A (en) 1997-12-09
US5401645A (en) 1995-03-28
DE69330905D1 (de) 2001-11-15
CA2091668A1 (en) 1993-09-17
PT624652E (pt) 2002-03-28
EP0624652B1 (en) 2001-10-10

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