CY1105772T1 - Συνθεσεις και μεθοδοι για βελτιωμενη κυτταρικη καλλιεργεια - Google Patents
Συνθεσεις και μεθοδοι για βελτιωμενη κυτταρικη καλλιεργειαInfo
- Publication number
- CY1105772T1 CY1105772T1 CY20061101630T CY061101630T CY1105772T1 CY 1105772 T1 CY1105772 T1 CY 1105772T1 CY 20061101630 T CY20061101630 T CY 20061101630T CY 061101630 T CY061101630 T CY 061101630T CY 1105772 T1 CY1105772 T1 CY 1105772T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cell culture
- methods
- compositions
- improved cell
- igf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0043—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Η εφεύρεση παρέχει βελτιωμένες μεθόδους παραγωγής ανασυνδυασμένης πρωτεΐνης σε κυτταρική καλλιέργεια. Ειδικότερα, η εφεύρεση σχετίζεται με την διαμόρφωση του μονοπατιού σηματοδότησης IGF-1 σε κύτταρα έτσι ώστε να βελτιωθούν τα χαρακτηριστικά παραγωγής.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15064599P | 1999-08-25 | 1999-08-25 | |
US16894899P | 1999-12-03 | 1999-12-03 | |
US17194999P | 1999-12-23 | 1999-12-23 | |
PCT/US2000/023483 WO2001014529A1 (en) | 1999-08-25 | 2000-08-25 | Compositions and methods for improved cell culture |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105772T1 true CY1105772T1 (el) | 2011-02-02 |
Family
ID=27387011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101630T CY1105772T1 (el) | 1999-08-25 | 2006-11-13 | Συνθεσεις και μεθοδοι για βελτιωμενη κυτταρικη καλλιεργεια |
Country Status (14)
Country | Link |
---|---|
US (3) | US6413744B1 (el) |
EP (1) | EP1210411B1 (el) |
JP (1) | JP2003507058A (el) |
AT (1) | ATE342962T1 (el) |
AU (1) | AU784506B2 (el) |
CA (1) | CA2383073A1 (el) |
CY (1) | CY1105772T1 (el) |
DE (1) | DE60031419T2 (el) |
DK (1) | DK1210411T3 (el) |
ES (1) | ES2272318T3 (el) |
IL (2) | IL148060A0 (el) |
NZ (2) | NZ529329A (el) |
PT (1) | PT1210411E (el) |
WO (1) | WO2001014529A1 (el) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
US7115231B1 (en) | 1998-06-09 | 2006-10-03 | Symyx Technologies, Inc. | Parallel reactor with knife-edge seal |
AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
ES2272318T3 (es) * | 1999-08-25 | 2007-05-01 | Immunex Corporation | Composiciones y metodos para el cultivo celular mejorado. |
IL136232A0 (en) * | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
US6439036B1 (en) | 2000-06-13 | 2002-08-27 | Symyx Technologics, Inc. | Method for evaluating a test fluid |
US6455007B1 (en) | 2000-06-13 | 2002-09-24 | Symyx Technologies, Inc. | Apparatus and method for testing compositions in contact with a porous medium |
US7018589B1 (en) | 2000-07-19 | 2006-03-28 | Symyx Technologies, Inc. | High pressure parallel reactor |
US7091004B1 (en) | 2001-06-08 | 2006-08-15 | Immunex Corporation | Regulation of translation for recombinant protein production |
US20060073141A1 (en) * | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
DK1404872T3 (da) * | 2001-07-04 | 2007-02-19 | Chromagenics Bv | Fremgangsmåde til selektion af en DNA-sekvens med transkriptionsmodulerende aktivitet med en vektor indeholdende et element med en gentranskriptionsundertrykkende aktivitet |
US20050014201A1 (en) * | 2001-10-25 | 2005-01-20 | Mordechai Deuthsch | Interactive transparent individual cells biochip processor |
US20030166147A1 (en) * | 2001-12-14 | 2003-09-04 | Lee Chichang | Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media |
NZ538094A (en) | 2002-07-09 | 2007-01-26 | Baxter Int | Serum free and animal protein free culture medium for cultivation of cells |
AU2003290453A1 (en) * | 2002-12-20 | 2004-07-14 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
IL154677A0 (en) | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
US8597597B2 (en) * | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
US20060240548A1 (en) * | 2003-06-26 | 2006-10-26 | Mordechai Deutsch | Materials for constructing cell-chips, cell-chip covers, cell-chips coats, processed cell-chips and uses thereof |
US7888110B2 (en) * | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
WO2005008626A1 (en) * | 2003-07-11 | 2005-01-27 | University Of North Carolina At Chapel Hill | Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop |
US20050064524A1 (en) * | 2003-08-11 | 2005-03-24 | Mordechai Deutsch | Population of cells utilizable for substance detection and methods and devices using same |
CA2554927A1 (en) * | 2004-02-03 | 2005-08-18 | Chemagis Ltd. | Stable amorphous forms of montelukast sodium |
US7403647B2 (en) * | 2004-09-13 | 2008-07-22 | Seng Enterprises Ltd. | Method for identifying an image of a well in an image of a well-bearing component |
WO2006003664A1 (en) * | 2004-07-07 | 2006-01-12 | Seng Enterprises Ltd. | Method and device for identifying an image of a well in an image of a well-bearing component |
US20080009051A1 (en) * | 2004-08-25 | 2008-01-10 | Seng Enterprises Ltd. | Method and Device for Isolating Cells |
JP5122292B2 (ja) * | 2004-10-15 | 2013-01-16 | モネル ケミカル センシズ センター | 哺乳動物の味覚細胞の培養方法 |
US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
SI1809750T1 (sl) * | 2004-11-08 | 2012-08-31 | Chromagenics Bv | Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina |
BRPI0517380A (pt) * | 2004-11-08 | 2008-10-07 | Chromagenics Bv | molécula de dna, cassete de expressão, célula hospedeira, e, métodos para gerar uma célula hospedeira que expressa um polipeptìdeo de interesse e para produzir um polipeptìdeo de interesse |
JP2008527980A (ja) * | 2005-01-25 | 2008-07-31 | アポロ ライフ サイエンシズ リミテッド | 分子およびそのキメラ分子 |
DE602005023534D1 (de) * | 2005-01-25 | 2010-10-21 | Seng Entpr Ltd | Mikrofluidische vorrichtung zur untersuchung zellen |
EP1707634A1 (en) * | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
US20060232821A1 (en) * | 2005-04-15 | 2006-10-19 | Sridharan Ranganathan | Parallel architecture for vector color error diffusion |
WO2007002210A2 (en) * | 2005-06-20 | 2007-01-04 | Bresagen, Inc. | Embryonic stem cell culture compositions and methods of use thereof |
EP1739179A1 (en) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
DE102005034043B4 (de) * | 2005-07-18 | 2019-12-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch |
US20070141555A1 (en) * | 2005-10-11 | 2007-06-21 | Mordechai Deutsch | Current damper for the study of cells |
WO2007052245A1 (en) * | 2005-11-03 | 2007-05-10 | Seng Enterprises Ltd. | Method and device for studying floating, living cells |
PT2522717E (pt) | 2006-01-04 | 2014-05-15 | Baxter Healthcare Sa | Meios de cultura celulares livres de oligopeptídeos |
US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
US7655191B2 (en) | 2007-05-14 | 2010-02-02 | Symyx Solutions, Inc. | Methods for chemical reactions in a parallel batch reactor |
US7807109B2 (en) | 2007-05-14 | 2010-10-05 | Freeslate, Inc. | Parallel batch reactor with pressure monitoring |
BRPI0812398A2 (pt) * | 2007-06-06 | 2019-09-24 | Domantis Ltd | domínio variável simples de imunoglobulina anti-vegf, antagonista anti-vegf, domínio variável simples de imunoglobulina resistente à protease, uso do antagonista vegf, método para a dispensação oral ou dispensação de um medicamento ao trato gi de um paciente ou ao pulmão ou tecido pulmonar ou olho de um paciente, dispositivo de dispensação pulmonar, formulação oral, ligando específico duplo, ácido nucleico isolado ou recombinante, vetor, célula hospedeira, método para produzir polipeptídeo, composição farmacêutica, polipeptídeo, e, proteína de fusão |
JP2010530228A (ja) * | 2007-06-29 | 2010-09-09 | エフ.ホフマン−ラ ロシュ アーゲー | Cho細胞 |
CN101815786A (zh) * | 2007-10-12 | 2010-08-25 | 弗·哈夫曼-拉罗切有限公司 | 来自多个核酸的蛋白质表达 |
US9975118B2 (en) | 2007-11-15 | 2018-05-22 | Seng Enterprises Ltd. | Device for the study of living cells |
US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
WO2009115495A1 (de) * | 2008-03-19 | 2009-09-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methode zur steigerung der reklonierungseffizienz |
RU2011116319A (ru) * | 2008-09-26 | 2012-11-10 | Шеринг Корпорейшн (US) | Производство высокого титра антител |
IN2012DN05169A (el) * | 2009-12-02 | 2015-10-23 | Acceleron Pharma Inc | |
RU2017126088A (ru) | 2011-02-07 | 2019-01-31 | Серени Терапеутикс Холдинг С.А. | Липопротеиновые комплексы и их получение и применения |
WO2012170938A1 (en) | 2011-06-08 | 2012-12-13 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life |
EP2906683B1 (en) | 2012-10-15 | 2017-05-31 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
WO2015010088A1 (en) * | 2013-07-19 | 2015-01-22 | Technical University Of Denmark | Methods for modeling chinese hamster ovary (cho) cell metabolism |
SI3303396T1 (sl) | 2015-05-29 | 2023-01-31 | Bristol-Myers Squibb Company | Protitelesa proti OX40 in njihova uporaba |
CN113493770A (zh) * | 2020-03-18 | 2021-10-12 | 苏州大学 | 人源glut5稳定转染细胞株及其在筛选glut5抑制剂中的应用 |
WO2022140389A1 (en) | 2020-12-22 | 2022-06-30 | Amgen Inc. | Cell culture method |
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IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
WO1991003554A1 (en) * | 1989-09-01 | 1991-03-21 | Genentech, Inc. | Cells transfected with nucleic acid encoding gtp |
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US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
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US5262308A (en) * | 1992-01-28 | 1993-11-16 | Thomas Jefferson University | Cell lines which constitutively express IGF-1 and IGF-1 R |
WO1993020200A1 (en) | 1992-04-02 | 1993-10-14 | Imperial Cancer Research Technology Limited | Modified cells and method of treatment |
US5663314A (en) | 1992-11-20 | 1997-09-02 | The Board Of Regents Of The University Of Washington | Human signal transduction MAPK kinase |
EP0666312A1 (en) | 1994-02-08 | 1995-08-09 | Wolfgang A. Renner | Process for the improvement of mammalian cell growth |
US5597719A (en) * | 1994-07-14 | 1997-01-28 | Onyx Pharmaceuticals, Inc. | Interaction of RAF-1 and 14-3-3 proteins |
AUPN442295A0 (en) | 1995-07-26 | 1995-08-17 | Commonwealth Scientific And Industrial Research Organisation | Regulated autocrine growth of mammalian cells |
CN1276832A (zh) * | 1997-09-26 | 2000-12-13 | 昂尼克斯药物公司 | 鉴定pkb激酶抑制剂的组合物及方法 |
ES2272318T3 (es) * | 1999-08-25 | 2007-05-01 | Immunex Corporation | Composiciones y metodos para el cultivo celular mejorado. |
-
2000
- 2000-08-25 ES ES00959455T patent/ES2272318T3/es not_active Expired - Lifetime
- 2000-08-25 US US09/648,667 patent/US6413744B1/en not_active Expired - Lifetime
- 2000-08-25 JP JP2001518843A patent/JP2003507058A/ja active Pending
- 2000-08-25 EP EP00959455A patent/EP1210411B1/en not_active Expired - Lifetime
- 2000-08-25 DK DK00959455T patent/DK1210411T3/da active
- 2000-08-25 PT PT00959455T patent/PT1210411E/pt unknown
- 2000-08-25 AT AT00959455T patent/ATE342962T1/de not_active IP Right Cessation
- 2000-08-25 DE DE2000631419 patent/DE60031419T2/de not_active Expired - Lifetime
- 2000-08-25 CA CA 2383073 patent/CA2383073A1/en not_active Abandoned
- 2000-08-25 AU AU70778/00A patent/AU784506B2/en not_active Ceased
- 2000-08-25 NZ NZ529329A patent/NZ529329A/en unknown
- 2000-08-25 WO PCT/US2000/023483 patent/WO2001014529A1/en active IP Right Grant
- 2000-08-25 NZ NZ517215A patent/NZ517215A/en unknown
- 2000-08-25 IL IL14806000A patent/IL148060A0/xx unknown
-
2002
- 2002-02-06 IL IL148060A patent/IL148060A/en not_active IP Right Cessation
- 2002-03-29 US US10/109,971 patent/US6897040B2/en not_active Expired - Lifetime
-
2005
- 2005-02-28 US US11/069,122 patent/US7166445B2/en not_active Expired - Lifetime
-
2006
- 2006-11-13 CY CY20061101630T patent/CY1105772T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20050170462A1 (en) | 2005-08-04 |
WO2001014529A1 (en) | 2001-03-01 |
NZ529329A (en) | 2005-06-24 |
DE60031419T2 (de) | 2007-09-27 |
NZ517215A (en) | 2004-01-30 |
WO2001014529A9 (en) | 2002-09-06 |
ATE342962T1 (de) | 2006-11-15 |
EP1210411A1 (en) | 2002-06-05 |
US6413744B1 (en) | 2002-07-02 |
DK1210411T3 (da) | 2007-02-19 |
US6897040B2 (en) | 2005-05-24 |
US7166445B2 (en) | 2007-01-23 |
IL148060A0 (en) | 2002-09-12 |
DE60031419D1 (de) | 2006-11-30 |
US20020160455A1 (en) | 2002-10-31 |
CA2383073A1 (en) | 2001-03-01 |
PT1210411E (pt) | 2006-12-29 |
EP1210411B1 (en) | 2006-10-18 |
JP2003507058A (ja) | 2003-02-25 |
AU784506B2 (en) | 2006-04-13 |
AU7077800A (en) | 2001-03-19 |
IL148060A (en) | 2009-07-20 |
ES2272318T3 (es) | 2007-05-01 |
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