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ES2163365A1 - Un procedimiento para elaborar derivados de camptotecina. - Google Patents

Un procedimiento para elaborar derivados de camptotecina.

Info

Publication number
ES2163365A1
ES2163365A1 ES009950083A ES9950083A ES2163365A1 ES 2163365 A1 ES2163365 A1 ES 2163365A1 ES 009950083 A ES009950083 A ES 009950083A ES 9950083 A ES9950083 A ES 9950083A ES 2163365 A1 ES2163365 A1 ES 2163365A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
manufacturing
hydroxy
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009950083A
Other languages
English (en)
Other versions
ES2163365B2 (es
Inventor
Chung Il Hong
Jung Woo Kim
Sang Joon Lee
Soon Kil Ahn
Nam Song Choi
Kye Kwang Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chong Kun Dang Corp
Original Assignee
Chong Kun Dang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Corp filed Critical Chong Kun Dang Corp
Publication of ES2163365A1 publication Critical patent/ES2163365A1/es
Application granted granted Critical
Publication of ES2163365B2 publication Critical patent/ES2163365B2/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invención se refiere a un procedimiento para elaborar el compuesto de fórmula general (1) a partir del compuesto de fórmula general (2); en las que Y y Z son iguales o diferentes y representan cada uno un átomo de hidrógeno, un grupo alquilo C1-C6, un grupo hidroxialquilo C1-C3 o un grupo protector general de amina tal como benciloxicarbonilo, bencilo, etc.; R1 es un átomo de hidrógeno, un grupo alquilo C1-C6 o un grupo hidroxi; R2 y R3 son iguales o diferentes y representan cada uno un átomo de hidrógeno o un grupo hidroxi, o pueden estar unidos conjuntamente para formar un resto cíclico, que es un grupo metilendioxi o etilendioxi; R4 es un átomo de hidrógeno o un grupo alquilo C1-C6; y R5 es hidrógeno, hidroxi, fluor, cloro, bromo, yodo o amino.
ES009950083A 1997-07-09 1998-07-08 Un procedimiento para elaborar derivados de camptotecina. Expired - Fee Related ES2163365B2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR19970031710 1997-07-09

Publications (2)

Publication Number Publication Date
ES2163365A1 true ES2163365A1 (es) 2002-01-16
ES2163365B2 ES2163365B2 (es) 2002-11-01

Family

ID=19513816

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009950083A Expired - Fee Related ES2163365B2 (es) 1997-07-09 1998-07-08 Un procedimiento para elaborar derivados de camptotecina.

Country Status (9)

Country Link
US (1) US6310207B1 (es)
KR (1) KR100266743B1 (es)
AU (1) AU8244998A (es)
BR (1) BRPI9813001B8 (es)
CH (1) CH693877A8 (es)
ES (1) ES2163365B2 (es)
IN (1) IN189180B (es)
RU (1) RU2181122C2 (es)
WO (1) WO1999002530A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109165B2 (en) * 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
CN118221763A (zh) 2019-03-29 2024-06-21 免疫医疗有限公司 化合物及其缀合物
CA3146385A1 (en) 2019-07-10 2021-01-14 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics
PE20220563A1 (es) 2019-07-10 2022-04-13 Cybrexa 2 Inc Conjugados peptidicos de citotoxinas como terapeuticos
CN116478175A (zh) * 2022-09-09 2023-07-25 杭州爱科瑞思生物医药有限公司 喜树碱-7-乙基胺衍生物及其制备方法和应用
CN116478051B (zh) * 2023-04-13 2024-06-21 戊言医药科技（上海）有限公司 一种贝洛替康盐酸盐及其关键中间体的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296597A2 (en) * 1987-06-24 1988-12-28 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
EP0471358A1 (en) * 1990-08-14 1992-02-19 Kyorin Pharmaceutical Co., Ltd. Fluoroethylcamptothecin derivatives
EP0495432A1 (en) * 1991-01-16 1992-07-22 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
WO1996021666A1 (en) * 1995-01-09 1996-07-18 Chong Kun Dang Corporation Camptothecin derivatives and its manufacturing method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296597A2 (en) * 1987-06-24 1988-12-28 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
EP0471358A1 (en) * 1990-08-14 1992-02-19 Kyorin Pharmaceutical Co., Ltd. Fluoroethylcamptothecin derivatives
EP0495432A1 (en) * 1991-01-16 1992-07-22 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
WO1996021666A1 (en) * 1995-01-09 1996-07-18 Chong Kun Dang Corporation Camptothecin derivatives and its manufacturing method

Also Published As

Publication number Publication date
US6310207B1 (en) 2001-10-30
BRPI9813001B8 (pt) 2021-07-06
RU2181122C2 (ru) 2002-04-10
AU8244998A (en) 1999-02-08
BRPI9813001B1 (pt) 2011-11-01
CH693877A8 (de) 2004-05-28
CH693877A5 (de) 2004-03-31
IN189180B (es) 2003-01-04
KR100266743B1 (ko) 2000-12-01
ES2163365B2 (es) 2002-11-01
KR19990013649A (ko) 1999-02-25
BRPI9813001A (pt) 2000-08-15
WO1999002530A1 (en) 1999-01-21

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