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ES2157991T3 - Cadn que codifica una nueva proteina humana, la tirosin-fosfatasa. - Google Patents

Cadn que codifica una nueva proteina humana, la tirosin-fosfatasa.

Info

Publication number
ES2157991T3
ES2157991T3 ES94929163T ES94929163T ES2157991T3 ES 2157991 T3 ES2157991 T3 ES 2157991T3 ES 94929163 T ES94929163 T ES 94929163T ES 94929163 T ES94929163 T ES 94929163T ES 2157991 T3 ES2157991 T3 ES 2157991T3
Authority
ES
Spain
Prior art keywords
ptp
human protein
phosphatase
tirosin
cadn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94929163T
Other languages
English (en)
Inventor
Gideon A Rodan
Su J Rutledge
Azriel Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2157991T3 publication Critical patent/ES2157991T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE HA IDENTIFICADO UNA NUEVA FOSFATASA DE TIROSINA DE PROTEINA HUMANA (PTP) Y SE HA AISLADO SU ADNC. ESTA NUEVA PTP IDENTIFICADA COMO PTP-OB, TIENE UNA ESTRUCTURA TRIDIMENSIONAL SIMILAR AL RECEPTOR Y ESTA PRESENTE EN LOS OSTEOBLASTOS. LA PTB-OB ESTA INVOLUCRADA EN LA DIFERENCIACION DEL OSTEOBLASTO, Y LOS MODULADORES DE LA ACTIVIDAD DE LA PTP-OB MODULAN A SU VEZ LA DIFERENCIACION DEL OSTEOBLASTO, LA DIFERENCIACION DEL OSTEOCLASTO Y LA ACTIVIDAD DEL OSTEOCLASTO.
ES94929163T 1993-09-14 1994-09-09 Cadn que codifica una nueva proteina humana, la tirosin-fosfatasa. Expired - Lifetime ES2157991T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12203293A 1993-09-14 1993-09-14

Publications (1)

Publication Number Publication Date
ES2157991T3 true ES2157991T3 (es) 2001-09-01

Family

ID=22400183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94929163T Expired - Lifetime ES2157991T3 (es) 1993-09-14 1994-09-09 Cadn que codifica una nueva proteina humana, la tirosin-fosfatasa.

Country Status (8)

Country Link
US (3) US5658756A (es)
EP (1) EP0725800B1 (es)
JP (1) JPH09502614A (es)
AT (1) ATE202571T1 (es)
CA (1) CA2171610A1 (es)
DE (1) DE69427588T2 (es)
ES (1) ES2157991T3 (es)
WO (1) WO1995007935A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821084A (en) * 1994-11-21 1998-10-13 The Regents Of The University Of Michigan Osteoblast-testicular protein tyrosine phosphatase
US6919434B1 (en) 1995-02-20 2005-07-19 Sankyo Co., Ltd. Monoclonal antibodies that bind OCIF
IL117175A (en) * 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US5719058A (en) * 1995-04-10 1998-02-17 Merck & Co., Inc. Method for producing a highly enriched population of osteoclast cells
AU709191B2 (en) * 1995-09-11 1999-08-26 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis
US7632922B1 (en) * 1995-12-22 2009-12-15 Amgen, Inc. Osteoprotegerin
US20050147611A1 (en) * 1995-12-22 2005-07-07 Amgen Inc. Combination therapy for conditions leading to bone loss
US6242213B1 (en) 1996-12-23 2001-06-05 Immunex Corporation Isolated DNA molecules encoding RANK-L
AU735355B2 (en) * 1997-04-15 2001-07-05 Daiichi Sankyo Company, Limited Novel protein and method for producing the protein
US6316408B1 (en) * 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
TR199902512T2 (xx) 1997-04-16 2000-06-21 Amgen Inc. Osteoprotegerin ba�lay�c� proteinler ve resept�rler.
WO1998054357A1 (en) * 1997-05-30 1998-12-03 David Jeston Baylink SCREENING METHODS TO IDENTIFY COMPOUNDS WHICH EFFECT OSTEOCLAST-SPECIFIC PHOSPHOTYROSYL PHOSPHATASE (PTP-oc) ACTIVITY
AU739304B2 (en) 1997-09-24 2001-10-11 Sankyo Company Limited Method of diagnosing metabolic bone diseases
WO1999021875A1 (en) 1997-10-24 1999-05-06 University Of Utah Research Foundation Kcnq2 and kcnq3-potassium channel genes which are mutated in benign familial neonatal convulsions (bfnc) and other epilepsies
US6780596B2 (en) * 1998-09-17 2004-08-24 Ashni Naturaceuticals, Inc. Methods for determining the activity of complex mixtures
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
WO2000053801A1 (en) * 1999-03-08 2000-09-14 Merck Frosst Canada & Co. Intact cell assay for protein tyrosine phosphatases
US20030103978A1 (en) * 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
PT1373215E (pt) * 2001-03-30 2006-12-29 Uni S Of A R By The S D Of H H Derivado de geldanamicina e metodo de tratamento de cancro utilizando o mesmo
US7247618B2 (en) * 2001-04-30 2007-07-24 Tripathi Rajavashisth Methods for inhibiting macrophage colony stimulating factor and c-FMS-dependent cell signaling
EP1494714A4 (en) 2002-04-05 2008-03-05 Amgen Inc HUMAN ANTI-OPGL NEUTRALIZING ANTIBODIES AS SELECTIVE OPGL PATH HEMMER
JP2006518738A (ja) * 2003-02-12 2006-08-17 トランス　テック　ファーマ，インコーポレイテッド 治療薬としての置換アゾール誘導体
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
JP4898458B2 (ja) * 2004-02-12 2012-03-14 トランス テック ファーマ，インコーポレイテッド 置換アゾール誘導体、組成物及び使用方法
NZ569329A (en) * 2006-01-30 2011-09-30 Transtech Pharma Inc Substituted imidazole derivatives and their use as PTPase inhibitors
US11119095B2 (en) * 2015-10-06 2021-09-14 Tokyo Institute Of Technology Method for measuring tyrosine phosphatase and tyrosine kinase activity

Also Published As

Publication number Publication date
DE69427588T2 (de) 2002-04-25
DE69427588D1 (de) 2001-08-02
WO1995007935A1 (en) 1995-03-23
US5658756A (en) 1997-08-19
EP0725800A1 (en) 1996-08-14
JPH09502614A (ja) 1997-03-18
ATE202571T1 (de) 2001-07-15
US6214564B1 (en) 2001-04-10
CA2171610A1 (en) 1995-03-23
EP0725800B1 (en) 2001-06-27
EP0725800A4 (en) 1997-09-10
US5866397A (en) 1999-02-02

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