[go: up one dir, main page]

PT832069E - Derivados de tetrahidro-isoquinolin-6-il amida do acido bifenilo-2-carboxilico sua preparacao e sua utilizacao como inibidores de proteina de transferencia de triglicerido microsomal e/ou da secrecao de apolipoproteina b (apo b) - Google Patents

Derivados de tetrahidro-isoquinolin-6-il amida do acido bifenilo-2-carboxilico sua preparacao e sua utilizacao como inibidores de proteina de transferencia de triglicerido microsomal e/ou da secrecao de apolipoproteina b (apo b)

Info

Publication number
PT832069E
PT832069E PT95918722T PT95918722T PT832069E PT 832069 E PT832069 E PT 832069E PT 95918722 T PT95918722 T PT 95918722T PT 95918722 T PT95918722 T PT 95918722T PT 832069 E PT832069 E PT 832069E
Authority
PT
Portugal
Prior art keywords
ylidate
triglycerid
microsomal
secrecy
transference
Prior art date
Application number
PT95918722T
Other languages
English (en)
Inventor
George J Quallich
George Chang
Peter H Dorff
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority claimed from EP95918722A external-priority patent/EP0832069B1/en
Publication of PT832069E publication Critical patent/PT832069E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT95918722T 1995-06-07 1995-06-07 Derivados de tetrahidro-isoquinolin-6-il amida do acido bifenilo-2-carboxilico sua preparacao e sua utilizacao como inibidores de proteina de transferencia de triglicerido microsomal e/ou da secrecao de apolipoproteina b (apo b) PT832069E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95918722A EP0832069B1 (en) 1995-06-07 1995-06-07 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION

Publications (1)

Publication Number Publication Date
PT832069E true PT832069E (pt) 2003-06-30

Family

ID=8222277

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95918722T PT832069E (pt) 1995-06-07 1995-06-07 Derivados de tetrahidro-isoquinolin-6-il amida do acido bifenilo-2-carboxilico sua preparacao e sua utilizacao como inibidores de proteina de transferencia de triglicerido microsomal e/ou da secrecao de apolipoproteina b (apo b)

Country Status (3)

Country Link
EP (1) EP1181954A3 (pt)
ES (1) ES2191706T3 (pt)
PT (1) PT832069E (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002307839B2 (en) 2001-06-28 2006-03-16 Zoetis P Llc Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion
PL1725234T5 (pl) 2004-03-05 2016-06-30 Univ Pennsylvania Sposoby leczenia zaburzeń lub chorób związanych z hiperlipidemią i hipercholesterolemią ze zminimalizowaniem efektów ubocznych
MX2007013133A (es) * 2005-04-19 2008-03-14 Surface Logix Inc Inhibidores de la proteina microsomal de transferencia de trigliceridos de la secrecion de apo-b.
CN101198588B (zh) * 2005-04-19 2013-04-24 瑟尔费斯罗季克斯公司 微粒体三酸甘油酯转运蛋白及载脂蛋白-b分泌的抑制剂
WO2007047725A2 (en) * 2005-10-18 2007-04-26 Aegerion Pharmaceuticals Methods for treating disorders associated with hyperlipidemia in a mammal

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268181A (en) * 1989-04-13 1993-12-07 Upsher-Smith Laboratories, Inc. Method of using niacin to control nocturnal cholesterol synthesis
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein

Also Published As

Publication number Publication date
ES2191706T3 (es) 2003-09-16
EP1181954A2 (en) 2002-02-27
EP1181954A3 (en) 2002-08-21

Similar Documents

Publication Publication Date Title
FI974440A (fi) Bifenyyli-2-karboksyylihappo-tetrahydro-isokinolin-6-yyli-amidijohdannaisia, niiden valmistus ja niiden käyttö mikrosomaalistatriglyseridiä siirtävän proteiinin ja/tai apolipoproteiini B:n (Apo B) erittymiseen inhibiittoreina
DE69712003D1 (de) Modifikation von xylanase zur Verbesserung von Thermophilicität, alkophilicität und thermostabilität
DE69315855D1 (de) Untersuchung von wiederkäuern
PT993439E (pt) Derivados de acido 4-bromo ou 4-iodofenilaminobenzidroxamico e sua utilizacao como inibidores de mek
FR2737118B1 (fr) Composition dermatologique ou pharmaceutique, procede de preparation et utilisation
FI973278A (fi) Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet
EE03590B1 (et) Peptiidide ja proteiinide aerosoolvormid
DE69631647D1 (de) Erfassung von möglichem betrügerischen gebrauch von kommunikation
BR9004274A (pt) Sistema de comunicacoes e estacao secundaria de modalidade dupla
IS4345A (is) Setin N-(indól-2-karbónýl)-b-alaninamíð, notkun þeirra og lyfjaefnablöndur
DE69433380D1 (de) Systeme zur interpulmonaren verabreichung von wässrigen lösungen
DE59601770D1 (de) Substituierte quaterrylentetracarbonsäurediimide
DE69913553D1 (de) Konfigurierung von systemeinheiten
FI963802L (fi) Trombolyyttisesti aktiivisten proteiinien ja antikoagulanttien yhdistelmiä ja niiden käyttöjä
IT8620017A0 (it) Procedimento e dispositivo di asportazione da balle di fibra.
PT836615E (pt) Novos inibidores da trombina sua preparacao e utilizacao
KR950700990A (ko) 신규의 분비단백질 에프-스폰딘의 클로닝, 발현 및 용도
ATE284225T1 (de) Verwendung von komplexen lipiden als stabilisierende zusätze zu pharmazeutischen zubereitungen von verdauungsenzymgemischen
DE69825625D1 (de) Aminobiguanide und ihre verwendung zur desinfektion von kontaktlinsen und konservierung von pharmazeutischen zubereitungen
DE69614078D1 (de) Korrektur von Kopplungsunterscheiden in seismischen Messungen
DE69032207D1 (de) Einführung von bakterien in ovo
ID15848A (id) Produksi dan sekresi protein-protein yang berasal dari bakteri dalam jamur berfilamen
DK403384D0 (da) Enteralt effektivt, biologisk aktivt peptid- eller proteinmiddel ogfremgangsmaader til fremstilling deraf
PT832069E (pt) Derivados de tetrahidro-isoquinolin-6-il amida do acido bifenilo-2-carboxilico sua preparacao e sua utilizacao como inibidores de proteina de transferencia de triglicerido microsomal e/ou da secrecao de apolipoproteina b (apo b)
FI960425L (fi) Fenyylisykloheksyylikarboksyylihappoamidien käyttö