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ES2157277T3 - Uso de glucosaminoglucanos para la fabricacion de un medicamento para el tratamiento de insuficiencia renal cronica. - Google Patents

Uso de glucosaminoglucanos para la fabricacion de un medicamento para el tratamiento de insuficiencia renal cronica.

Info

Publication number
ES2157277T3
ES2157277T3 ES95113868T ES95113868T ES2157277T3 ES 2157277 T3 ES2157277 T3 ES 2157277T3 ES 95113868 T ES95113868 T ES 95113868T ES 95113868 T ES95113868 T ES 95113868T ES 2157277 T3 ES2157277 T3 ES 2157277T3
Authority
ES
Spain
Prior art keywords
peritoneal
retal
sulodexide
low molecular
glucosaminoglucans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95113868T
Other languages
English (en)
Inventor
Bruno Baggio
Giorgio Bazzato
Agostino Fracasso
Giovanni Gambaro
Egidio Marchi
Gianfranco Tamagnone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Wasserman SpA
Original Assignee
Alfa Wasserman SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wasserman SpA filed Critical Alfa Wasserman SpA
Application granted granted Critical
Publication of ES2157277T3 publication Critical patent/ES2157277T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EL OBJETO DE LA PRESENTE INVENCION ES EL USO DE ALGUNOS GLICOSAMINOGLICANOS COMO SULODEXIDO, HEPARINA DE BAJO PESO MOLECULAR Y SULFATO DE DERMATANO DE BAJO PESO MOLECULAR Y DE LAS MEDICINAS MEDIANTE USO PARENTERAL QUE LOS CONTIENEN EN EL TRATAMIENTO DE PACIENTES QUE SUFREN DE INSUFICIENCIA RENAL CRONICA SOMETIDOS A DIALISIS PERITONEAL. LA EFECTIVIDAD DE ESTE USO SE HA DEMOSTRADO TANTO POR ESTUDIOS FARMACOLOGICOS REALIZADOS EN RATAS NEFRECTOMIZADAS A LAS QUE SE LES HA PRODUCIDO LESION PERITONEAL COMO POR ESTUDIOS CLINICOS LLEVADOS A CABO EN PACIENTES QUE SUFREN DE INSUFICIENCIA RENAL CRONICA SOMETIDOS A CAPD Y TRATADOS MEDIANTE RUTA INTRAPERITONEAL (I.P.) CON VIALES DE 2 ML DE VESSEL DUE CONTENIENDO 50 MG DE SULODEXIDO. SE HA OBSERVADO UN SIGNIFICATIVO AUMENTO DE LOS TRANSPORTES PERITONEALES DE UREA Y DE CREATININA UNIDOS A UNA SIGNIFICATIVA REDUCCION DE PERDIDA DE PROTEINA EN EL EFLUENTE PERITONEAL. NO SE HAN OBSERVADO DURANTE EL ESTUDIO CAMBIOS SIGNIFICATIVOS DE LA CAPACIDAD DE ULTRAFILTRACION Y DE COMPLICACIONES HEMORRAGICOCOAGULANTES.
ES95113868T 1994-10-06 1995-09-04 Uso de glucosaminoglucanos para la fabricacion de un medicamento para el tratamiento de insuficiencia renal cronica. Expired - Lifetime ES2157277T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO940436A IT1274351B (it) 1994-10-06 1994-10-06 Uso di alcuni glicosaminoglicani nella dialisi peritoneale.

Publications (1)

Publication Number Publication Date
ES2157277T3 true ES2157277T3 (es) 2001-08-16

Family

ID=11340040

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95113868T Expired - Lifetime ES2157277T3 (es) 1994-10-06 1995-09-04 Uso de glucosaminoglucanos para la fabricacion de un medicamento para el tratamiento de insuficiencia renal cronica.

Country Status (9)

Country Link
US (1) US5686432A (es)
EP (1) EP0710483B1 (es)
AT (1) ATE202282T1 (es)
DE (1) DE69521388T2 (es)
DK (1) DK0710483T3 (es)
ES (1) ES2157277T3 (es)
GR (1) GR3036158T3 (es)
IT (1) IT1274351B (es)
PT (1) PT710483E (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127896A0 (en) * 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
CN1371391A (zh) * 1999-06-30 2002-09-25 汉密尔顿市医院研究发展有限公司 抑制凝血相关凝血因子的肝素成分
ITMI991503A1 (it) * 1999-07-08 2001-01-08 Bidifarm S R L Uso di metaboliti oligosaccaridici di proteoglicani come maker in fluidi biologici di diagnosi del biabete e delle complicanze patologiche c
US7259152B2 (en) * 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
PL363047A1 (en) * 2000-09-08 2004-11-15 Hamilton Civic Hospitals Research Development Inc. Antithrombotic compositions
US20030008844A1 (en) * 2001-05-17 2003-01-09 Keryx Biopharmaceuticals, Inc. Use of sulodexide for the treatment of inflammatory bowel disease
NZ530037A (en) * 2001-06-12 2006-03-31 Keryx Biopharmaceuticals Inc Use of glycosaminoglycans for the treatment of HIV-associated nephropathy
PE20030263A1 (es) * 2001-07-31 2003-04-17 Novartis Ag Composicion farmaceutica oftalmica
JP2008541927A (ja) 2005-05-30 2008-11-27 ガンブロ・ルンディア・エービー 腹膜透析液
BRPI0620637A2 (pt) 2005-12-22 2011-11-16 Neurochem Int Ltd uso de compostos na preparação de medicamentos para a prevenção ou o tratamento de nefropatia diabética, complicação de desordem renal e dislipidemia, redução dos nìveis de lipìdeos e ácido úrico no soro, e aumento do clearance de creatinina e da função renal
US20070155672A1 (en) * 2006-01-05 2007-07-05 Markus Voges Sterilized peritoneal dialysis solutions containing heparin
CN101883794B (zh) 2007-10-01 2012-11-07 生化学工业株式会社 低分子化硫酸软骨素及其用途
CN101632686A (zh) * 2008-04-04 2010-01-27 马斯特里赫特大学 糖胺聚糖用于修复糖萼的用途
IT1401253B1 (it) 2010-04-23 2013-07-18 Uni Degli Studi Carlo Bo Urbino Uso del sulodexide per la riduzione delle metalloproteinasi di matrice.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1245907B (it) * 1991-05-17 1994-10-25 Alfa Wassermann Spa Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.
IT1270846B (it) * 1993-05-10 1997-05-13 Alfa Wassermann Spa Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.
KR950704362A (ko) * 1993-09-30 1995-11-20 야마야 구따루 항혈전제

Also Published As

Publication number Publication date
EP0710483A1 (en) 1996-05-08
ITBO940436A1 (it) 1996-04-06
ITBO940436A0 (it) 1994-10-06
IT1274351B (it) 1997-07-17
ATE202282T1 (de) 2001-07-15
EP0710483B1 (en) 2001-06-20
DK0710483T3 (da) 2001-09-03
US5686432A (en) 1997-11-11
GR3036158T3 (en) 2001-09-28
DE69521388T2 (de) 2001-10-11
PT710483E (pt) 2001-09-28
DE69521388D1 (de) 2001-07-26

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