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ES2118160T3 - Compuestos de azol, su produccion y su uso. - Google Patents

Compuestos de azol, su produccion y su uso.

Info

Publication number
ES2118160T3
ES2118160T3 ES93106772T ES93106772T ES2118160T3 ES 2118160 T3 ES2118160 T3 ES 2118160T3 ES 93106772 T ES93106772 T ES 93106772T ES 93106772 T ES93106772 T ES 93106772T ES 2118160 T3 ES2118160 T3 ES 2118160T3
Authority
ES
Spain
Prior art keywords
group
atom
independently
production
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93106772T
Other languages
English (en)
Inventor
Katsumi Itoh
Kenji Okonogi
Norikazu Tamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2118160T3 publication Critical patent/ES2118160T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Coloring (AREA)
  • Polymerization Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Lubricants (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PRESENTA UN COMPUESTO DE AZOL REPRESENTADO POR LA FORMULA (I): EN LA QUE AR ES UN GRUPO DE FENIL SUSTITUIDO; R1 Y R2 SON INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO DE ALQUIL INFERIOR, O R1 Y R2 PUEDEN COMBINARSE JUNTAS PARA FORMAR UN GRUPO DE ALQUILENO INFERIOR; R3 ES UN GRUPO UNIDO A TRAVES DE UN ATOMO DE CARBONO; R4 ES UN ATOMO DE HIDROGENO O UN GRUPO DE ACIL; X ES UN ATOMO DE NITROGENO O UN GRUPO DE METINO; E Y Y Z SON CADA UNA INDEPENDIENTEMENTE UN ATOMO DE NITROGENO O UN GRUPO DE METINO QUE PUEDE ESTAR OPCIONALMENTE SUSTITUIDO CON UN GRUPO DE ALQUIL INFERIOR O UNA SAL DE LOS MISMOS, LOS COMPUESTOS SON UTILES PARA LA PREVENCION Y TERAPIA DE INFECCIONES FUNGALES EN MAMIFEROS COMO AGENTE ANTIFUNGAL.
ES93106772T 1992-04-28 1993-04-27 Compuestos de azol, su produccion y su uso. Expired - Lifetime ES2118160T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11040092 1992-04-28
JP2262393 1993-02-10

Publications (1)

Publication Number Publication Date
ES2118160T3 true ES2118160T3 (es) 1998-09-16

Family

ID=26359882

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93106772T Expired - Lifetime ES2118160T3 (es) 1992-04-28 1993-04-27 Compuestos de azol, su produccion y su uso.

Country Status (18)

Country Link
US (2) US5371101A (es)
EP (1) EP0567982B1 (es)
JP (1) JP2818097B2 (es)
KR (1) KR100257619B1 (es)
CN (1) CN1040433C (es)
AT (1) ATE167857T1 (es)
AU (1) AU655544B2 (es)
CA (1) CA2094962A1 (es)
DE (1) DE69319380T2 (es)
DK (1) DK0567982T3 (es)
ES (1) ES2118160T3 (es)
FI (1) FI931901L (es)
HU (2) HUT64327A (es)
NO (1) NO303284B1 (es)
NZ (1) NZ247488A (es)
PH (1) PH31082A (es)
SG (1) SG48939A1 (es)
TW (1) TW218017B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2159488A1 (es) * 2000-03-07 2001-10-01 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifugica.

Families Citing this family (51)

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HU212458B (en) * 1993-09-23 1996-06-28 Richter Gedeon Vegyeszet New silyloxypropane derivatives substituted with triazole or imidazole pharmaceutical compositions containing them and process for producing them
TW297813B (es) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) * 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
EP0746318A1 (en) * 1994-02-25 1996-12-11 Takeda Chemical Industries, Ltd. Injectable emulsions containing antifungal triazole derivatives
CA2150533A1 (en) * 1994-05-31 1995-12-01 Katsumi Itoh Production of optically active triazole compounds and their intermediates
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
US5639754A (en) * 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
AU4675596A (en) * 1995-02-17 1996-09-04 Takeda Chemical Industries Ltd. Azole compounds, their production and use
TW318841B (es) * 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
US6060604A (en) 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
DE19520597A1 (de) * 1995-06-06 1996-12-12 Bayer Ag Mercapto-bis-triazole
ES2107376B1 (es) * 1995-08-02 1998-07-01 Uriach & Cia Sa J Nuevos derivados de pirimidona con actividad antifungica.
ES2120885B1 (es) * 1996-03-15 1999-06-16 Uriach & Cia Sa J Nuevas tienopirimidonas con actividad antifungica.
EP0783501B9 (en) * 1995-08-02 2001-07-25 J. URIACH & CIA. S.A. pyrimidone derivatives with antifungal activity
KR970705560A (ko) * 1995-08-02 1997-10-09 호아껭 우리아치 토렐로 항진균 활성을 갖는 신규한 카르복사미드(new carboxamides with antifungal activity)
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000507585A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシルタンパク質トランスフェラーゼの阻害剤
AU6119798A (en) * 1997-03-05 1998-09-22 Takeda Chemical Industries Ltd. Crystalline form of a bis 1,2,4-triazole compound
EP0973768B1 (en) * 1997-03-31 2003-07-09 Takeda Chemical Industries, Ltd. Azole compounds, their production and their use
EP0884311A3 (en) * 1997-06-06 1999-01-27 Takeda Chemical Industries, Ltd. Triazole Derivatives and their production
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
WO2000018401A1 (fr) * 1998-09-29 2000-04-06 Takeda Chemical Industries, Ltd. Composition de medicament antimycotique
WO2001066551A2 (en) * 2000-03-07 2001-09-13 Ranbaxy Laboratories Limited Azole compounds as therapeutic agents for fungal infections
IN191188B (es) 2000-03-07 2003-10-04 Ranbaxy Lab Ltd
US6710049B2 (en) * 2000-12-26 2004-03-23 Ranbaxy Laboratories Limited Azole compounds as anti-fungal agents
CA2439310C (en) * 2001-03-23 2009-09-29 Richter Gedeon Vegyeszeti Gyar Rt. Process for preparing fluconazole and its crystal modifications
IN191819B (es) * 2001-07-19 2004-01-03 Ranbaxy Lab Ltd
IN192526B (es) * 2001-09-25 2004-04-24 Ranbaxy Lab
US7028055B2 (en) * 2002-03-22 2006-04-11 Sun Microsystems, Inc. Method and apparatus for improving transaction specification by marking application states
BR0215702A (pt) * 2002-04-12 2005-10-18 Ranbaxy Lab Ltd Derivados de tetraidrofurano 2,2,4-trisubstituìdo como agentes antifúngicos
CA2489854A1 (en) 2002-06-18 2003-12-24 Pola Chemical Industries Inc. Antifungal medicinal compositions
AU2002328176A1 (en) * 2002-08-26 2004-03-11 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
MX2007005940A (es) * 2004-11-18 2007-06-19 Synta Pharmaceuticals Corp Compuestos de triazol que modulan la actividad hsp90.
CN1304376C (zh) * 2005-03-04 2007-03-14 清华大学 一种卤化烷基咪唑型离子液体的制备方法
JP5178515B2 (ja) * 2005-08-12 2013-04-10 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するピラゾール化合物
WO2007094819A2 (en) * 2005-08-18 2007-08-23 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
RS53446B (en) 2006-05-25 2014-12-31 Synta Pharmaceuticals Corp. TRIAZOLE UNITS MODULATING HSP90 ACTIVITY
US8318790B2 (en) * 2006-05-25 2012-11-27 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
WO2007139960A2 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Compounds that modulate hsp90 activity and methods for identifying same
CA2653332A1 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
US7879867B2 (en) 2006-08-07 2011-02-01 Palau Pharma, S.A. Crystalline antifungal compounds
EP2104665A2 (en) * 2006-10-19 2009-09-30 F. Hoffmann-Roche AG Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
CN102824342B (zh) * 2011-06-17 2016-03-30 全哲山 一类用作抗癫痫药的化合物及其可药用盐
JP2014534228A (ja) 2011-11-02 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 白金含有剤とｈｓｐ９０阻害剤の組合せ療法
EP2773345A1 (en) 2011-11-02 2014-09-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
EP2780010A1 (en) 2011-11-14 2014-09-24 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
DK105189A (da) * 1988-03-04 1989-09-05 Sankyo Co Triazolderivater og fremgangsmaade til fremstilling deraf samt fungicide midler indeholdende derivaterne
DE3837463A1 (de) * 1988-11-04 1990-05-10 Bayer Ag Substituierte bisazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2159488A1 (es) * 2000-03-07 2001-10-01 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifugica.
WO2001066519A3 (es) * 2000-03-07 2002-01-31 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica
KR100735583B1 (ko) * 2000-03-07 2007-07-04 제이. 유라이어크 이 콤파니아 소시에떼아노님 항진균 활성을 갖는 피리미돈 유도체의 제조 방법

Also Published As

Publication number Publication date
DK0567982T3 (da) 1999-04-12
DE69319380D1 (de) 1998-08-06
CN1079467A (zh) 1993-12-15
HU9301226D0 (en) 1993-07-28
AU3822193A (en) 1993-11-04
SG48939A1 (en) 1998-05-18
DE69319380T2 (de) 1998-10-29
HU211474A9 (en) 1995-11-28
US5466820A (en) 1995-11-14
NO931533L (no) 1993-10-29
TW218017B (es) 1993-12-21
AU655544B2 (en) 1994-12-22
NO931533D0 (no) 1993-04-27
JPH06293740A (ja) 1994-10-21
HUT64327A (en) 1993-12-28
KR940005616A (ko) 1994-03-21
NZ247488A (en) 1995-02-24
KR100257619B1 (en) 2000-07-01
CA2094962A1 (en) 1993-10-29
ATE167857T1 (de) 1998-07-15
JP2818097B2 (ja) 1998-10-30
CN1040433C (zh) 1998-10-28
PH31082A (en) 1998-02-05
US5371101A (en) 1994-12-06
FI931901A0 (fi) 1993-04-27
FI931901L (fi) 1993-10-29
EP0567982B1 (en) 1998-07-01
NO303284B1 (no) 1998-06-22
EP0567982A1 (en) 1993-11-03

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