[go: up one dir, main page]

ES2096560T3 - Compuestos de benzocicloheptapiridina sustituida con fluor, composiciones y metodos para uso como compuestos antihistaminicos. - Google Patents

Compuestos de benzocicloheptapiridina sustituida con fluor, composiciones y metodos para uso como compuestos antihistaminicos.

Info

Publication number
ES2096560T3
ES2096560T3 ES89309191T ES89309191T ES2096560T3 ES 2096560 T3 ES2096560 T3 ES 2096560T3 ES 89309191 T ES89309191 T ES 89309191T ES 89309191 T ES89309191 T ES 89309191T ES 2096560 T3 ES2096560 T3 ES 2096560T3
Authority
ES
Spain
Prior art keywords
compositions
benzocicloheptapiridina
fluorine
substituted
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89309191T
Other languages
English (en)
Inventor
Doris P Schumacher
Bruce L Murphy
Jon E Clark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22924039&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2096560(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2096560T3 publication Critical patent/ES2096560T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

CIERTOS COMPONENTES DE BENZOCICLOHEPTAPIRIDINA CONSUSTITUCION DE FLUORINA A TRAVES DEL DOBLE ENLACE EXOCICLICO SON PREPARADOS Y SON UTILES COMO AGENTES ANTIHISTAMINICOS.
ES89309191T 1988-09-15 1989-09-11 Compuestos de benzocicloheptapiridina sustituida con fluor, composiciones y metodos para uso como compuestos antihistaminicos. Expired - Lifetime ES2096560T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/244,768 US4863931A (en) 1988-09-15 1988-09-15 Antihistaminic fluoro substituted benzocycloheptapyridines

Publications (1)

Publication Number Publication Date
ES2096560T3 true ES2096560T3 (es) 1997-03-16

Family

ID=22924039

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89309191T Expired - Lifetime ES2096560T3 (es) 1988-09-15 1989-09-11 Compuestos de benzocicloheptapiridina sustituida con fluor, composiciones y metodos para uso como compuestos antihistaminicos.

Country Status (10)

Country Link
US (1) US4863931A (es)
EP (2) EP0434759A1 (es)
JP (1) JPH0631220B2 (es)
AT (1) ATE148114T1 (es)
AU (1) AU4337289A (es)
DE (1) DE68927697T2 (es)
ES (1) ES2096560T3 (es)
GR (1) GR3022966T3 (es)
HK (1) HK55797A (es)
WO (1) WO1990003375A2 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
KR920014799A (ko) * 1991-01-18 1992-08-25 나오가따 다이도 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
DK0723538T3 (da) * 1993-10-15 2002-03-18 Schering Corp Tricykliske carbamatforbindelser, der er nyttige til inhibition af funktion af G-protein og til behandling af proliferative sygdomme
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US6075025A (en) * 1993-10-15 2000-06-13 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6365588B1 (en) 1993-10-15 2002-04-02 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5464840A (en) * 1993-12-06 1995-11-07 Schering Corporation Tricyclic derivatives, compositions and methods of use
US5939268A (en) * 1994-07-26 1999-08-17 The Scripps Research Institute Combinatorial libraries of molecules and methods for producing same
ES2080700B1 (es) * 1994-07-27 1996-10-16 Farmihispania S A Nuevo procedimiento para la obtencion de loratadina.
ES2080699B1 (es) * 1994-07-27 1996-10-16 Farmahispania S A Nuevos derivados de 2-(1-etoxicarbonil-4-piperidiliden)metil)piridina y un procedimiento para su obtencion.
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5684013A (en) * 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5891872A (en) * 1995-04-07 1999-04-06 Schering Corporation Tricyclic compounds
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
JP3779349B2 (ja) * 1995-04-24 2006-05-24 興和株式会社 ピペリジン誘導体
JPH11504650A (ja) * 1995-05-08 1999-04-27 ヘキスト・マリオン・ルセル・インコーポレイテツド アルファ−（置換アルキルフェニル）−４−（ヒドロキシジフェニルメチル）−１−ピペリジンブタノール誘導体、その製造および抗ヒスタミン剤、抗アレルギー剤および気管支拡張剤としてのその使用
US5874442A (en) * 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
AU3924500A (en) * 1999-03-29 2000-10-16 Schering Corporation Methods and compositions for treating allergic and related disorders using fluorinated descarboethoxyloratadine
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6100274A (en) * 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
US6114346A (en) * 1999-10-22 2000-09-05 Schering Corporation Treating sleep disorders using desloratadine
SK287105B6 (sk) 1999-12-20 2009-12-07 Schering Corporation Dvojvrstvový orálny dávkový prostriedok s predĺženým uvoľňovaním
WO2001045668A2 (en) * 1999-12-20 2001-06-28 Schering Corporation Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
US6720002B2 (en) 2001-07-20 2004-04-13 R.P. Scherer Technologies, Inc. Antihistamine formulations for soft capsule dosage forms
US20040001885A1 (en) * 2002-06-27 2004-01-01 Unchalee Kositprapa Rapidly disintegrating antihistamine formulation
ES2232331T1 (es) * 2003-03-12 2005-06-01 Biogal Gyogyszergyar Rt. Procedimientos para la preparacion de formas polimorficas de desloratadina.
WO2007143382A2 (en) * 2006-06-07 2007-12-13 Morton Grove Pharmaceuticals, Inc. Oral liquid loratadine formulations and methods
US20090082385A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched desloratidine
CA2690490C (en) 2010-01-19 2012-06-26 Accucaps Industries Limited Pharmaceutical formulations of loratadine for encapsulation and combinations thereof
CN112341433A (zh) * 2020-11-16 2021-02-09 成都大学 一种氯雷他定的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (es) * 1963-04-24
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
US4731447A (en) * 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
DE3677842D1 (de) * 1985-05-13 1991-04-11 Schering Corp Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln.
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines

Also Published As

Publication number Publication date
US4863931A (en) 1989-09-05
WO1990003375A3 (en) 1990-05-31
DE68927697D1 (de) 1997-03-06
ATE148114T1 (de) 1997-02-15
JPH0631220B2 (ja) 1994-04-27
EP0359499B1 (en) 1997-01-22
GR3022966T3 (en) 1997-06-30
HK55797A (en) 1997-05-09
WO1990003375A2 (en) 1990-04-05
JPH03502696A (ja) 1991-06-20
EP0434759A1 (en) 1991-07-03
DE68927697T2 (de) 1997-06-12
EP0359499A3 (en) 1990-06-20
EP0359499A2 (en) 1990-03-21
AU4337289A (en) 1990-04-18

Similar Documents

Publication Publication Date Title
ES2096560T3 (es) Compuestos de benzocicloheptapiridina sustituida con fluor, composiciones y metodos para uso como compuestos antihistaminicos.
ES2058185T3 (es) Derivados de camptotecina y procedimiento para su preparacion.
ATE269290T1 (de) Benzoylderivate
ES2080739T3 (es) Nitro-compuestos insecticidamente activos.
DE59005097D1 (de) Verwendung härtbarer Cycloaliphaten-Derivate in Dübelmassen.
MX9207074A (es) Piperazinil- y piperidinil -ciclohexanoles y composicion farmaceutica que los comprende
DK0674641T3 (da) Pyrrolopyrimidiner som CRF-antagonister
ES2148476T3 (es) Derivados de azabicicloalcano n-substituidos como neurolepticos asf.
MX9201356A (es) Derivados de piperidina, procedimiento para su preparacion y composicion farmaceutica que los contiene.
AR241082A1 (es) Nuevos derivados de pirazol utiles como agentes herbicidas, las composiciones herbicidas que los contienen y los procedimientos para producir estos derivados de pirazol".
ES2093099T3 (es) Preparacion de piperidinas sustituidas.
ES2095068T3 (es) Peroxicarbonatos polimericos y procedimiento para prepararlos.
ES2135722T3 (es) 1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina.
ES2171743T3 (es) Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico.
FI892222A (fi) Peptidalkoholer med antikoagulantverkan.
ES2140672T3 (es) Compuestos biciclicos sustituidos, fusionados y puentes utilizados como agentes terapeuticos.
ES525297A0 (es) Procedimiento para la obtencion de derivados de terc.-butanol sustituidos
ES2053535T3 (es) Derivados heterociclicos de cinco miembros de n,n'-diacilhidrazinas n' sustituidas.
DK0720597T3 (da) Triarylethylenderivater til terapeutisk anvendelse
ATE18035T1 (de) Zusammensetzungen von ferrosilikatmolekularsieben.
DE58907569D1 (de) Isomere Trimethylbicyclo[4.3.0]nonan-Derivate.
ES2129401T3 (es) Uso de un compuesto terapeutico para el tratamiento de bronquitis.
DK0457215T3 (da) 3-deamino-4-desoxy-4-amino-8-fluoranthracycliner samt fremgangsmåder til fremstilling deraf
ES2101531T3 (es) Derivados de benzo(f)quinoxalinadiona, su preparacion y su utilizacion en medicamentos.
ES2134879T3 (es) Metalocenos que contienen compuestos de fluorenilo sustituidos en la posicion 9 y uso de los metalocenos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 359499

Country of ref document: ES