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ES2115679T3 - Preparacion de reactivos de tiempo de protrombina a partir de factor de tejido humano recombinante y de fosfolipidos sinteticos y naturales purificados. - Google Patents

Preparacion de reactivos de tiempo de protrombina a partir de factor de tejido humano recombinante y de fosfolipidos sinteticos y naturales purificados.

Info

Publication number
ES2115679T3
ES2115679T3 ES92921544T ES92921544T ES2115679T3 ES 2115679 T3 ES2115679 T3 ES 2115679T3 ES 92921544 T ES92921544 T ES 92921544T ES 92921544 T ES92921544 T ES 92921544T ES 2115679 T3 ES2115679 T3 ES 2115679T3
Authority
ES
Spain
Prior art keywords
tissue factor
recombinant human
human tissue
protrombine
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921544T
Other languages
English (en)
Inventor
Pamela L Hawkins
Liliana Tejidor
James Maynard
Kevin B Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dade Behring Inc
Original Assignee
Dade Behring Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Inc filed Critical Dade Behring Inc
Application granted granted Critical
Publication of ES2115679T3 publication Critical patent/ES2115679T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE REVELA UN REACTIVO DIFERIDO PROTROMBINA PARA EMPLEARLO EN UN TEST DE PROTROMBINA DIFERIDA. EL REACTIVO EMPLEA FACTOR HISTIOLOGICO HUMANO RECOMBINANTE, FOSFOLIPIDOS DE ORIGEN NATURAL O SINTETICO, UNA COMPOSICION REGULADORA Y UN ION DE CALCIO. EN EL REACTIVO SE PUEDEN USAR TAMBIEN SALES Y ESTABILIZADORES. ADEMAS, SE REVELA UN METODO PARA CREAR AGREGADOS LIPIDOS MOLECULARES QUE CONTIENEN EL FACTOR HISTIOLOGICO.
ES92921544T 1991-10-04 1992-09-25 Preparacion de reactivos de tiempo de protrombina a partir de factor de tejido humano recombinante y de fosfolipidos sinteticos y naturales purificados. Expired - Lifetime ES2115679T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77129491A 1991-10-04 1991-10-04

Publications (1)

Publication Number Publication Date
ES2115679T3 true ES2115679T3 (es) 1998-07-01

Family

ID=25091357

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921544T Expired - Lifetime ES2115679T3 (es) 1991-10-04 1992-09-25 Preparacion de reactivos de tiempo de protrombina a partir de factor de tejido humano recombinante y de fosfolipidos sinteticos y naturales purificados.

Country Status (11)

Country Link
US (1) US5625036A (es)
EP (1) EP0565665B1 (es)
JP (1) JP3416778B2 (es)
AT (1) ATE163768T1 (es)
AU (1) AU663343B2 (es)
CA (1) CA2097199C (es)
DE (1) DE69224622T2 (es)
DK (1) DK0565665T3 (es)
ES (1) ES2115679T3 (es)
NZ (1) NZ244597A (es)
WO (1) WO1993007492A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5418141A (en) * 1994-05-06 1995-05-23 Avocet Medical, Inc. Test articles for performing dry reagent prothrombin time assays
IL115849A0 (en) * 1994-11-03 1996-01-31 Merz & Co Gmbh & Co Tangential filtration preparation of liposomal drugs and liposome product thereof
AT403437B (de) * 1995-02-15 1998-02-25 Immuno Ag Physiologisch aktive gewebefaktor-präparation
WO1997019357A1 (en) * 1995-11-22 1997-05-29 Oklahoma Medical Research Foundation Assay for blood clotting factors viii and ix
US5858724A (en) * 1996-07-16 1999-01-12 Pel-Freez Recombinant rabbit tissue factor
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
WO1998048283A1 (en) * 1997-04-23 1998-10-29 Instrumentation Laboratory S.P.A. Recombinant rabbit tissue factor based prothrombin time reagent
AU9114598A (en) * 1997-08-26 1999-03-16 University Of North Carolina At Chapel Hill, The Method of monitoring blood low molecular weight heparin and heparin
US6245573B1 (en) 1998-02-12 2001-06-12 University Of Medicine And Dentistry Of New Jersey Rapid assessment of the coagulant activity of blood
DE69941563D1 (de) 1999-02-23 2009-12-03 Asulab Sa Elektrochemisches System zur Bestimmung der Blutgerinnungszeit
US6733985B1 (en) 1999-05-19 2004-05-11 International Technidyne Corporation Preparation of stable liquid and dried synthetic prothrombin time reagents
AU6933900A (en) * 1999-09-03 2001-04-10 Roche Diagnostics Corporation Method, reagent and test cartridge for determining clotting time
US6248353B1 (en) 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
US6800298B1 (en) * 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
US6645768B1 (en) * 2000-10-27 2003-11-11 Biomerieux, Inc. Reagent and kit for determining global coagulability and hemostatic potential
US6743596B1 (en) 2000-10-27 2004-06-01 Biomerieux, Inc. Method of determining global coagulability hemostatic potential
US6855509B2 (en) 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US6596543B2 (en) 2001-03-22 2003-07-22 Dade Behring Inc. Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
US7358337B2 (en) * 2002-08-16 2008-04-15 International Technidyne Corporation Assay for low molecular weight heparin
US7049087B2 (en) * 2002-11-05 2006-05-23 Lifescan, Inc. Method for manufacturing a tissue factor-based prothrombin time reagent
AU2003282351A1 (en) * 2002-11-12 2004-06-03 Inverness Medical Switzerland Gmbh Photometric determination of coagulation time in undiluted whole blood
WO2004043991A2 (en) * 2002-11-13 2004-05-27 Haematologic Technologies, Inc. Assay for tissue factor and factor viia
US20050221414A1 (en) * 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
EP1853926A2 (en) * 2005-02-16 2007-11-14 The Board Of Trustees Of The University Of Illinois Procoagulants based on metal-chelating lipids
AT501650A1 (de) * 2005-02-22 2006-10-15 Technoclone Ges M B H Verfahren zur bestimmung der gerinnungsaktivierung sowie gerät zur durchführung des verfahrens
ATE505488T1 (de) 2005-03-04 2011-04-15 Univ Illinois Modulator von coagulationskaskaden und fibrinolytischen kaskaden
JP5073270B2 (ja) 2006-11-14 2012-11-14 シスメックス株式会社 凝固検査用試薬及びその製造方法
EP2040073A1 (en) * 2007-09-20 2009-03-25 Iline Microsystems, S.L. Microfluidic device and method for fluid clotting time determination
WO2009046194A2 (en) 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Fibrin sealant
WO2009061697A1 (en) 2007-11-09 2009-05-14 The Board Of Trustees Of The University Of Illinois Anticoagulant antagonist and hemophilia procoagulant
WO2011144953A1 (en) * 2010-05-18 2011-11-24 Diagon Kft. Procedure for producing recombinant human tissue factor
EP2576813A1 (en) 2010-05-28 2013-04-10 Diagon Kft. Procedure for biphasic preparation of liposomes and application thereof in manufacturing diagnostic reagents
CN102608337B (zh) * 2011-04-22 2014-05-14 武汉塞力斯生物技术有限公司 凝血酶原时间测定试剂盒及其制备方法
CN112481355B (zh) * 2020-11-16 2023-05-30 武汉市长立生物技术有限责任公司 液体型凝血酶原时间测定试剂盒及其制备方法
CN115508569A (zh) * 2022-09-15 2022-12-23 上海太阳生物技术有限公司 蛋白s试剂及检测试剂盒

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
US4461833A (en) * 1982-06-23 1984-07-24 University Patents, Inc. Chromatographically purifying proteolytic procoagulant enzyme from animal tissue extract
US4721572A (en) * 1985-07-12 1988-01-26 Miles Laboratories, Inc. Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices
SE458342B (sv) * 1987-07-06 1989-03-20 Alfa Laval Ab Centrifugalseparator innefattande en rotor med en separeringskammare bestaaende av tvaa avdelningar
US4865984A (en) * 1988-02-08 1989-09-12 Mount Sinai School Of Medicine Of The City University Of New York Dynamic continuous flow enzyme reactor
US5472850A (en) * 1991-04-10 1995-12-05 Oklahoma Medical Research Foundation Quantitative clotting assay for activated factor VII
SE464135B (sv) * 1989-07-14 1991-03-11 Kabivitrum Ab Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov
US5314695A (en) * 1990-11-13 1994-05-24 Corvas International, Inc. Tissue factor based prothrombin time reagent

Also Published As

Publication number Publication date
JPH06505562A (ja) 1994-06-23
DK0565665T3 (da) 1998-09-28
DE69224622D1 (de) 1998-04-09
US5625036A (en) 1997-04-29
JP3416778B2 (ja) 2003-06-16
EP0565665A1 (en) 1993-10-20
EP0565665B1 (en) 1998-03-04
CA2097199C (en) 2001-05-08
AU663343B2 (en) 1995-10-05
WO1993007492A1 (en) 1993-04-15
CA2097199A1 (en) 1993-04-05
AU2769292A (en) 1993-05-03
ATE163768T1 (de) 1998-03-15
DE69224622T2 (de) 1998-11-05
NZ244597A (en) 1993-09-27

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