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ES2110573T3 - Produccion de microcapsulas de farmacos solubles en agua. - Google Patents

Produccion de microcapsulas de farmacos solubles en agua.

Info

Publication number
ES2110573T3
ES2110573T3 ES93306124T ES93306124T ES2110573T3 ES 2110573 T3 ES2110573 T3 ES 2110573T3 ES 93306124 T ES93306124 T ES 93306124T ES 93306124 T ES93306124 T ES 93306124T ES 2110573 T3 ES2110573 T3 ES 2110573T3
Authority
ES
Spain
Prior art keywords
microcapsules
water
production
soluble
drugs soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93306124T
Other languages
English (en)
Inventor
Koichi Maedera
Masuhisa Hori
Tomomichi Futo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2110573T3 publication Critical patent/ES2110573T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

SE SUMINISTRA UN PROCESO PARA PRODUCIR MICROCAPSULAS DE UNA DROGA SOLUBLE EN AGUA MEDIANTE UN PROCESO DE SECADO EN AGUA, QUE COMPRENDE EL DESARROLLO DEL PROCESO EN LA PRESENCIA DE UNA SUSTANCIA PARA EL AJUSTE DE LA PRESION OSMOTICA PRESENTE EN LA FASE ACUOSA EXTERNA. ESTE PROCESO MEJORA EN LA DROGA DISPUESTA EN EL INTERIOR DE MICROCAPSULAS.
ES93306124T 1992-08-07 1993-08-03 Produccion de microcapsulas de farmacos solubles en agua. Expired - Lifetime ES2110573T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21146292 1992-08-07

Publications (1)

Publication Number Publication Date
ES2110573T3 true ES2110573T3 (es) 1998-02-16

Family

ID=16606344

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93306124T Expired - Lifetime ES2110573T3 (es) 1992-08-07 1993-08-03 Produccion de microcapsulas de farmacos solubles en agua.

Country Status (11)

Country Link
US (1) US5611971A (es)
EP (1) EP0582459B1 (es)
JP (1) JP2608242B2 (es)
KR (1) KR100328098B1 (es)
AT (1) ATE161716T1 (es)
CA (1) CA2103518C (es)
DE (1) DE69316101T2 (es)
DK (1) DK0582459T3 (es)
ES (1) ES2110573T3 (es)
GR (1) GR3026291T3 (es)
HU (1) HU209976B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2194590A1 (es) * 2001-10-10 2003-11-16 Pierre Fabre Iberica S A Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.

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CA2192782C (en) * 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
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FR2830448B1 (fr) * 2001-10-10 2004-03-19 Pf Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
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EP1466596B8 (en) * 2001-12-26 2017-01-11 Takeda Pharmaceutical Company Limited Microsphere and method for production thereof
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ES2605402T3 (es) 2002-06-25 2017-03-14 Takeda Pharmaceutical Company Limited Procedimiento para producir una composición de liberación sostenida
AU2003261298A1 (en) * 2002-08-02 2004-02-23 Penwest Pharmaceuticals Company Sustained release formulations of metformin
KR20040017002A (ko) * 2002-08-20 2004-02-26 한국화학연구원 삼투압유도제가 첨가된 국소이식형 항암제제
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Cited By (1)

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Also Published As

Publication number Publication date
ATE161716T1 (de) 1998-01-15
HU9302284D0 (en) 1993-10-28
EP0582459A3 (en) 1994-06-29
CA2103518A1 (en) 1994-02-08
CA2103518C (en) 2004-03-30
DE69316101T2 (de) 1998-10-22
KR100328098B1 (ko) 2002-08-13
EP0582459A2 (en) 1994-02-09
HU209976B (en) 1995-01-30
HUT65235A (en) 1994-05-02
JPH06145046A (ja) 1994-05-24
JP2608242B2 (ja) 1997-05-07
DE69316101D1 (de) 1998-02-12
KR940003540A (ko) 1994-03-12
GR3026291T3 (en) 1998-06-30
DK0582459T3 (da) 1998-04-27
EP0582459B1 (en) 1998-01-07
US5611971A (en) 1997-03-18

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