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ES2108855T3 - Derivados de acido oxamico como agentes hipocolesteremicos. - Google Patents

Derivados de acido oxamico como agentes hipocolesteremicos.

Info

Publication number
ES2108855T3
ES2108855T3 ES93810495T ES93810495T ES2108855T3 ES 2108855 T3 ES2108855 T3 ES 2108855T3 ES 93810495 T ES93810495 T ES 93810495T ES 93810495 T ES93810495 T ES 93810495T ES 2108855 T3 ES2108855 T3 ES 2108855T3
Authority
ES
Spain
Prior art keywords
lower alkyl
hydrogen
trifluoromethyl
cycloalkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93810495T
Other languages
English (en)
Inventor
Naokata Yokoyama
Gordon Northrop Walker
Alan Joseph Main
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2108855T3 publication Critical patent/ES2108855T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
    • C07C323/37—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCUBREN COMPUESTOS DE FORMULA EN DONDE R ES HIDROGENO, HIDROXILO, HIDROXILO ESTERIFICADO O HIDROXILO ETERIFICADO; R1 ES HIDROGENO, HALOGENO, TRIFLUOROMETILO O ALQUILO INFERIOR; R2 ES HIDROGENO, HALOGENO, TRIFLUOROMETILO O ALQUILO INFERIOR; R3 ES HALOGENO, TRIFLUOROMETILO, ALQUILO INFERIOR, ARILO, ALQUILO ARILO INFERIOR, CICLOALQUILO O ALQUILO CICLOALQUILO INFERIOR; O R3 ES EL RADICAL EN DONDE R8 ES HIDROGENO, ALQUILO INFERIOR, ARILO, CICLOALQUILO, ALQUILO ARILO INFERIOR O ALQUILO CICLOALQUILO INFERIOR; R9 ES HIDROXILO O ACILOXILO; R10 REPRESENTA HIDROGENO O ALQUILO INFERIOR; O R9 Y R10 JUNTOS REPRESENTAN OXO; R4 ES HIDROGENO, HALOGENO, TRIFLUOROMETILO O ALQUILO INFERIOR; X ES -NR7; W ES O O S; R5 Y R6 JUNTOS REPRESENTAN OXO; R7 REPRESENTA HIDROGENO O ALQUILO INFERIOR; Z REPRESENTA CARBOXILO, DERIVADO DE CARBOXILO COMO UN ESTER FARMACEUTICAMENTE ACEPTABLE O COMO UNA AMIDA FARMACEUTICAMENTE ACEPTABLE; Y SALES DE ELLOS FARMACEUTICAMENTE ACEPTABLES; LOS CUALES SE USAN COMO AGENTES HIPOCOLESTEREMICOS.
ES93810495T 1992-07-21 1993-07-12 Derivados de acido oxamico como agentes hipocolesteremicos. Expired - Lifetime ES2108855T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91854492A 1992-07-21 1992-07-21

Publications (1)

Publication Number Publication Date
ES2108855T3 true ES2108855T3 (es) 1998-01-01

Family

ID=25440554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93810495T Expired - Lifetime ES2108855T3 (es) 1992-07-21 1993-07-12 Derivados de acido oxamico como agentes hipocolesteremicos.

Country Status (19)

Country Link
US (3) US5401772A (es)
EP (1) EP0580550B1 (es)
JP (1) JP3616119B2 (es)
KR (1) KR100294381B1 (es)
AT (1) ATE159515T1 (es)
AU (1) AU667924B2 (es)
CA (1) CA2100817C (es)
DE (1) DE69314718T2 (es)
DK (1) DK0580550T3 (es)
ES (1) ES2108855T3 (es)
FI (1) FI114633B (es)
GR (1) GR3025517T3 (es)
HU (1) HU214875B (es)
IL (1) IL106360A0 (es)
NO (1) NO304111B1 (es)
NZ (1) NZ248181A (es)
SA (1) SA94140579B1 (es)
TW (1) TW350771B (es)
ZA (1) ZA935196B (es)

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Also Published As

Publication number Publication date
HUT64512A (en) 1994-01-28
AU4208193A (en) 1994-01-27
JP3616119B2 (ja) 2005-02-02
US5401772A (en) 1995-03-28
CA2100817C (en) 2004-10-12
DE69314718T2 (de) 1998-02-26
EP0580550A1 (en) 1994-01-26
NO932614D0 (no) 1993-07-20
IL106360A0 (en) 1993-11-15
ZA935196B (en) 1994-07-07
ATE159515T1 (de) 1997-11-15
SA94140579B1 (ar) 2006-07-10
DK0580550T3 (da) 1998-02-02
FI933260A (fi) 1994-01-22
AU667924B2 (en) 1996-04-18
KR100294381B1 (ko) 2001-09-17
HU214875B (hu) 1998-07-28
US5654468A (en) 1997-08-05
JPH06172275A (ja) 1994-06-21
NO932614L (no) 1994-01-24
US5569674A (en) 1996-10-29
CA2100817A1 (en) 1994-01-22
HU9302095D0 (en) 1993-10-28
DE69314718D1 (de) 1997-11-27
NO304111B1 (no) 1998-10-26
EP0580550B1 (en) 1997-10-22
GR3025517T3 (en) 1998-02-27
KR940005555A (ko) 1994-03-21
TW350771B (en) 1999-01-21
FI933260A0 (fi) 1993-07-19
NZ248181A (en) 1995-11-27
FI114633B (fi) 2004-11-30

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