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ES2100129B1 - Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion. - Google Patents

Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.

Info

Publication number
ES2100129B1
ES2100129B1 ES09501965A ES9501965A ES2100129B1 ES 2100129 B1 ES2100129 B1 ES 2100129B1 ES 09501965 A ES09501965 A ES 09501965A ES 9501965 A ES9501965 A ES 9501965A ES 2100129 B1 ES2100129 B1 ES 2100129B1
Authority
ES
Spain
Prior art keywords
compounds
preparation
new
acetylcholinesterase inhibitors
polyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09501965A
Other languages
English (en)
Other versions
ES2100129A1 (es
Inventor
Pelayo Camps-Garcia
Lopez-Ibarra Die Munoz-Torrero
Romeu Diana Marina Gorbig
Lascorz Joan Contreras
Fornell Montserrat Simon
Cardoner Jordi Morral
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PELAYO CAMPS GARCIA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09501965A priority Critical patent/ES2100129B1/es
Application filed by Medichem SA filed Critical Medichem SA
Priority to JP9514739A priority patent/JPH11500144A/ja
Priority to BR9606755A priority patent/BR9606755A/pt
Priority to NZ319617A priority patent/NZ319617A/en
Priority to CA002206446A priority patent/CA2206446A1/en
Priority to AU72176/96A priority patent/AU706760B2/en
Priority to EP96933447A priority patent/EP0796849B1/en
Priority to PCT/ES1996/000192 priority patent/WO1997013754A1/es
Priority to DE69630772T priority patent/DE69630772T2/de
Priority to US08/849,709 priority patent/US5965569A/en
Priority to AT96933447T priority patent/ATE254604T1/de
Priority to ES96933447T priority patent/ES2211978T3/es
Publication of ES2100129A1 publication Critical patent/ES2100129A1/es
Priority to MXPA/A/1997/004289A priority patent/MXPA97004289A/es
Application granted granted Critical
Publication of ES2100129B1 publication Critical patent/ES2100129B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

NUEVOS COMPUESTOS AMINOPIRIDINICOS POLICICLICOS INHIBIDORES DE ACETILCOLINESTERASA, PROCEDIMIENTO PARA SU PREPARACION Y SU UTILIZACION. LOS COMPUESTOS AMINOPIRIDINICOS POLICICLICOS RESPONDE A LA FORMULA FORMULA EN DONDE LOS DISTINTOS RADICALES TIENEN LOS SIGNIFICADOS INDICADOS EN LA MEMORIA DESCRIPTIVA. EL PROCEDIMIENTO PRA LA PREPARACION DE ESTOS COMPUESTOS SE CARACTERIZA PORQUE SE HACEN REACCIONAR CETONAS DE FORMULA GENERAL (II) CON AMINONITRILOS DE FORMULA GENERAL (III) Y, EN CASO NECESARIO, LOS COMPUESTOS DE LA FORMULA (I) SE ALQUILAN, ARALQUILAN O ACILAN O BIEN SE REDUCE EL CORRESPONDIENTE PRECURSOS CETONICO. LOS COMPUESTOS DE LA FORMULA GENERAL (I) SON ESPECIALMENTE ADECUADOS PARA LA PREPARACION DE MEDICAMENTOS CONTRA TRASTORNOS DE LA MEMORIA, TALES COMO LA DEMENCIA SENIL O LA ENFERMEDAD DE ALZHEIMER.
ES09501965A 1995-10-11 1995-10-11 Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion. Expired - Fee Related ES2100129B1 (es)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ES09501965A ES2100129B1 (es) 1995-10-11 1995-10-11 Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.
AT96933447T ATE254604T1 (de) 1995-10-11 1996-10-11 Neue polycyclische aminopyridine als acetylcholinesterase hemmer, verfahren zur herstellung und deren verwendung
NZ319617A NZ319617A (en) 1995-10-11 1996-10-11 Polycyclic aminopyridine derivatives, preparation and use as acetylcholinesterase inhibitors for treating memory disorders
CA002206446A CA2206446A1 (en) 1995-10-11 1996-10-11 Novel polycyclic aminopyridine compounds as acetylcholinesterase inhibitors, preparation process and use thereof
AU72176/96A AU706760B2 (en) 1995-10-11 1996-10-11 New polycyclic aminopyridine compounds which are acetylcholinesterase inhibitors, process for preparing them and their use
EP96933447A EP0796849B1 (en) 1995-10-11 1996-10-11 Novel polycyclic aminopyridine compounds as acetylcholinesterase inhibitors, preparation process and use thereof
JP9514739A JPH11500144A (ja) 1995-10-11 1996-10-11 アセチルコリンエラスターゼのインヒビターである新規な多環式アミノピリジン化合物、それらの製造方法およびそれらの使用
DE69630772T DE69630772T2 (de) 1995-10-11 1996-10-11 Neue polycyclische aminopyridine als acetylcholinesterase hemmer, verfahren zur herstellung und deren verwendung
US08/849,709 US5965569A (en) 1995-10-11 1996-10-11 Polycyclic aminopyridine compounds which are acetylcholinesterase inhibitors, process for preparing them and their use
BR9606755A BR9606755A (pt) 1995-10-11 1996-10-11 Novos compostos de aminopiridina policíclica os quais são inibidores da aceticolinesterase processo para a sua preparação e seu uso
ES96933447T ES2211978T3 (es) 1995-10-11 1996-10-11 Nuevos compuestos aminopirimidinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento de preparacion y su uso.
PCT/ES1996/000192 WO1997013754A1 (es) 1995-10-11 1996-10-11 Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion
MXPA/A/1997/004289A MXPA97004289A (es) 1995-10-11 1997-06-10 Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09501965A ES2100129B1 (es) 1995-10-11 1995-10-11 Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.

Publications (2)

Publication Number Publication Date
ES2100129A1 ES2100129A1 (es) 1997-06-01
ES2100129B1 true ES2100129B1 (es) 1998-02-16

Family

ID=8291815

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09501965A Expired - Fee Related ES2100129B1 (es) 1995-10-11 1995-10-11 Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.
ES96933447T Expired - Lifetime ES2211978T3 (es) 1995-10-11 1996-10-11 Nuevos compuestos aminopirimidinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento de preparacion y su uso.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES96933447T Expired - Lifetime ES2211978T3 (es) 1995-10-11 1996-10-11 Nuevos compuestos aminopirimidinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento de preparacion y su uso.

Country Status (11)

Country Link
US (1) US5965569A (es)
EP (1) EP0796849B1 (es)
JP (1) JPH11500144A (es)
AT (1) ATE254604T1 (es)
AU (1) AU706760B2 (es)
BR (1) BR9606755A (es)
CA (1) CA2206446A1 (es)
DE (1) DE69630772T2 (es)
ES (2) ES2100129B1 (es)
NZ (1) NZ319617A (es)
WO (1) WO1997013754A1 (es)

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Also Published As

Publication number Publication date
ATE254604T1 (de) 2003-12-15
EP0796849A1 (en) 1997-09-24
JPH11500144A (ja) 1999-01-06
ES2211978T3 (es) 2004-07-16
DE69630772T2 (de) 2004-09-30
DE69630772D1 (de) 2003-12-24
ES2100129A1 (es) 1997-06-01
EP0796849B1 (en) 2003-11-19
CA2206446A1 (en) 1997-04-17
AU7217696A (en) 1997-04-30
AU706760B2 (en) 1999-06-24
WO1997013754A1 (es) 1997-04-17
US5965569A (en) 1999-10-12
NZ319617A (en) 2000-02-28
BR9606755A (pt) 1998-01-06

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