[go: up one dir, main page]

ES2089503T3 - Nuevos nitrilos del acido 1-aril-4-piperazinil-ciclohexanocarboxilico, su obtencion y empleo. - Google Patents

Nuevos nitrilos del acido 1-aril-4-piperazinil-ciclohexanocarboxilico, su obtencion y empleo.

Info

Publication number
ES2089503T3
ES2089503T3 ES92905289T ES92905289T ES2089503T3 ES 2089503 T3 ES2089503 T3 ES 2089503T3 ES 92905289 T ES92905289 T ES 92905289T ES 92905289 T ES92905289 T ES 92905289T ES 2089503 T3 ES2089503 T3 ES 2089503T3
Authority
ES
Spain
Prior art keywords
ciclohexanocarboxilico
piperazinil
nitrils
aril
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92905289T
Other languages
English (en)
Inventor
Hans-Jorg Treiber
Hans Peter Hofmann
Laszlo Szabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2089503T3 publication Critical patent/ES2089503T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE FORMULA (I) Y SU PRODUCCION. TENIENDO AR, R1, R2, P Y Q UN SIGNIFICADO DESCRITO EN LA REIVINDICACION. LOS COMPUESTOS SON APROPIADOS PARA EL TRATAMIENTO DE ENFERMEDADES.
ES92905289T 1991-03-15 1992-03-05 Nuevos nitrilos del acido 1-aril-4-piperazinil-ciclohexanocarboxilico, su obtencion y empleo. Expired - Lifetime ES2089503T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4108527A DE4108527A1 (de) 1991-03-15 1991-03-15 Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
ES2089503T3 true ES2089503T3 (es) 1996-10-01

Family

ID=6427416

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92905289T Expired - Lifetime ES2089503T3 (es) 1991-03-15 1992-03-05 Nuevos nitrilos del acido 1-aril-4-piperazinil-ciclohexanocarboxilico, su obtencion y empleo.

Country Status (15)

Country Link
US (1) US5371088A (es)
EP (1) EP0575361B1 (es)
JP (1) JPH06505717A (es)
AT (1) ATE139773T1 (es)
AU (1) AU658173B2 (es)
CA (1) CA2099870A1 (es)
CZ (1) CZ118893A3 (es)
DE (2) DE4108527A1 (es)
DK (1) DK0575361T3 (es)
ES (1) ES2089503T3 (es)
FI (1) FI933883A0 (es)
NZ (1) NZ241962A (es)
TW (1) TW218872B (es)
WO (1) WO1992016516A1 (es)
ZA (1) ZA921866B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022402B2 (en) * 2003-07-14 2006-04-04 E. I. Du Pont De Nemours And Company Dielectric substrates comprising a polymide core layer and a high temperature fluoropolymer bonding layer, and methods relating thereto

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2722529A (en) * 1955-11-01 Amides of certain l-amevoalkyl-x-phenyl
DE1793383C3 (de) * 1968-09-10 1979-03-01 Knoll Ag, 6700 Ludwigshafen 4-Cyan-4-phenyl-aminocyclohexane und deren wasserlösliche Salze, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE1795362A1 (de) * 1968-09-19 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
US3773939A (en) * 1971-11-24 1973-11-20 Janssen Pharmaceutica Nv N-arallyl-n'-aralkyl piperazine pharmaceutical compositions
GB1452413A (es) * 1973-08-16 1976-10-13 Fuji Chem Ind Co Ltd
IL48309A (en) * 1974-10-25 1980-01-31 Robins Co Inc A H 1-aryloxy-4-amino-2-butanols and pharmaceutical compositions containing them
US4369184A (en) * 1980-01-24 1983-01-18 Janssen Pharmaceutica N.V. 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives
JPS59101475A (ja) * 1982-12-02 1984-06-12 Nippon Chemiphar Co Ltd 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤
JPS60222472A (ja) * 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
JPH08776B2 (ja) * 1986-08-20 1996-01-10 日本ケミフア株式会社 脳細胞保護作用を有する医薬組成物
DE3643009A1 (de) * 1986-12-17 1988-06-30 Basf Ag Fungizide cyclohexylamine
US4880808A (en) * 1987-04-01 1989-11-14 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for improving sleep

Also Published As

Publication number Publication date
DE4108527A1 (de) 1992-09-17
NZ241962A (en) 1993-05-26
EP0575361A1 (de) 1993-12-29
CA2099870A1 (en) 1992-09-16
DK0575361T3 (da) 1996-07-29
FI933883L (fi) 1993-09-06
CZ118893A3 (en) 1994-02-16
AU1360192A (en) 1992-10-21
JPH06505717A (ja) 1994-06-30
AU658173B2 (en) 1995-04-06
DE59206667D1 (de) 1996-08-01
ZA921866B (en) 1993-09-13
EP0575361B1 (de) 1996-06-26
TW218872B (es) 1994-01-11
WO1992016516A1 (de) 1992-10-01
US5371088A (en) 1994-12-06
FI933883A0 (fi) 1993-09-06
ATE139773T1 (de) 1996-07-15

Similar Documents

Publication Publication Date Title
ES2040838T3 (es) Compuestos piperazinil-heterociclicos.
MX9203018A (es) Fluoroalcoxibencilamino-derivados de heterociclos nitrogenados.
ES2150567T3 (es) Antagonistas del factor de liberacion de la corticotropina.
ES2093694T3 (es) Nuevos derivados de dihidro-isoquinoleina.
ES2115985T3 (es) Dihidropirazolopirroles.
ES2147759T3 (es) Heterociclos no aromaticos sustituidos con aminometileno y uso como antagonistas de la sustancia p.
ES2038627T3 (es) Derivados del acido (met)-acrilico que contienen grupos uretano.
ES2012527A6 (es) Procedimiento de obtencion de benzo(b) piranos y piranopiridinas.
ES2032613T3 (es) Procedimiento para la preparacion de derivados de la didehidro-vitamina d3. (reserva del art. 167.2 cpe).
ES2148476T3 (es) Derivados de azabicicloalcano n-substituidos como neurolepticos asf.
PA8432901A1 (es) Compuestos de piridilpirrol
ES2153820T3 (es) Derivados de benzimidazol, procedimiento para su preparacion y aplicaciones.
ES2090855T3 (es) Derivados de naftaleno, procedimientos para su preparacion y productos intermediarios apropiados.
ES2131830T3 (es) Benzamidinas sustituidas, su preparacion y uso como medicamentos.
ES2084339T3 (es) Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central.
ES8800222A1 (es) Procedimiento para la obtencion del acido 2,6-dicloro-5-fluor-piridin-3-carboxilico
ES2089136T3 (es) Tratamiento de enfermedades inflamatorias con la ayuda de derivados 15-ceto-prostaglandinas.
YU78092A (sh) Postupak za dobijanje derivata beta-fenilizoserina i njihova primena
IT8025159A0 (it) Preparato medicinale ad azione citostatica, nonche' derivati dell'acido isocianurico eprocedimento per la loro preparazione.
ES2155621T3 (es) Derivados azo del acido 5-aminosalicilico para el tratamiento de la enfermedad inflamatoria intestinal.
ES2116612T3 (es) Nuevas bis-naftalimidas para el tratamiento del cancer.
SE9300758L (sv) Förfarande för framställning av kavulansyrasalter
ES545194A0 (es) Un procedimiento para preparar derivados de purina
SE7906287L (sv) Nya indol-(2,3-a)-kinolizidiner, sett att framstella dessa och deras anvendning som terapeutika
ES2054738T3 (es) Derivados de acido 3-desmetil-4-fluoromevalonico, procedimiento para su preparacion, preparados farmaceuticos a base de estos compuestos, su empleo y productos intermedios.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 575361

Country of ref document: ES

FG2A Definitive protection

Ref document number: 575361

Country of ref document: ES