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ES2131830T3 - Benzamidinas sustituidas, su preparacion y uso como medicamentos. - Google Patents

Benzamidinas sustituidas, su preparacion y uso como medicamentos.

Info

Publication number
ES2131830T3
ES2131830T3 ES95921824T ES95921824T ES2131830T3 ES 2131830 T3 ES2131830 T3 ES 2131830T3 ES 95921824 T ES95921824 T ES 95921824T ES 95921824 T ES95921824 T ES 95921824T ES 2131830 T3 ES2131830 T3 ES 2131830T3
Authority
ES
Spain
Prior art keywords
medicines
preparation
substituted benzamidines
sub
benzamidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95921824T
Other languages
English (en)
Inventor
Ralf Anderskewitz
Kurt Schromm
Ernst-Otto Renth
Franz Birke
Armin Fugner
Hubert Heuer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Application granted granted Critical
Publication of ES2131830T3 publication Critical patent/ES2131830T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LOS NUEVOS COMPUESTOS DE FORMULA (I) (EL SIGNIFICADO DE A Y DE R{SUB,1} A R{SUB,4} SE EXPLICA EN LA DESCRIPCION) SE PUEDEN OBTENER SEGUN PROCEDIMIENTOS CONVENCIONALES Y SE PUEDE UTILIZAR TERAPEUTICAMENTE EN OTRAS COSAS COMO ANTAGONISTAS DEL LTB{SUB,4}.
ES95921824T 1994-07-13 1995-06-03 Benzamidinas sustituidas, su preparacion y uso como medicamentos. Expired - Lifetime ES2131830T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4424713A DE4424713A1 (de) 1994-07-13 1994-07-13 Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe

Publications (1)

Publication Number Publication Date
ES2131830T3 true ES2131830T3 (es) 1999-08-01

Family

ID=6523047

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95921824T Expired - Lifetime ES2131830T3 (es) 1994-07-13 1995-06-03 Benzamidinas sustituidas, su preparacion y uso como medicamentos.

Country Status (37)

Country Link
US (1) US5731332A (es)
EP (1) EP0770059B1 (es)
JP (1) JP2931410B2 (es)
KR (1) KR100421580B1 (es)
CN (1) CN1083830C (es)
AT (1) ATE178590T1 (es)
AU (1) AU700585B2 (es)
BG (1) BG62090B1 (es)
BR (1) BR9508374A (es)
CA (1) CA2194885C (es)
CO (1) CO4410184A1 (es)
CZ (1) CZ289376B6 (es)
DE (2) DE4424713A1 (es)
DK (1) DK0770059T3 (es)
EE (1) EE03311B1 (es)
ES (1) ES2131830T3 (es)
FI (1) FI970094L (es)
GR (1) GR3030043T3 (es)
HK (1) HK1011966A1 (es)
HR (1) HRP950365B1 (es)
HU (1) HU224823B1 (es)
IL (1) IL114571A (es)
MX (1) MX9700273A (es)
MY (1) MY117090A (es)
NO (1) NO307373B1 (es)
NZ (1) NZ287883A (es)
PE (1) PE32496A1 (es)
PL (1) PL179595B1 (es)
RO (1) RO118653B1 (es)
RU (1) RU2159228C2 (es)
SA (1) SA95160355B1 (es)
SK (1) SK281744B6 (es)
TW (1) TW555738B (es)
UA (1) UA45351C2 (es)
WO (1) WO1996002497A1 (es)
YU (1) YU48934B (es)
ZA (1) ZA955780B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486181B1 (en) 1992-08-28 2002-11-26 City Of Hope Human leukocutye 12-lipoxygenase and its role in the pathogenesis of disease states
US6191169B1 (en) 1992-08-28 2001-02-20 City Of Hope Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
ATE251141T1 (de) * 1995-03-10 2003-10-15 Berlex Lab Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
WO1996036347A1 (en) * 1995-05-17 1996-11-21 Eli Lilly And Company Use of leukotriene antagonists for alzheimer's disease
DE19636689A1 (de) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg Neue Benzamidinderivate
DE19718334A1 (de) * 1997-04-30 1998-11-05 Boehringer Ingelheim Pharma Neue Benzylaminderivate und Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
TW513402B (en) * 1997-05-30 2002-12-11 Daiichi Seiyaku Co Process for preparing 3-(7-amidino-2-naphthyl)-2-phenylpropionic acid derivatives
US6046224A (en) * 1997-10-15 2000-04-04 City Of Hope 12 (S)--hete receptor blockers
ID24720A (id) 1997-12-12 2000-08-03 Novartis Ag Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis
DE19834713A1 (de) * 1998-07-31 2000-02-03 Boehringer Ingelheim Pharma Neue Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6291531B1 (en) * 1999-10-07 2001-09-18 Boehringer Ingelheim Pharma Kg LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition
US6417382B2 (en) 2000-01-12 2002-07-09 Boehringer Ingelheim Pharma Kg Process for preparing aryl-iminomethyl-carbamino acid esters
DE10000907A1 (de) * 2000-01-12 2001-07-19 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aryl-iminomethyl-carbaminsäureestern
US6528491B2 (en) * 2000-10-24 2003-03-04 Boehringer Ingelheim Pharma Kg Pyranoside derivatives
MXPA03006328A (es) * 2001-01-16 2004-04-05 Boehringer Ingelheim Pharma Uso de antagonista de ltb4 para tratamiento y/o prevencion de enfermedades causadas por aumento de expresion de genes de mucina.
US20030119901A1 (en) * 2001-07-14 2003-06-26 Boehringer Ingelheim Pharma Kg Pharmaceutical formulation containing an LTB4 antagonist
JP2005502630A (ja) * 2001-07-14 2005-01-27 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト Ｌｔｂ４拮抗薬を含有する医薬製剤
KR20040036908A (ko) * 2001-08-31 2004-05-03 뉴로겜 인터내셔널 리미티드 아밀로이드증 치료용 아미딘 유도체
RS20050390A (en) * 2002-11-26 2008-04-04 Boehringer Ingelheim Pharma Gmbh. & Co.Kg., Pharmaceutical composition comprising a ltb4 antagonist and a cox-2 inhibitor or a combined cox 1/2 inhibitor
DE10350528A1 (de) * 2003-10-29 2005-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arzneimittelformulierung, enthaltend einen LTB4-Antagonisten, sowie Verfahren zu deren Herstellung und deren Verwendung
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
EP3623368A4 (en) 2017-05-12 2021-04-07 Riken CLASS A GPCR BINDING COMPOUND MODIFIER

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518818A3 (en) * 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
DK0518819T3 (da) * 1991-06-11 1995-09-25 Ciba Geigy Ag Amidino-forbindelser, deres fremstilling og anvendelse som lægemiddel
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
ATE180770T1 (de) * 1992-02-05 1999-06-15 Boehringer Ingelheim Pharma Neue amidinderivate, ihre herstellung und verwendung als arzneimittel mit ltb4- antagonistischer wirkung
US5455274A (en) * 1992-12-09 1995-10-03 Ciba-Geigy Corporation Hydroxyamidine derivatives

Also Published As

Publication number Publication date
CZ289376B6 (cs) 2002-01-16
HU224823B1 (en) 2006-02-28
HK1011966A1 (en) 1999-07-23
MX9700273A (es) 1997-05-31
HU9700059D0 (en) 1997-02-28
FI970094A0 (fi) 1997-01-10
JPH10502645A (ja) 1998-03-10
UA45351C2 (uk) 2002-04-15
HRP950365A2 (en) 1997-08-31
KR970704675A (ko) 1997-09-06
SA95160355B1 (ar) 2005-06-13
DE59505600D1 (de) 1999-05-12
PE32496A1 (es) 1996-08-12
CZ6697A3 (cs) 1998-02-18
NO970122D0 (no) 1997-01-10
CN1152304A (zh) 1997-06-18
CA2194885A1 (en) 1996-02-01
PL318115A1 (en) 1997-05-12
BG101105A (en) 1998-04-30
NO307373B1 (no) 2000-03-27
BG62090B1 (bg) 1999-02-26
TW555738B (en) 2003-10-01
CA2194885C (en) 2006-04-25
JP2931410B2 (ja) 1999-08-09
RU2159228C2 (ru) 2000-11-20
AU700585B2 (en) 1999-01-07
AU2674295A (en) 1996-02-16
EP0770059B1 (de) 1999-04-07
MY117090A (en) 2004-05-31
EP0770059A1 (de) 1997-05-02
CO4410184A1 (es) 1997-01-09
KR100421580B1 (ko) 2004-07-31
HUT77220A (hu) 1998-03-02
PL179595B1 (pl) 2000-09-29
YU48934B (sh) 2002-12-10
BR9508374A (pt) 1998-05-26
GR3030043T3 (en) 1999-07-30
ATE178590T1 (de) 1999-04-15
FI970094L (fi) 1997-01-10
ZA955780B (en) 1996-01-15
WO1996002497A1 (de) 1996-02-01
CN1083830C (zh) 2002-05-01
NO970122L (no) 1997-01-10
SK281744B6 (sk) 2001-07-10
IL114571A (en) 2003-09-17
HRP950365B1 (en) 2000-04-30
US5731332A (en) 1998-03-24
EE03311B1 (et) 2000-12-15
IL114571A0 (en) 1995-11-27
SK1997A3 (en) 1997-08-06
YU45295A (sh) 1997-12-05
DK0770059T3 (da) 1999-10-18
DE4424713A1 (de) 1996-01-18
RO118653B1 (ro) 2003-08-29
NZ287883A (en) 1999-02-25

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