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ES2086517T3 - Metodo y dispositivo de separacion analiticos para el analisis de las muestras de productos quimicos. - Google Patents

Metodo y dispositivo de separacion analiticos para el analisis de las muestras de productos quimicos.

Info

Publication number
ES2086517T3
ES2086517T3 ES91810991T ES91810991T ES2086517T3 ES 2086517 T3 ES2086517 T3 ES 2086517T3 ES 91810991 T ES91810991 T ES 91810991T ES 91810991 T ES91810991 T ES 91810991T ES 2086517 T3 ES2086517 T3 ES 2086517T3
Authority
ES
Spain
Prior art keywords
carrier
separation zone
refractive index
optical detector
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91810991T
Other languages
English (en)
Inventor
Francois Dr Maystre
Alfredo Emilio Dr Bruno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2086517T3 publication Critical patent/ES2086517T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2219/00—Aspects relating to the form of the liquid crystal [LC] material, or by the technical area in which LC material are used
    • C09K2219/17—Aspects relating to the form of the liquid crystal [LC] material, or by the technical area in which LC material are used used as a medium, in which detection of chemical compounds takes place
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/621—Detectors specially adapted therefor signal-to-noise ratio
    • G01N2030/625—Detectors specially adapted therefor signal-to-noise ratio by measuring reference material, e.g. carrier without sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8429—Preparation of the fraction to be distributed adding modificating material
    • G01N2030/8435—Preparation of the fraction to be distributed adding modificating material for chemical reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/78—Detectors specially adapted therefor using more than one detector

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Seal Device For Vehicle (AREA)
  • Control Of Resistance Heating (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

UN EQUIPO PARA UNA SEPARACION ANALITICA (1) QUE CONSTA DE UN SISTEMA DE TUBOS (2 (6), PREFERENTEMENTE UNA COLUMNA DE SEPARACION, EN DONDE LOS TUBOS QUE SE ENCUENTRAN CORRIENTE ARRIBA DE LA ZONA DE SEPARACION (6) ESTAN CONECTADOS A UNOS DEPOSITOS (10, 11) PARA UN PORTADOR (E) Y UNA MUESTRA QUIMICA (S) A SEPARAR Y ANALIZAR Y CORRIENTE ABAJO DE LA ZONA DE SEPARACION (6) SE ENCUENTRAN CONECTADOS A UN RECIPIENTE DE DESECHOS (12) PARA EL PORTADOR QUE CONTIENE LA MUESTRA (W) Y SE ENCUENTRAN CONECTADOS TAMBIEN A UNOS ELEMENTOS DE TRANSPORTE (13, 14) PARA EL PORTADOR Y PARA LA MUESTRA. EL SISTEMA DE TUBOS SE ENCUENTRA ASOCIADO A UN DETECTOR OPTICO (15) PARA CONTROLAR LOS CAMBIOS DE ABSORCION, DE FLUORESCENCIA O DE ACTIVIDAD OPTICA DEL PORTADOR (E) CUANDO ESTE ES TRANSPORTADO A TRAVES DEL SISTEMA DE TUBOS Y PASA EL DETECTOR OPTICO, QUE SE ENCUENTRA COLOCADO EN LA TRAYECTORIA DEL PORTADOR DETRAS DE LA ZONA DE SEPARACION (6) PERO DELANTE DEL RECIPIENTE DE DESECHOS (12). ENTRE LA ZONA DE SEPARACION (6)Y EL DETECTOR OPTICO (15) HAY COLOCADA, EN LA TRAYECTORIA DEL PORTADOR (E), UNA UNIDAD DE IGUALACION DEL INDICE DE REFRACCION (16). SEGUN LA INVENCION, EL PORTADOR (E) PROCEDENTE DE LA ZONA DE SEPARACION (6), ANTES DE SER TRANSPORTADO Y DE QUE PASE EL DETECTOR OPTICO (15), ES DIRIGIDO A TRAVES DE LA UNIDAD DE IGUALACION DEL INDICE DE REFRACCION, DONDE SU INDICE DE REFRACCION ES CONTROLADO PREFERENTEMENTE DE MANERA CONSTANTE Y DONDE TRAS LA DETECCION DE LOS CAMBIOS DEL INDICE DE REFRACCION DEL PORTADOR, LA DESVIACION SE COMPENSA A BASE DE AÑADIR AL PORTADOR UN AGENTE COMPENSATORIO.
ES91810991T 1989-06-09 1991-12-19 Metodo y dispositivo de separacion analiticos para el analisis de las muestras de productos quimicos. Expired - Lifetime ES2086517T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1147995A JPH0312490A (ja) 1989-06-09 1989-06-09 強誘電性カイラルスメクチック液晶組成物およびこれを含む液晶素子
EP91810991A EP0547282B1 (en) 1989-06-09 1991-12-19 Analytic separation arrangement and method for the analysis of chemical samples

Publications (1)

Publication Number Publication Date
ES2086517T3 true ES2086517T3 (es) 1996-07-01

Family

ID=40292551

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91810991T Expired - Lifetime ES2086517T3 (es) 1989-06-09 1991-12-19 Metodo y dispositivo de separacion analiticos para el analisis de las muestras de productos quimicos.

Country Status (9)

Country Link
US (1) US5290520A (es)
EP (1) EP0547282B1 (es)
JP (2) JPH0312490A (es)
AT (1) ATE137582T1 (es)
DE (1) DE69119233T2 (es)
DK (1) DK0547282T3 (es)
ES (1) ES2086517T3 (es)
FI (1) FI925723A (es)
NO (1) NO924918L (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE156911T1 (de) * 1994-03-04 1997-08-15 Waters Investments Ltd Verfahren zum nachweis von polymeren in einer lösung, detektorsystem und eine ein solches detektorsystem beinhaltende chromatographievorrichtung
SE506791C2 (sv) * 1996-06-03 1998-02-09 Arom Pak Ab Doseringsanordning för att med ett kontinuerligt förfarande blanda en strömmande primärvätska med en eller flera tillförda sekundärvätskor samt sätt att sammanblanda två eller flera vätskor
US6260407B1 (en) * 1998-04-03 2001-07-17 Symyx Technologies, Inc. High-temperature characterization of polymers
WO2004034026A2 (en) * 2002-10-10 2004-04-22 Irm, Llc Capacity altering device, holder and methods of sample processing
WO2006029017A1 (en) * 2004-09-03 2006-03-16 Symyx Technologies, Inc. System and method for rapid chromatography with fluid temperature and mobile phase composition control
EP1764405A1 (en) * 2005-09-20 2007-03-21 Rolic AG Functionalized photoreactive compounds
CA2764678C (en) 2009-06-04 2017-12-12 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
US8689439B2 (en) 2010-08-06 2014-04-08 Abbott Laboratories Method for forming a tube for use with a pump delivery system
US8377000B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Enteral feeding apparatus having a feeding set
US8377001B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Feeding set for a peristaltic pump system
CA2814720C (en) 2010-10-15 2016-12-13 Lockheed Martin Corporation Micro fluidic optic design
US8570521B2 (en) * 2010-11-21 2013-10-29 Reach Devices, LLC Optical system design for wide range optical density measurements
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
EP3407869A1 (en) 2016-01-27 2018-12-05 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042304A (en) * 1972-11-06 1977-08-16 Gow-Mac Instruments, Inc. Christiansen effect detector
US4019372A (en) * 1974-05-16 1977-04-26 E. I. Dupont De Nemours And Company Chromatographic detector system
US4199260A (en) * 1978-08-21 1980-04-22 Technicon Instruments Corporation Apparatus and method for determining the concentration in a sample
US4403503A (en) * 1981-11-09 1983-09-13 Sujit Banerjee Apparatus and method for the reduction of interferences in chromatography
US4659934A (en) * 1983-08-31 1987-04-21 Isco, Inc. Method and apparatus for reducing Schlieren noise in a liquid chromatograph
US4795262A (en) * 1987-07-29 1989-01-03 The Regents Of The Univerity Of Michigan Liquid chromatography absorbance detector
EP0326511B1 (de) * 1988-01-14 1992-02-26 Ciba-Geigy Ag Mikrodurchflusszelle
US4990250A (en) * 1988-02-12 1991-02-05 Spectra Physics, Inc. Reference flow liquid chromatography system with stable baseline
ATE112625T1 (de) * 1990-01-22 1994-10-15 Ciba Geigy Ag Interferometrische messanordnung.

Also Published As

Publication number Publication date
FI925723A (fi) 1993-06-20
DK0547282T3 (da) 1996-06-03
JPH05249094A (ja) 1993-09-28
JPH0312490A (ja) 1991-01-21
ATE137582T1 (de) 1996-05-15
DE69119233D1 (de) 1996-06-05
EP0547282B1 (en) 1996-05-01
EP0547282A1 (en) 1993-06-23
NO924918L (no) 1993-06-21
NO924918D0 (no) 1992-12-18
US5290520A (en) 1994-03-01
FI925723A0 (fi) 1992-12-16
DE69119233T2 (de) 1996-08-14

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