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ES2083315B1 - Procedimiento para preparar compuestos de isoquinolina como agentes bloqueadores neuromusculares. - Google Patents

Procedimiento para preparar compuestos de isoquinolina como agentes bloqueadores neuromusculares.

Info

Publication number
ES2083315B1
ES2083315B1 ES09250007A ES9250007A ES2083315B1 ES 2083315 B1 ES2083315 B1 ES 2083315B1 ES 09250007 A ES09250007 A ES 09250007A ES 9250007 A ES9250007 A ES 9250007A ES 2083315 B1 ES2083315 B1 ES 2083315B1
Authority
ES
Spain
Prior art keywords
procedure
blocking agents
neuromuscular blocking
isoquinoline compounds
preparing isoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09250007A
Other languages
English (en)
Other versions
ES2083315A1 (es
Inventor
Derek Anthony Hill
Geoffrey Lloyd Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES2083315A1 publication Critical patent/ES2083315A1/es
Application granted granted Critical
Publication of ES2083315B1 publication Critical patent/ES2083315B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Semiconductor Lasers (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Led Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Paper (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE ISOQUINOLINA COMO AGENTES BLOQUEADORES NEUROMUSCULARES, QUE COMPRENDE SOMETER UNA SAL DE 1R, 1''R-ATRACURIO CORRESPONDIENTE A CONDICIONES O REACTIVOS QUE SIRVAN PARA EFECTUAR EL AISLAMIENTO DEL ISOMERO 1R-RBA,CIS, 1''R-RBA,CIS DE LOS ISOMEROS GEOMETRICOS CORRESPONDIENTES EN DICHA SAL DE 1R-RBA,CIS, 1''R-RBA,CIS-ATRACURIO.
ES09250007A 1990-07-13 1991-07-12 Procedimiento para preparar compuestos de isoquinolina como agentes bloqueadores neuromusculares. Expired - Lifetime ES2083315B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015473A GB9015473D0 (en) 1990-07-13 1990-07-13 Neuromuscular blocking agents

Publications (2)

Publication Number Publication Date
ES2083315A1 ES2083315A1 (es) 1996-04-01
ES2083315B1 true ES2083315B1 (es) 1997-11-16

Family

ID=10679071

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09250007A Expired - Lifetime ES2083315B1 (es) 1990-07-13 1991-07-12 Procedimiento para preparar compuestos de isoquinolina como agentes bloqueadores neuromusculares.
ES91913479T Expired - Lifetime ES2088009T3 (es) 1990-07-13 1991-07-12 Agentes de bloqueo neuromuscular.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES91913479T Expired - Lifetime ES2088009T3 (es) 1990-07-13 1991-07-12 Agentes de bloqueo neuromuscular.

Country Status (40)

Country Link
EP (1) EP0539470B1 (es)
JP (3) JP2823356B2 (es)
KR (1) KR0174284B1 (es)
AT (1) ATE138369T1 (es)
AU (2) AU8190491A (es)
BE (1) BE1003407A3 (es)
CA (1) CA2087104C (es)
CH (1) CH683427A5 (es)
CY (1) CY1985A (es)
CZ (1) CZ284645B6 (es)
DE (2) DE69119768T2 (es)
DK (2) DK0539470T3 (es)
ES (2) ES2083315B1 (es)
FI (2) FI103507B (es)
FR (1) FR2665701B1 (es)
GB (2) GB9015473D0 (es)
GE (1) GEP19981163B (es)
GR (1) GR3020792T3 (es)
HK (1) HK80196A (es)
HU (2) HU218766B (es)
IE (1) IE912440A1 (es)
IL (1) IL98814A (es)
IT (1) IT1249677B (es)
LT (1) LT3317B (es)
LU (1) LU88198A1 (es)
LV (1) LV10432B (es)
MX (1) MX9203220A (es)
MY (1) MY113017A (es)
NL (1) NL9120017A (es)
NZ (1) NZ238964A (es)
PA (1) PA8401801A1 (es)
PL (1) PL167302B1 (es)
PT (1) PT98306B (es)
RU (1) RU2104005C1 (es)
SA (1) SA91120073B1 (es)
SE (1) SE9300052D0 (es)
SK (1) SK383392A3 (es)
UA (1) UA32536C2 (es)
WO (1) WO1992000965A1 (es)
ZA (1) ZA915468B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
DE19535762A1 (de) * 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
US6177445B1 (en) * 1997-03-25 2001-01-23 Glaxo Wellcome Inc. Substituted isoquinolines as ultra short acting neuromuscular blockers
BRPI0808272A2 (pt) 2007-03-08 2014-07-08 Chemagis Ltd "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
BRPI0808581A2 (pt) * 2007-03-26 2014-09-16 Chemagis Ltd "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
US8357807B2 (en) 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
EP2155684B1 (en) 2007-05-01 2014-04-09 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
BRPI0811687A2 (pt) * 2007-06-18 2015-02-18 Chemagis Ltd MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
CN101337935B (zh) * 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CN101337936B (zh) * 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
BRPI0816519A2 (pt) 2007-10-29 2015-03-24 Chemagis Ltd Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio
IT1396543B1 (it) 2008-07-16 2012-12-14 Farmabios Spa Processo per la purificazione di bloccanti neuromuscolari
WO2010128518A2 (en) * 2009-05-04 2010-11-11 Gland Pharma Limited Novel process for the preparation of cisatracurium besylate
CN107056700A (zh) * 2017-04-18 2017-08-18 哈尔滨医科大学 一种四氢异喹啉类化合物外消旋体的半量拆分法
CN112939862B (zh) * 2021-02-03 2023-01-10 江苏诚信药业有限公司 一种苯磺顺阿曲库铵杂质h的分离制备方法及其应用
CN115850169B (zh) * 2022-10-17 2025-04-04 上海医药集团(本溪)北方药业有限公司 苯磺顺阿曲库铵杂质及其中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB1579822A (en) * 1976-10-29 1980-11-26 Wellcome Found Tetrahydroisoquinolinium muscle relaxants
AU506657B2 (en) 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
ES454090A1 (es) * 1976-12-09 1978-01-16 Wellcome Found Un metodo para preparar compuestos heterociclicos.
DE3328664A1 (de) * 1983-08-09 1985-02-21 Robert Bosch Gmbh, 7000 Stuttgart Zuckerziehmaschine
BG41897A1 (en) * 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation

Also Published As

Publication number Publication date
AU1134695A (en) 1995-03-30
MY113017A (en) 2001-11-30
DK149692D0 (da) 1992-12-14
ITRM910518A1 (it) 1992-01-14
FI982342A0 (fi) 1998-10-28
GB9224764D0 (en) 1993-02-03
HK80196A (en) 1996-05-17
IE912440A1 (en) 1992-01-15
UA32536C2 (uk) 2001-02-15
PL297606A1 (es) 1992-07-13
GB9015473D0 (en) 1990-08-29
BE1003407A3 (fr) 1992-03-17
JPH05508648A (ja) 1993-12-02
JP2823356B2 (ja) 1998-11-11
PT98306A (pt) 1992-06-30
SE9300052L (sv) 1993-01-12
HUT67613A (en) 1995-04-28
SK279907B6 (sk) 1999-05-07
DK149692A (da) 1992-12-14
IL98814A (en) 1995-12-08
SE9300052D0 (sv) 1993-01-12
CY1985A (en) 1997-09-05
DE4191541T1 (de) 1993-05-13
IT1249677B (it) 1995-03-09
CZ383392A3 (en) 1994-02-16
GB2260763A (en) 1993-04-28
CZ284645B6 (cs) 1999-01-13
AU687481B2 (en) 1998-02-26
PL167302B1 (en) 1995-08-31
EP0539470A1 (en) 1993-05-05
DE69119768T2 (de) 1996-10-02
LU88198A1 (fr) 1993-05-17
LV10432A (lv) 1995-02-20
RU2104005C1 (ru) 1998-02-10
ES2088009T3 (es) 1996-08-01
FI925894L (fi) 1992-12-28
PT98306B (pt) 1999-01-29
CA2087104A1 (en) 1992-01-14
NZ238964A (en) 1992-06-25
FI103507B1 (fi) 1999-07-15
CH683427A5 (fr) 1994-03-15
CA2087104C (en) 1998-08-18
FR2665701B1 (fr) 1995-03-03
LTIP274A (en) 1994-10-25
ATE138369T1 (de) 1996-06-15
HU9300052D0 (en) 1993-04-28
JPH10139763A (ja) 1998-05-26
MX9203220A (es) 1992-07-01
GB2260763B (en) 1994-01-05
JP3462165B2 (ja) 2003-11-05
PA8401801A1 (es) 1997-01-03
SA91120073B1 (ar) 2002-10-26
ES2083315A1 (es) 1996-04-01
DE69119768D1 (de) 1996-06-27
JP2001058981A (ja) 2001-03-06
FI982342L (fi) 1998-10-28
FI925894A0 (fi) 1992-12-28
EP0539470B1 (en) 1996-05-22
HU218766B (hu) 2000-11-28
DK0539470T3 (da) 1996-08-05
FR2665701A1 (fr) 1992-02-14
IL98814A0 (en) 1992-07-15
KR0174284B1 (ko) 1999-02-18
GR3020792T3 (en) 1996-11-30
SK383392A3 (en) 1999-05-07
FI103507B (fi) 1999-07-15
AU8190491A (en) 1992-02-04
LV10432B (en) 1995-08-20
ITRM910518A0 (it) 1991-07-12
LT3317B (en) 1995-06-26
ZA915468B (en) 1993-03-31
NL9120017A (nl) 1993-04-01
GEP19981163B (en) 1998-07-06
WO1992000965A1 (en) 1992-01-23
HU211169A9 (en) 1995-11-28

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