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ES2062425T3 - Piridinas, procedimientos de preparacion y medicamentos que las contienen. - Google Patents

Piridinas, procedimientos de preparacion y medicamentos que las contienen.

Info

Publication number
ES2062425T3
ES2062425T3 ES90400006T ES90400006T ES2062425T3 ES 2062425 T3 ES2062425 T3 ES 2062425T3 ES 90400006 T ES90400006 T ES 90400006T ES 90400006 T ES90400006 T ES 90400006T ES 2062425 T3 ES2062425 T3 ES 2062425T3
Authority
ES
Spain
Prior art keywords
group
atom
piridines
fluorobenzoil
ilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90400006T
Other languages
English (en)
Inventor
Gerard Ferrand
Herve Dumas
Jean-Claude Depin
Gilles Chavernac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Application granted granted Critical
Publication of ES2062425T3 publication Critical patent/ES2062425T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A PIPERIDINAS REPRESENTADAS POR LA FORMULA: (FIG. A), EN LA QUE X ES EL GRUPO 4-FLUOROBENZOILO, 2-(4-FLUOROFENIL)-1,3-DIOXOLAN-2-ILO O 6-FLUORO-1,2-BENCISOXAZOL-3-ILO; Y ES UN ATOMO DE HIDROGENO O EL GRUPO HIDROXI; M ES UN NUMERO ENTERO COMPRENDIDO ENTRE 0 Y 4 INCLUSIVE; N ES 0 O 1; Q ES UN ATOMO DE NITROGENO O EL GRUPO METINO; CUANDO Q ES UN ATOMO DE NITROGENO, R ES EL GRUPO CIANO O CARBAMOILO; CUANDO Q ES EL GRUPO METINO, R ES EL GRUPO NITRO; R1 Y R2 PUEDEN SER IGUALES O DIFERENTES Y SON HIDROGENO, UN RADICAL ALCOHILO INFERIOR, EL RADICAL FENILO, EL GRUPO 2,2,2-TRIFLUOROETILO O EL GRUPO 2-[4-(4-FLUOROBENZOIL)-1-PIPERIDINIL)]ETILO; O EL GRUPO ESTRUCTURAL NR1R2 ES PIPERIDINO O EL GRUPO 4-(4-FLUOROBENZOIL)-1-PIPERIDINILO. APLICACION DE ESTOS COMPUESTOS COMO MEDICAMENTOS ANTI-HIPERTENSIVOS.
ES90400006T 1989-01-05 1990-01-03 Piridinas, procedimientos de preparacion y medicamentos que las contienen. Expired - Lifetime ES2062425T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8900071A FR2641278B1 (fr) 1989-01-05 1989-01-05 Piperidines, procedes de preparation et medicaments les contenant

Publications (1)

Publication Number Publication Date
ES2062425T3 true ES2062425T3 (es) 1994-12-16

Family

ID=9377487

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90400006T Expired - Lifetime ES2062425T3 (es) 1989-01-05 1990-01-03 Piridinas, procedimientos de preparacion y medicamentos que las contienen.

Country Status (23)

Country Link
US (1) US5001134A (es)
EP (1) EP0377528B1 (es)
JP (1) JP2927480B2 (es)
AT (1) ATE98231T1 (es)
AU (1) AU634739B2 (es)
CA (1) CA2007127A1 (es)
DD (1) DD291323A5 (es)
DE (1) DE69004973T2 (es)
DK (1) DK0377528T3 (es)
ES (1) ES2062425T3 (es)
FR (1) FR2641278B1 (es)
HU (1) HUT58053A (es)
IL (1) IL92950A0 (es)
MA (1) MA21719A1 (es)
MX (1) MX26760A (es)
NO (1) NO900019L (es)
NZ (1) NZ232023A (es)
OA (1) OA09433A (es)
PT (1) PT92782A (es)
RU (1) RU1838299C (es)
TN (1) TNSN90002A1 (es)
YU (1) YU2290A (es)
ZA (1) ZA9061B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
JPH07502268A (ja) * 1991-11-27 1995-03-09 ノボ　ノルディスク　アクティーゼルスカブ 化学化合物、それらの製法および使用
WO1994006765A1 (en) * 1992-09-17 1994-03-31 Nippon Soda Co., Ltd. Nitrogenous heterocyclic compound, process for producing the same, and pest control agent
US5512591A (en) * 1993-02-18 1996-04-30 President And Fellows Of Harvard College Treatments for diseases characterized by neovascularization
US5633274A (en) * 1993-02-18 1997-05-27 President And Fellows Of Harvard College Cancer treatments
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60893D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Piperidinderivater, deres fremstilling og anvendelse
DK60693D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
US5453425A (en) * 1994-07-11 1995-09-26 Janssen Pharmaceutica N.V. Risperidone oral formulation
US5556871A (en) * 1995-04-24 1996-09-17 President & Fellows Of Harvard College Method for treating epithelial precancerous lesions with topical inidazoles
WO2000035449A1 (en) * 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
CA2350730A1 (en) * 1998-12-18 2000-06-22 George V. Delucca N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6605623B1 (en) * 1998-12-18 2003-08-12 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
CA2347909A1 (en) * 1998-12-18 2000-06-22 Joseph B. Santella, Iii N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
WO2001064670A1 (en) * 2000-02-29 2001-09-07 Mitsubishi Pharma Corporation Novel cyclic amide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
FR2527205A1 (fr) * 1982-05-18 1983-11-25 Bouchara Emile Nouvelles phenyloxoalcoyl piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles

Also Published As

Publication number Publication date
NO900019D0 (no) 1990-01-04
EP0377528A1 (fr) 1990-07-11
DE69004973D1 (de) 1994-01-20
ZA9061B (en) 1990-10-31
HU900039D0 (en) 1990-03-28
MX26760A (es) 1994-02-28
IL92950A0 (en) 1990-09-17
CA2007127A1 (fr) 1990-07-05
MA21719A1 (fr) 1990-10-01
JPH02225465A (ja) 1990-09-07
FR2641278A1 (fr) 1990-07-06
PT92782A (pt) 1990-07-31
FR2641278B1 (fr) 1991-03-22
NO900019L (no) 1990-07-06
DE69004973T2 (de) 1994-06-23
EP0377528B1 (fr) 1993-12-08
ATE98231T1 (de) 1993-12-15
OA09433A (fr) 1992-10-15
NZ232023A (en) 1992-05-26
US5001134A (en) 1991-03-19
JP2927480B2 (ja) 1999-07-28
YU2290A (en) 1992-05-28
AU4771390A (en) 1990-07-12
DD291323A5 (de) 1991-06-27
HUT58053A (en) 1992-01-28
RU1838299C (ru) 1993-08-30
TNSN90002A1 (fr) 1991-03-05
DK0377528T3 (da) 1994-04-11
AU634739B2 (en) 1993-03-04

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