[go: up one dir, main page]

ES2054919T3 - Acidos y esteres 4-(quinolin-2-il-metoxi)fenilaceticos alfa-substituidos en caso dado. - Google Patents

Acidos y esteres 4-(quinolin-2-il-metoxi)fenilaceticos alfa-substituidos en caso dado.

Info

Publication number
ES2054919T3
ES2054919T3 ES89106816T ES89106816T ES2054919T3 ES 2054919 T3 ES2054919 T3 ES 2054919T3 ES 89106816 T ES89106816 T ES 89106816T ES 89106816 T ES89106816 T ES 89106816T ES 2054919 T3 ES2054919 T3 ES 2054919T3
Authority
ES
Spain
Prior art keywords
metoxi
substituted
alpha
phenylacetics
quinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89106816T
Other languages
English (en)
Inventor
Klaus Dr Mohrs
Siegfried Dr Raddatz
Romanis Fruchtmann
Christian Kohlsdorfer
Reiner Prof Muller-Peddinghaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2054919T3 publication Critical patent/ES2054919T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ACIDO ACETICO Y ESTER ALFA - SUSTITUIDO - 4 (QUINOLEINA - 2 - ILO - METOXI) FENILO SE PUEDE OBTENER POR TRANSFORMACION DE LOS FENOLES CORRESPONDIENTES CON 2 - HALOGENO - METILQUINOLEINA O POR TRANSFORMACION DE LAS QUINOLEINAS SUSTITUIDAS CORRESPONDIENTES CON HALOGENIDOS. LOS NUEVOS COMPUESTOS PUEDEN SER INCLUIDOS EN MEDICAMENTOS COMO ACTIVADORES.
ES89106816T 1988-04-29 1989-04-17 Acidos y esteres 4-(quinolin-2-il-metoxi)fenilaceticos alfa-substituidos en caso dado. Expired - Lifetime ES2054919T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3814504A DE3814504A1 (de) 1988-04-29 1988-04-29 (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
ES2054919T3 true ES2054919T3 (es) 1994-08-16

Family

ID=6353182

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89106816T Expired - Lifetime ES2054919T3 (es) 1988-04-29 1989-04-17 Acidos y esteres 4-(quinolin-2-il-metoxi)fenilaceticos alfa-substituidos en caso dado.

Country Status (20)

Country Link
US (1) US4929626A (es)
EP (1) EP0339416B1 (es)
JP (1) JPH01313466A (es)
KR (1) KR900016136A (es)
CN (1) CN1027068C (es)
AT (1) ATE89819T1 (es)
AU (1) AU614358B2 (es)
CA (1) CA1333803C (es)
DD (1) DD283811A5 (es)
DE (2) DE3814504A1 (es)
DK (1) DK168009B1 (es)
ES (1) ES2054919T3 (es)
FI (1) FI91855C (es)
HU (1) HU205079B (es)
IE (1) IE62888B1 (es)
IL (1) IL90052A (es)
NO (1) NO175149C (es)
NZ (1) NZ228899A (es)
PT (1) PT90382B (es)
ZA (1) ZA893171B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3632329A1 (de) * 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
GB8728051D0 (en) * 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
DE3900261A1 (de) * 1988-05-31 1989-12-07 Bayer Ag Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
US5232916A (en) * 1988-06-27 1993-08-03 Merck Frosst Canada, Inc. Quinoline ether alkanoic acids
US5102881A (en) * 1988-06-27 1992-04-07 Merck Frosst Canada, Inc. Quinoline ether alkanoic acids
US5194438A (en) * 1988-07-15 1993-03-16 Basf Aktiengesellschaft α-arylacrylates substituted by a trifluoromethylpyrimidinyloxy radical, fungicidal compositions and methods
DE3927931A1 (de) * 1989-08-24 1991-02-28 Bayer Ag Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate
DE3927930A1 (de) * 1989-08-24 1991-02-28 Bayer Ag Cyclisch substituierte (chinolin-2-yl-methoxy)phenyl-essig-saeure-derivate
US5021576A (en) * 1989-10-27 1991-06-04 American Home Products Corporation 2-Anilino phenylacetic acid derivatives
US5071988A (en) * 1989-10-27 1991-12-10 American Home Products Corporation Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives
US5008283A (en) * 1990-03-19 1991-04-16 Pfizer Inc. Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) * 1990-03-19 1991-04-09 Pfizer Inc. Tenidap as an inhibitor of the release of elastase by neutrophils
US5204329A (en) * 1990-06-11 1993-04-20 Du Pont Merck Pharmaceutical Company Treatment of organ transplantation rejection
US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
US4996214A (en) * 1990-06-28 1991-02-26 Smithkline Beecham Corporation Quinolinyl substituted phenyl/thioalkanoic acid substituted propionic acids and leucotriene antagonist use thereof
US5187180A (en) * 1990-07-26 1993-02-16 Merck Frosst Canada, Inc. (quinolin-2-ylmethoxy)heterotetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
US5221678A (en) * 1990-07-26 1993-06-22 Merck Frosst Canada, Inc. (quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
US5856322A (en) * 1990-10-12 1999-01-05 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5266568A (en) * 1990-10-12 1993-11-30 Merck Frosst Canada, Inc. Hydroxyalkylquinoline ether acids as leukotriene antagonists
US5304563A (en) * 1991-02-22 1994-04-19 Bayer Aktiengesellschaft 2-substituted quinolines, and their use in medicaments
DE4139751A1 (de) * 1991-12-03 1993-06-09 Bayer Ag, 5090 Leverkusen, De Thiazolyl substituierte chinolylmethoxyphenylessigsaeurederivate
DE4105551A1 (de) * 1991-02-22 1992-08-27 Bayer Ag 2-substituierte chinoline, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE4226649A1 (de) * 1992-08-12 1994-02-17 Bayer Ag Neue isobutylsubstituierte Methansulfonyl-chinolylmethoxyphenyl-cycloalkylessigsäureaminole
DE4112533A1 (de) * 1991-04-17 1992-10-22 Bayer Ag Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
EP0540165A1 (en) * 1991-10-03 1993-05-05 Zeneca Limited Alkanoic acid derivatives
DE4139750A1 (de) * 1991-12-03 1993-06-09 Bayer Ag, 5090 Leverkusen, De Chinolylmethoxyphenylessigsaeure-acylamide und -harnstoffe
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
DE4219765A1 (de) * 1992-06-17 1993-12-23 Bayer Ag Substituierte (Benzothiazolyl- und Chinoxalyl-methoxy)phenylessigsäurederivate
DE4226519A1 (de) * 1992-08-11 1994-02-17 Bayer Ag 3-Substituierte Chinolylmethoxy-phenylessigsäurederivate
ES2061406B1 (es) * 1993-05-07 1995-06-01 Uriach & Cia Sa J Nuevos derivados de la 2-(quinolina) con actividad farmacologica.
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
DE4443891A1 (de) * 1994-12-09 1996-06-13 Bayer Ag Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide
JP2010511632A (ja) 2006-11-30 2010-04-15 アミラ ファーマシューティカルス，インコーポレーテッド ５−リポキシゲナーゼ活性化タンパク質インヒビターおよび一酸化窒素モジュレーターを含んでいる組成物および治療法
DK3102209T3 (da) 2014-02-04 2021-07-12 Bioscience Pharma Partners Llc Anvendelse af flap-hæmmere til at reducere neuroinflammationsmedieret læsion i centralnervesystemet

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
ZA858347B (en) * 1984-10-30 1986-09-24 Usv Pharma Corp Anti-inflammatory/anti-allergic compounds
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4642347A (en) * 1985-05-21 1987-02-10 American Home Products Corporation 3(2-quinolinylalkoxy)phenols
US4661499A (en) * 1985-06-18 1987-04-28 Merck Frosst Canada, Inc. 2-[(substituted)-phenoxymethyl]quinolines

Also Published As

Publication number Publication date
PT90382A (pt) 1989-11-10
IL90052A (en) 1993-07-08
ATE89819T1 (de) 1993-06-15
NO175149B (no) 1994-05-30
FI91855C (fi) 1994-08-25
DE58904459D1 (de) 1993-07-01
FI892016L (fi) 1989-10-30
FI892016A0 (fi) 1989-04-27
DK208789D0 (da) 1989-04-28
EP0339416A1 (de) 1989-11-02
EP0339416B1 (de) 1993-05-26
DE3814504A1 (de) 1989-11-09
NZ228899A (en) 1991-06-25
AU3385289A (en) 1989-11-02
DD283811A5 (de) 1990-10-24
JPH01313466A (ja) 1989-12-18
US4929626A (en) 1990-05-29
AU614358B2 (en) 1991-08-29
IE891402L (en) 1989-10-29
PT90382B (pt) 1994-09-30
FI91855B (fi) 1994-05-13
CN1045777A (zh) 1990-10-03
NO891523D0 (no) 1989-04-13
IL90052A0 (en) 1989-12-15
NO175149C (no) 1994-09-07
IE62888B1 (en) 1995-03-08
DK168009B1 (da) 1994-01-17
HU205079B (en) 1992-03-30
KR900016136A (ko) 1990-11-12
DK208789A (da) 1989-10-30
HUT50779A (en) 1990-03-28
NO891523L (no) 1989-10-30
CN1027068C (zh) 1994-12-21
CA1333803C (en) 1995-01-03
ZA893171B (en) 1989-12-27

Similar Documents

Publication Publication Date Title
ES2054919T3 (es) Acidos y esteres 4-(quinolin-2-il-metoxi)fenilaceticos alfa-substituidos en caso dado.
ES2053864T3 (es) Derivados de acido 4-(quinolin-2-il-metoxi)fenil-acetico substituido.
NO921002D0 (no) Nye estere av tienylkarboksylsyrer og aminoalkoholer, deres kvartaeriseringsprodukter, og fremstilling og anvendelseav forbindelsene
MX7108A (es) Nuevos esteres del acido alginico.
ES2026870T3 (es) Esteres del acido (met)-acrilico de materiales dentales.
ES8407049A1 (es) Un procedimiento para la preparacion de compuestos biciclicos.
ES2038627T3 (es) Derivados del acido (met)-acrilico que contienen grupos uretano.
ES2047033T3 (es) Un metodo para preparar compuestos de hidroxivitamina d.
ES2033483T3 (es) Derivados de acido alquenoico
BR8407262A (pt) Utilizacao de esteres de acido salicilico como substancias odoriferas,composicoes de substancias odoriferas que os contem,bem como novos esteres de acido salicilico
DE69009237D1 (de) Verfahren zur Herstellung von optisch aktiven Estern der 6-t-Butoxy-3,5-dihydroxyhexansäure.
ATE55991T1 (de) 2,6-substituierte pyridinverbindungen mit weiteren substituenten.
MX9206816A (es) Derivados de cromano substituidos con piperidilmetilo, procedimiento para su obtencion y medicamentoque los contiene.
DE3667462D1 (de) Herstellung von dicarbonsaeuren oder dicarbonsaeureestern.
DE59006594D1 (de) Heterocyclisch sustituierte Acrylsäureester.
AR241108A2 (es) Insecticidas piretroides, acidos ciclopropancarboxilicos y esteres intermediarios y sus precedimientos de preparacion
DK72282A (da) Fremgangsmaade til fremstilling af bis-estere af 1,1-alkandioler med 2beta-acetoxymethyl-2alfa-methyl-(5r)penam-3alfa-carboxylsyre-1,1-dioxid og en 6-acylaminopenicillansyre eller farmaceutisk acceptable salte deraf
DE3680832D1 (de) Herstellung von kristallinen estern von hydrophenylpropionsaeure.
ES2021797B3 (es) Procedimiento para obtencion de esteres del acido omega-formilalcancarboxilico.
DE3679213D1 (de) Herstellung von estern der butandikarbonsaeure.
AT388727B (de) Substituierte alpha-fluoracrylsaeurephenylester
DE3762613D1 (de) Verfahren zur razemisierung von optisch aktiver chrysanthemsaeure oder ihres esters.
ES2058372T3 (es) Procedimiento para la obtencion de esteres del acido 5-cloro-3-clorosulfonil-2-tiofenocarboxilico.
CH512541A (de) Verwendung von Di(epoxyalkyl)ester von Bicyclo(2,2,1)heptan 2,3-dicarbonsäuren zur Herstellung von härtbaren Massen
IT7923608A0 (it) Combinazione di esteri di acidi ossicarbossilici alifatici mono ebabisici con antiossidanti, come deodorante.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 339416

Country of ref document: ES