DK3102209T3 - Anvendelse af flap-hæmmere til at reducere neuroinflammationsmedieret læsion i centralnervesystemet - Google Patents
Anvendelse af flap-hæmmere til at reducere neuroinflammationsmedieret læsion i centralnervesystemet Download PDFInfo
- Publication number
- DK3102209T3 DK3102209T3 DK15705756.3T DK15705756T DK3102209T3 DK 3102209 T3 DK3102209 T3 DK 3102209T3 DK 15705756 T DK15705756 T DK 15705756T DK 3102209 T3 DK3102209 T3 DK 3102209T3
- Authority
- DK
- Denmark
- Prior art keywords
- inflammation
- nervous system
- central nervous
- flap inhibitors
- mediated laser
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461935763P | 2014-02-04 | 2014-02-04 | |
| PCT/US2015/014443 WO2015120038A1 (en) | 2014-02-04 | 2015-02-04 | Use of flap inhibitors to reduce neuroinflammation mediated injury in the central nervous system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3102209T3 true DK3102209T3 (da) | 2021-07-12 |
Family
ID=53753907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15705756.3T DK3102209T3 (da) | 2014-02-04 | 2015-02-04 | Anvendelse af flap-hæmmere til at reducere neuroinflammationsmedieret læsion i centralnervesystemet |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10080748B2 (da) |
| EP (2) | EP3906925A1 (da) |
| CN (1) | CN106456624B (da) |
| AU (1) | AU2015214317B2 (da) |
| CA (1) | CA2938879C (da) |
| DK (1) | DK3102209T3 (da) |
| ES (1) | ES2878405T3 (da) |
| WO (1) | WO2015120038A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9949934B1 (en) * | 2016-10-20 | 2018-04-24 | Intelgenx Corp. | Device and method of treating conditions associated with neuroinflammation |
| EP3618824A4 (en) * | 2017-05-02 | 2021-06-23 | Neuronasal, LLC | Use of n-acetylcysteine to treat central nervous system disorders |
| CA3164091A1 (en) * | 2019-12-26 | 2021-07-15 | Centro De Investigacion Y Desarrollo De Medicamentos Cidem | Use of a benzodiazepine derivative and method of treatment of traumatic brain injury |
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| US5081138A (en) | 1986-12-17 | 1992-01-14 | Merck Frosst Canada, Inc. | 3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith |
| DE3814504A1 (de) | 1988-04-29 | 1989-11-09 | Bayer Ag | (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| DE3900261A1 (de) | 1988-05-31 | 1989-12-07 | Bayer Ag | Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate |
| US5204344A (en) | 1989-08-22 | 1993-04-20 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5272145A (en) | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| DE3927931A1 (de) | 1989-08-24 | 1991-02-28 | Bayer Ag | Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate |
| US5229516A (en) | 1989-10-27 | 1993-07-20 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| US5221678A (en) | 1990-07-26 | 1993-06-22 | Merck Frosst Canada, Inc. | (quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes |
| US5095031A (en) | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| US5304563A (en) | 1991-02-22 | 1994-04-19 | Bayer Aktiengesellschaft | 2-substituted quinolines, and their use in medicaments |
| DE4139751A1 (de) | 1991-12-03 | 1993-06-09 | Bayer Ag, 5090 Leverkusen, De | Thiazolyl substituierte chinolylmethoxyphenylessigsaeurederivate |
| DE4128681A1 (de) | 1991-08-29 | 1993-03-04 | Bayer Ag | Substituierte mandelsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| CA2129429A1 (en) | 1992-02-13 | 1993-08-14 | Richard Frenette | (azaaromaticalkoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5334719A (en) | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
| DE4226519A1 (de) | 1992-08-11 | 1994-02-17 | Bayer Ag | 3-Substituierte Chinolylmethoxy-phenylessigsäurederivate |
| US5288743A (en) | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
| IL109254A (en) | 1993-04-29 | 1999-03-12 | Zeneca Ltd | History of the tetrahydropyran and tetrahydropuran site preparation and pharmaceutical preparations containing them |
| US5399699A (en) | 1994-01-24 | 1995-03-21 | Abbott Laboratories | Indole iminooxy derivatives which inhibit leukotriene biosynthesis |
| US5512581A (en) | 1994-07-18 | 1996-04-30 | Abbott Laboratories | Iminoxycarboxylates and derivatives as inhibitors of leukotriene biosynthesis |
| US5714488A (en) | 1995-10-03 | 1998-02-03 | Abbott Laboratories | Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis |
| US5795900A (en) | 1995-10-03 | 1998-08-18 | Abbott Laboratories | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US5668146A (en) | 1995-10-03 | 1997-09-16 | Abbott Laboratories | Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US5691351A (en) | 1996-02-06 | 1997-11-25 | Abbott Laboratories | Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US5668150A (en) | 1996-07-26 | 1997-09-16 | Abbott Laboratories | Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US5783586A (en) | 1996-10-01 | 1998-07-21 | Abbott Laboratories | Heteroarylmethoxyphenylthioalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| ATE342918T1 (de) | 1998-04-15 | 2006-11-15 | Serono Genetics Inst Sa | Genomische sequenz des 5-lipoxygenase- aktivierenden proteins (flap), polymorphische marker und ihre anwendung in der diagnose von asthma |
| DE10007203A1 (de) | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
| AU2002222910A1 (en) | 2000-07-13 | 2002-01-30 | Bristol-Myers Squibb Company | Method of modulating microglial activation for the treatment of acute and chronic neurodegenerative disorders |
| US6756399B2 (en) | 2001-06-29 | 2004-06-29 | The United States Of America As Represented By The Department Of Health And Human Services | Use of lipoxygenase inhibitors and PPAR ligands as anti-cancer therapeutic and intervention agents |
| US7851486B2 (en) | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
| US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| JP2008526894A (ja) | 2005-01-10 | 2008-07-24 | レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア | Ｃｏｘ阻害剤および５−ｌｏｘ阻害剤の活性を助けるための可溶性エポキシドヒドロラーゼの阻害剤の使用 |
| CA2594777A1 (en) | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflamation |
| AU2006279325B2 (en) * | 2005-08-18 | 2013-06-27 | Accelalox, Inc. | Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway |
| EP1926708B1 (en) | 2005-09-21 | 2014-06-18 | Decode Genetics EHF | Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation |
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| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
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| AU2012318391A1 (en) | 2011-10-07 | 2014-05-15 | Florida State University Research Foundation | Prophylactic and post-acute use of progesterone to better outcomes associated with concussion |
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| CN103110945A (zh) * | 2013-03-04 | 2013-05-22 | 中国药科大学 | 一种单核细胞抗体在治疗炎症相关抑郁症中的应用 |
-
2015
- 2015-02-04 DK DK15705756.3T patent/DK3102209T3/da active
- 2015-02-04 CA CA2938879A patent/CA2938879C/en active Active
- 2015-02-04 CN CN201580018167.3A patent/CN106456624B/zh active Active
- 2015-02-04 ES ES15705756T patent/ES2878405T3/es active Active
- 2015-02-04 US US14/613,658 patent/US10080748B2/en active Active
- 2015-02-04 EP EP21166657.3A patent/EP3906925A1/en not_active Withdrawn
- 2015-02-04 AU AU2015214317A patent/AU2015214317B2/en active Active
- 2015-02-04 WO PCT/US2015/014443 patent/WO2015120038A1/en active Application Filing
- 2015-02-04 EP EP15705756.3A patent/EP3102209B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106456624B (zh) | 2020-05-22 |
| ES2878405T3 (es) | 2021-11-18 |
| AU2015214317A1 (en) | 2016-09-01 |
| US20150216854A1 (en) | 2015-08-06 |
| EP3102209A1 (en) | 2016-12-14 |
| CN106456624A (zh) | 2017-02-22 |
| US10080748B2 (en) | 2018-09-25 |
| CA2938879A1 (en) | 2015-08-13 |
| AU2015214317B2 (en) | 2020-01-16 |
| EP3906925A1 (en) | 2021-11-10 |
| CA2938879C (en) | 2023-05-09 |
| WO2015120038A1 (en) | 2015-08-13 |
| EP3102209B1 (en) | 2021-04-07 |
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