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ES2054053T5 - Procedimiento de preparacion de sistemas coloidales dispersables de lipidos anfifilos en forma de liposomas submicronicos. - Google Patents

Procedimiento de preparacion de sistemas coloidales dispersables de lipidos anfifilos en forma de liposomas submicronicos.

Info

Publication number
ES2054053T5
ES2054053T5 ES89401857T ES89401857T ES2054053T5 ES 2054053 T5 ES2054053 T5 ES 2054053T5 ES 89401857 T ES89401857 T ES 89401857T ES 89401857 T ES89401857 T ES 89401857T ES 2054053 T5 ES2054053 T5 ES 2054053T5
Authority
ES
Spain
Prior art keywords
liposomes
lipids
substance
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89401857T
Other languages
English (en)
Other versions
ES2054053T3 (es
Inventor
Serge Stainmesse
Hatem Fessi
Jean-Philippe Devissaguet
Francis Puisieux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9367941&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2054053(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of ES2054053T3 publication Critical patent/ES2054053T3/es
Application granted granted Critical
Publication of ES2054053T5 publication Critical patent/ES2054053T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE SISTEMAS COLOIDALES DISPERSABLES DE LIQUIDOS ANFIFILICOS, BAJO FORMA DE LIPOSOMAS OLIGOLAMINARES SUBMICRONIOS, CUYA PARED ESTA CONSTITUIDA POR LOS LIPIDOS Y, EVENTUALMENTE, UNA SUSTANCIA A, Y CUYO NUCLEO ESTA CONSTITUIDO POR AGUA O UNA DISOLUCION ACUOSA, Y QUE CONTIENE EVENTUALMENTE UNA SUSTANCIA B, CARACTERIZADO PORQUE: (1) SE PREPARA UNA FASE LIQUIDA CONSTITUIDA ESENCIALMENTE POR UNA DISOLUCION DE LIPIDOS Y, EVENTUALMENTE, DE LA SUSTANCIA A EN UN DISOLVENTE O EN UNA MEZCLA DE DISOLVENTES, Y PUDIENDO CONTENER LA SUSTANCIA B EN DISOLUCION, (2) SE PREPARA UNA SEGUNDA FASE LIQUIDA CONSTITUIDA ESENCIALMENTE POR AGUA O UNA DISOLUCION ACUOSA DE LA SUSTANCIA B, (3) SE AÑADE, CON AGITACION MODERADA, LA PRIMERA FASE A LA SEGUNDA, PARA OBTENER UNA SUSPENSION COLOIDAL DE LIPOSOMAS, (4) SI SE DESEA, SE ELIMINA TODO O PARTE DEL DISOLVENTE O DE LA MEZCLA DE DISOLVENTES Y DEL AGUA PARA OBTENER UNA SUSPENSION COLOIDAL DE CONCENTRACION DESEADA EN LIPOSOMAS. APLICACIONES: MEDICINA, PRODUCTOS COSMETICOS.
ES89401857T 1988-06-30 1989-06-28 Procedimiento de preparacion de sistemas coloidales dispersables de lipidos anfifilos en forma de liposomas submicronicos. Expired - Lifetime ES2054053T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8808874A FR2634375B3 (fr) 1988-06-30 1988-06-30 Procede de preparation de systemes colloidaux dispersibles de lipide amphiphiles sous forme de liposomes submicroniques

Publications (2)

Publication Number Publication Date
ES2054053T3 ES2054053T3 (es) 1994-08-01
ES2054053T5 true ES2054053T5 (es) 1997-01-16

Family

ID=9367941

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89401857T Expired - Lifetime ES2054053T5 (es) 1988-06-30 1989-06-28 Procedimiento de preparacion de sistemas coloidales dispersables de lipidos anfifilos en forma de liposomas submicronicos.

Country Status (8)

Country Link
EP (1) EP0349429B2 (es)
JP (1) JPH0824840B2 (es)
KR (1) KR960014869B1 (es)
AT (1) ATE85888T1 (es)
DE (1) DE68904999T3 (es)
ES (1) ES2054053T5 (es)
FR (1) FR2634375B3 (es)
GR (2) GR3007265T3 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
DE4013580A1 (de) * 1990-04-24 1991-10-31 Schering Ag Verfahren zur herstellung von wirkstoffhaltigen waessrigen liposomensuspensionen
EP0461333B1 (en) * 1990-06-11 1995-03-29 Idi Farmaceutici S.P.A. Phospholipidic liposomes containing active principles and a process for the production thereof
FR2668063A1 (fr) * 1990-10-17 1992-04-24 Fabre Pierre Cosmetique Liposomes d'eaux thermales stabilises dans un gel d'adn.
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
ES2113119T3 (es) * 1993-08-06 1998-04-16 Opperbas Holding Bv Un metodo para la preparacion de vesiculas cargadas con estructuras biologicas, biopolimeros y/o oligomeros.
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US20010003580A1 (en) * 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
AU2006200015B8 (en) * 1998-01-14 2008-02-21 Dupont Pharmaceuticals Company Preparation of a lipid blend and a phospholipid suspension containing a lipid blend, and contrast agents based on these
JP4758915B2 (ja) * 2004-08-06 2011-08-31 バイオスペクトラム，インコーポレイテッド 多重層リポソームおよびその製造方法
KR101405417B1 (ko) * 2007-07-19 2014-06-12 (주)아모레퍼시픽 라이소인지질 콜로이드의 상거동을 이용하여 경피흡수도가조절된 피부 외용제의 제조방법
JP6155387B2 (ja) 2014-04-30 2017-06-28 富士フイルム株式会社 リポソームの製造方法
WO2016109400A2 (en) 2014-12-31 2016-07-07 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
KR20180133527A (ko) 2016-05-04 2018-12-14 랜티우스 메디컬 이메징, 인크. 초음파 조영제의 제조 방법 및 장치
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
IT201900004877A1 (it) 2019-04-01 2020-10-01 Res Pharma Ind S R L Processo di preparazione di sistemi colloidali concentrati

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621479A5 (es) * 1977-08-05 1981-02-13 Battelle Memorial Institute
GR77320B (es) * 1980-12-22 1984-09-11 Procter & Gamble
DE3269611D1 (en) * 1981-07-02 1986-04-10 Hoffmann La Roche Process for preparing liposome solutions
JPS607932A (ja) * 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd リポソーム懸濁液およびその製法
US4753788A (en) * 1985-01-31 1988-06-28 Vestar Research Inc. Method for preparing small vesicles using microemulsification

Also Published As

Publication number Publication date
EP0349429B2 (fr) 1996-11-20
FR2634375B3 (fr) 1991-07-05
ES2054053T3 (es) 1994-08-01
EP0349429A2 (fr) 1990-01-03
KR900000074A (ko) 1990-01-30
ATE85888T1 (de) 1993-03-15
GR3022121T3 (en) 1997-03-31
JPH02149336A (ja) 1990-06-07
EP0349429A3 (en) 1990-08-22
DE68904999T2 (de) 1993-09-02
KR960014869B1 (ko) 1996-10-21
DE68904999D1 (de) 1993-04-01
JPH0824840B2 (ja) 1996-03-13
FR2634375A1 (fr) 1990-01-26
GR3007265T3 (en) 1993-07-30
EP0349429B1 (fr) 1993-02-24
DE68904999T3 (de) 1997-06-12

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