[go: up one dir, main page]

ES2042807T3 - 6-fenil-dihidro-3(2h)-piridazinonas, procedimiento para su preparacion, y medicamentos que contienen estos compuestos. - Google Patents

6-fenil-dihidro-3(2h)-piridazinonas, procedimiento para su preparacion, y medicamentos que contienen estos compuestos.

Info

Publication number
ES2042807T3
ES2042807T3 ES89100153T ES89100153T ES2042807T3 ES 2042807 T3 ES2042807 T3 ES 2042807T3 ES 89100153 T ES89100153 T ES 89100153T ES 89100153 T ES89100153 T ES 89100153T ES 2042807 T3 ES2042807 T3 ES 2042807T3
Authority
ES
Spain
Prior art keywords
piridazinones
dihidro
fenil
medicines
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89100153T
Other languages
English (en)
Inventor
Rolf Dr Dipl-Chem Herter
Heidrun Dr Med Vet Engler
Peter Dr Dipl-Chem Morsdorf
Helmut Dr Dipl-Ch Schickaneder
Volker Dr Pfahlert
Kurt Henning Dr Ahrens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Pharma GmbH and Co
Original Assignee
Heumann Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma GmbH and Co filed Critical Heumann Pharma GmbH and Co
Application granted granted Critical
Publication of ES2042807T3 publication Critical patent/ES2042807T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN NUEVAS 6 - FENILDIHIDRO - 3(2H) - PIRIDAZINONAS DE FORMULA GENERAL 1. ESTOS COMPUESTOS SE CARACTERIZAN POR UNA BUENA DISPONIBILIDAD ORAL, POR UNA ALTA EFECTIVIDAD POSITIVA INOTROPA. INFLUYEN MINIMAMENTE SOBRE LA PRESION SANGUINEA Y LA FRECUENCIA CARDIACA. TAMBIEN SE DESCRIBEN UN PROCESO DE PRODUCCION Y MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS.
ES89100153T 1988-02-12 1989-01-05 6-fenil-dihidro-3(2h)-piridazinonas, procedimiento para su preparacion, y medicamentos que contienen estos compuestos. Expired - Lifetime ES2042807T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3804490A DE3804490A1 (de) 1988-02-12 1988-02-12 Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ES2042807T3 true ES2042807T3 (es) 1993-12-16

Family

ID=6347332

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89100153T Expired - Lifetime ES2042807T3 (es) 1988-02-12 1989-01-05 6-fenil-dihidro-3(2h)-piridazinonas, procedimiento para su preparacion, y medicamentos que contienen estos compuestos.

Country Status (17)

Country Link
US (1) US4954501A (es)
EP (1) EP0327800B1 (es)
JP (1) JPH01246268A (es)
KR (1) KR890012974A (es)
AT (1) ATE76640T1 (es)
AU (1) AU609922B2 (es)
CA (1) CA1316535C (es)
DE (2) DE3804490A1 (es)
DK (1) DK705888A (es)
ES (1) ES2042807T3 (es)
GR (1) GR3004789T3 (es)
HU (1) HU200337B (es)
IE (1) IE62116B1 (es)
IL (1) IL88784A (es)
NZ (1) NZ227543A (es)
PT (1) PT89468B (es)
ZA (1) ZA889559B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2717687B2 (ja) * 1988-02-13 1998-02-18 日本曹達株式会社 ピリダジノン誘導体及びその製造方法
GB8824458D0 (en) * 1988-10-19 1988-11-23 Orion Yhtymae Oy Substituted pyridazinones
IL94394A (en) * 1989-05-17 1994-10-21 Nissan Chemical Ind Ltd History of pyridazinone, process for their preparation and preparations for controlling and / or preventing insects, mites, nematodes and mollusks
US5142021A (en) * 1990-10-19 1992-08-25 The Dow Chemical Company Use of reducing agents in polybenzazole synthesis
EP1406621A2 (en) * 2001-06-26 2004-04-14 Beth Israel Deaconess Medical Center Compositions and methods for inhibiting platelet activation and thrombosis
WO2005000795A2 (en) * 2003-06-10 2005-01-06 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
DE102004011512B4 (de) * 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
ES2631879T3 (es) * 2005-11-14 2017-09-05 Boehringer Ingelheim Vetmedica Gmbh Uso de pimobendano para el tratamiento de la insuficiencia cardíaca asintomática (oculta)
JP5335675B2 (ja) * 2006-07-25 2013-11-06 セファロン、インク． ピリジジノン誘導体
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
DK2370070T3 (da) 2008-11-25 2013-12-02 Boehringer Ingelheim Vetmed Pimobendan til anvendelse i behandling af hypertrofisk cardiomyopati hos katte
HUE060093T2 (hu) 2012-03-15 2023-01-28 Boehringer Ingelheim Vetmedica Gmbh Gyógyszerészeti tablettakészítmény az állatgyógyászati ágazat számára, eljárás annak elõállítására és annak alkalmazása
EP2970145B1 (en) * 2013-03-11 2020-05-06 The Broad Institute, Inc. Compounds and compositions for the treatment of cancer
WO2015007760A1 (en) 2013-07-19 2015-01-22 Boehringer Ingelheim Vetmedica Gmbh Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
CA3176466A1 (en) 2013-12-04 2015-06-11 Boehringer Ingelheim Vetmedica Gmbh Improved pharmaceutical compositions of pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
WO2021217040A1 (en) * 2020-04-24 2021-10-28 Immvention Therapeutix Carbamate and urea derivatives

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL37788A0 (en) * 1970-10-09 1971-12-29 American Cyanamid Co New pyridazinone compounds,their preparation and pharmaceutical compositions containing them
US4088762A (en) * 1971-02-22 1978-05-09 Bdh Pharmaceuticals Limited 6-(P-PIPERAZINO)-PHENYL-4,5-DIHYDRO-3(2H)pyridazinones
GB1383906A (en) * 1971-02-22 1974-02-12 Bdh Pharmaceuticals Ltd Pyridazinones
DE2837161A1 (de) * 1978-08-25 1980-03-06 Thomae Gmbh Dr K Neue benzimidazole und deren verwendung
HU190412B (en) * 1981-09-17 1986-09-29 Warner-Lambert Co,Us Process for producing substituted 4,5-dihiydro-6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones and 6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones
JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
US4584299A (en) * 1984-05-21 1986-04-22 Warner-Lambert Company Method of treating heart failure and medicaments therefor
DE3425632A1 (de) * 1984-07-12 1986-01-16 Basf Ag, 6700 Ludwigshafen (pyrrol-1-yl)-phenyl-dihydropyridazinone, ihre herstellung und verwendung
JPS6153270A (ja) * 1984-08-17 1986-03-17 チバ・ガイギー・アクチエンゲゼルシヤフト 置換ピリダジノン、その製造方法及び該化合物を含む医薬製剤
JPS61158969A (ja) * 1984-12-24 1986-07-18 ワーナー‐ランバート・コンパニー ４，５‐ジヒドロ‐４，４‐ジアルキル‐６‐（置換）フエニル‐３（２ｈ）‐ピリダジノン類
JPS62298820A (ja) * 1986-06-18 1987-12-25 Omron Tateisi Electronics Co 座標入力装置
JPS648666A (en) * 1987-06-30 1989-01-12 Sharp Kk Contact type image sensor
DE3728491A1 (de) * 1987-08-26 1989-03-09 Heumann Pharma Gmbh & Co Dihydropyridazinon-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPH046570A (ja) * 1990-04-25 1992-01-10 Toshiba Corp 画像形成装置

Also Published As

Publication number Publication date
GR3004789T3 (es) 1993-04-28
JPH01246268A (ja) 1989-10-02
KR890012974A (ko) 1989-09-20
IE883823L (en) 1989-08-12
AU2758088A (en) 1989-08-17
DK705888A (da) 1989-08-13
IL88784A (en) 1993-05-13
ZA889559B (en) 1989-09-27
EP0327800B1 (de) 1992-05-27
CA1316535C (en) 1993-04-20
EP0327800A2 (de) 1989-08-16
HU200337B (en) 1990-05-28
US4954501A (en) 1990-09-04
EP0327800A3 (en) 1990-04-11
NZ227543A (en) 1990-04-26
PT89468B (pt) 1993-12-31
HUT49349A (en) 1989-09-28
IE62116B1 (en) 1994-12-14
PT89468A (pt) 1990-03-08
DK705888D0 (da) 1988-12-19
ATE76640T1 (de) 1992-06-15
AU609922B2 (en) 1991-05-09
IL88784A0 (en) 1989-07-31
DE58901510D1 (de) 1992-07-02
DE3804490A1 (de) 1989-08-24

Similar Documents

Publication Publication Date Title
ES2042807T3 (es) 6-fenil-dihidro-3(2h)-piridazinonas, procedimiento para su preparacion, y medicamentos que contienen estos compuestos.
ES2128013T3 (es) Nuevos derivados de la piperidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
AR245447A1 (es) Procedimiento para preparar derivados de 2,4-diamino-5-(biciclo-sustituido)metilpirimidinas.
ES2039522T3 (es) Procedimiento para preparar un nuevo benzotiazol.
DK633088A (da) Kollagenaseinhibitorer
MX9304647A (es) 7-(sustituido)-9-[(glicilo sustituido)amido]-6-desmetil-6-desoxitetraciclinas y metodo para su produccion.
PT91602A (pt) Processo para a preparacao de compostos espiro com accao antibacteriana e de composicoes farmaceuticas que os contem
PT83725B (pt) Processo para preparacao de novos derivados da 3-oxadiol-beta-carbolina e 3-carboxilato-beta-carbolina e de composicoes farmaceuticas que os contem
ES2147749T3 (es) Procedimiento para la preparacion de derivados de ciano-metoxiiminometilo.
PT92180A (pt) Processo para a preparacao de novas mevalonolactonas do tipo tienopiridina e de composicoes farmaceuticas que as contem
DE3882438D1 (de) Alkansulfonanilid-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
ES2160197T3 (es) Empleo de una sal de sodio o de lisinio de derivados de amida del acido crotonico para la preparacion de un medicamento para el tratamiento de enfermedades cancerigenas.
ES2061964T3 (es) Compuestos de diamina.
PT97286A (pt) Processo para a preparacao de novos derivados do 3-aminocromano e de composicoes farmaceuticas que os contem
ES2086442T3 (es) Derivados de fluoroetilcamptotecina.
ES8405391A1 (es) Un procedimiento para la preparacion de un derivado de tetrahidro-1h-piridoindol.
MX9205921A (es) Derivados de bis(fenil)etano, proceso para su preparacion y composicion farmaceutica que los contiene
ES2065192T3 (es) Nuevos nicotinatos de diacil-glicerol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
GR3034748T3 (en) Bis imide derivatives, process for their preparation and pharmaceutical compositions containing them
BR9101973A (pt) Compostos quimicos,processo para a sua preparacao e composicoes farmaceutica e terapeutica
ES2064619T3 (es) Derivados tetrahidropiranilicos, procedimiento para su preparacion y composiciones farmaceuticas o veterinarias que los contienen.
ES2038704T3 (es) Un procedimiento para preparar un derivado de 4-acetoxi-3-hidroxietilazetidin-2-ona.
ATE194140T1 (de) Thiophenverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zubereitungen
PT92668A (pt) Processo para a preparacao de derivados de azabiciclo-heptano
MX9304444A (es) Nuevos derivados de acido piridinecarboxilico, proceso para preparar los mismos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 327800

Country of ref document: ES