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ES2005163A6 - Un procedimiento para la produccion de derivados de tiofen-2-carboxamida. - Google Patents

Un procedimiento para la produccion de derivados de tiofen-2-carboxamida.

Info

Publication number
ES2005163A6
ES2005163A6 ES8701096A ES8701096A ES2005163A6 ES 2005163 A6 ES2005163 A6 ES 2005163A6 ES 8701096 A ES8701096 A ES 8701096A ES 8701096 A ES8701096 A ES 8701096A ES 2005163 A6 ES2005163 A6 ES 2005163A6
Authority
ES
Spain
Prior art keywords
alkyl
deriv
prepn
carboxamide
thiophene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8701096A
Other languages
English (en)
Inventor
Isabel Fernandez
Terrence Michae Hotten
David Edward Tupper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly SA
Lilly Industries Ltd
Original Assignee
Lilly SA
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly SA, Lilly Industries Ltd filed Critical Lilly SA
Priority to ES8701096A priority Critical patent/ES2005163A6/es
Publication of ES2005163A6 publication Critical patent/ES2005163A6/es
Expired legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PRODUCCION DE DERIVADOS DE TIOFEN-2-CARBOXAMIDA DE FORMULA (I) DONDE R1 Y RY SON INDEPENDIENTEMENTE HIDROGENO, HALOGENO, NITRO, AMINO, ACILAMINO C2-5, ALQUILO C1-4, ALCOXI C1-4, ALQUILTIO C1-4, ALQUILSULFONILO C1-4, HETEROCICLILAMINO O FENILO, FENILTIO, FENILSULFONILO O FENILSULFONAMIDO OPCIONALMENTE SUSTITUDOS O BIEN R1 Y RY UNIDOS FORMAN UN PUENTE ALQUILENICO C3-5; R3 ES ALQUILO C1-4 O ALQUENILO C2-4; R4 ES CADA UNO DE ELLOS INDEPENDIENTEMENTE ALQUILO C1-4, ALQUENILO C2-4 O C6H5CH2- Y N ES 1, 2 O 3; QUE COMPRENDE HACER REACCIONAR UN COMPUESTO (II) CON UNA AMINA (R4)2N(CH2)NNH2.LOS COMPUESTOS (I) EJERCEN UTILES EFECTOS SOBRE EL SISTEMA NERVIOSO CENTRAL, BLOQUEAN LOS RECEPTORES POSTSINAPTICOS DE LA DOPAMINA Y SON ADECUADOS PARA EL TRATAMIENTO DE LA EMESIS, DEPRESION, ANSIEDAD, ESQUIZOFRENIA Y MANIA AGUDA.
ES8701096A 1987-04-14 1987-04-14 Un procedimiento para la produccion de derivados de tiofen-2-carboxamida. Expired ES2005163A6 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES8701096A ES2005163A6 (es) 1987-04-14 1987-04-14 Un procedimiento para la produccion de derivados de tiofen-2-carboxamida.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8701096A ES2005163A6 (es) 1987-04-14 1987-04-14 Un procedimiento para la produccion de derivados de tiofen-2-carboxamida.

Publications (1)

Publication Number Publication Date
ES2005163A6 true ES2005163A6 (es) 1989-03-01

Family

ID=8250468

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8701096A Expired ES2005163A6 (es) 1987-04-14 1987-04-14 Un procedimiento para la produccion de derivados de tiofen-2-carboxamida.

Country Status (1)

Country Link
ES (1) ES2005163A6 (es)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7309497B2 (en) 2000-08-24 2007-12-18 Schwarz Pharma Ag Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients
WO2008074835A1 (en) * 2006-12-20 2008-06-26 Novartis Ag 2-substituted 5-membered heterocycles as scd inhibitors
US8273782B2 (en) 2007-02-07 2012-09-25 Glaxosmithkline Llc Inhibitors of Akt activity
US8604076B2 (en) 2000-08-24 2013-12-10 Ucb Pharma Gmbh Method for producing a pharmaceutical composition comprising rotigotine
US8609711B2 (en) 2009-01-30 2013-12-17 Glaxosmithkline Llc Crystalline N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamic hydrochloride

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7309497B2 (en) 2000-08-24 2007-12-18 Schwarz Pharma Ag Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients
US8604076B2 (en) 2000-08-24 2013-12-10 Ucb Pharma Gmbh Method for producing a pharmaceutical composition comprising rotigotine
WO2008074835A1 (en) * 2006-12-20 2008-06-26 Novartis Ag 2-substituted 5-membered heterocycles as scd inhibitors
JP2010513403A (ja) * 2006-12-20 2010-04-30 ノバルティス アーゲー Ｓｃｄ阻害剤としての２−置換５員ヘテロ環
US8258160B2 (en) 2006-12-20 2012-09-04 Novartis Ag SCD1 inhibitors triazole and tetrazole compounds
CN101595105B (zh) * 2006-12-20 2013-01-23 诺瓦提斯公司 作为scd抑制剂的2-取代的5元杂环化合物
US8273782B2 (en) 2007-02-07 2012-09-25 Glaxosmithkline Llc Inhibitors of Akt activity
US8410158B2 (en) 2007-02-07 2013-04-02 Glaxosmithkline Llc Inhibitors of Akt activity
US8946278B2 (en) 2007-02-07 2015-02-03 Glaxosmithkline Llc Inhibitors of AkT activity
US8609711B2 (en) 2009-01-30 2013-12-17 Glaxosmithkline Llc Crystalline N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamic hydrochloride

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020401