ES2005163A6 - Thiophene 2-carboxamide deriv. prepn. - Google Patents
Thiophene 2-carboxamide deriv. prepn.Info
- Publication number
- ES2005163A6 ES2005163A6 ES8701096A ES8701096A ES2005163A6 ES 2005163 A6 ES2005163 A6 ES 2005163A6 ES 8701096 A ES8701096 A ES 8701096A ES 8701096 A ES8701096 A ES 8701096A ES 2005163 A6 ES2005163 A6 ES 2005163A6
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- deriv
- prepn
- carboxamide
- thiophene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DENPQNAWGQXKCU-UHFFFAOYSA-N thiophene-2-carboxamide Chemical compound NC(=O)C1=CC=CS1 DENPQNAWGQXKCU-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 nitro, amino Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000001242 postsynaptic effect Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The derivs. of formula (I), in which R1 and R2 are H, halogen, nitro, amino, 2-5C acylamino, 1-4C alkyl, alkoxy, alkylthio, or alkylsulphonyl, heterocyclylamino, opt. substd. phenyl, phenylthio, phenylsulphonyl or phenylsulphonamido, or together form a 3-5C alkylene link, R3 is 1-4C alkyl or 2-4C alkenyl, R4 is 1-4C alkyl, 2-4C alkenyl or benzyl, and n is 1, 2 or 3, for action on the central nervous system to block the dopamine post-synaptic receptors and for treatment of emesis, depression, anxiety, schizophrenia and acute mania, are made by reacting a cpd. (II) with an amine of formula (R4)2N(CH2)nNH2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8701096A ES2005163A6 (en) | 1987-04-14 | 1987-04-14 | Thiophene 2-carboxamide deriv. prepn. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8701096A ES2005163A6 (en) | 1987-04-14 | 1987-04-14 | Thiophene 2-carboxamide deriv. prepn. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2005163A6 true ES2005163A6 (en) | 1989-03-01 |
Family
ID=8250468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8701096A Expired ES2005163A6 (en) | 1987-04-14 | 1987-04-14 | Thiophene 2-carboxamide deriv. prepn. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2005163A6 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7309497B2 (en) | 2000-08-24 | 2007-12-18 | Schwarz Pharma Ag | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients |
| WO2008074835A1 (en) * | 2006-12-20 | 2008-06-26 | Novartis Ag | 2-substituted 5-membered heterocycles as scd inhibitors |
| US8273782B2 (en) | 2007-02-07 | 2012-09-25 | Glaxosmithkline Llc | Inhibitors of Akt activity |
| US8604076B2 (en) | 2000-08-24 | 2013-12-10 | Ucb Pharma Gmbh | Method for producing a pharmaceutical composition comprising rotigotine |
| US8609711B2 (en) | 2009-01-30 | 2013-12-17 | Glaxosmithkline Llc | Crystalline N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamic hydrochloride |
-
1987
- 1987-04-14 ES ES8701096A patent/ES2005163A6/en not_active Expired
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7309497B2 (en) | 2000-08-24 | 2007-12-18 | Schwarz Pharma Ag | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients |
| US8604076B2 (en) | 2000-08-24 | 2013-12-10 | Ucb Pharma Gmbh | Method for producing a pharmaceutical composition comprising rotigotine |
| WO2008074835A1 (en) * | 2006-12-20 | 2008-06-26 | Novartis Ag | 2-substituted 5-membered heterocycles as scd inhibitors |
| JP2010513403A (en) * | 2006-12-20 | 2010-04-30 | ノバルティス アーゲー | 2-Substituted 5-membered heterocycles as SCD inhibitors |
| US8258160B2 (en) | 2006-12-20 | 2012-09-04 | Novartis Ag | SCD1 inhibitors triazole and tetrazole compounds |
| CN101595105B (en) * | 2006-12-20 | 2013-01-23 | 诺瓦提斯公司 | 2-substituted 5-membered heterocycles as SCD inhibitors |
| US8273782B2 (en) | 2007-02-07 | 2012-09-25 | Glaxosmithkline Llc | Inhibitors of Akt activity |
| US8410158B2 (en) | 2007-02-07 | 2013-04-02 | Glaxosmithkline Llc | Inhibitors of Akt activity |
| US8946278B2 (en) | 2007-02-07 | 2015-02-03 | Glaxosmithkline Llc | Inhibitors of AkT activity |
| US8609711B2 (en) | 2009-01-30 | 2013-12-17 | Glaxosmithkline Llc | Crystalline N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamic hydrochloride |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20020401 |