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ES2005031A6 - Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos. - Google Patents

Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos.

Info

Publication number
ES2005031A6
ES2005031A6 ES8702901A ES8702901A ES2005031A6 ES 2005031 A6 ES2005031 A6 ES 2005031A6 ES 8702901 A ES8702901 A ES 8702901A ES 8702901 A ES8702901 A ES 8702901A ES 2005031 A6 ES2005031 A6 ES 2005031A6
Authority
ES
Spain
Prior art keywords
group
compounds
dioxolanes
disubstituted
aromatic cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8702901A
Other languages
English (en)
Inventor
Javier Bartoli
Manuel Anguita
Elena Carceller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES8702901A priority Critical patent/ES2005031A6/es
Priority to JP63258320A priority patent/JPH01132576A/ja
Priority to US07/257,092 priority patent/US4940706A/en
Priority to EP88116990A priority patent/EP0312041A3/en
Publication of ES2005031A6 publication Critical patent/ES2005031A6/es
Priority to US07/515,379 priority patent/US5070139A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

EN LA PRESENTE INVENCION SE DESCRIBE UN PROCEDIMIENTO PARA OBTENER 1,3-DIOXOLANOS 2,4-DISUSTITUIDOS DE FORMULA I:DONDE R1 REPRESENTA UN GRUPO ALQUILO; X ES UN ENLACE COVALENTE SIMPLE O BIEN ES UN GRUPO CARBONILO, CARBOXILO, CARBAMOILO O UN GRUPO -O-(=0)(O-)-; N ES UN NUMERO ENTERO DE 2 A 10; RY, R3 Y R4 SON GRUPOS ALQUILO INFERIOR, O RYR3R4N- REPRESENTA UN GRUPO AMONIO CICLICO DE TIPO AROMATICO, Y A- ES UN ANION FARMACEUTICAMENTE ACEPTABLE. DICHOS COMPUESTOS SON INHIBIDORES IN VITRO DE LA AGREGACION PLAQUETARIA INDUCIDA POR EL FACTOR ACTIVADOR DE LAS PLAQUETAS (PAF) Y, POR LO TANNTO, UTILES EN EL TRATAMIENTO DE LAS ENFERMEDADES EN LAS QUE DICHA SUSTANCIA SE HALLE IMPLICADA. POR OTRO LADO, ALGUNOS DE DICHOS COMPUESTOS POSEEN ACTIVIDAD HIPOTENSORA SIN PROVOCAR ACTIVACION DE LAS PLAQUETAS.
ES8702901A 1987-10-13 1987-10-13 Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos. Expired ES2005031A6 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES8702901A ES2005031A6 (es) 1987-10-13 1987-10-13 Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos.
JP63258320A JPH01132576A (ja) 1987-10-13 1988-10-13 ２，４−二置換１．３−ジオキソラン
US07/257,092 US4940706A (en) 1987-10-13 1988-10-13 2,4-disubstituted 1,3-dioxolanes and pharmaceutical use
EP88116990A EP0312041A3 (en) 1987-10-13 1988-10-13 2,4-disubstituted 1,3-dioxolanes
US07/515,379 US5070139A (en) 1987-10-13 1990-04-27 2,4-disubstituted 1,3-dioxolanes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8702901A ES2005031A6 (es) 1987-10-13 1987-10-13 Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos.

Publications (1)

Publication Number Publication Date
ES2005031A6 true ES2005031A6 (es) 1989-02-16

Family

ID=8252811

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8702901A Expired ES2005031A6 (es) 1987-10-13 1987-10-13 Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos.

Country Status (4)

Country Link
US (2) US4940706A (es)
EP (1) EP0312041A3 (es)
JP (1) JPH01132576A (es)
ES (1) ES2005031A6 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0687723A1 (en) * 1994-06-16 1995-12-20 Unilever Plc Fabric conditioning molecules derived from glycerol and betaine

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2010145A6 (es) * 1989-03-02 1989-10-16 Uriach & Cia Sa J Procedimiento para la obtencion de derivados de la 2-picolilamina.
JPH07121953B2 (ja) * 1991-11-30 1995-12-25 株式會社眞露 新規なピロリジン誘導体類及びこれらの塩類、その製造方法、薬用組成物及び経皮投与用調合物
EP0607374B1 (en) * 1992-06-30 1999-04-07 Pohang Iron & Steel Co., Ltd. Novel cyclic lipid derivatives as potent paf antagonists
US5700817A (en) * 1992-06-30 1997-12-23 Pohang Iron & Steel Co., Ltd. Cyclic lipid derivatives as potent PAF antagonists
ES2062943B1 (es) * 1993-03-23 1995-11-16 Uriach & Cia Sa J Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas.
JP2007057623A (ja) * 2005-08-22 2007-03-08 Fuji Seal International Inc 収納ラベル
AU2009226465B2 (en) * 2008-03-21 2011-11-17 Ito En, Ltd. Plucking propriety assessment method, plucking propriety assessment apparatus and plucking propriety assessment system for tea leaf, and computer-usable medium.
EP2717699B1 (en) * 2011-06-06 2020-06-03 Veiled Therapeutics LLC Acid-labile lipophilic prodrugs of chemo-therapeutic anti-cancer agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1189549A (en) * 1967-12-18 1970-04-29 Takeda Chemical Industries Ltd A Method for Production of Cytidine (Deoxycytidine)-5'-Diphosphate Choline and Intermediates therefor
JPS57165394A (en) * 1981-04-02 1982-10-12 Ono Pharmaceut Co Ltd Phospholipid derivative, its preparation, and blood platelet activating factor antagonistic agent contraining the same
JPS6081194A (ja) * 1983-10-11 1985-05-09 Takeda Chem Ind Ltd ケトアルキルリン脂質
JPS60104066A (ja) * 1983-11-10 1985-06-08 Ono Pharmaceut Co Ltd グリセリン誘導体
DK160818C (da) * 1983-12-30 1991-10-07 Hoffmann La Roche N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse
DE3586746T2 (de) * 1984-04-03 1993-03-04 Takeda Chemical Industries Ltd Lipidderivate, ihre produktion und verwendung.
GB2205833B (en) * 1987-06-12 1991-03-27 Scras Aminoacylates of glycerol acetal

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0687723A1 (en) * 1994-06-16 1995-12-20 Unilever Plc Fabric conditioning molecules derived from glycerol and betaine

Also Published As

Publication number Publication date
EP0312041A3 (en) 1990-07-25
US5070139A (en) 1991-12-03
JPH01132576A (ja) 1989-05-25
EP0312041A2 (en) 1989-04-19
US4940706A (en) 1990-07-10

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2007-10-13