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EP4446007A1 - Trousse chromatographique de test rapide pour l'analyse d'un echantillon vis-a-vis de molecules pathogenes, de biomolecules, de biomarqueurs et de substances chimiques - Google Patents

Trousse chromatographique de test rapide pour l'analyse d'un echantillon vis-a-vis de molecules pathogenes, de biomolecules, de biomarqueurs et de substances chimiques Download PDF

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Publication number
EP4446007A1
EP4446007A1 EP23167713.9A EP23167713A EP4446007A1 EP 4446007 A1 EP4446007 A1 EP 4446007A1 EP 23167713 A EP23167713 A EP 23167713A EP 4446007 A1 EP4446007 A1 EP 4446007A1
Authority
EP
European Patent Office
Prior art keywords
sample
test
area
sample receiving
plug connection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23167713.9A
Other languages
German (de)
English (en)
Inventor
Hans Hermann SÖFFING
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vellap Diagnostics GmbH
Original Assignee
Vellap Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vellap Diagnostics GmbH filed Critical Vellap Diagnostics GmbH
Priority to EP23167713.9A priority Critical patent/EP4446007A1/fr
Priority to PCT/EP2024/060055 priority patent/WO2024213753A1/fr
Publication of EP4446007A1 publication Critical patent/EP4446007A1/fr
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Definitions

  • the invention relates to a chromatographic rapid test kit for examining a sample, such as blood, using the so-called lateral flow assay principle.
  • Lateral flow assay also called lateral flow test
  • lateral flow test is a long-established laboratory medical procedure for detecting substances in liquids using labelled antibodies. It is a combination of thin layer chromatography and immunoassay. This test principle is behind many common rapid tests, such as those in US 8,399,261 B2 or US 6,372,516 B1 .
  • This type of immunochromatography is a variant of affinity chromatography based on antigen-antibody reactions.
  • Photo-based methods have been established for detection, for example by simple reading.
  • DE 10 2004 006 470 A1 describes a single-use cuvette for detection by means of extinction, which is filled with a porous matrix with a reflective inner surface.
  • the substance to be determined is embedded or deposited in the pores or on the surface of the matrix and the evaluation is carried out by quantitatively recording the transmitted light.
  • test kits widely used rapid corona test kits have a test cassette with a field for dripping on a sample solution. Too much solution is often added to the test strip, which in the worst case floods the planar test strip from all sides, so that the test can no longer be used for reliable determination and has to be disposed of unused, or produces incorrect results. In addition, air bubbles are often trapped in the liquid added, which also leads to incorrect tests. Adding too small a sample volume also leads to incorrect results and reduced analysis performance.
  • connection systems In the pharmaceutical sector, universally applicable connection systems have now become established; for example, the well-known Luer-Lock system is used to connect syringes to cannulas.
  • a Luer-Lock type plug connection for connecting an elongated sample collector with a flexible sponge at the lower end.
  • the sample collector has a handle at one end and a sponge at the other, lower end, for example, for taking a sample to be analyzed, such as blood or urine.
  • a test device that is also described is intended for inserting a planar test strip.
  • the sample to be analyzed is transferred from the sponge by wringing out the sponge by rotating the elongated sample collector.
  • the disadvantage is that the test device has to be held firmly or a holder is necessary.
  • Another disadvantage is that a noticeable amount of the sample to be analyzed remains in the sponge and is lost. Rinsing the sponge from the outside and accurately dripping the rinsing solution into the opening of the test device is not suitable for use by laypeople.
  • US 2005/0180882 A1 describes the sample application by wringing a sample applicator to apply the solution to a planar test strip.
  • a downward flowing test device is also known, for example from US 2011/0256638 A1 .
  • the object of the invention is to overcome the aforementioned disadvantages of the prior art.
  • the invention is intended to provide a chromatographic rapid test set that can be operated by the end user. This is intended to exclude sources of error that would cause an inaccurate or incorrect determination of the result. For example, it is intended to prevent the test strip for chromatography from being accidentally flooded with liquid from all sides. Accidental flooding from above, e.g. through the reading opening should be prevented. Handling should be easy, ie no holders are required. One-handed operation is desirable. It should be possible to no longer lift the test set after the sample to be tested has been placed on the test strip. However, slight movements in the horizontal plane should not affect the invention.
  • the "opening" in the sense of the invention creates a pressure equalization to the outside during operation (i.e. when plugged together), so that liquids inside the sample collection device can flow downwards through the counterpart of the plug connection solely through hydrodynamic pressure.
  • This opening is to be distinguished from, for example, merely hanging openings for threading a thread through.
  • the diameter described is to be understood in terms of the width of the opening. That is, in the case of a square opening, this corresponds to the side length; in the case of a rectangular opening, it corresponds to the shorter of the two side lengths in terms of width. In the case of an oval opening, as would be obtained by cutting an oblique section of a tubular sample holder, "diameter” stands for the width of the ellipse, not the length.
  • the test cassette according to the invention has a flat, elongated shape, in the manner of currently widely used rapid corona tests, in which a test strip is moistened with a sample on the inside and the sample "runs" along the test strip by means of capillary action and a color reaction can be read in a window opening/reading opening.
  • a test strip is bent when inserted and then extends from the area below the plug connection of the test cassette into the test area, where a viewing window (reading opening) is also provided in the lid through which the color reactions can be read.
  • the test cassette has a flow opening visible at the holder for the sample collection device through which the sample to be tested can flow and onto a test strip.
  • the “lower end” of the sample collection device when used when plugging it into the test cassette means the end that is in or on the test cassette.
  • the “upper end” is the corresponding opposite end.
  • the filling area according to the invention with the opening of at least 5 mm diameter is suitable for filling process liquids (such as running buffer or lysis buffer).
  • the supports for a test strip can also be several supports each, or for example an edge etc. or a rectangular closed edge pointing upwards onto which the test strip is placed (and sensibly otherwise locked or clamped in place).
  • the test strip is pressed downwards by the plug connection (as a holder for the sample collection device).
  • the invention also relates to the use of the chromatographic rapid test set according to the invention for the detection of pathogens selected from viruses, bacteria, fungi and parasites, biomolecules, biomarkers or chemical substances, each in a sample.
  • the sample to be examined is preferably filled into the sample collection device (in the case of a capillary or frit, sucked up from below or, in the case of the film with two noses, inserted from above).
  • the sample collection device is plugged into or onto the test cassette (plug connection as a receptacle for the sample collection device) (using the counterpart of the plug connection).
  • a process liquid can then be added from above through the filling area of the sample collection device with opening according to the invention. This rinses the sample to be examined out of the sample collection device.
  • the sample or the resulting mixture reaches the test strip. After a normal running time, the result can be read.
  • the plug connection between the sample collection device and the test cassette advantageously allows for a clean transfer of the liquids from the sample collection device to the test cassette, whereby the invention ensures that a constant volume is always applied. It is advantageously prevented that the solutions do not reach the intended target point on the test strip. The patient can operate the device themselves.
  • test cassette can be placed on a table and does not necessarily have to be lifted to read it.
  • the invention can also easily cope with slight horizontal movements. It also does not have to be held in place.
  • the opening according to the invention in the filling area at the top of the sample collection device also advantageously ensures that no holder is necessary during use. This is because process liquids/rinsing liquids (such as a running buffer or lysis buffer) can be filled directly into the attached sample collection device (i.e. attached to the test cassette) from above into the opening. Even if the user shakes relatively strongly, no holder is necessary.
  • process liquids/rinsing liquids such as a running buffer or lysis buffer
  • the process fluid can be accurately filled from standard ampoules, for example. Due to the opening towards the ambient pressure (meaning the opening in the filling area of the sample intake device), the process fluid can flush out the sample that has accumulated in the frit downwards solely due to the hydrodynamic pressure.
  • the opening is advantageously designed so that the head of an ampoule (in the sense of "hanging" along the edge on the head into the opening in the filling area of the sample collection device) can be easily guided into the opening and, above all, so that the user can easily and reliably see when the ampoule can be pressed so that the process liquid drips into the filling area of the sample collection device and when it cannot. Accidental dripping is prevented.
  • test strip cannot become "flooded”.
  • the above-mentioned opening with the specified minimum opening width prevents process fluids from accidentally running past the outside of the sample collection device, which would flood the test cassette from above, for example through the reading opening (as could happen when filling in process fluids during operation, i.e. when the sample collection device and test cassette are plugged together).
  • the opening advantageously allows the samples (possibly together with a process liquid) to flow down into the test cassette by themselves when the sample collection device is opened upwards. Wringing or pressing the sample collection device (to build up pressure) is not necessary. Displacement using the positive displacement principle (e.g. as with a syringe) is also not necessary.
  • the sample can be flushed down by an added process liquid, simply by means of hydrodynamic pressure.
  • the sample to be examined is a biological sample selected from blood, urine, sweat and a stool sample, particularly preferably blood.
  • the opening in the filling area of the sample collection device has a diameter of 5-10 mm.
  • the opening has a maximum dimension of 7 mm in diameter in the case of the circular opening and a maximum width of 7 mm in the case of the oval opening.
  • the oval opening is most preferably designed to form a tongue for easy gripping of the sample collection device by the user.
  • the tongue is the area (on the sample collection device from bottom to top (looking in the direction inserted into the cassette) starting with the lower edge where the opening begins, up to the upper edge on the opposite side, which is the upper end of the tongue for gripping.
  • the ampoule can, for example, be placed on the lower edge of the opening.
  • the cutting plane (for producing this oval opening) has an inclination to the longitudinal axis of rotation of the sample receiving device of 25-65°, particularly preferably 30-60°, in particular 35-45°.
  • Versions with an oval opening are particularly preferred.
  • the set according to the invention (or even the test cassette) comprises a test strip which has the bend according to the invention and is therefore held in the test cassette while being bent in such a way that it lies lower in the sample receiving area below the receptacle in the test cassette than in the test area.
  • the decisive factors for the bend are the first, high support in the test area according to the invention and the second, low support in the sample receiving area.
  • the plug connection of the test cassette is designed as a female plug connection and the counterpart on the sample collection device is designed as a male plug connection (the male plug connection fits exactly into the female one, i.e. there is a positive contact, whereby rotation along the longitudinal axis of the sample collection device remains possible).
  • female connector in the sense of the invention means a receptacle pointing inwards (i.e. towards the inside of the test cassette (downwards when in use) (e.g. as a bulge). Accordingly, "male connector” means a protuberance of the sample collection device, whereby when in use this protuberance can be inserted into the female receptacle in a form-fitting but detachable or non-detachable manner.
  • Non-detachable includes, for example, a design in which clips prevent the device from coming loose. This is practical in the present case, since the set according to the invention is suitable for single use.
  • the Luer-Lock system is a standardized, state-of-the-art connection system for infusions and injections in the medical field.
  • the seal is achieved by a precisely fitting truncated cone-shaped construction of both connecting parts, which are designed in such a way that they can be inserted into one another in a clamping manner, whereby the truncated cone shape is referred to as the Luer cone.
  • both connectors male and female
  • locking means such as a spiral and a beaded edge on the counterpart in the case of Luer-Lock.
  • the female connector has an inner diameter of >4mm so that the test strip in a common dimension is completely covered by the opening which the female connector opens.
  • the first, high support for the test strip in the test area is 2-5mm (particularly preferably 3-4mm, or even 4-5mm) higher than the second, low support in the sample receiving area (or more precisely the upper end points of the supports that touch the test strip from below).
  • the resulting degree of bending of the test strip is particularly suitable for preventing the test strip from flooding from all sides when the interior of the test cassette is flooded, but also for allowing the sample to flow upwards in the test strip without any problems, as the capillary forces are just sufficient.
  • the thickness of the test cassette is still practical with this selected range and can be easily handled on a large scale.
  • the reservoir sensibly has access to the interior of the test cassette so that liquid from the interior (especially from the sample collection area) can be drawn into the reservoir by means of capillary forces.
  • the reservoir preferably extends over the entire width of the test cassette.
  • the side walls of the reservoir are preferably made of the same material as the test cassette
  • the sample receiving device is an injection-molded part, i.e. it is cast in one piece from one part (only a frit or film can be made of a different material). This means that in this embodiment, the sample receiving device is in one piece and can therefore be easily manufactured.
  • a capillary that may be present is particularly preferably made of the same material as the sample receiving device itself, so that it can also be manufactured with the capillary by injection molding.
  • the sample receiving device comprises a capillary or a frit or a film with at least two lugs at the lower end in the region of the counterpart of the plug connection.
  • a capillary is suitable for samples with little liquid, such as a drop of blood, which is collected from below into the sample collection device using the capillary. This is later heavily diluted during use, i.e. when the liquid from the upper part of the sample collection device passes through the filled capillary.
  • “Frit” in the sense of the invention is a porous or filamentous material in which capillary forces can act on a liquid and can absorb the liquid by itself due to the capillary forces. It is preferably a material that is less than 65 vol% compressible, particularly preferably less than 60 vol%; in particular even less than 10 vol%, such as glass, plastic or ceramic ("less than 65 vol% compressible” means that the so-called "void volume” is less than 65 vol%). It is also possible for the material to be 40-65 vol% compressible.
  • a frit is suitable for larger volumes than a capillary.
  • a reactant for the sample can already be contained or immobilized in the frit.
  • the pH value of the sample can also be determined in this way. can be set or changed. By functionalizing the frit, it is possible to filter out individual substances (e.g. red blood cells) from the sample. It is also possible to functionalize the frit to make it hydrophilic.
  • the film would seal the sample collection device at the bottom.
  • the tabs protrude outwards and downwards.
  • the tabs break into the interior of the sample collection device and pierce the film.
  • the liquid inside the sample collection device can then escape to the outside and run downwards into the test cassette.
  • This embodiment with film and tabs is suitable for SWAP tests, in which a swab is first filled into the sample collection device, then a process liquid is added from above and only after homogeneous mixing can the resulting mixture be applied to the test strip in the test cassette.
  • the advantage of the versions with a frit or capillary is that it only absorbs a certain and constant volume (when the sample is taken up via the frit or capillary by placing/dipped the end with the frit/capillary onto the sample). No further sample is taken up, because the absorption takes place solely by means of the capillary forces within the frit/capillary.
  • a version with a frit or capillary is therefore particularly preferred.
  • a frit i.e. a filter material
  • a frit allows large volumes of liquid to be sucked up homogeneously and bubble-free from below into the sample collection device and then applied downwards onto the test cassette.
  • the advantage of the lack of negative pressure inside the sample collection device when taking the sample is that it can be taken up slowly and thus bubble-free. This slow and controlled take-up is made possible by the capillary forces with the inventive opening of the sample collection device at the top (pressure equalization). This is because with sample collection devices (also called sampling tools) from the state of the art, uncontrolled flow behavior inevitably occurs with larger volumes (from approx. 100 ⁇ L), which means that no constant volume reaches the test strip.
  • the frit absorbs itself advantageously.
  • the expert knows the materials that are suitable for such a frit
  • the capillary has an internal volume of 1-15 ⁇ L, i.e. it can be used to collect samples of this volume.
  • the frit is preferably 5mm high ( ⁇ 1mm, preferably ⁇ 0.3mm) and has a diameter of 5mm ( ⁇ 1mm, preferably ⁇ 0.3mm). This most preferably corresponds to a volume of 0.098cm3, i.e. 98 ⁇ L.
  • this has a volume of 50-100 ⁇ L.
  • the noses are preferably noses that point outwards
  • the noses are designed in such a way that when inserted into the test cassette they bend inwards and upwards so that they pierce a sensitive base above them (preferably made of plastic or aluminum foil) so that a liquid above them can pass through downwards. It is possible to provide predetermined breaking points on the noses so that controlled bending is possible. This is because the bent noses can, for example, push through slots above or below (preferably above) the foil so that the area of the foil that is pierced by the noses is always the same, so that the subsequent passage of liquid can take place in a controlled manner and in a reproducible amount.
  • this is made of plastic and/or in the case of a frit, this is made of sterilised polyethylene (PE), whereby these are preferably hydrophilised PE frits.
  • PE sterilised polyethylene
  • a base is provided directly above the frit, which is designed on the underside (i.e. between the frit and the base) in such a way that a homogeneous and large-area wetting of the frit is possible, for example by means of a spiral-shaped or star-shaped depression with at least one hole in the middle of the spiral or star (as exemplified for the spiral shape in Fig. 6 shown).
  • the advantage of this is that the liquid from the sample collection device passes through the hole and then flows along the spiral or star-shaped trench (i.e. one after upward-facing depression) and wets the frit as widely and homogeneously as possible, so that a "running front" with almost no bubbles is created at the upper end of the frit.
  • This advantageously prevents the frit from forming an oblique liquid front with only point-based wetting, which would trap air bubbles when running.
  • the test cassette has a reading opening on the top and bottom opposite each other in the test area, which advantageously enables automatic detection by means of transmitted light measurement.
  • test cassette has a housing that is closed off at the two smallest surfaces. This prevents the test cassette from leaking out the sides, which would make it cumbersome and complicated to use.
  • the two smallest surfaces in the sense of the invention relate to the two front sides of the naturally elongated, rectangular test cassette.
  • the material of both the test cassette and the sample collection device is ABS (acrylonitrile butadiene styrene).
  • ABS acrylonitrile butadiene styrene
  • the foil in the example with foil and noses is an aluminum foil and the frit in the example with frit is made of sintered polyethylene.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP23167713.9A 2023-04-13 2023-04-13 Trousse chromatographique de test rapide pour l'analyse d'un echantillon vis-a-vis de molecules pathogenes, de biomolecules, de biomarqueurs et de substances chimiques Pending EP4446007A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP23167713.9A EP4446007A1 (fr) 2023-04-13 2023-04-13 Trousse chromatographique de test rapide pour l'analyse d'un echantillon vis-a-vis de molecules pathogenes, de biomolecules, de biomarqueurs et de substances chimiques
PCT/EP2024/060055 WO2024213753A1 (fr) 2023-04-13 2024-04-12 Ensemble de test rapide chromatographique pour analyser un échantillon à la recherche d'agents pathogènes, de biomolécules, de biomarqueurs et de substances chimiques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP23167713.9A EP4446007A1 (fr) 2023-04-13 2023-04-13 Trousse chromatographique de test rapide pour l'analyse d'un echantillon vis-a-vis de molecules pathogenes, de biomolecules, de biomarqueurs et de substances chimiques

Publications (1)

Publication Number Publication Date
EP4446007A1 true EP4446007A1 (fr) 2024-10-16

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EP23167713.9A Pending EP4446007A1 (fr) 2023-04-13 2023-04-13 Trousse chromatographique de test rapide pour l'analyse d'un echantillon vis-a-vis de molecules pathogenes, de biomolecules, de biomarqueurs et de substances chimiques

Country Status (2)

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EP (1) EP4446007A1 (fr)
WO (1) WO2024213753A1 (fr)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296724A2 (fr) * 1987-06-01 1988-12-28 Quidel Essai et dispositif utilisant une membrane non-buvant permettant un courant latéral
WO2000072012A2 (fr) * 1999-05-24 2000-11-30 Abbott Laboratories Appareil de pretraitement d'un echantillon contenant un analysat
US6372516B1 (en) 2000-09-07 2002-04-16 Sun Biomedical Laboratories, Inc. Lateral flow test device
US20030064526A1 (en) 2001-09-28 2003-04-03 Orasure Technologies, Inc. Sample collector and test device
US20050180882A1 (en) 2003-11-14 2005-08-18 Tung Hsiaoho E. Rapid sample analysis and storage devices and methods of use
DE102004006470A1 (de) 2004-02-06 2005-09-01 Senova Gesellschaft für Biowissenschaft und Technik mbH Photometrische Einmalmessküvette mit erhöhter Sensitivität
EP1813949A1 (fr) * 2006-01-03 2007-08-01 Dräger Safety AG & Co KGaA Cassette de test pour analyses de liquides
DE102007025311A1 (de) 2007-05-30 2008-12-04 Senova Gesellschaft für Biowissenschaft und Technik mbH Quantitativer heterogener schneller Bindungsassay mit breitem dynamischen Bereich und einfacher photometrischer Detektion
US20110256638A1 (en) 2008-10-17 2011-10-20 Medmira Inc. Downward or vertical flow diagnostic device and assay
US8399261B2 (en) 2007-06-27 2013-03-19 Inbios International, Inc. Lateral flow assay system and methods for its use
US20170227536A1 (en) * 2014-08-20 2017-08-10 Shin Corporation Test apparatus

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296724A2 (fr) * 1987-06-01 1988-12-28 Quidel Essai et dispositif utilisant une membrane non-buvant permettant un courant latéral
WO2000072012A2 (fr) * 1999-05-24 2000-11-30 Abbott Laboratories Appareil de pretraitement d'un echantillon contenant un analysat
US6372516B1 (en) 2000-09-07 2002-04-16 Sun Biomedical Laboratories, Inc. Lateral flow test device
US20030064526A1 (en) 2001-09-28 2003-04-03 Orasure Technologies, Inc. Sample collector and test device
US20050180882A1 (en) 2003-11-14 2005-08-18 Tung Hsiaoho E. Rapid sample analysis and storage devices and methods of use
DE102004006470A1 (de) 2004-02-06 2005-09-01 Senova Gesellschaft für Biowissenschaft und Technik mbH Photometrische Einmalmessküvette mit erhöhter Sensitivität
EP1813949A1 (fr) * 2006-01-03 2007-08-01 Dräger Safety AG & Co KGaA Cassette de test pour analyses de liquides
DE102007025311A1 (de) 2007-05-30 2008-12-04 Senova Gesellschaft für Biowissenschaft und Technik mbH Quantitativer heterogener schneller Bindungsassay mit breitem dynamischen Bereich und einfacher photometrischer Detektion
US8399261B2 (en) 2007-06-27 2013-03-19 Inbios International, Inc. Lateral flow assay system and methods for its use
US20110256638A1 (en) 2008-10-17 2011-10-20 Medmira Inc. Downward or vertical flow diagnostic device and assay
US20170227536A1 (en) * 2014-08-20 2017-08-10 Shin Corporation Test apparatus

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Publication number Publication date
WO2024213753A1 (fr) 2024-10-17

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