EP4161475A1

EP4161475A1 - Ecobiological lipo-alcoholic composition

Info

Publication number: EP4161475A1
Application number: EP20767531.5A
Authority: EP
Inventors: Jean-Noël THOREL
Original assignee: Naos Institute of Life Science SAS
Current assignee: Naos Institute of Life Science SAS
Priority date: 2020-06-08
Filing date: 2020-09-03
Publication date: 2023-04-12
Also published as: KR20230028722A; CA3180754A1; CN115697283A; FR3111073A1; BR112022025027A2; JP2023529899A; MX2022015619A; US20240285490A1; FR3111073B1; WO2021249661A1

Abstract

The invention relates to an ecobiological, lipo-alcoholic topical disinfectant composition that is virucidal, where appropriate bactericidal and/or yeasticidal, by friction and without rinsing, capable of regenerating the skin lipid barrier and perfectly well tolerated by the skin, including during repeated daily intensive use, characterized in that it comprises: - at least 65% w/w of a C₁-C₈ alcohol; - at least 10% by total weight of the composition of an oily phase comprising at least one component chosen from the list of the following components: plant oils, mineral oils, silicone oils, butters, esters, plant waxes, mineral waxes, silicone waxes, fatty acids, and fatty alcohols with fatty chains of more than 10 carbon atoms in length.

Description

Title of the invention ECOBIOLOGICAL LIPOALCOOLIC COMPOSITION

Field of the invention

The invention relates to a new category of ecobiological cosmetic topical products comprising alcohol at a defined dose to be endowed with virucidal, bactericidal and yeasticidal activities and a lipid substrate at a defined dose to preserve and promote the lipid film of the skin, thus making it possible to maintain its properties in terms of its barrier effect and its hydration. This combination is particularly well tolerated, including during intensive use (repeated several times a day). The invention also relates to the use of this composition for disinfecting the skin and to a method of manufacturing said composition.

Prior state of the art

The skin generally contains millions of different microorganisms (bacteria, viruses, yeasts, etc.) present at concentrations exceeding millions or even billions of colony forming units (CFU) per square centimeter (cm ² ).

Many of these microorganisms are harmless, but there are also various pathogenic types or subspecies, such as Escherichia colie t Staphylococcus aureus. Several other bacteria can be found in the skin flora (or skin microbiome), such as Staphylococcus epidermidis which is generally non-pathogenic. The hands are also factors of viral or bacterial propagation.

For these reasons, washing and / or disinfecting the skin, in particular the hands, is recommended by healthcare professionals. In times of health crisis and epidemic, hand cleaning is particularly recommended since it is one of the most effective actions to repeat to limit the risk of transmission and / or contamination.

The hands are cleaned in particular with washing compositions, washing gels or else by friction with hydro-alcoholic solutions or gels.

Among the traditional solutions commonly used for washing / disinfecting the skin, in particular the hands, there are many cosmetic or dermo-pharmaceutical products capable of having virucidal, bactericidal and yeasticidal effects such as Pevaryl®, Econazole®, Mycoapaisyl®, Betadine®, Dakin® or even Exomedine®. These products are formulated either using biocides, a list of substances toxic to bacteria, yeasts or viruses that are highly regulated in Europe, or by using a necessary and sufficient quantity of an alcohol, in particular isopropanol or ethanol, capable of penetrating through the membranes of microorganisms and of destroying them.

In the case of biocides, they are particularly aggressive for the skin and for the skin microbiome, that is to say the community of microorganisms that make up the skin flora. Biocides are therefore the cause of side effects such as intolerance, allergies or skin lesions which have been frequently noted by health professionals; their use is generally limited.

In the case of alcohol, it induces a rupture or complete destruction of the hydrolipidic film, which causes an alteration of the skin film and its barrier effect as well as very uncomfortable side effects. These effects are widely described in the scientific literature during intensive use of these alcohols in the form of hydroalcoholic solutions or gels, for example for disinfecting the hands of hospital staff in order to prevent the spread of viral infections (for example the article de Lan J, et al. Skin damage among healthcare workers managing coronavirus disease-2019, Journal of the American Academy of Dermatology (2020) or the article by Cavanagh G, Wambier C, Rational hand hygiene during COVID-19 pandemic, Journal of the American Academy of Dermatology (2020) or the article by Yan Y et al. Consensus of Chinese experts on protection of skin and mucous membrane barrier for health-care workers fighting against coronavirus disease 2019.

Dermatol Ther. 2020 or the article by Wan Y et al. Receptor Recognition by the Novei Coronavirus from Wuhan: an analysis based on decade-long structural studies ofSARS Coronavirus. 2020. J Virol 94: e00127-20).

However, the skin is the first protective barrier against external aggressions (pathogens, contamination, chemical attacks, etc.). Through its barrier function, the skin plays a protective role against external stress factors and also prevents the evaporation of water. Regularly attacked by these cleansing compositions, the skin can lose its natural defense and protection capacities over time. Repeated multi-daily washes have an undeniable effect on the skin ecosystem by eliminating the lipids which naturally preserve and protect the skin. This is even more true when disinfectants are used several times a day, because their high alcohol concentration alters the lipid film of the skin, which in particular has the effect of causing it to lose its barrier effect, inducing a significant increase in transepidermal water loss, strong penetration of substances applied to its surface and increasingly frequent intolerances (redness, dryness, cracks, lesions, etc.).

Cleaning products that can be used routinely on a daily basis and repeatedly, without a water point, by friction, are effective in eliminating viruses, bacteria and yeasts, in particular those present on the surface of the hands, and therefore in combating the transmission of a pathology. However, these formulations attack the skin barrier and their use is at the origin of harmful consequences for health. Certain formulations of the prior art (exemplified below in Example 7) combine microbicidal (bactericidal and / or yeasticidal) and virucidal compositions which ensure disinfection of the hands and hydration of the skin. However, these compositions are poorly tolerated by human tissues and induce redness and irritation, which is uncomfortable for users, in particular hospital staff who often have to disinfect their hands, up to 50 times a day.

Consequently and in order to combat the undesirable effects of hydroalcoholic gels or solutions, users frequently apply a moisturizing composition (cream, solution, lotion, etc.) after having applied the hydroalcoholic solution or gel.

There therefore remains an obvious need to develop topical formulations allowing, in a very simple application, to obtain by friction, the virucidal, bactericidal and yeasticidal effects of a gel or hydroalcoholic solution without its drawbacks (intolerance, dehydration, desquamation, etc. alteration of the skin barrier function, etc.), while allowing reconstruction of the skin barrier by improving the quality of its lipid film and which is perfectly tolerated by the skin tissues.

Disclosure of the invention

The Applicant has developed a new category of innovative products making it possible, in a single product called an ecobiological lipoalcoholic topical formulation, to obtain the properties of several products without their respective drawbacks. This new category of innovative products makes it possible to ensure effective cleaning of the skin, for example effective disinfection of the hands, without having the drawbacks of the products of the prior art. In other words, the Applicant has developed formulations capable of providing unexpectedly three complementary properties: disinfection, hydration / protection of the skin barrier and very high tolerance.

According to a first aspect, the invention relates to a topical lipoalcoholic composition, ecobiological disinfectant virucidal, where appropriate bactericidal and / or levuricidal, by friction and without rinsing, capable of regenerating the skin lipid barrier and perfectly well tolerated by the skin including during repeated daily intensive use, characterized in that it includes:

- at least 65% w / w of a Ci-Cs alcohol;

- at least 10% by total weight of the composition of an oily phase comprising at least one component chosen from the list of the following components: vegetable oils, mineral oils, silicone oils, butters, esters, vegetable waxes, mineral waxes, silicone waxes , fatty acids, fatty alcohols with fatty chains greater than 10 carbons.

According to the invention, the alcohol content must be greater than or equal to 65% by weight of the composition to ensure a virucidal, where appropriate bactericidal and optionally yeasticidal effect. According to the invention, the oily phase must be greater than or equal to 10% by weight of the composition to ensure true reconstruction of the lipid film, lower concentrations not making it possible to truly reconstruct the barrier effect of the skin destructured by the. alcohol.

In other words, the Applicant has developed a composition which provides a virucidal effect, where appropriate bactericidal and optionally yeasticidal by friction, regenerating the surface hydrolipidic film, without major intolerance phenomena being observed.

For the purposes of the invention, the term “ecobiological composition” denotes a composition which respects the biology of the skin, in particular the lipid or hydrolipid barrier, and is well tolerated by the skin. An ecobiological composition according to the invention therefore makes it possible to respect the barrier property of the skin consisting of:

- prevent the entry of poorly tolerated or even toxic components, liable to generate the production of inflammation mediators; and

- limit / prevent an insensible water loss (PIE) despite the use of alcohol used in high concentration.

The quality of the barrier function of the skin can be assessed by an in vivo measurement of the insensitive water loss (IEP). Unlike sweating, the insensible loss of water is not visible to the naked eye. The quantity of water crossing the stratum corneum (outermost layer of the skin) by this route is evaluated between 300 and 400 ml / d under normal conditions, but can be multiplied by 10 or 20 in the event of irritation or breaking of the barrier effect. The IEP is measured using, for example, the TM300 Tewameter (Monaderm), and the results are expressed as a% reduction in the IEP (improvement of the barrier effect) compared to the mean values of the IEP measured after application of a hydroalcoholic solution. commercial standard. Thus, a PIE greater than or equal to 50% indicates an improvement in the barrier effect.

According to a particular embodiment, the composition according to the invention exhibits a reduction in the IEP of greater than or equal to 50% (Tewameter TM300 (Monaderm) of that measured with a standard commercial hydroalcoholic solution.

In other words, within the meaning of the invention, an ecobiological composition provides a tolerance effect with respect to the skin and ensures the prevention / regeneration of the skin lipid barrier.

For the purposes of the invention, the term “lipoalcoholic composition” denotes a composition comprising an alcohol phase, an oily phase and optionally water. In the case where the composition comprises water, the water concentration is lower than the concentration of oily components and the concentration of alcohol (water <oily phase and water <alcohol phase). According to a particular embodiment, the water represents less than 20% by total weight of the composition according to the invention, advantageously less than 15%, preferably less than 10%.

The composition according to the invention provides a virucidal and / or antimicrobial effect (that is to say a bactericidal and / or yeasticidal effect), advantageously a virucidal, bactericidal and yeasticidal effect, while allowing the preservation and / or the restoration. intrinsic properties of the skin, that is to say by providing a barrier and tolerance effect.

According to a particular embodiment, the Ci-Cs alcohol is chosen from the list of the following components: ethanol, isopropanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, each being in linear or branched form and their mixtures.

Advantageously, the Ci-Cs alcohol is chosen from the list of the following components: ethanol, isopropanol and their mixture.

According to a particular embodiment, the ecobiological lipoalcoholic composition according to the invention comprises between 65% and 80% w / w of a C1-Cs alcohol, advantageously between 70% and 80% w / w.

According to a particular embodiment, the oily phase of the composition according to the invention comprises at least one vegetable oil chosen from the list of the following components (INCI name): vegetable squalane, hexyl laurate, octododecanol, dibutyl adipate, coco-caprylate / caprate, dicaprylyl carbonate, decyl oleate, dicaprylyl ether, cocoglycerides, 00-18 triglyceride, caprylic / capric triglyceride, prunus oil and prunus kernel oil, ribes seed oil, pongamia seed oil, corylus seed oil, brassica seed oil, butyrospermum helianthus annuus seed oil, olea europaea fruit oil, coco nucifera oil, simmondsia chinensis seed oil, canola oil, cyperus esculentus root oil, limnanthes seed oil, mangifera seed butter, oryza sativa bran oil, camellia japonica seed oil, polyglyceryl-3 diisostearate and their mixtures.

According to a particular embodiment, the oily phase of the composition according to the invention comprises at least one fatty substance chosen from the list of the following components (INCI name): isohexadecane, isododecane, propylheptyl caprylate, cetearyl isononanoate, ethylhexyl hydrostearate, ethylhexyl palmitate , diisopropyl sebacate, butyloctyl salicylate, propylene glycol dicaprylate / dicaprate, tridecyl trimellitate, C12-C15 alkyl benzoate, hydrogenated polydecene, caprylyl methicone, triethylhexanoin, paraffinum liquidum / minerallyicone oil, dipethlenethritylhexyprylate / minerallyicone oil, dipetherythritylhexacaobutylate / minerallyicone oil, dipetherythritylhexacaobutylate / dimentaprerylate, dimentaprerythritylhexyprylate / minerallyicone and their mixtures.

According to a particular embodiment, the oily phase of the composition according to the invention comprises at least one polymer chosen from the list of the following components (INCI name): hydroxypropylcellulose, PVP, Vinyl alcohol / butyl maleate / isobornyl acrylate copolymer, methyl hydroxypropylcellulose, hydroxypropylguar, polyacrylate crosspolymer-6, ammonium acryloyldimethyltaurate / VP copolymer, carbomer, acrylate copolymer, hydroxyethylacrylate / sodium acryloyldimethyl taurate copolymer, acrylamide / sodiumacryloyldimethyl taurate, vinyl acrylate / C10-C30 alkyl crosspolymate and acrylate / crosspolymate mixtures thereof.

According to a particular embodiment, the composition according to the invention, advantageously the oily phase, comprises at least one natural or chemical molecule having specific properties in virology such as glycerrhizin, baicalin, quercetin, theaflavin, or their respective derivatives. .

It emerges from the foregoing that the oily phase of the composition according to the invention can comprise all the combinations of components mentioned above. In other words, the oily phase according to the invention can comprise at least one vegetable oil and / or at least one fatty substance and / or at least one polymer and / or at least one purified vegetable substance having specific properties in virology. .

According to a particular embodiment, the eco-organic lipoalcoholic composition according to the invention comprises at least 12% by total weight of the composition of the oily phase, advantageously at least 20%.

According to a particular embodiment, when the composition according to the invention comprises at least 80% w / w of Ci-Cs alcohol, it comprises at least 11% by total weight of the composition of the oily phase.

According to another embodiment, when the composition according to the invention comprises between 75% and strictly less than 80% w / w of Ci-Cs alcohol, it comprises between 10% and 30% by total weight of the composition of the oily phase, advantageously between 20% and 30%.

According to a particular embodiment, the composition according to the invention further comprises:

- at least one lipophilic component, advantageously a lipophilic component chosen from natural lipophilic constituents of skin tissue, and / or lipophilic biomimetic constituents; and or

- at least one hydrophilic component, advantageously a hydrophilic component chosen from natural hydrophilic constituents of skin tissue, and / or hydrophilic biomimetic constituents

- at least one component chosen from surfactants, gelling agents, dyes of the aqueous phase and / or of the oily phase, and / or

- pure hydrogen peroxide at a concentration of less than 1% w / w.

For the purposes of the invention, the term “biomimetic component” denotes a component which has a structure close to a natural component of the skin and makes it possible to activate the same effectors as said. compound or product of the skin; or which mimics the action of a component naturally present in the skin, in order to produce the same effects.

According to a particular embodiment, the composition according to the invention has a pH of between 5 and 7.5; advantageously between 5.5 and 6.8.

According to a particular embodiment, the ecobiological lipoalcoholic composition according to the invention is a two-phase composition in the form of two immiscible phases each present in continuous form and free of surfactant.

According to another embodiment, the ecobiological lipoalcoholic composition according to the invention is in the form of a gel and comprises a gelling agent representing, advantageously, between 0.1% and 5% by total weight of the composition.

Advantageously, the gelling agent is chosen from the list of the following components (INCI name): Sodium Hyaluronate, Xanthan gum, Cellulose Gum, Sodium Acrylates Copolymer, Algin,

Acrylates / Vinyl Isodecanoate Crosspolymer, Sodium Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Acrylates / C10-30 Alkyl Acrylate Crosspolymer, Disteardimonium Hectorite, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Microcrystalline Cellulose, Sclerotium Gum and mixtures thereof.

According to another particular embodiment, the ecobiological lipoalcoholic composition according to the invention is in the form of an emulsion.

According to a particular embodiment, the ecobiological lipoalcoholic composition according to the invention does not contain any of the following components:

- perfumes; and

- essential oils, advantageously the essential oils of eucalyptus, tea tree, bay leaf, rosemary, spearmint, pepper, rose, sage, peppermint, camphor tree, mukurossi and soapberry; and

- terpenes, preferably orange terpenes,

- emulsifiers based on silicones; and

- foaming surfactant type cleaning agents, advantageously ammonium lauryl sulfoccinate and lauramidopropyl betaine; and

- pH stabilizers, advantageously lactic acid and fumed silica.

All these components, which are well known to those skilled in the art for producing conventional formulations, cannot be used in the formulation of the composition according to the invention. intended to be used without rinsing and repeatedly during the day, since they generate under these conditions of use, intolerances which can in certain cases prove to be very severe and side effects such as sensitization or polysensitization, inflammation generating redness, wounds, cracking, etc. The difficulty was therefore to develop compositions which were just as effective in terms of virucidal properties in particular, but which were well tolerated and did not affect the barrier function of the skin.

According to another embodiment, the composition according to the invention is incorporated into a wipe or a compress.

The ecobiological lipoalcoholic composition according to the invention:

- ensures microbiocidal (i.e. bactericidal and / or yeasticidal) and / or virucidal effects,

- reconstructs and / or maintains and / or improves the lipid barrier function of the skin, and

- is perfectly well tolerated by human skin tissue, including during intensive use.

The composition according to the invention is used for disinfecting the skin by eliminating viruses, where appropriate bacteria and optionally yeasts.

For the purposes of the invention, the term "skin" denotes any keratinous substrate on the external surface of the body, including, but not limited to, the hands, the face, the armpits, the hair and the scalp.

Advantageously, the composition according to the invention is used for disinfecting the hands.

Advantageously, it is a non-therapeutic use of the composition according to the invention in that it involves removing bacteria, viruses and yeasts from healthy skin, which is not necessarily prophylactic. since, even in the presence of potentially pathogenic bacteria, viruses and yeasts on their skin, an individual is not necessarily going to develop a pathology.

According to another aspect, the invention relates to a non-therapeutic method of disinfecting the hands consisting of:

- Provide an ecobiological lipoalcoholic composition without rinsing as described above;

- apply the composition to the hands by friction with a contact time of at least 30 seconds, advantageously at least 60 seconds.

According to another aspect, the invention relates to a process for manufacturing the composition as described above, consisting in: a) mixing the oily components to produce the oily phase; b) adding the Ci-Cs alcohol, preferably ethanol, advantageously absolute ethanol, to the oily phase prepared in step a).

According to a particular embodiment, step a) further comprises the addition:

- at least one natural lipophilic constituent of skin tissue; and or

- at least one natural hydrophilic constituent of skin tissue; and or

- at least one component chosen from surfactants and / or gelling agents and / or dyes of the aqueous phase and / or of the oily phase; and or

- pure hydrogen peroxide at a concentration of less than 1% w / w.

- at least one lipophilic biomimetic component; and or

- at least one hydrophilic biomimetic component.

According to another embodiment, step a) further comprises the addition:

- at least one natural lipophilic constituent of skin tissue; and or

- at least one natural hydrophilic constituent of skin tissue; and or

- pure hydrogen peroxide at a concentration of less than 1% w / w; and or

- a gelling agent, advantageously representing between 0.1% and 5% by total weight of the composition.

Advantageously, the gelling agent is chosen from the list of the following components (INCI name): Sodium Hyaluronate, Xanthan gum, Cellulose Gum, Sodium Acrylates Copolymer, Algin, Acrylates / Vinyl Isodecanoate Crosspolymer, Sodium Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Acrylates / C10- Alkyl Acrylate Crosspolymer, Disteardimonium Hectorite, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Microcrystalline Cellulose, Sclerotium Gum and mixtures thereof.

The manufacturing process according to the invention has the advantages of being particularly simple, inexpensive, and usable on an industrial scale.

The invention and the advantages which result therefrom will emerge more clearly from the following examples given in order to illustrate the invention and not in a limiting manner.

Description of the implementation examples

Example 1: Two-phase cosmetic compositions according to the invention

The ingredients are identified according to the INCI nomenclature and the percentages are given by weight / weight, in Table 1 below:

[Tables 1]

Bactericidal, virucidal and yeasticidal effect:

The formulas are tested according to standard NF EN 13727 according to the specific protocol for cleaning products / hygienic friction. Briefly, the formulas to be evaluated are brought into contact with various microorganisms in suspensions after a contact time of 30 and 60 seconds at 20 ° C., at a test concentration of 50 and 80%.

The minimum test strains evaluated are: Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus hirae, Echerichia coli K12, Candida albicans DSM1386, Poliovirus 1 sabine strain, Adenovirus type 5, Murine norovirus S99, vaccinia virus strain Ankara ATCC VR-1508.

If the microorganisms are destroyed, the test is validated and noted "+", if the microorganisms are not all destroyed, the result is noted "+/-", if the microorganisms are not destroyed under the conditions of the test, the result is noted "-".

Skin barrier reconstruction effect:

The in vivo measurement of insensitive water loss (IWP) is used to assess, in a non-invasive manner, the quality of the barrier function of the stratum corneum.

Series of 20 healthy volunteers are recruited and use daily either a commercial hydroalcoholic solution or gel, or the product of the invention (double-blind studies). Before use then after 1 week and after 1 month of use, the IEP is measured using a TM300 Tewameter (Monaderm), and the results are expressed as a% reduction in the IEP (improvement in the barrier effect) compared to mean PIE values obtained with the commercial hydroalcoholic solution or gel, at each test time.

If the results of the improvement in the barrier effect are greater than 50% either at 1 week or at 1 month, the test is noted "+", if the improvement shows variations depending on the time of the measurement but remains fairly close to 50%, the test is noted "+/-", if this improvement is less than 50%, the test is noted "-".

Tolerance effect: During the PIE study above, the evaluation of the skin quality (presence of inflammation, irritation, redness, injuries) of the hands of the volunteers who continued to use the products tested on a daily basis is carried out. by a dermatologist. If redness or intolerance is observed on more than 30% of the hands evaluated, the result is noted "-", if they are observed on more than 10% of the hands evaluated, the result is noted "+/-", if they are observed on less than 10% of the hands evaluated, the result is noted "-".

Results:

The results are described in Table 2. [Tables 2]

The formulations of Example 1, in particular Examples IB to 1E, are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed. The virucidal effect is obtained from 65% alcohol. The barrier effect is obtained with more than 10% lipids. Tolerance varies with the level of lipids provided by the formulation.

Example 2: Two-phase cosmetic compositions

The ingredients are identified according to the INCI nomenclature and the percentages are given by weight / weight in Table 3.

[Tables 3] The measurements of the bactericidal, virucidal, yeasticidal, barrier and tolerance effects are carried out by following the protocols described in Example 1 of the invention.

Results:

The results are described in Table 4. [Tables 4]

The formulations of Example 2, in particular Examples 2B to 2E, are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed.

Example 3: Two-phase cosmetic compositions

The ingredients are identified according to the INCI nomenclature and the percentages are given by weight / weight in Table 5.

[Tables 5]

The measurements of the bactericidal, virucidal, yeasticidal, barrier and tolerance effects are carried out by following the protocols described in Example 1 of the invention.

Results:

The results are described in Table 6. [Tables 6]

The formulations of Example 3, in particular Examples 3B to 3E, are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed.

Example 4: Two-phase cosmetic compositions

The ingredients are identified according to the INCI nomenclature and the percentages are given by weight / weight in Table 7.

[Tables 7]

Results

The results are described in Table 8. [Tables 8]

The formulations of Example 4, in particular Examples 4B to 4F are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed.

Example 5: Cosmetic compositions of lipoalcoholic gel type

The ingredients are identified according to the INCI nomenclature and the percentages are given by weight / weight in Table 9.

[Tables 9]

Results:

The results are described in Table 10. [Tables 10]

The formulations of Example 5 are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions commonly marketed.

Example 6: Cosmetic compositions of lipoalcoholic emulsion type

The ingredients are identified according to the INCI nomenclature and the percentages are given by weight / weight in Table 11.

[Tables 11]

Results:

The results are described in Table 12. [Tables 12]

The formulations of Example 6 are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed.

Example 7: Comparative cosmetic compositions according to the invention The ingredients are identified according to the INCI nomenclature and the percentages are given by weight / weight in tables 13 and 14. T corresponds to a formulation of the composition according to the invention and the formulations 7A to 7N are formulations of the prior art.

[Tables 13]

[Tables 14]

Results:

The results are described in Tables 15 and 16. [Tables 15]

[Tables 16]

The formulations of Example 7 (7A to 7N) are therefore not capable of exerting all the expected effects of the invention, unlike the control T which corresponds to a formulation of the composition according to invention. Strong to very strong intolerance problems have been demonstrated after only a few days of multiple daily applications, in particular with the use of essential oils, perfumes, pH adjusters, bactericides, and more. more surprising with emulsifiers derived from silicone and foaming surfactants.

Claims

[Claim 1] Lipoalcoholic topical composition, ecobiological disinfectant virucidal, where appropriate bactericidal and / or levuricidal, by friction and without rinsing, capable of regenerating the skin lipid barrier and perfectly well tolerated by the skin, including during repeated daily intensive use, characterized in that it comprises:

- at least 65% w / w of a Ci-Cs alcohol;

[Claim 2] Ecobiological lipoalcoholic topical composition according to claim 1, characterized in that the Ci-Cs alcohol is chosen from the list of the following components: ethanol, isopropanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, each being in linear or branched form and their mixtures, and advantageously chosen from ethanol, isopropanol and their mixture.

[Claim 3] Ecobiological lipoalcoholic topical composition according to one of the preceding claims, characterized in that, when it comprises water, the water concentration is lower than the concentration of components of the oily phase and the concentration of 'alcohol.

[Claim 4] Ecobiological lipoalcoholic topical composition according to one of the preceding claims, characterized in that it comprises between 65% and 80% w / w of a C1-Cs alcohol, advantageously between 70% and 80% w / p.

[Claim 5] Ecobiological lipoalcoholic topical composition according to one of the preceding claims, characterized in that it comprises at least 12% by total weight of the composition, of oily phase, advantageously at least 20%.

[Claim 6] Ecobiological lipoalcoholic topical composition according to one of claims 1 to 4, characterized in that it comprises between 75% and strictly less than 80% w / w of Ci-Cs alcohol and between 10% and 30% by total weight of the composition of the oily phase, advantageously between 20% and 30%.

[Claim 7] Ecobiological lipoalcoholic topical composition according to one of claims 1 to 4, characterized in that it comprises at least 80% w / w of Ci-Cs alcohol and at least 11% by total weight of the composition of the oily phase.

[Claim 8] Ecobiological lipoalcoholic topical composition according to one of the preceding claims, characterized in that it further comprises:

- pure hydrogen peroxide at a concentration of less than 1% w / w.

[Claim 9] Ecobiological lipoalcoholic topical composition according to one of the preceding claims, characterized in that it has a pH of between 5 and 7.5; advantageously between 5.5 and 6.8.

[Claim 10] Ecobiological lipoalcoholic topical composition according to one of the preceding claims, characterized in that it is a two-phase composition in the form of two immiscible phases each present in continuous form and free of surfactant.

[Claim 11] Ecobiological lipoalcoholic topical composition according to one of claims 1 to 9, characterized in that it is in the form of a gel and comprises a gelling agent representing, advantageously, between 0.1% and 5% by weight of the composition.

[Claim 12] Ecobiological lipoalcoholic topical composition according to claim 11, characterized in that the gelling agent is chosen from the list of the following components: Sodium Hyaluronate, Xanthan gum, Cellulose Gum, Sodium Acrylates Copolymer, Algin, Acrylates / Vinyl Isodecanoate Crosspolymer, Sodium Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Acrylates / C10-30 Alkyl Acrylate Crosspolymer, Disteardimonium Hectorite, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Microcrystalline Cellulose, Sclerotium Gum and their mixtures.

[Claim 13] Ecobiological lipoalcoholic topical composition according to one of claims 1 to 9, characterized in that it is in the form of an emulsion.

[Claim 14] Ecobiological lipoalcoholic topical composition according to one of the preceding claims, characterized in that it does not contain any of the following components:

- perfumes; and

- terpenes, preferably orange terpenes,

- silicone-based surfactants; and

- pH stabilizers, advantageously lactic acid and fumed silica.

[Claim 15] Ecobiological lipoalcoholic topical composition according to one of the preceding claims, characterized in that it comprises at least one natural or chemical molecule having specific properties in virology such as glycerrhizin, baicalin, quercetin, theaflavin, or their respective derivatives.