JP2004107667A - Sterilization detergent for hand - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a detergent for hand as a sterilizer (a kind of liquid detergent), effectively decreasing number of bacteria existing on the hand by washing the hand in a short time, and drying the skin rapidly and without injuring the skin. <P>SOLUTION: The ingredients of a sterilization detergent include an effective amount of alcohol, decrease bacteria on the skin, contain a kind of additive keeping skin pH between 4.0 and 6.0. The detergent ingredients may contain a silicone and thereby rapidly dry the skin, or contain a humectant or an oil to make the skin keeping moisture. <P>COPYRIGHT: (C)2004,JPO

Description

The present invention relates to a disinfecting composition which exhibits a disinfecting effect without water when applied to the skin and which is used as it is left in a local part. In particular, the disinfecting composition of the present invention uses an alcohol-based solution to immediately reduce microorganisms on the skin, uses a silicone additive to dry the skin, and an emollient ( an emolliento).

As is well known, washing hands with soap and hot water is a very effective way to reduce microbes on the skin surface. However, if you wash your hands and do not dry them completely, the tiny amount of remaining water can carry bacteria. Normally, such bacteria do not cause serious harm to humans, but in hospitals that are susceptible to infection, it is desirable to minimize the risk of contamination as much as possible.

Over the last few years, much research has been directed at developing liquid cleaning products that can effectively disinfect the skin without using water. Many of these liquid cleaning products have a relatively high concentration or weight percent of alcohol in the composition. Alcohol is effective for drying quickly when using cleaning products, but it can cause unacceptable dehydration of the skin, making the skin irritable, cracking and scratching.

目的 An object of the present invention is to provide a disinfecting composition which solves the above-mentioned problems of the prior art, exhibits a disinfecting effect without water when applied to skin, and is used as it is left in a local part.

This development is related to non-water based liquid cleaning products. When used on topical skin, the present cleaning products effectively reduce bacterial levels on the skin in a relatively short time. In addition, the cleaning product dries quickly without causing skin damage or dry skin when used repeatedly. Yet another advantage is that the present cleaning products can moisturize the skin.

The present invention provides an effective amount of alcohol to reduce microorganisms on the skin surface, and additives to keep the pH of the skin in the range of about 4.0-6.0, especially to balance skin pH values. A disinfecting cleaning composition having a bactericidal action, comprising an effective amount of lactic acid, fumed silica, sodium lactate or a mixture thereof. In addition, the present cleaning compositions can include silicones to aid drying and emollients, ie, oils, to provide wetting to the skin.
The present invention also relates to a method of reducing the level of microorganisms on the skin using a disinfecting composition that is used locally, as described in detail below.

This development is a non-water based disinfecting hand cleaning product composition. This product is alcohol-based and contains additives that bring the pH of the skin to about 4.0-6.0, which reduces the bacterial count of the skin but reduces the normal flora of the skin. maintain. The composition may also include a silicone component to aid in drying and an emollient to leave the skin moist and comfortable. The disinfecting composition of the present invention is very effective in reducing the number of microorganisms present on the skin, and at the same time, can moisturize and protect the skin. In addition, the composition is not water-based and has some other unique advantages over conventional water-containing hand-washing products.
The rate of evaporation of the composition from the skin is more constant than that containing water, since the composition of the invention contains no or very little water. Because the humidity of the surrounding air affects the evaporation of water, compositions containing large amounts of water will evaporate slowly from the skin when the humidity is high. Consumers spend more time not only rubbing the compounds on the skin, but also giving the skin a greasy or staple feel. The composition of the present application does not cause such inconvenience because water is not added to the composition, and the evaporation rate of the alcohol and the silicone component which is likely to be exerted is not affected by the air humidity.

Disinfecting hand cleaners contain one or more alcohols, which have a germicidal function, help to dry and act as a solvent. Alcohols such as ethanol, isopropanol or mixtures thereof have proven safe to use on human skin. These alcohols are present in the formulation at a concentration of about 60% to about 90% by weight.

The disinfecting hand washes contain one or more additives to maintain the pH of the skin at about 4.0 to about 6.0, such as lactic acid, amorphous silica, fumed silica, Sodium and their mixtures. In this range of H values, the number of bacteria on the skin is low, and the skin maintains a normal flora, resulting in an additional bactericidal effect on the cleaning product. The formulation contains an effective amount of an additive to maintain the desired skin pH value. The amount of additive can range from about 0% to about 12% by weight, i.e., up to about 12% by weight, based on the additive or additive mixture to be included in the formulation.

One or more silicone-based materials are included in the hand cleaning formulations to further aid in drying the skin. The performable silicones used in the compositions of the present invention have a lower heat of vaporization than alcohol and do not feel the unpleasant cold on the skin observed in formulations with low alcohol content. Further, the use of silicone-based materials can reduce the surface tension of the liquid composition. This phenomenon means that the substance is brought into extensive contact with the skin, thereby allowing a greater amount of fluid to come in contact with harmful microorganisms and a vigorous microbicidal activity. Silicone-based materials such as cyclomethicone, trimethylsiloxy silicate and mixtures thereof may be present at a concentration of about 4% to about 50% by weight, preferably about 5% by weight. It is included in the formulation at a concentration of about 35% by weight, more preferably at a concentration of about 11% to about 25% by weight.
As is known in the art, humectants are added to help retain liquids in the product and thickening agents are added to adjust the viscosity of the product. In this development, any humectant or thickener that does not significantly affect the efficacy of the formulation can be added to maintain the skin at the desired pH. Such wetting agents are present at a concentration of about 0% to about 5% by weight, i.e. up to about 5% by weight, and such thickeners are present at a concentration of about 0% to 6.5% by weight, i.e. about 6% by weight. 0.5 wt% or less. The thickener is a cellulose-based material, amorphous silica (fumed silica) or mixtures thereof. Methylcellulose is at a concentration of about 0% to about 1.5% by weight, i.e., no more than about 1.5% by weight, and amorphous silica is at a concentration of about 0% to about 5.0% by weight. Ie, less than about 5.0% by weight.
The disinfecting hand cleaner enhances the bactericidal effect of alcohol, so that another bactericide can be used in combination as needed. Typical fungicides are as follows: PCMX (para-chloro-meta-xylenol), CHG (chlorhexidene gluconate), triclosan (triclosan), quaternary ammonium (e.g., benzalkonium chloride and cetrimide) and other recognized in the industry It is a fungicide. The content of these fungicides in the composition can be between about 0.25% by weight and about 10% by weight, or at a known concentration that exerts a bactericidal action. PCMX can be included in the composition of the present invention at a concentration of about 2% to about 3.75% by weight which is known to have a safe bactericidal action, but the present invention is not limited to this example. Not something.

Optionally, emollients and aesthetic additives, such as, for example, fragrances and / or colorants, can be added to the disinfecting hand-wash formulation. Emollients or moisturizing agents, fragrances and colorings are added as needed and in a concentration acceptable to the consumer. For example, the formulation may be added at a concentration of about 0% to about 1.5% by weight, ie, up to about 1.5% by weight of a fragrance, dye or mixture thereof. Formulations may also include tea oil, hemp oil, aloe base oil, wool fat, jojoba, chamomile, floral oils, herbal materials, or mixtures thereof to further aid skin wettability. Such additional emollients can be included at about 0% to about 5% by weight, ie, up to about 5% by weight.

This product is manufactured as follows. At room temperature, the alcohol, silicone-based material, humectant, and lactic acid or sodium lactate are placed in a batch mixing vessel and mixed until well mixed. A part of the obtained alcohol mixture is transferred to another mixing vessel, a thickener is added, and the mixture is stirred and mixed until the mixture slightly thickens. If necessary, amorphous silica (fumed silica) can be added as a thickener to further thicken the mixture. The thickener mixture is continuously mixed with the remaining alcohol mixture under stirring. The resulting product has a constant viscosity such that it can be manufactured using a pump that is manually operated as if it were manufactured using a liquid soap manufacturing bottle. For example, the viscosity at about 25 ° C. ranges from about 100 cp to 100,000 cp. The fragrance can be added at any time under stirring, for example, together with the alcohol.

The final product can be incorporated into a coating tool and used for special purposes. For example, the product can be used on a surgical scourer sponge. The hand-washed scrubber in which the product is incorporated is used by the surgeon in a sterile setting prior to surgery. In another aspect, the product can be incorporated into a woven or nonwoven fabric. The cloth can be wrapped one by one or several together. Cloth with a disinfectant cleaner is an easy-to-use product that can also disinfect local parts of the patient's body before or after a doctor's hand or consultation.

The following examples are representative examples of hand cleaners manufactured according to the present invention. Includes data on the germicidal performance of some detergents. The presented detergent formulations are given only by way of example and the invention is in no way limited by these examples.

The disinfecting hand cleaner is manufactured as follows.
About 70% by weight anhydrous ethanol (3% isopropyl alcohol), about 18.6% by weight "Dow Corning 345 Fluid" (cyclomethicone, registered trademark of Dow Corning), about 4.5% by weight isopropyl myristate, about 1.5% by weight % Lactic acid, about 1.5% by weight sodium lactate (activity 40%), about 1.3% by weight "Dow Corning 749" (a reaction product of cyclomethicone and trimethylsiloxy silicate, registered trademark of Dow Corning), about 0.6% by weight % "Dow Methocel OS" (methylated cellulose, registered trademark of Dow Corning) and about 2.0% by weight "Cabosil M5" (amorphous silica, purchased from Cabot).
At room temperature, absolute ethanol, `` 345 Fluid '', isopropyl myristate, lactic acid, sodium lactate and `` Dow Corning 749 '' are placed in at least one stirrer or batch mixing tank with stirring blades, and the alcohol mixture is added. Mix until well mixed. Next, transfer about 30% from the alcohol mixture to another mixing vessel with a stirring blade, then add "Methocel" and mix until the mixture is slightly concentrated. Add amorphous silica (fumed silica) to the “Methocel” mixture and continue to stir the mixture to make it even thicker. The amorphous silica / "Methocel" mixture is combined with the remaining alcohol mixture and subsequently stirred until the amorphous silica mixture is completely dissolved in the alcohol mixture. The resulting product has a pH of about 4.5 and a viscosity of about 350 cp at 25 ° C.

The disinfecting hand cleaner is manufactured as follows.
About 77.6% by weight of absolute ethanol (3% isopropyl alcohol) about 15.5% by weight “Dow Corning 345 Fluid” (cyclomethicone, registered trademark of Dow Corning), about 1.5% by weight of isopropyl myristate, about 3. 6% by weight sodium lactate (activity 40%), about 1.0% by weight "Dow Corning 749" (reaction product of cyclomethicone and trimethylsiloxy silicate, registered trademark of Dow Corning), about 0.5% by weight "Dow Methocel OS" (Methylated cellulose, Dow Corning®) and about 0.3% by weight fragrance.
At room temperature, add absolute ethanol, "345 Fluid", isopropyl myristate, sodium lactate, "Dow Corning 749" and fragrance to at least one stirrer or batch-type mixing tank with a stirrer blade. Mix until well mixed. Next, transfer about 30% from the alcohol mixture to another mixing vessel with a stirring blade, then add "Methocel" and mix until the mixture is slightly concentrated. Add amorphous silica (fumed silica) to the “Methocel” mixture and continue to stir the mixture to make it even thicker. The amorphous silica / "Methocel" mixture is combined with the remaining alcohol mixture and subsequently stirred until the amorphous silica mixture is completely dissolved in the alcohol mixture. The resulting product has a pH of about 4.3 and a viscosity of about 340 cp at 25 ° C.

The method of manufacturing the disinfecting hand washer was the same as in Example 2 except that about 1.5% by weight of the anhydrous ethanol (3% isopropyl alcohol) of Example 2 was replaced with about 1.5% by weight of tea oil. Exactly the same as 2. As shown in Example 2, it was made by adding tea oil to an alcohol mixture. The resulting product has a pH of about 4.4 and a viscosity of about 360 cp at 25 ° C.

The method of manufacturing the disinfectant hand washer was the same as that of Example 2 except that about 1.8% by weight of the anhydrous ethanol (3% isopropyl alcohol) of Example 2 was replaced with about 1.8% by weight of hemp oil. Exactly the same as 2. As shown in Example 2, it was made by adding cannabis oil to an alcohol mixture. The resulting product has a pH of about 4.3 and a viscosity of about 350 cp at 25 ° C.

The method for producing the disinfecting hand cleaner is as follows: about 1.5% by weight of the absolute ethanol (3% isopropyl alcohol) of Example 2 is added to about 1.0% by weight of tea oil and about 0.5% by weight of cannabis oil. Except for the substitution, it is exactly the same as Example 2. As shown in Example 2, it was made by adding tea oil and hemp oil to an alcohol mixture. The resulting product has a pH of about 4.3 and a viscosity of about 365 cp at 25 ° C.

基 づ き Based on Table 1 and the above manufacturing method, add some disinfectant hand cleaner formulations. Table 1 shows the results of visually observing the quality of the formulation. The unit is% by weight of the total amount. It is noteworthy that formulations E29, E31, E32 and E33 have become "separated" products. This is because the alcohol concentration is about 40%, which is too low and lower than the concentration specified in the present invention.

Measurement of sterilization performance The sterilization effect of the disinfecting hand cleaner can be evaluated by various methods. For example, a minimum inhibitory concentration study can determine the minimum inhibitory concentration of a detergent that suppresses microbial growth, or a rapid germicidal study can use a known number of microbial organisms. The ability of the detergent to rapidly reduce the number can be measured. These methods can be carried out using known bacteria and fungi in Table 2.

Minimum Inhibitory Concentration Method Minimum Inhibitory Concentration (MIC) is the minimum concentration of fungicide that inhibits the growth of microorganisms. Serial dilutions of the sterilized test article are made in broth or agar, and then placed on agar containing the diluted test article with a standard concentration of microorganisms to be run on a plate (plane). .
Experiments were performed on various microorganisms to determine the maximum dilution of this material that would retain bactericidal effects.
In particular, an experiment is performed to determine the lowest inhibitory concentration (MIC) for the product of Example 2 (Product 2). This experiment follows a certain procedure,
Make a 1: 2 dilution (based on weight) of the experimental material in a Mueller-Hinton Broth or Brain Heart Infusion Broth. Add 200 μL of the dilution to the first well of the in-line microtiter plate. Starting with the first well, the product dilutions were 1: 2, 1: 4, 1: 8, 1:10, 1:20, 1:50, 1:80, 1: 100, 1 of the experimental material. Wells containing 1: 150 and 1: 200 dilutions are prepared. Bacteria and vehicle control wells are also included.

The bacteria to be tested are detached from the culture plate and suspended in a phosphate buffered saline at a concentration of approximately 1.0 × 10 ⁵ cells. Approximately 5 × 10 ⁴ CFU (colony forming units) of the inoculum of each experimental microorganism is added to the test wells of the aligned plate and mixed. Plates are incubated at a temperature of 37 ± 2 ° C. for about 23 hours. Table 3 summarizes the growth of the microorganisms in the test wells, labeled as showing growth (+) or not showing growth (0). MIC is the lowest concentration diluent that completely inhibits bacterial growth.

Rapid Disinfection Rapid disinfection is used to measure the ability of fungicides to rapidly reduce the number of known microorganisms. The fractionated amount of the sterilizing experimental substance is brought into contact with experimental bacteria or fungi whose concentration is known for a predetermined time. The test substance is then neutralized and the concentration of viable microorganisms is determined. The efficacy of the fungicide is calculated based on the percentage of microorganisms that cannot survive the action of the fungicide.
For example, the product of Example 2 (Product 2) is determined for its rapid bactericidal activity using the following protocol.
An aliquot of 5 mL of undiluted "Product 2" is placed in a sterile glass jar at 25 ± 1 ° C, and a 0.5 mL sample is mixed with the aliquot of the bactericidal substance. The sample is a microbial broth chosen to provide a dilution of the microorganism of about 10 ⁸ CFU / mL.
After waiting a predetermined time (exposure time), add 45 mL of the neutralizer solution to the glass jar and stir for 60 seconds. Take 1 mL of the aliquot from the jar (containing about 10 ^-1 microbial diluent in it), dilute up to 10 times to about 10 ^-6 diluent and dilute the serially diluted diluent. to make. These dilutions are plated in two using the Pour Plate Technique. The plates are incubated at a temperature of 35 ± 2 ° C. for 48 ± 2 hours with inversion. During incubation, the number of colony forming units per mL of living microorganisms (CFU / mL) is counted and compared to the starting colony number. A control sample was also prepared for each microorganism, and the exposure time followed substantially the same procedure, except that product 2 was not added at the beginning of the procedure.
Table 4 shows the microorganisms used in the rapid disinfection method, the number of colony forming units per mL of the control and experimental samples (Report 2), and the efficacy of "Product 2" (reduction of the number of microorganisms in percentage and log ₁₀₎ . ) Are listed.

As described above, based on the disclosure in the above specification, those skilled in the art will recognize various specific embodiments and modifications of the present invention. For example, dyes, colorants, emollients, skin-protecting agents such as sunscreen substances, and the drying provided by alcohol or the high alcohol content of the system may result in increased consumer acceptance. Other silicone or non-silicone compounds to relieve skin discomfort and dryness, or other additives such as solvents, can be included in the formulation. These and other variations are within the scope of the present invention.

Claims (60)

From about 60% to about 90% by weight of one or more organic alcohols; from about 5% to about 35% by weight of one or more silicone-based materials; Humectant, one or more skin pH maintaining additives up to about 12% by weight, and one or more than one added at a concentration that results in a product having a viscosity in the range of 100 cp to 100,000 cp at about 25 ° C. A disinfecting hand cleaner that does not require water, consisting of a thickener. {Circle around (2)} The hand cleaning agent according to claim 1, wherein the alcohol is selected from anhydrous ethanol, anhydrous isopropyl alcohol, anhydrous propanol, anhydrous butanol, anhydrous phenylethyl alcohol, anhydrous benzyl alcohol and a mixture thereof. 手 The hand cleanser of claim 1 wherein said pH maintaining additive maintains skin pH at about 4.0 to about 6.0. The hand washing agent according to claim 3, wherein the pH maintaining additive is selected from the group consisting of amorphous silica, lactic acid, sodium lactate and a mixture thereof. (4) The hand cleaning agent according to (3), wherein the pH maintaining additive is amorphous silica. {Circle around (6)} The hand cleaner according to claim 5, wherein the amorphous silica is added at a concentration of about 5.0% by weight or less. (4) The hand cleaning agent according to (3), wherein the pH maintaining additive is lactic acid. (8) The hand cleaning composition according to the above (7), wherein the lactic acid is added at a concentration of about 5.0% by weight or less. (7) The hand cleaning agent according to the above (6), further comprising lactic acid added at a concentration of about 5.0% by weight or less. 手 順 The procedural cleaning agent according to claim 3, wherein the pH maintaining additive is sodium lactate. 11. The hand cleaning composition according to claim 10, wherein the sodium lactate is added at a concentration of about 2.0% by weight or less. 手 Hand wash according to claim 1, wherein said silicone-based material is cyclomethicone, trimethylsiloxysilicate and mixtures thereof. 手 The hand cleaning composition according to claim 1, wherein the wetting agent is isopropyl myristate. 手 The hand-washing agent according to claim 1, wherein the thickening agent is a cellulose-based thickening agent. 15. The hand-washing agent according to claim 14, wherein the thickener is methylcellulose. 手 The hand-washing agent according to claim 1, wherein the thickening agent is amorphous silica. 17. The hand cleaner of claim 16, wherein said amorphous silica is present at a concentration of about 5.0% by weight or less. <4> The hand cleaning composition according to claim 1, further comprising a fragrance. 20. The hand cleanser of claim 18, wherein said fragrance is added at a concentration of about 1.5% by weight or less. (6) The hand cleaning agent according to (1), further comprising a coloring agent. 手 The hand washing composition according to claim 1, further comprising one or more emollients. 22. The hand cleanser of claim 21, wherein said emollient is added at a concentration of about 5% by weight or less. 23. The hand cleanser of claim 22, wherein said emollient is selected from the group consisting of tea oil, hemp oil, aloe base oil and mixtures thereof. The hand wash of claim 1 wherein said viscosity is in the range of about 250 cp to about 450 cp at about 25 ° C. a) from about 60% to about 90% by weight of one or more alcohols, from about 5% to about 35% by weight of one or more silicone-based materials, about 5% by weight or less of myristic acid; An alcohol mixture of isopropyl, up to about 5.0% by weight lactic acid, and up to about 2.0% by weight sodium lactate at room temperature until mixed well;
b) an enriched mixture prepared by transferring a portion of the above alcohol mixture to another mixing vessel and adding up to about 1.5% by weight of methylcellulose under stirring;
The above concentrated mixture and alcohol mixture prepared in the absence of water were obtained by mixing at room temperature and continuing to mix at about 25 ° C. until a product viscosity in the range of about 250 cp to about 450 cp was reached. Disinfecting hand cleaning agent, which is essential. 26. The hand cleaning agent according to claim 25, wherein the alcohol is selected from anhydrous ethanol, anhydrous isopropyl alcohol, anhydrous propanol, anhydrous butanol, anhydrous phenylethyl alcohol, anhydrous benzyl alcohol, and a mixture thereof. 26. The hand cleanser of claim 25, wherein said silicone-based material is cyclomethicone, trimethylsiloxysilicate and mixtures thereof. 26. The handwash of claim 25, further comprising up to about 5.0% by weight of amorphous silica added to the thickening mixture. 26. The hand cleaner of claim 25, further comprising a fragrance added to the alcohol mixture at a concentration of about 1.5% by weight or less. 28. The hand of claim 25, comprising up to about 5% by weight of one or more emollients selected from the group consisting of tea oil, hemp oil, aloe base oil and mixtures thereof, added to the alcohol mixture. Washing soap. A method for producing a hand cleaning agent for disinfection, comprising the following steps a) to c).
a) from about 60% to about 90% by weight of one or more alcohols, from about 5% to about 35% by weight of one or more silicone-based materials, about 5% by weight or less of myristic acid; Mix with isopropyl, about 5.0% by weight or less lactic acid, and about 2.0% by weight or less of sodium lactate at room temperature until well mixed.
b) Add about 1.5% by weight or less of methylcellulose to a portion of the alcohol mixture prepared in step a) above and mix until well mixed.
c) mixing the enriched mixture prepared in step b) above and the alcohol mixture prepared in step a) above at room temperature until a product viscosity in the range of about 250 cp to about 450 cp is reached at about 25 ° C. Continue. 32. The method according to claim 31, wherein the alcohol is selected from anhydrous ethanol, anhydrous isopropyl alcohol, anhydrous propanol, anhydrous butanol, anhydrous phenylethyl alcohol, anhydrous benzyl alcohol and a mixture thereof. 26. The method of claim 25, wherein the silicone-based material is cyclomethicone, trimethylsiloxysilicate, or a mixture thereof. 32. The method of claim 31, wherein the thickening mixture further comprises about 5.0% by weight or less of amorphous silica. 32. The method of claim 31, wherein the alcohol mixture further comprises a fragrance at a concentration of about 1.5% by weight or less. 32. The alcohol mixture further comprises up to about 5% by weight of one or more emollients selected from the group consisting of tea oil, hemp oil, aloe base oil and mixtures thereof, up to about 5% by weight. Of manufacturing a hand cleaning agent for disinfection. From about 60% to about 90% by weight of one or more alcohols; from about 11% to about 35% by weight of one or more silicone-based materials; Wetting agents, up to about 10% by weight of one or more fungicides, up to about 12% by weight of one or more skin pH preserving additives, and a viscosity at about 25 ° C. ranging from 100 cp to 100,000 cp. A disinfecting hand cleaner consisting of one or more thickeners added at a concentration that results in a product that has a weight loss. 38. The hand cleaning agent of claim 37, wherein the alcohol is selected from anhydrous ethanol, anhydrous isopropyl alcohol, anhydrous propanol, anhydrous butanol, anhydrous phenylethyl alcohol, anhydrous benzyl alcohol, and mixtures thereof. 38. The hand cleanser of claim 37, wherein said pH maintaining additive maintains the pH of the skin at about 4.0 to about 6.0. 38. The hand cleaner according to claim 37, wherein the pH maintaining additive is selected from the group consisting of amorphous silica, lactic acid, sodium lactate, and a mixture thereof. 42. The hand cleanser of claim 40, wherein said pH maintaining additive is amorphous silica added at a concentration of about 5.0% by weight or less. The hand washing agent according to claim 40, wherein the pH maintaining additive is lactic acid added at a concentration of about 5.0% by weight or less. 42. The hand cleaning composition of claim 41, further comprising lactic acid added at a concentration of about 5.0% by weight or less. 手 The hand cleaner according to claim 40, wherein the pH maintaining additive is sodium lactate added at a concentration of about 2.0% by weight or less. 38. The hand cleanser of claim 37, wherein said silicone-based material is cyclomethicone, trimethylsiloxysilicate and mixtures thereof. 手 The hand cleaning composition of claim 37, wherein the wetting agent is isopropyl myristate. 手 The hand cleaner of claim 37, wherein the thickener is a cellulose-based thickener. 手 The hand cleaner according to claim 37, wherein the thickener is methylcellulose. 38. The hand cleaner of claim 37, wherein said thickener is amorphous silica present at a concentration of about 5% by weight or less. The hand cleaner of claim 37, further comprising a fragrance added at a concentration of about 1.5% by weight or less. 38. The hand cleanser of claim 37, further comprising one or more emollients added at a concentration of about 5% by weight or less. 52. The hand cleanser of claim 51, wherein said emollient is selected from the group consisting of tea oil, hemp oil, aloe base oil and mixtures thereof. 38. The hand cleanser of claim 37, wherein said viscosity ranges from about 250 cp to about 450 cp at about 25 ° C. The hand cleaning agent according to claim 37, wherein the bactericide is selected from the group consisting of PCMX (para-chloro-meta-xylenol), CHG (chlorhexidene gluconate), triclosan (triclosan), quaternary ammonium salts, and mixtures thereof. 38. The hand cleanser of claim 37, wherein said disinfectant is PCMX (para-chloro-meta-xylenol) added at a concentration of about 2% to about 3.75% by weight. Alcohol is present at a level of from about 74% to about 77% by weight, silicone-based material is present at a level of from about 14% to about 17% by weight, and fungicide is present at a level of from about 1% to about 3.75% by weight. 38. The hand cleaner of claim 37. (6) The hand cleaning agent according to the above (1), wherein the product is taken into a surgical brush. 38. The hand cleaning agent according to claim 37, wherein the product is taken into a surgical brush. (4) The hand cleaning agent according to the above (1), wherein the product is taken into a wipe. 38. The hand cleanser of claim 37, wherein the product is incorporated into a wipe.