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EP3858866A4 - Protéine de fusion glp1-fc et conjugué associé - Google Patents

Protéine de fusion glp1-fc et conjugué associé Download PDF

Info

Publication number
EP3858866A4
EP3858866A4 EP19866716.4A EP19866716A EP3858866A4 EP 3858866 A4 EP3858866 A4 EP 3858866A4 EP 19866716 A EP19866716 A EP 19866716A EP 3858866 A4 EP3858866 A4 EP 3858866A4
Authority
EP
European Patent Office
Prior art keywords
glp1
conjugate
fusion protein
fusion
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19866716.4A
Other languages
German (de)
English (en)
Other versions
EP3858866A1 (fr
Inventor
Yali Wang
Xian Chen
Luyan ZHU
Bin Liu
Xiaoshan WANG
Zijia REN
Tingting Zhou
Haixia YAN
Yingying XU
Huihui GAO
Jin Wang
Yang Xu
Yahui Liu
Weichuan MO
Xin Chen
Jie Gao
Hongsheng Su
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Gensciences Inc
Original Assignee
Jiangsu Gensciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Gensciences Inc filed Critical Jiangsu Gensciences Inc
Publication of EP3858866A1 publication Critical patent/EP3858866A1/fr
Publication of EP3858866A4 publication Critical patent/EP3858866A4/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/915—Fusion polypeptide containing a motif for post-translational modification containing a motif for acylation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
EP19866716.4A 2018-09-26 2019-09-25 Protéine de fusion glp1-fc et conjugué associé Pending EP3858866A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811125762.9A CN110964116A (zh) 2018-09-26 2018-09-26 GLP1-Fc融合蛋白及其缀合物
PCT/CN2019/107709 WO2020063628A1 (fr) 2018-09-26 2019-09-25 Protéine de fusion glp1-fc et conjugué associé

Publications (2)

Publication Number Publication Date
EP3858866A1 EP3858866A1 (fr) 2021-08-04
EP3858866A4 true EP3858866A4 (fr) 2021-12-01

Family

ID=69950347

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19866716.4A Pending EP3858866A4 (fr) 2018-09-26 2019-09-25 Protéine de fusion glp1-fc et conjugué associé

Country Status (11)

Country Link
US (1) US20220000984A1 (fr)
EP (1) EP3858866A4 (fr)
JP (1) JP7174149B2 (fr)
KR (1) KR102649941B1 (fr)
CN (1) CN110964116A (fr)
AU (1) AU2019349201B2 (fr)
BR (1) BR112021005419A2 (fr)
CA (1) CA3113738A1 (fr)
EA (1) EA202190744A1 (fr)
MX (1) MX2021003349A (fr)
WO (1) WO2020063628A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116438312A (zh) * 2020-08-24 2023-07-14 宾夕法尼亚州大学信托人 编码glp-1受体激动剂融合物的病毒载体和其在治疗代谢性疾病中的用途
US12122817B2 (en) 2020-09-22 2024-10-22 Serpentide Inc. Long-lasting GLP1 analogue drug for type-2 diabetes
WO2023168411A1 (fr) * 2022-03-03 2023-09-07 The Trustees Of The University Of Pennsylvania Vecteurs aav pour l'administration de fusions agonistes du récepteur glp-1
WO2024067401A1 (fr) * 2022-09-26 2024-04-04 中美华世通生物医药科技(武汉)股份有限公司 Plate-forme à action ultra-longue comprenant une chaîne d'acides gras avancée fc
CN118240917B (zh) * 2024-05-27 2024-12-10 正大天晴药业集团股份有限公司 一种检测glp—1、glp—1类似物或glp—1融合蛋白生物学活性的方法
CN118307684B (zh) * 2024-06-11 2024-10-18 北京志道生物科技有限公司 一种经脂肪酸链修饰的glp-1-fgf21融合蛋白及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006124529A1 (fr) * 2005-05-13 2006-11-23 Eli Lilly And Company Composes glp-1 pegyles
WO2012054822A1 (fr) * 2010-10-22 2012-04-26 Nektar Therapeutics Conjugués polymère-glp 1 pharmacologiquement actifs
WO2012173422A1 (fr) * 2011-06-17 2012-12-20 Hanmi Science Co., Ltd. Conjugué comprenant de l'oxyntomoduline et un fragment d'immunoglobuline, et son utilisation

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US478017A (en) 1892-06-28 Mariner s compass
US478425A (en) 1892-07-05 Process of generating gas
US477967A (en) 1892-06-28 Folding bed
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5541087A (en) 1994-09-14 1996-07-30 Fuji Immunopharmaceuticals Corporation Expression and export technology of proteins as immunofusins
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
DE69929311T2 (de) 1998-03-24 2006-09-07 Nof Corp. Oximanderivate und verfahren zu ihrer herstellung
ATE406384T1 (de) * 2000-12-07 2008-09-15 Lilly Co Eli Glp-1 fusion proteine
EP1245608B1 (fr) 2001-03-27 2004-05-19 Nof Corporation Polyéthylène glycol et procédé pour son préparation
US7026440B2 (en) 2001-11-07 2006-04-11 Nektar Therapeutics Al, Corporation Branched polymers and their conjugates
JP2010535781A (ja) * 2007-08-03 2010-11-25 イーライ リリー アンド カンパニー 肥満に対する処置
EP3178835B1 (fr) * 2009-02-03 2019-04-10 Amunix Pharmaceuticals, Inc. Polypeptides recombines etendus et compositions les comprenant
WO2011156407A2 (fr) * 2010-06-09 2011-12-15 Amylin Pharmaceuticals, Inc. Agonistes de récepteur de glp-1 pour le traitement d'une pancréatite
CN102952192A (zh) * 2011-08-19 2013-03-06 天津拓飞生物科技有限公司 一种含有Exendin-4的融合蛋白及其用途
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WO2006124529A1 (fr) * 2005-05-13 2006-11-23 Eli Lilly And Company Composes glp-1 pegyles
WO2012054822A1 (fr) * 2010-10-22 2012-04-26 Nektar Therapeutics Conjugués polymère-glp 1 pharmacologiquement actifs
WO2012173422A1 (fr) * 2011-06-17 2012-12-20 Hanmi Science Co., Ltd. Conjugué comprenant de l'oxyntomoduline et un fragment d'immunoglobuline, et son utilisation

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DATABASE KEGG Drug [online] DBGET; 2 August 2011 (2011-08-02), ANONYMOUS: "KEGG DRUG: Dulaglutide", XP055854035, retrieved from https://www.genome.jp/dbget-bin/www_bget?drug:D09889 Database accession no. D09889 *
JONATHAN DOZIER ET AL: "Site-Specific PEGylation of Therapeutic Proteins", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, no. 11, 28 October 2015 (2015-10-28), pages 25831 - 25864, XP055248269, DOI: 10.3390/ijms161025831 *
MILTON HARRIS J ET AL: "EFFECT OF PEGYLATION ON PHARMACEUTICALS", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, vol. 2, no. 3, 1 March 2003 (2003-03-01), pages 214 - 221, XP009042217, ISSN: 1474-1784, DOI: 10.1038/NRD1033 *
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Also Published As

Publication number Publication date
WO2020063628A1 (fr) 2020-04-02
US20220000984A1 (en) 2022-01-06
AU2019349201A1 (en) 2021-04-29
KR20210062053A (ko) 2021-05-28
MX2021003349A (es) 2021-05-27
JP7174149B2 (ja) 2022-11-17
AU2019349201B2 (en) 2024-03-28
KR102649941B1 (ko) 2024-03-22
CN110964116A (zh) 2020-04-07
EA202190744A1 (ru) 2021-08-24
EP3858866A1 (fr) 2021-08-04
BR112021005419A2 (pt) 2021-06-22
JP2022501405A (ja) 2022-01-06
CA3113738A1 (fr) 2020-04-02

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