[go: up one dir, main page]

EP3454844A4 - COMBINATION THERAPIES OF HDAC INHIBITORS AND PD-1 INHIBITORS - Google Patents

COMBINATION THERAPIES OF HDAC INHIBITORS AND PD-1 INHIBITORS Download PDF

Info

Publication number
EP3454844A4
EP3454844A4 EP17796865.8A EP17796865A EP3454844A4 EP 3454844 A4 EP3454844 A4 EP 3454844A4 EP 17796865 A EP17796865 A EP 17796865A EP 3454844 A4 EP3454844 A4 EP 3454844A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
combination therapies
hdac
hdac inhibitors
therapies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17796865.8A
Other languages
German (de)
French (fr)
Other versions
EP3454844A1 (en
EP3454844B1 (en
Inventor
Reid P. Bissonnette
Alain Rolland
Mireille GILLINGS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Huyabio International LLC
Original Assignee
Huya Bioscience International LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huya Bioscience International LLC filed Critical Huya Bioscience International LLC
Priority to EP24185599.8A priority Critical patent/EP4450085A3/en
Publication of EP3454844A1 publication Critical patent/EP3454844A1/en
Publication of EP3454844A4 publication Critical patent/EP3454844A4/en
Application granted granted Critical
Publication of EP3454844B1 publication Critical patent/EP3454844B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP17796865.8A 2016-05-11 2017-05-11 Treatment of colon cancer with a combination of the hdac inhibitor hbi-8000 and a pd-l1 inhibitor Active EP3454844B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP24185599.8A EP4450085A3 (en) 2016-05-11 2017-05-11 Treatment of colon cancer with a combination of the hdac inhibitor hbi-800 and a pd-l1 inhibitor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662335044P 2016-05-11 2016-05-11
US201662436361P 2016-12-19 2016-12-19
PCT/US2017/032218 WO2017197153A1 (en) 2016-05-11 2017-05-11 Combination therapies of hdac inhibitors pd-1 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP24185599.8A Division EP4450085A3 (en) 2016-05-11 2017-05-11 Treatment of colon cancer with a combination of the hdac inhibitor hbi-800 and a pd-l1 inhibitor

Publications (3)

Publication Number Publication Date
EP3454844A1 EP3454844A1 (en) 2019-03-20
EP3454844A4 true EP3454844A4 (en) 2020-01-15
EP3454844B1 EP3454844B1 (en) 2024-07-03

Family

ID=60267478

Family Applications (2)

Application Number Title Priority Date Filing Date
EP17796865.8A Active EP3454844B1 (en) 2016-05-11 2017-05-11 Treatment of colon cancer with a combination of the hdac inhibitor hbi-8000 and a pd-l1 inhibitor
EP24185599.8A Pending EP4450085A3 (en) 2016-05-11 2017-05-11 Treatment of colon cancer with a combination of the hdac inhibitor hbi-800 and a pd-l1 inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP24185599.8A Pending EP4450085A3 (en) 2016-05-11 2017-05-11 Treatment of colon cancer with a combination of the hdac inhibitor hbi-800 and a pd-l1 inhibitor

Country Status (16)

Country Link
US (4) US10385130B2 (en)
EP (2) EP3454844B1 (en)
JP (2) JP7013387B2 (en)
KR (2) KR102469268B1 (en)
CN (1) CN109562177A (en)
AU (2) AU2017263478B2 (en)
BR (1) BR112018073329A2 (en)
CA (1) CA3023549A1 (en)
DK (1) DK3454844T3 (en)
ES (1) ES2988149T3 (en)
IL (1) IL262814B2 (en)
MA (1) MA44991A (en)
MX (2) MX2018013591A (en)
PT (1) PT3454844T (en)
TW (1) TWI808055B (en)
WO (1) WO2017197153A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2905525T3 (en) 2015-05-06 2022-04-11 Snipr Tech Ltd Alteration of microbial populations and modification of the microbiota
TWI808055B (en) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-1 inhibitors
TWI794171B (en) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-l1 inhibitors
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
JP7187486B2 (en) 2017-05-25 2022-12-12 レイドス， インコーポレイテッド PD-1 and CTLA-4 Dual Inhibitor Peptides
JOP20200024A1 (en) 2017-08-04 2020-02-02 Bayer Ag Dihydrooxadiazinones
EP3661917B1 (en) 2017-08-04 2022-05-11 Bayer Aktiengesellschaft 6-((3-trifluoromethyl)phenyl)-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
AU2019200033B2 (en) * 2018-01-05 2020-09-10 Gnt Biotech & Medicals Corporation A pharmaceutical combination and method for regulation of tumor microenvironment and immunotherapy
US12128018B2 (en) 2018-01-12 2024-10-29 KDAc Therapeutics, Inc. Combination of a selective histone deacetylase 3 (HDAC3) inhibitor and an immunotherapy agent for the treatment of cancer
JP7170737B2 (en) 2018-02-27 2022-11-14 レイドス， インコーポレイテッド PD-1 peptide inhibitor
US10760075B2 (en) 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
US11851663B2 (en) 2018-10-14 2023-12-26 Snipr Biome Aps Single-vector type I vectors
CN111195249B (en) * 2018-11-20 2023-11-28 深圳微芯生物科技股份有限公司 Application of Sidamide combined with R-CHOP and combined medicine
CN109912686B (en) * 2019-03-13 2022-07-05 北京大学深圳研究生院 Stable polypeptide inhibitor targeting HDAC (Histone deacetylase) and application thereof
CA3141162A1 (en) 2019-05-22 2020-11-26 Leidos, Inc. Lag3 binding peptides
WO2020247830A1 (en) * 2019-06-06 2020-12-10 Huya Bioscience International, Llc Triplet therapies of hdac inhibitors, pd-l1 and/or pd-1 inhibitors, and ctla-4 inhibitors
WO2021037128A1 (en) * 2019-08-28 2021-03-04 深圳微芯生物科技股份有限公司 Chidamide-containing pharmaceutical composition and use thereof
KR20210028339A (en) 2019-09-04 2021-03-12 크리스탈지노믹스(주) Pharmaceutical composition using hdac inhibitor and anti pd-1 antibody or anti pd-l1 antibody
US11878009B2 (en) * 2019-09-10 2024-01-23 Great Novel Therapeutics Biotech & Medicals Corporation Anticancer combination of chidamide and celecoxib salts
CA3153597A1 (en) 2019-09-11 2021-03-18 Gnt Biotech & Medicals Corporation An anticancer combination of chidamide and celecoxib
TW202128224A (en) * 2019-12-23 2021-08-01 大陸商信達生物製藥（蘇州）有限公司 Pharmaceutical combination of anti-pd-1 antibody and histone deacetylase inhibitor, use and application method thereof
CN111190006A (en) * 2020-03-09 2020-05-22 上海市东方医院（同济大学附属东方医院） Use of histone deacetylase 6 in the preparation of a marker for assessing peritoneal function in maintenance peritoneal dialysis patients
JP2023529839A (en) 2020-06-04 2023-07-12 レイドス， インコーポレイテッド immunomodulatory compounds
EP4188947A2 (en) 2020-07-31 2023-06-07 Leidos, Inc. Lag3 binding peptides
US20220110924A1 (en) * 2020-08-25 2022-04-14 Huyabio International, Llc Methods and compositions for genetic modulation of tumor microenvironments
WO2022081426A1 (en) 2020-10-12 2022-04-21 Leidos, Inc. Immunomodulatory peptides
GB202209518D0 (en) 2022-06-29 2022-08-10 Snipr Biome Aps Treating & preventing E coli infections
KR20240043709A (en) * 2022-09-27 2024-04-03 사회복지법인 삼성생명공익재단 Composition for treating cancer comprising histone deacetylase inhibitor, and anticancer adjuvant for cancer immunotherapy
WO2024231293A1 (en) * 2023-05-05 2024-11-14 Euro-Celtique S.A. Combinations for treating cancer
CN117924505B (en) * 2024-03-25 2024-09-13 青岛宝迈得生物科技有限公司 Recombinant HDAC2 protein monoclonal antibody and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015157162A1 (en) * 2014-04-06 2015-10-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Histone deacetylase as a modulator of pdl1 expression and activity

Family Cites Families (538)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH627446A5 (en) 1978-01-17 1982-01-15 Debiopharm Sa NEW BENZAMIDE DERIVATIVES.
GB8302483D0 (en) 1983-01-29 1983-03-02 Beecham Group Plc Compounds
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
CZ284687B6 (en) 1986-04-30 1999-02-17 Dainippon Pharmaceutical Co., Ltd. Substituted benzamide derivative, process of its preparation and pharmaceutical composition based thereon
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
ATE356869T1 (en) 1990-01-12 2007-04-15 Amgen Fremont Inc FORMATION OF XENOGENE ANTIBODIES
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
DE69127627T2 (en) 1990-08-29 1998-02-19 Genpharm Int Production and Use Non-human transgene heterologous antibodies for production
JP2529912B2 (en) 1990-10-16 1996-09-04 帝国化学産業株式会社 Benzamide derivative
US5395832A (en) 1991-02-15 1995-03-07 Hokuriku Seiyaku Co., Ltd. Benzamide derivatives
TW219935B (en) 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
US5236931A (en) 1992-03-26 1993-08-17 A. H. Robins Company, Incorporated 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol
US5610052A (en) 1992-08-26 1997-03-11 Ribozyme Pharmaceuticals Inc. Enzymatic RNA with activity to ras
AU2351895A (en) 1994-04-28 1995-11-29 Yamanouchi Pharmaceutical Co., Ltd. N-(3-pyrrolidinyl)benzamide derivative
US5783568A (en) 1994-06-10 1998-07-21 Sugen, Inc. Methods for treating cancer and other cell proliferative diseases
JPH0823980A (en) 1994-07-15 1996-01-30 Terumo Corp Nucleus receptor formed in apotosis of cerebral neurocyte and nucleus receptor gene coding the receptor
EP1978033A3 (en) 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
CA2219486A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5958792A (en) 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
GB9525620D0 (en) 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
EP0827742A1 (en) 1996-09-04 1998-03-11 Vrije Universiteit Brussel Use of histone deacetylase inhibitors for treating fribosis or cirrhosis
GB9821483D0 (en) 1998-10-03 1998-11-25 Glaxo Group Ltd Chemical compounds
JP3354090B2 (en) 1996-09-30 2002-12-09 シエーリング アクチエンゲゼルシャフト Differentiation inducer
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
JP4215172B2 (en) 1996-12-03 2009-01-28 アムジェン フレモント インク． Transgenic mammal having human Ig locus comprising a plurality of V {lower H} and V {lower κ} regions, and antibodies produced therefrom
GB9625145D0 (en) 1996-12-03 1997-01-22 Smithkline Beecham Plc Novel compounds
JPH10330254A (en) 1997-04-01 1998-12-15 Kissei Pharmaceut Co Ltd Suppressant for progress of pterygium and postoperative relapse
US6444849B1 (en) 1997-06-25 2002-09-03 Mitsubishi Chemical Corporation Amide derivatives
CA2298480A1 (en) 1997-07-25 1999-02-04 Tsumura & Co. Pyridylacrylamide derivatives and nephritis remedies and tgf-.beta. inhibitors containing the same
ATE531812T1 (en) 1997-12-05 2011-11-15 Scripps Research Inst HUMANIZATION OF RODENT ANTIBODIES
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
US6673827B1 (en) 1999-06-29 2004-01-06 The Uab Research Foundation Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
JP4405602B2 (en) 1998-04-16 2010-01-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト Histone deacetylase inhibitor
HUP0102367A3 (en) 1998-05-15 2002-11-28 Astrazeneca Ab Benzamide derivatives for the treatment of diseases mediated by cytokines
DE69919212T2 (en) 1998-12-23 2005-07-28 Eli Lilly And Co., Indianapolis AROMATIC AMIDES
JP2000256194A (en) 1999-01-06 2000-09-19 Mitsui Chemicals Inc Intranuclear receptor agonist and agent for enhancing its effect
AU3857300A (en) 1999-02-11 2000-08-29 Cor Therapeutics, Inc. Inhibitors of factor xa
ATE303357T1 (en) 1999-03-17 2005-09-15 AMIDE DERIVATIVES
CA2366650A1 (en) 1999-03-19 2000-09-28 Michael Su Oral low dose butyrate compositions
JP2001081031A (en) 1999-08-30 2001-03-27 Schering Ag Benzamide derivative-containing preparation having improved solubility and oral adsorption
US6511990B1 (en) 1999-09-08 2003-01-28 Sloan-Kettering Institute For Cancer Research Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
JP4360660B2 (en) 1999-11-09 2009-11-11 三井化学株式会社 Purification method of monoacylphenylenediamine derivatives
WO2001042451A2 (en) 1999-12-08 2001-06-14 Genset FULL-LENGTH HUMAN cDNAs ENCODING POTENTIALLY SECRETED PROTEINS
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
AU2001248701A1 (en) 2000-03-24 2001-10-03 Methylgene, Inc. Inhibitors of histone deacetylase
US7005439B2 (en) 2000-06-20 2006-02-28 Astrazeneca Ab Compounds
EP1170008A1 (en) 2000-07-07 2002-01-09 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Valproic acid and derivatives thereof as histone deacetylase inhibitors
DE60115279T2 (en) 2000-09-29 2006-12-28 Topotarget Uk Ltd., Abingdon CARBOXIC ACID DERIVATIVES CONTAIN AN AMID GROUP AS HDAC INHIBITORS
US20020103192A1 (en) 2000-10-26 2002-08-01 Curtin Michael L. Inhibitors of histone deacetylase
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
US6706686B2 (en) 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
TW200304374A (en) 2001-11-30 2003-10-01 Smithkline Beecham Plc Novel compounds
US7993626B2 (en) 2007-01-11 2011-08-09 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US20060089410A1 (en) 2002-07-17 2006-04-27 Titan Pharmaceuticals, Inc. Combination of chemotherapeutic drugs for increasing antitumor activity
US20050215601A1 (en) 2002-09-25 2005-09-29 Santen Pharmaceutical Co., Ltd. Therapeutic agent for rheumatic disease comprising benzamide derivative as active ingredient
US8163896B1 (en) 2002-11-14 2012-04-24 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US7790867B2 (en) 2002-12-05 2010-09-07 Rosetta Genomics Inc. Vaccinia virus-related nucleic acids and microRNA
US20050054647A1 (en) 2002-12-27 2005-03-10 Detlev Schuppan New pharmaceutical combination
US7244751B2 (en) 2003-02-14 2007-07-17 Shenzhen Chipscreen Biosciences Ltd. Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
PE20050206A1 (en) 2003-05-26 2005-03-26 Schering Ag PHARMACEUTICAL COMPOSITION CONTAINING AN INHIBITOR OF HISTONE DEACETILASE
TWI287010B (en) 2003-06-12 2007-09-21 Euro Celtique Sa Therapeutic agents useful for treating pain
US9005613B2 (en) 2003-06-16 2015-04-14 Immunomedics, Inc. Anti-mucin antibodies for early detection and treatment of pancreatic cancer
CN1284772C (en) 2003-07-04 2006-11-15 深圳微芯生物科技有限责任公司 Benzamide histone deacetylase inhibitor with differentiation and anti-proliferation activities and medicinal preparation thereof
WO2005049105A2 (en) 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
US20130189364A1 (en) 2004-07-09 2013-07-25 Robert Sabin Compositions and methods of potentiating adjuvant pharmaceuticals targeting latent viral infections
EP2522396A1 (en) 2005-02-03 2012-11-14 TopoTarget UK Limited Combination therapies using HDAC inhibitors
US9707302B2 (en) 2013-07-23 2017-07-18 Immunomedics, Inc. Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
SG160373A1 (en) 2005-03-04 2010-04-29 John Oaeneil Adult pancreatic derived stromal cells
AU2006244885B2 (en) * 2005-05-09 2011-03-31 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
WO2006135479A2 (en) 2005-05-10 2006-12-21 Angiotech International Ag Anti-scarring agents, therapeutic compositions, and use thereof
WO2006121521A2 (en) 2005-05-10 2006-11-16 Angiotech International Ag Soft tissue implants, anti-scarring agents, and therapeutic compositions
WO2006121522A2 (en) 2005-05-10 2006-11-16 Angiotech International Ag Implantable sensors and pumps, anti-scarring agents, and therapeutic compositions
US20090280153A1 (en) 2005-05-10 2009-11-12 Angiotech International Ag electrical devices, anti-scarring agents, and therapeutic compositions
EP1948195A2 (en) 2005-11-17 2008-07-30 Innate Pharma Improved methods of using phosphoantigen for the treatment of cancer
US20090247734A1 (en) 2005-12-14 2009-10-01 Hendrickson Wayne A Chemically Derivatized CD4 and Uses Thereof
EP2010916A2 (en) 2006-04-13 2009-01-07 Oncomethylome Sciences SA Novel tumour suppressor
WO2008012692A2 (en) 2006-05-26 2008-01-31 Methylgene Inc. Assay for efficacy of histone deacetylase inhibitors
EP2090577B1 (en) 2006-10-19 2017-04-05 Signal Pharmaceuticals, LLC Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
EA201201640A1 (en) 2007-01-30 2013-09-30 Фармасайкликс, Инк. METHODS FOR DETERMINING CANCER STABILITY TO INHIBITORS HISTONEDEISETHYLASE
CA2693707A1 (en) 2007-07-13 2009-03-05 The Johns Hopkins University B7-dc variants
US8088793B2 (en) 2007-08-15 2012-01-03 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
CN101861151B (en) 2007-09-14 2014-08-13 梅特希尔基因公司 Cancer combination therapy with a selective inhibitor of histone deacetylase HDAC1, HDAC2 and/or HDAC3 and a microtubule stabilizer
GB0802009D0 (en) 2008-02-04 2008-03-12 Chroma Therapeutics Ltd Biomarkers of aminopeptidase inhibition
JP2009209090A (en) 2008-03-04 2009-09-17 Mitsui Chemicals Inc Insecticide, compound contained in the insecticide, and method of using the compound
US9226934B2 (en) 2008-06-02 2016-01-05 The University Of Tokyo Anti-cancer drug
KR20110074850A (en) 2008-08-25 2011-07-04 앰플리뮨, 인크. PD-1 antagonists and methods of use thereof
TWI453207B (en) 2008-09-08 2014-09-21 Signal Pharm Llc Aminotriazolopyridines, compositions thereof, and methods of treatment therewith
US20160041153A1 (en) 2008-11-12 2016-02-11 Kirk Brown Biomarker compositions and markers
CN101757626B (en) 2008-12-26 2012-12-12 鼎泓国际投资（香港）有限公司 Pharmaceutical composition containing insulin-like growth factor-I receptor inhibitor and histone deacetylase inhibitor and application thereof
CN101756957B (en) 2008-12-26 2012-11-14 鼎泓国际投资（香港）有限公司 Pharmaceutical composition containing artemisinin, artemisinin derivatives and histone deacetylase inhibitor and application thereof
CN101836989B (en) 2009-03-19 2013-02-13 鼎泓国际投资（香港）有限公司 Pharmaceutical composition containing tetrandrine, tetrandrine derivatives and histone deacetylase inhibitor and application thereof
CN101837129B (en) 2009-03-19 2012-12-12 鼎泓国际投资（香港）有限公司 Pharmaceutical composition containing cMet inhibitor, HDAC inhibitor and EGFR tyrosine kinase inhibitor and application thereof
US20160186266A1 (en) 2009-10-27 2016-06-30 Carislife Sciences, Inc. Molecular profiling for personalized medicine
JP2013510180A (en) 2009-11-06 2013-03-21 インフィニティ ファーマスーティカルズ、インク． Oral formulation of hedgehog pathway inhibitor
EP2499486A4 (en) 2009-11-13 2013-11-27 Infinity Pharmaceuticals Inc Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
AU2010321773A1 (en) 2009-11-20 2012-06-14 Infinity Pharmaceuticals, Inc. Methods and compositions for treating hedgehog-associated cancers
LT2536706T (en) 2010-02-11 2017-10-25 Celgene Corporation Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
NZ602634A (en) 2010-03-26 2015-06-26 Dartmouth College Vista regulatory t cell mediator protein, vista binding agents and use thereof
EP2556172A4 (en) 2010-04-06 2013-10-30 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
JO2998B1 (en) 2010-06-04 2016-09-05 Amgen Inc Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer
US8993622B2 (en) 2010-06-11 2015-03-31 Eirium Ab Antiviral compounds
US20120010230A1 (en) 2010-07-08 2012-01-12 Macdougall John R Methods and compositions for identification, assessment and treatment of cancers associated with hedgehog signaling
WO2012006584A2 (en) 2010-07-08 2012-01-12 Infinity Pharmaceuticals, Inc. Therapeutic regimens for hedgehog-associated cancers
EP2606353A4 (en) 2010-08-18 2014-10-15 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
CN102441167B (en) 2010-10-12 2014-05-07 鼎泓国际投资（香港）有限公司 Pharmaceutical composition containing apigenin, apigenin derivatives and histone deacetylase inhibitors and application thereof
US9808434B2 (en) 2011-01-27 2017-11-07 City Of Hope Compound for treating cancer and diabetes
EP2678448A4 (en) 2011-02-22 2014-10-01 Caris Life Sciences Luxembourg Holdings S A R L Circulating biomarkers
US20140349938A1 (en) 2011-06-03 2014-11-27 President And Fellows Of Harvard College Methods of diagnosing and treating amyotrophic lateral sclerosis
CN103782174A (en) 2011-06-07 2014-05-07 卡里斯生命科学卢森堡控股有限责任公司 Circulating biomarkers for cancer
CN103797131A (en) 2011-06-16 2014-05-14 卡里斯生命科学卢森堡控股有限责任公司 Biomarker compositions and methods
AU2012298794A1 (en) 2011-08-23 2013-04-04 Infinity Pharmaceuticals, Inc. Biomarkers predictive of therapeutic responsiveness to HSP90 inhibitors and uses thereof
WO2013039956A2 (en) 2011-09-14 2013-03-21 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating mood disorders
PT2760471T (en) 2011-09-30 2017-03-22 Dana Farber Cancer Inst Inc Therapeutic peptides
EP2785683B1 (en) 2011-11-30 2020-02-05 Ludwig Institute for Cancer Research Ltd. Inkt cell modulators and methods of using the same
WO2013085902A1 (en) 2011-12-05 2013-06-13 The University Of Texas M.D. Combination therapy methods for treating an inflammatory breast cancer
IN2014KN00848A (en) 2012-02-01 2015-10-02 Compugen Ltd
WO2013124867A1 (en) 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules
WO2013134786A2 (en) 2012-03-09 2013-09-12 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarker compositions and methods
WO2013182661A1 (en) 2012-06-06 2013-12-12 Bionor Immuno As Peptides derived from viral proteins for use as immunogens and dosage reactants
EP2858665A1 (en) 2012-06-06 2015-04-15 Bionor Immuno AS Vaccine
WO2013190555A1 (en) 2012-06-21 2013-12-27 Compugen Ltd. Lsr antibodies, and uses thereof for treatment of cancer
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
ES2941477T3 (en) 2012-08-13 2023-05-23 Univ Rockefeller LXRbeta agonist for cancer treatment
US9382329B2 (en) 2012-08-14 2016-07-05 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to Trop-2 expressing cells
US9682143B2 (en) 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
AU2013302696B9 (en) 2012-08-14 2018-08-09 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
CN104884065B (en) 2012-09-21 2019-01-01 强烈治疗剂公司 The method for the treatment of cancer
EP2914722A1 (en) 2012-11-05 2015-09-09 Pronai Therapeutics, Inc. Dosing and administration of oligonucleotide cancer therapies
CN105051043B (en) 2012-11-16 2017-05-10 默克专利有限公司 Novel heterocyclic derivatives as modulators of kinase activity
EP2922861A4 (en) 2012-11-26 2016-09-14 Caris Life Sciences Switzerland Holdings Gmbh Biomarker compositions and methods
CN103833626B (en) 2012-11-27 2015-11-25 深圳微芯生物科技有限责任公司 Crystal formation of chidamide and preparation method thereof and application
ES2821102T3 (en) 2012-11-29 2021-04-23 Merck Patent Gmbh Azaquinazolinecarboxamide derivatives
ES2819573T3 (en) 2012-12-13 2021-04-16 Immunomedics Inc Method for Producing Antibody-SN-38 Immunoconjugates with a CL2A Linker
CN107753954A (en) 2012-12-13 2018-03-06 免疫医疗公司 The dosage of the antibody that effect is improved and toxicity reduces and SN 38 immunoconjugates
US10137196B2 (en) 2012-12-13 2018-11-27 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
US9492566B2 (en) 2012-12-13 2016-11-15 Immunomedics, Inc. Antibody-drug conjugates and uses thereof
RU2644411C2 (en) 2013-02-07 2018-02-12 Филипс Лайтинг Холдинг Б.В. Lighting system having controller that supports selected light scene, and method for controlling such system
CN105209068A (en) 2013-02-07 2015-12-30 免疫医疗公司 Pro-drug form (P2PDox) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer
CN104056270B (en) 2013-02-21 2018-11-09 中国人民解放军军事医学科学院野战输血研究所 It is used to prepare the histon deacetylase (HDAC) inhibitor that multiple organ injury gives treatment to drug
EP2964648B1 (en) 2013-03-05 2016-11-16 Merck Patent GmbH 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents
EP2964649B1 (en) 2013-03-05 2017-05-10 Merck Patent GmbH Triazolo[4,5-d]pyrimidine derivatives for the treatment of diseases such as cancer
WO2014151899A1 (en) 2013-03-14 2014-09-25 Seragon Pharmaceuticals, Inc. Polycyclic estrogen receptor modulators and uses thereof
PL2970473T3 (en) 2013-03-14 2018-01-31 Bristol Myers Squibb Co Combination of dr5 agonist and anti-pd-1 antagonist and methods of use
AR095363A1 (en) 2013-03-15 2015-10-14 Genentech Inc BIOMARKERS AND METHODS FOR THE TREATMENT OF CONDITIONS RELATED TO PD-1 AND PD-L1
EP3666886A1 (en) 2013-03-15 2020-06-17 Dana-Farber Cancer Institute, Inc. Therapeutic peptides
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
EP2970965A2 (en) 2013-03-15 2016-01-20 Pronai Therapeutics, Inc. Dnai for the modulation of genes
CN104069106A (en) 2013-03-27 2014-10-01 南通瑞思医药技术有限公司 Application of benzamide compound in preparation of medicine for activating latent human immunodeficiency virus
WO2014172637A1 (en) 2013-04-18 2014-10-23 Immune Design Corp. Gla monotherapy for use in cancer treatment
JP2016519166A (en) 2013-05-24 2016-06-30 クーパー ヒューマン システムズ エルエルシー Methods and compositions for treating HIV infection
WO2014193999A2 (en) 2013-05-28 2014-12-04 Caris Science, Inc. Biomarker methods and compositions
BR112015030595A2 (en) 2013-06-19 2017-07-25 Seragon Pharmaceuticals Inc azetidine estrogen receptor modulators and uses thereof
AU2014281511A1 (en) 2013-06-19 2015-12-03 Seragon Pharmaceuticals, Inc. Estrogen receptor modulator and uses thereof
ES2661437T3 (en) 2013-06-21 2018-04-02 Zenith Epigenetics Corp. New substituted bicyclic compounds as bromodomain inhibitors
WO2015007337A1 (en) 2013-07-19 2015-01-22 Bionor Immuno As Method for the vaccination against hiv
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
BR112016001978A2 (en) 2013-07-29 2017-08-01 Merck Patent Gmbh 1,3-disubstituted cyclopentane derivatives
WO2015017546A1 (en) 2013-07-30 2015-02-05 H. Lee Moffitt Cancer Center And Research Institute, Inc. Selective histone deactylase 6 inhibitors
MX359656B (en) 2013-07-31 2018-10-05 Merck Patent Gmbh Oxoquinazolinyl-butanamide derivatives.
EA201690087A1 (en) 2013-07-31 2016-08-31 Зенит Эпидженетикс Корп. NEW QUINAZOLINONS AS BROMOMODENIAL INHIBITORS
WO2015019284A2 (en) 2013-08-05 2015-02-12 Cambridge Enterprise Limited Inhibition of cxcr4 signaling in cancer immunotherapy
MX366140B (en) 2013-08-07 2019-06-27 Merck Patent Gmbh Piperidine urea derivatives.
WO2015023938A1 (en) 2013-08-16 2015-02-19 Rana Therapeutics, Inc. Epigenetic regulators of frataxin
CN103432077A (en) 2013-08-21 2013-12-11 北京淦航医药科技有限公司 Chidamide solid dispersion preparation
US10966998B2 (en) 2013-09-05 2021-04-06 The Johns Hopkins University Cancer therapy via a combination of epigenetic modulation and immune modulation
US20160272707A1 (en) 2013-09-11 2016-09-22 Compugen Ltd. Vstm5 antibodies, and uses thereof for treatment of cancer, infectious diseases and immune related diseases
WO2015037000A1 (en) 2013-09-11 2015-03-19 Compugen Ltd Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases
WO2015048547A2 (en) 2013-09-26 2015-04-02 Rigel Pharmaceuticals, Inc. Methods for using and biomarkers for ampk-activating compounds
US20150094518A1 (en) 2013-09-27 2015-04-02 The Regents Of The University Of California Modular polymer platform for the treatment of cancer
EP3060654B1 (en) 2013-10-21 2023-03-15 Hemoshear, LLC In vitro model for a tumor microenvironment
MX2016005054A (en) 2013-10-21 2016-07-19 Merck Patent Gmbh Heteroaryl compounds as btk inhibitors and uses thereof.
US20170080093A1 (en) 2013-10-22 2017-03-23 Tyme, Inc. Tyrosine Derivatives And Compositions Comprising Them
PE20160546A1 (en) 2013-10-25 2016-05-26 Novartis Ag BICYCLE PYRIDYL DERIVED COMPOUNDS FUSED TO RING AS INHIBITORS OF FGFR4
CN108464981B (en) 2013-11-07 2022-06-24 德西费拉制药有限责任公司 Use of composition for inhibiting TIE2 kinase in preparing medicine for treating cancer
US9457019B2 (en) 2013-11-07 2016-10-04 Deciphera Pharmaceuticals, Llc Methods for inhibiting tie-2 kinase useful in the treatment of cancer
EP3068443B1 (en) 2013-11-12 2019-04-10 Centre for Probe Development and Commercialization Residualizing linkers and uses thereof
US20150140036A1 (en) 2013-11-13 2015-05-21 Novartis Institutes For Biomedical Research, Inc. Low, immune enhancing, dose mtor inhibitors and uses thereof
NZ720004A (en) 2013-11-18 2020-03-27 Forma Therapeutics Inc Tetrahydroquinoline compositions as bet bromodomain inhibitors
EP3071205B1 (en) 2013-11-18 2020-02-05 Forma Therapeutics, Inc. Benzopiperazine compositions as bet bromodomain inhibitors
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
KR20160090904A (en) 2013-12-06 2016-08-01 다나-파버 캔서 인스티튜트 인크. Therapeutic peptides
WO2015086738A2 (en) 2013-12-11 2015-06-18 Bionor Immuno As Hiv vaccine
WO2015089380A2 (en) 2013-12-12 2015-06-18 Celcuity Llc Assays and methods for determining the responsiveness of an individual subject to a therapeutic agent
US20160263092A1 (en) 2013-12-19 2016-09-15 Twi Biotechnology, Inc. Therapeutic uses of berberine formulations
JP7060324B2 (en) 2013-12-20 2022-04-26 ザ・ブロード・インスティテュート・インコーポレイテッド Combination therapy with neoantigen vaccine
MY186311A (en) 2013-12-20 2021-07-08 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
HUE037606T2 (en) 2013-12-23 2018-09-28 Merck Patent Gmbh Imidazopyrazinone derivatives
WO2015096982A1 (en) 2013-12-23 2015-07-02 Bayer Pharma Aktiengesellschaft Antibody drug conjugates (adcs) with kinesin spindel protein (ksp)
AU2015204572B2 (en) 2014-01-10 2020-07-30 Inspirna, Inc. LXR agonists and uses thereof
CN104771363A (en) 2014-01-14 2015-07-15 深圳微芯生物科技有限责任公司 Chidamide solid dispersion and preparing method and application thereof
JOP20200094A1 (en) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc Antibody Molecules of PD-1 and Their Uses
US10143737B2 (en) 2014-01-27 2018-12-04 Bionor Pharma Asa Method for the vaccination against HIV
CA2936335A1 (en) 2014-01-27 2015-07-30 Bionor Immuno As Dosage regimen for hiv vaccine
WO2015110659A1 (en) 2014-01-27 2015-07-30 Bionor Immuno As Methods of immunization with a vaccine inducing a humoral immune response and with a vaccine inducing a cellular immune response
US9631013B2 (en) 2014-01-28 2017-04-25 Fibrogen, Inc. Therapeutic method for pancreatic cancer
WO2015113927A1 (en) 2014-01-29 2015-08-06 Bayer Pharma Aktiengesellschaft Amino-substituted isothiazoles
EP3099682A1 (en) 2014-01-29 2016-12-07 Bayer Pharma Aktiengesellschaft Amino-substituted isothiazoles
JOP20200096A1 (en) 2014-01-31 2017-06-16 Children’S Medical Center Corp Antibody molecules to tim-3 and uses thereof
WO2015120382A1 (en) 2014-02-07 2015-08-13 The Johns Hopkins University Predicting response to epigenetic drug therapy
JP6577479B2 (en) 2014-02-27 2019-09-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Heterocyclic compounds and their use as NAV channel inhibitors
WO2015127548A1 (en) 2014-02-28 2015-09-03 The Royal Institution For The Advancement Of Learning / Mcgill University Tc-ptp inhibitors as apc activators for immunotherapy
MX2016011612A (en) 2014-03-11 2016-12-12 The Council Of The Queensland Inst Of Medical Res Determining cancer agressiveness, prognosis and responsiveness to treatment.
EP3116496A1 (en) 2014-03-13 2017-01-18 F. Hoffmann-La Roche AG Methods and compositions for modulating estrogen receptor mutants
EP3116497A2 (en) 2014-03-13 2017-01-18 F. Hoffmann-La Roche AG Therapeutic combinations with estrogen receptor modulators
ME03558B (en) 2014-03-14 2020-07-20 Novartis Ag Antibody molecules to lag-3 and uses thereof
JP6701088B2 (en) 2014-03-19 2020-05-27 インフィニティー ファーマシューティカルズ， インコーポレイテッド Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
UY36060A (en) 2014-04-02 2015-10-30 Bayer Pharma AG AZOL COMPOUNDS REPLACED WITH AMIDA
CN104974079A (en) 2014-04-02 2015-10-14 C&C生物医药有限公司 Amide derivatives of aniline-related compound and composition of amide derivatives of aniline-related compound
US12146874B2 (en) 2014-04-03 2024-11-19 University Of Maryland, Baltimore Microtentacle imaging in patient tumor samples
CN103880736B (en) 2014-04-04 2017-05-17 深圳微芯生物科技有限责任公司 E-configuration benzamide compounds, and pharmaceutical preparation application thereof
JP6767875B2 (en) 2014-04-08 2020-10-14 ライジェル ファーマシューティカルズ， インコーポレイテッド 2,3-Disubstituted pyridine compound as a TGF-beta inhibitor and how to use it
NO2776305T3 (en) 2014-04-23 2018-01-27
JP2015209376A (en) 2014-04-24 2015-11-24 国立大学法人北海道大学 Tumor-specific immuno-enhancing agent
EP3137447B1 (en) 2014-04-30 2021-06-30 Rgenix, Inc. Inhibitors of creatine transport and uses thereof
WO2015168614A2 (en) 2014-05-01 2015-11-05 Board Of Regents Of The University Of Nebraska Polymer compositions of histone deacetylase inhibitors and methods of use thereof
WO2015172747A1 (en) 2014-05-16 2015-11-19 Zhaoyin Wang Spirocyclic molecules as mth1 inhibitors
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
PL3155017T4 (en) 2014-05-28 2024-06-17 Mederis Diabetes, Llc Improved peptide pharmaceuticals for insulin resistance
WO2015184405A1 (en) 2014-05-30 2015-12-03 Medivation Technologies, Inc. Aromatic compounds, compositions and uses thereof
WO2015191568A2 (en) 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies using agents that target tumor-associated stroma or tumor cells and tumor vasculature
TWI729644B (en) 2014-06-12 2021-06-01 美商西爾拉癌症醫學公司 N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide
US10221197B2 (en) 2014-06-13 2019-03-05 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
SG11201609527PA (en) 2014-06-13 2016-12-29 Gilead Sciences Inc Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
EA201692265A1 (en) 2014-06-13 2017-05-31 Джилид Сайэнс, Инк. PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS
JP6454736B2 (en) 2014-06-13 2019-01-16 ギリアード サイエンシーズ， インコーポレイテッド Phosphatidylinositol 3-kinase inhibitor
EP3154960A1 (en) 2014-06-13 2017-04-19 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
ES2769648T3 (en) 2014-06-16 2020-06-26 Fundacion Para La Investig Medica Aplicada Novel compounds as dual inhibitors of histone methyltransferases and DNA methyltransferases ASAS
CA2952307A1 (en) 2014-06-17 2015-12-23 Bayer Pharma Aktiengesellschaft 3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones
NO2717902T3 (en) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
SG11201610341PA (en) 2014-06-24 2017-01-27 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
WO2015200790A2 (en) 2014-06-26 2015-12-30 Yale University Compositions and methods to regulate renalase in the treatment of diseases and disorders
US20170165321A1 (en) 2014-07-11 2017-06-15 Bionor Immuno As Method for reducing and/or delaying pathological effects of human immunodeficiency virus i (hiv) or for reducing the risk of developing acquired immunodeficiency syndrome (aids)
PL3166607T3 (en) 2014-07-11 2023-02-20 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
CN114099686B (en) 2014-07-15 2024-04-16 约翰·霍普金斯大学 Inhibition of myeloid-derived suppressor cells and immune checkpoint blockade
CN104083763A (en) 2014-07-16 2014-10-08 中国人民解放军军事医学科学院野战输血研究所 Application of histone deacetylase inhibitor in preparation of latent virus activator
AU2015289044A1 (en) 2014-07-17 2016-12-08 Cancer Research Technology Limited Novel naphthryidines and isoquinolines and their use as CDK8/19 inhibitors
WO2016014890A1 (en) 2014-07-24 2016-01-28 Calithera Biosciences, Inc. Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase
JP2017522332A (en) 2014-07-25 2017-08-10 バイエル ファーマ アクチエンゲゼルシャフト Amino-substituted isoxazoles
WO2016018920A1 (en) 2014-07-29 2016-02-04 Admune Therapeutics Llc Il-15 and il-15ralpha heterodimer dose escalation regimens for treating conditions
TWI700283B (en) 2014-08-04 2020-08-01 德商拜耳製藥公司 2-(morpholin-4-yl)-1,7-naphthyridines
EP4180041A1 (en) 2014-08-07 2023-05-17 Mayo Foundation for Medical Education and Research Compounds and methods for treating cancer
GB201414464D0 (en) 2014-08-14 2014-10-01 Technion Res & Dev Foundation Compositions and methods for therapeutics prescreening
MX2017002199A (en) 2014-08-18 2017-08-18 Ono Pharmaceutical Co ACID-ADDITION SALT OF Trk-INHIBITING COMPOUND.
JO3663B1 (en) 2014-08-19 2020-08-27 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
US10912933B2 (en) 2014-08-19 2021-02-09 The Regents Of The University Of California Implants for localized drug delivery and methods of use thereof
US20170231931A1 (en) 2014-08-26 2017-08-17 Fundación Para La Investigación Médica Aplicada Products for the treatment and prevention of neurological disorders coursing with a cognition deficit or impairment, and of neurodegenerative diseases
JP6491321B2 (en) 2014-08-29 2019-03-27 ギリアード サイエンシーズ， インコーポレイテッド Antiretroviral agent
WO2016036759A1 (en) 2014-09-04 2016-03-10 Gilead Sciences, Inc. Methods of treating or preventing hiv in patients using a combination of tenofovir alafenamide and dolutegravir
RU2718914C2 (en) 2014-09-13 2020-04-15 Новартис Аг Combined treatment methods using alk inhibitors
SI3194401T1 (en) 2014-09-16 2020-12-31 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
JP2017529353A (en) 2014-09-19 2017-10-05 バイエル ファーマ アクチエンゲゼルシャフト Benzyl-substituted indazoles as Bub1 kinase inhibitors
WO2016042080A1 (en) 2014-09-19 2016-03-24 Bayer Pharma Aktiengesellschaft Benzyl substituted indazoles as bub1 kinase inhibitors
BR112017005444A2 (en) 2014-09-19 2018-04-24 Bayer Pharma AG benzyl substituted indazoles as bub1 inhibitors.
CN107148420A (en) 2014-09-19 2017-09-08 拜耳制药股份公司 The indazole compounds of benzyl substitution
EP3194368B1 (en) 2014-09-19 2020-12-23 MacKay Medical Foundation the Presbyterian Church in Taiwan MacKay Memorial Hospital Benzo-heterocyclic compounds and their applications
EP3198276B1 (en) 2014-09-24 2023-09-20 Exscientia GmbH Monolayer of pbmcs or bone-marrow cells and uses thereof
CN104530415B (en) 2014-10-01 2017-09-01 厦门赛诺邦格生物科技股份有限公司 A kind of different functionalization Y types polyethyleneglycol derivative, preparation method and its bio-related substance
CN104530413B (en) 2014-10-01 2017-08-25 厦门赛诺邦格生物科技股份有限公司 A kind of bio-related substance of multiple functionalized H types polyethyleneglycol derivative modification
CN104725628B (en) 2014-10-01 2018-04-17 厦门赛诺邦格生物科技股份有限公司 A kind of single functionalization branched polyethylene glycol, preparation method and its bio-related substance containing degradable group
CA2963281A1 (en) 2014-10-03 2016-04-07 Novartis Ag Combination therapies
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
AU2015328285B2 (en) 2014-10-06 2019-07-18 Merck Patent Gmbh Heteroaryl compounds as BTK inhibitors and uses thereof
US9732119B2 (en) 2014-10-10 2017-08-15 Bristol-Myers Squibb Company Immunomodulators
CN107001478B (en) 2014-10-14 2022-01-11 诺华股份有限公司 Antibody molecules against PD-L1 and uses thereof
CN107106638A (en) 2014-10-14 2017-08-29 激流生物科学有限公司 Peptide with anti-inflammatory property
WO2016061495A1 (en) 2014-10-16 2016-04-21 Predictive Therapeutics Ltd. Atavarsitic systems and methods for biomarker discovery
WO2016065349A2 (en) 2014-10-24 2016-04-28 University Of Maryland, Baltimore Short non-coding protein regulatory rnas (sprrnas) and methods of use
EP3212228A2 (en) 2014-10-27 2017-09-06 Ruprecht-Karls-Universität Heidelberg Use of ccr5 antagonists alone or in combination therapy for the treatment of cancer
DK3643709T3 (en) 2014-10-30 2021-12-20 Kangpu Biopharmaceuticals Inc ISOINDOLINE DERIVATIVE, INTERMEDIATE PRODUCT, METHOD OF MANUFACTURE, PHARMACEUTICAL COMPOSITION AND USE
WO2016070089A2 (en) 2014-10-31 2016-05-06 Abbvie Biotherapeutics Inc. Anti-cs1 antibodies and antibody drug conjugates
WO2016070051A2 (en) 2014-10-31 2016-05-06 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
EP3215182B1 (en) 2014-11-05 2023-01-04 The Regents of The University of California Combination immunotherapy
WO2016071477A1 (en) 2014-11-07 2016-05-12 Rheinische Friedrich-Wilhelms-Universität Bonn Institut Für Rekonstruktive Neurobiologie Methods for assessing the treatment response of cancer patients and for treating cancer patients by analysing cpg methylation
CA2967188A1 (en) 2014-11-14 2016-05-19 Novartis Ag Antibody drug conjugates
US9856292B2 (en) 2014-11-14 2018-01-02 Bristol-Myers Squibb Company Immunomodulators
ES2978534T3 (en) 2014-11-17 2024-09-13 Cellectar Biosciences Inc Phospholipid ether analogues as anticancer drug carriers
WO2016081384A1 (en) * 2014-11-17 2016-05-26 Genentech, Inc. Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
US10526341B2 (en) 2014-11-19 2020-01-07 Memorial Sloan-Kettering Cancer Center Thienopyrimidines and uses thereof
US9790221B2 (en) 2014-11-20 2017-10-17 Merck Patent Gmbh Heteroaryl compounds as IRAK inhibitors and uses thereof
WO2016087936A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Corp. Substituted pyridinones as bromodomain inhibitors
WO2016089928A1 (en) 2014-12-01 2016-06-09 Weitz Andrew C Methods for treating and assessing tumor invasion and metastasis
WO2016087942A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Corp. Substituted pyridines as bromodomain inhibitors
WO2016087490A1 (en) 2014-12-03 2016-06-09 Bayer Pharma Aktiengesellschaft Combination of pi3k-inhibitors
WO2016087488A1 (en) 2014-12-03 2016-06-09 Bayer Pharma Aktiengesellschaft Administration regime for aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives
JP2018500930A (en) 2014-12-04 2018-01-18 アブルッツォ・セラノスティックス・エッセ・エッレ・エッレ Humanized anti-TROP-2 monoclonal antibody and use thereof
CA2968352A1 (en) 2014-12-08 2016-06-16 Dana-Farber Cancer Institute, Inc. Methods for upregulating immune responses using combinations of anti-rgmb and anti-pd-1 agents
HUE055290T2 (en) 2014-12-09 2021-11-29 Bayer Ag Benzamide derivatives substituted with 1,3-thiazol-2-yl
WO2016094309A1 (en) 2014-12-10 2016-06-16 Myosotis Inhibition of tnf signaling in cancer immunotherapy
US20170343554A1 (en) 2014-12-12 2017-11-30 Celcuity Llc Methods of measuring erbb signaling pathway activity to diagnose and treat cancer patients
EP3233127A1 (en) 2014-12-15 2017-10-25 Bayer Pharma Aktiengesellschaft Antibody-drug conjugates (adcs) of ksp inhibitors with aglycosylated anti-tweakr antibodies
WO2016100619A2 (en) 2014-12-17 2016-06-23 Rgenix, Inc. Treatment and diagnosis of cancer
US9845291B2 (en) 2014-12-18 2017-12-19 Genentech, Inc. Estrogen receptor modulators and uses thereof
US9861680B2 (en) 2014-12-18 2018-01-09 Bristol-Myers Squibb Company Immunomodulators
US20160175284A1 (en) 2014-12-18 2016-06-23 Genentech, Inc. Estrogen receptor modulators and uses thereof
US10172814B2 (en) 2014-12-18 2019-01-08 Bayer Pharma Aktiengesellschaft Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof
IL311006A (en) 2014-12-18 2024-04-01 Hoffmann La Roche TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
US9944678B2 (en) 2014-12-19 2018-04-17 Bristol-Myers Squibb Company Immunomodulators
EP3233918A1 (en) 2014-12-19 2017-10-25 Novartis AG Combination therapies
ES2724367T3 (en) 2014-12-19 2019-09-10 Epigenomics Ag Methods to detect CpG methylation and to diagnose cancer
WO2016100975A1 (en) 2014-12-19 2016-06-23 Massachsetts Institute Ot Technology Molecular biomarkers for cancer immunotherapy
WO2016102493A1 (en) 2014-12-22 2016-06-30 Bayer Pharma Aktiengesellschaft Imidazopyridine ezh2 inhibitors
DE102014226903A1 (en) 2014-12-23 2016-06-23 Olympus Winter & Ibe Gmbh RF adjuvant, medical system and method for selectively treating cancerous tissue
WO2016102427A1 (en) 2014-12-23 2016-06-30 Bayer Pharma Aktiengesellschaft 6-hydroxybenzofuranyl- and 6-alkoxybenzofuranyl-substituted imidazopyridazines
TWI695003B (en) 2014-12-23 2020-06-01 美商基利科學股份有限公司 Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
CN107207472B (en) 2014-12-23 2020-08-14 卑尔根生物股份公司 Inhibitors of AKT kinase
TWI699355B (en) 2014-12-24 2020-07-21 美商基利科學股份有限公司 Quinazoline compounds
NZ733125A (en) 2014-12-24 2018-06-29 Gilead Sciences Inc Isoquinoline compounds for the treatment of hiv
BR112017013491A2 (en) 2014-12-24 2018-01-09 Gilead Sciences, Inc. fused pyrimidine compounds for the treatment of hiv
US20160200815A1 (en) 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
EP3242671A4 (en) 2015-01-08 2018-08-08 Hackensack University Medical Center Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation
EP3693022A3 (en) 2015-01-09 2020-09-16 Reiley Pharmaceuticals, Inc. Cox-2-targeting, platinum-containing conjugates and their use in the treatment of tumors and cancers
WO2016117666A1 (en) 2015-01-23 2016-07-28 国立大学法人鹿児島大学 Agent for killing hiv-1-infected cell and application thereof
EP3247353A4 (en) 2015-01-23 2018-07-04 Confluence Life Sciences, Inc. Heterocyclic itk inhibitors for treating inflammation and cancer
SG11201705908VA (en) 2015-01-28 2017-08-30 Bayer Pharma AG 4h-pyrrolo[3,2-c]pyridin-4-one derivatives
PL3250208T3 (en) 2015-01-30 2021-04-06 Oncoceutics, Inc. 7-BENZYLO-4- (4- (TRIFLUOROMETHYL) BENZYLO) -1,2,6,7,8,9-HEXAHYDROIMIDAZO [1,2-A] PYRIDO [3,4-E] PYRIMIDIN-5 (4H) - HE AND HIS SALTS AND THEIR APPLICATION IN THERAPY
TW201639573A (en) 2015-02-03 2016-11-16 吉李德科學股份有限公司 Combination therapies for treating cancers
US20160222060A1 (en) 2015-02-04 2016-08-04 Bristol-Myers Squibb Company Immunomodulators
EP3253764B1 (en) 2015-02-05 2021-06-09 Merck Patent GmbH Macrocyclic compounds as irak1/4 inhibitors and uses thereof
CA2970550C (en) 2015-02-06 2023-09-19 Merck Patent Gmbh Pyridazinone macrocycles as irak inhibitors and uses thereof
MY193968A (en) 2015-02-12 2022-11-03 Beyondspring Pharmaceuticals Inc Use of plinabulin in combination with immune checkpoint inhibitors
WO2016133910A1 (en) 2015-02-17 2016-08-25 Cantex Pharmaceuticals, Inc. Treatment of cancers and hematopoietic stem cell disorders privileged by cxcl12-cxcr4 interaction
WO2016133194A1 (en) 2015-02-20 2016-08-25 第一三共株式会社 Combination method for treating cancer
MY186133A (en) 2015-03-02 2021-06-24 Rigel Pharmaceuticals Inc Tgf-? inhibitors
KR101756050B1 (en) 2015-03-04 2017-07-07 길리애드 사이언시즈, 인코포레이티드 Toll like receptor modulator compounds
US20180042929A1 (en) 2015-03-09 2018-02-15 Bayer Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines
BR112017019188A2 (en) 2015-03-09 2018-04-24 Bayer Pharma Aktiengesellschaft COMBINATIONS CONTAINING 2,3-DI-HYDROIMIDAZO [1,2-C] REPLACED QUINAZOLINE
WO2016145150A2 (en) 2015-03-11 2016-09-15 The Broad Institute Inc. Selective treatment of prmt5 dependent cancer
EP3988106A1 (en) 2015-03-13 2022-04-27 Ospedale San Raffaele S.r.l. Il-10-producing cd4+ t cells and uses thereof
US10195237B2 (en) 2015-03-16 2019-02-05 Imagilin Technology Llc Compositions and methods for treating inflammatory related diseases or conditions using Pediococcus acidilactici probiotics
WO2016149366A1 (en) 2015-03-16 2016-09-22 The Johns Hopkins University Methods and compositions for treating cancer
US10946050B2 (en) 2015-03-16 2021-03-16 Imagilin Technology Llc Compositions comprising probiotics and methods of use thereof
US9809625B2 (en) 2015-03-18 2017-11-07 Bristol-Myers Squibb Company Immunomodulators
WO2016153948A1 (en) 2015-03-20 2016-09-29 Deuterx, Llc Combination therapy using enantiopure, oxy-substituted, deuterium-enriched 5-(benzyl)-5-deutero-thiazolidine-2, 4-diones for treatment of medical disorders
MX2017012113A (en) 2015-03-20 2018-07-06 Syndax Pharmaceuticals Inc Combination of hdac inhibitor and anti-pd-1 antibody for treatment of cancer.
US20180044418A1 (en) 2015-03-20 2018-02-15 Merck Sharp & Dohme Corp. Combination of a pd-1 antagonist and vorinostat for treating cancer
WO2016154082A2 (en) 2015-03-23 2016-09-29 Tang Yao Methods of primary tissue culture and drug screening using autologous serum and fluids
CA2979712C (en) 2015-03-25 2024-01-23 The Regents Of The University Of Michigan Nanoparticle compositions for delivery of biomacromolecules
US10302629B2 (en) 2015-03-30 2019-05-28 University Of Maryland, Baltimore Compositions and methods for treating cancer by rational targeting of protein translation
KR20190057158A (en) 2015-04-02 2019-05-27 길리애드 사이언시즈, 인코포레이티드 Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
JP6921001B2 (en) 2015-04-13 2021-08-18 ファイザー・インク Chimeric antigen receptor that targets B cell maturation antigens
WO2016166600A1 (en) 2015-04-15 2016-10-20 Trojantec Technologies Ltd Delivery of microrna using mesenchymal stem cell microparticles
EP3283463B1 (en) 2015-04-17 2021-01-20 The Trustees Of The University Of Pennsylvania Dimeric quinacrine derivatives as autophagy inhibitors for cancer therapy
CN108135177B (en) 2015-04-29 2021-06-01 雷迪厄斯制药公司 Methods for treating cancer
UY36660A (en) 2015-04-30 2016-11-30 Bayer Pharma AG IRAK4 INHIBITORS COMBINATIONS
US20180140694A1 (en) 2015-05-04 2018-05-24 Bionor Immuno As Dosage regimen for hiv vaccine
TN2017000467A1 (en) 2015-05-05 2019-04-12 Bayer Pharma AG Amido-substituted cyclohexane derivatives
US9840503B2 (en) * 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
WO2016187122A1 (en) 2015-05-15 2016-11-24 University Of Iowa Research Foundation Methods for treating tumors in situ including intratumor injection of cytotoxic particles and immune checkpoint blockade therapy
WO2016184973A1 (en) 2015-05-19 2016-11-24 Innavirvax Treatment of hiv-infected individuals
US20160339030A1 (en) 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
WO2016184963A1 (en) 2015-05-19 2016-11-24 Innavirvax Treatment of hiv-infected individuals
WO2016184962A1 (en) 2015-05-19 2016-11-24 Innavirvax Treatment of hiv-infected individuals
IL255769B2 (en) 2015-05-20 2023-09-01 Broad Inst Inc Shared neoantigens
CA2985194C (en) 2015-05-21 2024-05-21 Chemocentryx, Inc. Ccr2 modulators
CN107708674A (en) 2015-05-22 2018-02-16 阿菲欧斯公司 combination HIV therapy
EP3303326B1 (en) 2015-05-26 2020-12-16 H. Hoffnabb-La Roche Ag Heterocyclic estrogen receptor modulators and uses thereof
CN104892648A (en) 2015-05-27 2015-09-09 天津工业大学 Preparation and application of target metal organic frameworks carrying antitumor drug
US20180164317A1 (en) 2015-05-28 2018-06-14 Bayer Pharma Aktiengesellschaft Method for stratification of melanoma patients by determination of oxygen consumption, ppargc1a, ppargc1b and mitf levels
WO2016196471A1 (en) 2015-06-02 2016-12-08 Cooper Human Systems Llc Methods and compositions for treatment of hiv infection
WO2016197009A1 (en) 2015-06-05 2016-12-08 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
CA2986949C (en) 2015-06-05 2020-07-21 MiRagen Therapeutics, Inc. Mir-155 inhibitors for treating cutaneous t cell lymphoma (ctcl)
US10370339B2 (en) 2015-06-08 2019-08-06 Bayer Pharma Aktiengesellschaft N-Methylbenzimidazoles as mIDH1 inhibitors
US10702527B2 (en) 2015-06-12 2020-07-07 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
WO2015151078A2 (en) 2015-06-15 2015-10-08 Suzhou M-Conj Biotech Co., Ltd Hydrophilic linkers for conjugation
WO2016205566A1 (en) 2015-06-16 2016-12-22 The Regents Of The University Of California Fzd7 specific antibodies and vaccines to treat cancer and control stem cell function
US10975112B2 (en) 2015-06-16 2021-04-13 Hangzhou Dac Biotech Co., Ltd. Linkers for conjugation of cell-binding molecules
US10766962B2 (en) 2015-06-16 2020-09-08 The Regents Of The University Of California FZD7 specific antibodies and vaccines to treat cancer and control stem cell function
WO2016202756A1 (en) 2015-06-18 2016-12-22 Bayer Pharma Aktiengesellschaft Substituted 2-(1h-pyrazol-1-yl)-1h-benzimidazole compounds
WO2016202758A1 (en) 2015-06-18 2016-12-22 Bayer Pharma Aktiengesellschaft Substituted 2-(1h-pyrazol-1-yl)-1h-benzimidazole compounds
CN116712552A (en) 2015-06-19 2023-09-08 波士顿大学托管委员会 Methods and compositions for treating herpes virus-induced conditions
CN107921144B (en) 2015-06-20 2023-11-28 杭州多禧生物科技有限公司 Aureostatin analogs and conjugate conjugates thereof with cell-binding molecules
MX2017017172A (en) 2015-06-22 2018-02-23 Bayer Pharma AG BINDING-ACTIVE PRINCIPLE CONJUGATES (ADCS) AND BINDING-PROFARMACO CONJUGATES (APDCS) WITH ENZYMATICALLY SCINDIBLE GROUPS.
EP3313521A1 (en) 2015-06-23 2018-05-02 Bayer Pharma Aktiengesellschaft Antibody drug conjugates of kinesin spindel protein (ksp) inhibitors with anti-tweakr-antibodies
CA2990300A1 (en) 2015-06-23 2016-12-29 Hans-Georg Lerchen Site specific homogeneous conjugates with ksp inhibitors
US10744205B2 (en) 2015-06-23 2020-08-18 Bayer Pharma Aktiengesellschaft Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with anti-CD123-antibodies
WO2016210247A1 (en) 2015-06-24 2016-12-29 Duke University New methods of use for an anti-diarrhea agent
EP3313388A4 (en) 2015-06-24 2019-05-15 Duke University CHEMICAL MODULATORS OF SIGNALING PATHWAYS AND THERAPEUTIC USE
KR20240090657A (en) 2015-06-29 2024-06-21 아브락시스 바이오사이언스, 엘엘씨 Methods of treating solid tumors using nanoparticle mtor inhibitor combination therapy
CA2985859A1 (en) 2015-06-29 2017-01-05 Merck Patent Gmbh Tbk/ikk.epsilon. inhibitor compounds and uses thereof
AU2016285597A1 (en) 2015-06-29 2018-01-18 Syndax Pharmaceuticals, Inc. Combination of HDAC inhibitor and anti-PD-L1 antibody for treatment of cancer
CN107921050A (en) 2015-06-29 2018-04-17 阿布拉科斯生物科学有限公司 Use the method for nano particle MTOR inhibitor conjoint therapy treatment haematological malignancies
UY36758A (en) 2015-06-30 2016-12-30 Glaxosmithkline Ip No 2 Ltd INHIBITORS OF THE ZESTE 2 HOMOLOGIST POTENTIATOR
US10925852B2 (en) 2015-06-30 2021-02-23 The Trustees Of Columbia University In The City Of New York Talc-bound compositions and uses thereof
CA2991384C (en) 2015-07-04 2022-11-08 Suzhou M-Conj Biotech Co., Ltd Bridge linkers for conjugation of a cell-binding molecule
US10179123B2 (en) 2015-07-07 2019-01-15 Bayer Pharma Aktiengesellschaft 2-aryl- and 2-arylalkyl-benzimidazoles as mIDH1 inhibitors
WO2017008046A1 (en) 2015-07-08 2017-01-12 Children's Hospital Medical Center Loss of transcriptional fidelity leads to immunotherapy resistance in cancers
US10045985B2 (en) 2015-07-09 2018-08-14 Merck Patent Gmbh Heteroaryl compounds as BTK inhibitors and uses thereof
WO2017005711A1 (en) 2015-07-09 2017-01-12 Bayer Pharma Aktiengesellschaft Phosphorous-and sulfur-substituted benzodiazepine derivatives
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US10292961B2 (en) 2015-07-15 2019-05-21 Hangzhou Dac Biotech Co., Ltd. Disulfur bridge linkers for conjugation of a cell-binding molecule
US10414734B2 (en) 2015-07-16 2019-09-17 Bayer Pharma Aktiengesellschaft 5-hydroxyalkylbenzimidazoles as mIDH1 inhibitors
EP3121166A1 (en) 2015-07-21 2017-01-25 Bayer Pharma Aktiengesellschaft Fused imidazoles as midh1 inhibitors
GB201512869D0 (en) 2015-07-21 2015-09-02 Almac Diagnostics Ltd Gene signature for minute therapies
WO2017019767A1 (en) 2015-07-27 2017-02-02 Myosotis, Llc Inhibition of CXCL12 in Cancer Immunotherapy
CA2993644A1 (en) 2015-07-28 2017-02-02 Beta Cat Pharmaceuticals, Inc. Anthracene-9, 10-dione dioxime compounds prodrugs and their uses
ES2878188T3 (en) 2015-07-29 2021-11-18 Novartis Ag Combination therapies comprising antibody molecules against LAG-3
US20180207273A1 (en) 2015-07-29 2018-07-26 Novartis Ag Combination therapies comprising antibody molecules to tim-3
CN108025051B (en) 2015-07-29 2021-12-24 诺华股份有限公司 Combination therapy comprising anti-PD-1 antibody molecules
EP3124609A1 (en) 2015-07-29 2017-02-01 IFOM Fondazione Istituto Firc di Oncologia Molecolare Therapeutics oligonucleotides
WO2017018476A1 (en) 2015-07-29 2017-02-02 塩野義製薬株式会社 Salt of quinazoline derivative or crystal thereof, and method for producing salt of quinazoline derivative or crystal thereof
CA2993796C (en) 2015-07-29 2024-02-20 Onkimmune Limited Modified natural killer cells and natural killer cell lines having increased cytotoxicity
EP3735977A1 (en) 2015-07-31 2020-11-11 Vascular Biogenics Ltd. Motile sperm domain containing protein 2 and cancer
WO2017024009A1 (en) 2015-08-03 2017-02-09 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof
WO2017021348A1 (en) 2015-08-05 2017-02-09 Bayer Pharma Aktiengesellschaft 1h-pyrrol-3-amines
WO2017023994A1 (en) 2015-08-06 2017-02-09 Yale University Small molecule based antibody-recruiting compounds for cancer treatment
CA2993624A1 (en) 2015-08-07 2017-02-16 Thomas Helledays Stiftelse For Medicinsk Forskning Method for diagnosisng cancer or cancer-associated thrombosis by measuring levels of h3cit in plasma
US10363226B2 (en) 2015-08-12 2019-07-30 North Carolina State University Platelet membrane-coated drug delivery system
WO2017025493A1 (en) 2015-08-12 2017-02-16 Bayer Pharma Aktiengesellschaft Quinoline ezh2 inhibitors
WO2017031041A1 (en) 2015-08-17 2017-02-23 Channel Therapeutics, Inc. Functionalized aminobenzoboroxoles
EP3133165A1 (en) 2015-08-17 2017-02-22 F. Hoffmann-La Roche AG Methods for personalizing patient cancer therapy with anti angiogenic compounds
GB201514756D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compound and method of use
WO2017034234A1 (en) 2015-08-21 2017-03-02 서울대학교 산학협력단 Composite formulation for treating cancer having hdac inhibitor resistance
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
US20180250320A1 (en) 2015-08-26 2018-09-06 The Johns Hopkins University Compositions and methods for treating solid tumors
US20210292327A1 (en) 2015-08-26 2021-09-23 Gilead Sciences, Inc. Deuterated toll-like receptor modulators
US11096934B2 (en) 2015-09-01 2021-08-24 The Broad Institute, Inc. Compounds and methods useful for treating or preventing hematological cancers
RU2018111407A (en) 2015-09-02 2019-10-03 Синдакс Фармасьютикалз, Инк. SELECTION OF PATIENTS FOR COMBINED THERAPY
US10588985B2 (en) 2015-09-02 2020-03-17 Wayne State University Compositions and methods relating to RAD6 inhibition
JP6971970B2 (en) 2015-09-03 2021-11-24 エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics, Inc. Peptidomimetic macrocyclic molecules and their use
DE102015012050A1 (en) 2015-09-15 2017-03-16 Merck Patent Gmbh Compounds as ASIC inhibitors and their uses
DE102015012049A1 (en) 2015-09-15 2017-03-16 Merck Patent Gmbh Compounds as ASIC inhibitors and their uses
ES2980858T3 (en) 2015-09-15 2024-10-03 Stichting Radboud Univ Medisch Centrum Improved method for ex vivo expansion of CD34+ HSPCs into NK cells using an aryl hydrocarbon receptor antagonist
MX2018002986A (en) 2015-09-18 2018-05-02 Merck Patent Gmbh Heteroaryl compounds as irak inhibitors and uses thereof.
EP3350177B1 (en) 2015-09-18 2021-07-07 Merck Patent GmbH Heteroaryl compounds as irak inhibitors and uses thereof
US20210393674A1 (en) 2015-09-20 2021-12-23 Air Cross, Inc. Ozonolysis for activation of compounds and degradation of ozone
RU2018114459A (en) 2015-09-21 2019-10-23 Ифом Фондационе Иституто Фирк Ди Онколоджа Молеколаре NEW BLOOD CANCER TREATMENT STRATEGIES
MX377124B (en) 2015-09-21 2025-03-07 Plexxikon Inc HETEROCYCLIC COMPOUNDS AND THEIR USES.
WO2017053823A1 (en) 2015-09-25 2017-03-30 Pharmacyclics Llc Treatment using hdac inhibitors and immunotherapy
US20180271849A1 (en) 2015-09-29 2018-09-27 Kangpu Biopharmaceuticals, Ltd. Pharmaceutical composition and application thereof
CA2999516A1 (en) 2015-09-30 2017-04-06 Gilead Sciences, Inc. Compounds and combinations for the treatment of hiv
WO2017055313A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
ES2900482T3 (en) 2015-10-01 2022-03-17 Gilead Sciences Inc Combination of a Btk inhibitor and a checkpoint inhibitor for cancer treatment
WO2017055316A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
EP3355888B8 (en) 2015-10-02 2022-04-13 Pierre Fabre Medicament Hemi-synthetic trilobine analogs for use as a drug
WO2017059252A1 (en) 2015-10-02 2017-04-06 Gilead Sciences, Inc. Combinations of the btk inhibitor gs-4059 with inhibitors selected from a jak, ask1, brd and/or mmp9 inhibitor to treat cancer, allergic disorders, autoimmune diseases or inflammatory diseases
HUE054985T2 (en) 2015-10-09 2021-11-29 Boehringer Ingelheim Int Spiro [3H-indole-3,2'-pyrrolidin] -2 (1H) -one compounds and numbers as MDM2-P53 inhibitors
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
WO2017063966A1 (en) 2015-10-13 2017-04-20 Bayer Pharma Aktiengesellschaft Substituted 2-(1h-pyrazol-1-yl)-benzothiazole compounds
CN105288648B (en) 2015-10-14 2018-11-06 东南大学 A kind of phosphatide cpd of hydrophilic medicament, its pharmaceutical composition and application
US20180346877A1 (en) 2015-10-15 2018-12-06 Celularity, Inc. Natural killer cells and ilc3 cells and uses thereof
WO2017063959A1 (en) 2015-10-15 2017-04-20 Bayer Pharma Aktiengesellschaft N-sulphoximinophenyl-substituted benzodiazepine derivatives as bet protein inhibitors
US20190055563A1 (en) 2015-10-19 2019-02-21 Dana-Farber Cancer Institute, Inc. Polymerase q as a target in hr-deficient cancers
KR20180067677A (en) 2015-10-23 2018-06-20 다이이찌 산쿄 가부시키가이샤 Pharmaceutical compositions for use in the treatment of AML and methods of treating AML in subjects in need thereof
US20170115275A1 (en) 2015-10-23 2017-04-27 Arizona Board Of Regents On Behalf Of Arizona State University Engineered substrates for high-throughput generation of 3d models of tumor dormancy, relapse and micrometastases for phenotype specific drug discovery and development
JP6855472B2 (en) 2015-10-23 2021-04-07 第一三共株式会社 MDM2 inhibitor dosing regimen to treat cancer
WO2017074788A1 (en) 2015-10-27 2017-05-04 The Broad Institute Inc. Compositions and methods for targeting cancer-specific sequence variations
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
WO2017075478A2 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
LT3370768T (en) 2015-11-03 2022-05-25 Janssen Biotech, Inc. Antibodies specifically binding pd-1 and their uses
US20190038713A1 (en) 2015-11-07 2019-02-07 Multivir Inc. Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
CN105457038A (en) 2015-11-09 2016-04-06 东南大学 Quick release type medicine phosphatide compound and medicine composition thereof
MX2018005830A (en) 2015-11-10 2018-11-12 Univ Yale Compositions and methods for treating autoimmune diseases and cancers.
AU2016352572B2 (en) 2015-11-12 2023-10-19 Hookipa Biotech Gmbh Arenavirus particles as cancer vaccines
WO2017086367A1 (en) 2015-11-18 2017-05-26 中外製薬株式会社 Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
TWI724056B (en) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Inhibitors of cxcr2
TWI734715B (en) 2015-11-19 2021-08-01 美商卡默森屈有限公司 Modulators of chemokine receptors
AU2016355268B2 (en) 2015-11-20 2021-08-19 Senhwa Biosciences, Inc. Combination therapy of tetracyclic quinolone analogs for treating cancer
EP3440579A4 (en) 2015-11-24 2020-03-25 Klaritos, Inc. Novel healthcare delivery, treatment, and payment model for specialty drugs
UA126897C2 (en) 2015-12-01 2023-02-22 Генмаб Б.В. ANTIBODIES AGAINST DR5 AND METHODS OF THEIR APPLICATION
WO2017091865A1 (en) 2015-12-03 2017-06-08 Alfred Health Monitoring treatment or progression of myeloma
US10654818B2 (en) 2015-12-03 2020-05-19 Bayer Pharma Aktiengesellschaft Furane derivatives as inhibitors of ATAD2
US10722529B2 (en) 2015-12-03 2020-07-28 Temple University—Of the Commonwealth System of Higher Education Modulation of NAD+ metabolic pathways for treatment of disease
PH12018501155B1 (en) 2015-12-04 2024-06-28 Boehringer Ingelheim Int Biparatopic polypeptides antagonizing wnt signaling in tumor cells
CN106821965A (en) 2015-12-04 2017-06-13 中国科学院大连化学物理研究所 A kind of vitamin A acid multiple medicine delivers nanoparticle solution and its preparation and application altogether
CN108368143B (en) 2015-12-09 2022-02-01 维也纳医科大学 Monomaleimide functionalized platinum compounds for cancer therapy
US10969392B2 (en) 2015-12-10 2021-04-06 Vanderbilt University Methods and systems for predicting response to immunotherapies for treatment of cancer
TWI814056B (en) 2015-12-15 2023-09-01 美商基利科學股份有限公司 Human immunodeficiency virus neutralizing antibodies
US20200216439A1 (en) 2015-12-16 2020-07-09 Bayer Pharma Aktiengesellschaft Hetero-1,5,6,7-tetrahydro-4h-indol-4-ones
CN109069570A (en) 2015-12-16 2018-12-21 默沙东公司 Anti- LAG3 antibody and antigen-binding fragment
JP6882299B2 (en) 2015-12-17 2021-06-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Polycyclic TLR7 / 8 antagonists and their use in the treatment of immune disorders
CA3006772A1 (en) 2015-12-17 2017-06-22 Gilead Sciences, Inc. Tank-binding kinase inhibitor compounds
US20180371093A1 (en) 2015-12-17 2018-12-27 Novartis Ag Antibody molecules to pd-1 and uses thereof
EP3389711A1 (en) 2015-12-18 2018-10-24 Novartis AG Antibodies targeting cd32b and methods of use thereof
WO2017102091A1 (en) 2015-12-18 2017-06-22 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
US20200268720A1 (en) 2015-12-22 2020-08-27 Glaxosmithkline Llc Methods of use of a class iia hdac inhibitor
EP3405587A4 (en) 2015-12-23 2019-10-30 Moonshot Pharma LLC METHODS OF INDUCING AN IMMUNE RESPONSE BY ENABLING READING OF PREMATURE STOP CODONS
WO2017117196A1 (en) 2015-12-28 2017-07-06 Syndax Pharmaceuticals, Inc. Combination of hdac inhibitor and anti-pd-l1 antibody for treatment of ovarian cancer
US10189797B2 (en) 2015-12-30 2019-01-29 Duke University Chemical modulators of immune checkpoints and therapeutic use
ES2964746T3 (en) 2015-12-30 2024-04-09 Celgene Corp Methods of production of T lymphocytes and T lymphocytes produced by the same
US20190183870A1 (en) 2016-01-05 2019-06-20 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Combination of histone deacetylase inhibitor and immunotherapy
DK3400291T4 (en) 2016-01-08 2024-04-02 Replimune Ltd Engineered virus
AU2017207291B2 (en) 2016-01-11 2023-06-15 The Rockefeller University Methods for the treatment of myeloid derived suppressor cells related disorders
WO2017121684A1 (en) 2016-01-14 2017-07-20 Bayer Pharma Aktiengesellschaft 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
WO2017127414A1 (en) 2016-01-19 2017-07-27 Celgene Corporation Transgenic mouse expressing human cereblon
EP3405177A1 (en) 2016-01-19 2018-11-28 Janssen Pharmaceutica NV Formulations/compositions comprising a btk inhibitor
US10973843B2 (en) 2016-01-27 2021-04-13 University Of Maryland, Baltimore Method for monitoring cancer and for regulation of semaphorin 4D to improve cancer immunotherapy regimens
RU2018130831A (en) 2016-01-28 2020-03-02 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн APPLICATION OF HISTONIC DEACETHYLASE INHIBITORS TO IMPROVE IMMUNOTHERAPY
DK3408407T3 (en) 2016-01-29 2021-02-08 Epigenomics Ag METHODS FOR DETECTING CPG METHYLATION OF TUMOR-DERIVATED DNA IN BLOOD SAMPLES
TN2018000271A1 (en) 2016-02-01 2020-01-16 Bayer Pharma AG Copanlisib biomarkers.
GB201601773D0 (en) 2016-02-01 2016-03-16 Renishaw Plc Method
AU2017215096A1 (en) 2016-02-01 2018-08-09 Bayer Pharma Aktiengesellschaft Copanlisib biomarkers
WO2017134116A1 (en) 2016-02-02 2017-08-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer
WO2017136342A1 (en) 2016-02-02 2017-08-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells
MY195114A (en) 2016-02-04 2023-01-10 Robert Yongxin Zhao Specific Conjugation Linkers, Specific Immunoconjugates Thereof, Methods of Making and uses Such Conjugates Thereof
CA3013402C (en) 2016-02-05 2024-05-28 Bayer Pharma Aktiengesellschaft Compounds, compositions and methods for cancer patient stratification and cancer treatment
US10912748B2 (en) 2016-02-08 2021-02-09 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
CN108601841A (en) 2016-02-10 2018-09-28 免疫医疗公司 The combination of ABCG2 inhibitor and SACITUZUMAB GOVITECAN (IMMU-132) overcome the resistance to SN-38 in the cancer for expressing TROP-2
WO2017143035A2 (en) 2016-02-17 2017-08-24 The Penn State Research Foundation Method and therapeutic use of pign and other genes or genes products that pign interacts with for prognosis and treatment of hematological neoplasias
WO2017143237A1 (en) 2016-02-17 2017-08-24 Acetylon Pharmaceuticals, Inc. Increasing expression of interferon regulated genes with combinatons of histone deacetylase inhibitors and immunomodulatory drugs
US20200121699A1 (en) 2016-02-22 2020-04-23 Onxeo Combination therapies comprising immuno-oncology agents and belinostat
JP2019511919A (en) 2016-02-23 2019-05-09 ブローディ，チャヤ Production of cancer stem cells and use thereof
US20170247690A1 (en) 2016-02-25 2017-08-31 Agenovir Corporation Oncoviral treatment with nuclease and chemotherapeutic
AU2017228371A1 (en) 2016-03-04 2018-09-13 Gilead Sciences, Inc. Compositions and combinations of autotaxin inhibitors
US10143746B2 (en) 2016-03-04 2018-12-04 Bristol-Myers Squibb Company Immunomodulators
WO2017148995A1 (en) 2016-03-04 2017-09-08 Bayer Pharma Aktiengesellschaft 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity
CN109071669A (en) 2016-03-07 2018-12-21 查尔斯顿制药有限责任公司 Anti- paranuclein antibody
EP3426657B1 (en) 2016-03-08 2022-07-13 Bayer Pharma Aktiengesellschaft 2 amino n [7 methoxy 2, 3-dihydroimidazo-[1, 2-c]quinazolin-5-yl]pyrimidine 5 carboxamides
WO2017156147A1 (en) 2016-03-08 2017-09-14 The Board Of Regents For Oklahoma State University Office Of Intellectual Property Management Technology Development Center Immune boosting dietary compounds for disease control and prevention
US10717774B2 (en) 2016-03-14 2020-07-21 Kiromic, Inc. Compositions and methods for treating cancers
WO2017160717A2 (en) 2016-03-15 2017-09-21 Memorial Sloan Kettering Cancer Center Method of treating diseases using kinase modulators
WO2017157418A1 (en) 2016-03-15 2017-09-21 Bayer Pharma Aktiengesellschaft Combination of mknk1-inhibitors
US20170268001A1 (en) 2016-03-16 2017-09-21 The University Of Chicago Rnas with tumor radio/chemo-sensitizing and immunomodulatory properties and methods of their preparation and application
EP3219329A1 (en) 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinations of copanlisib
WO2017157991A1 (en) 2016-03-18 2017-09-21 Bayer Pharma Aktiengesellschaft 1-alkyl-pyrazoles and -indazoles as bub1 inhibitors for the treatment of hyperproliferative diseases
WO2017157992A1 (en) 2016-03-18 2017-09-21 Bayer Pharma Aktiengesellschaft Annulated pyrazoles as bub1 kinase inhibitors for treating proliferative disorders
WO2017161331A1 (en) 2016-03-18 2017-09-21 Procept Biorobotics Corporation Minimally invasive methods and systems for hemostasis in a bleeding closed tissue volume
US20170273926A1 (en) 2016-03-24 2017-09-28 Orbus Therapeutics, Inc. Compositions and methods for use of eflornithine and derivatives and analogs thereof to treat cancers, including gliomas
TWI808055B (en) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-1 inhibitors
TWI794171B (en) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-l1 inhibitors
CN105949114A (en) 2016-06-27 2016-09-21 山东川成医药股份有限公司 Synthesis method of chidamide
EP3487492A4 (en) 2016-07-20 2020-03-11 Eisai R&D Management Co., Ltd. Use of eribulin and histone deacetylase inhibitors in the treatment of cancer
CN106866571B (en) 2017-01-20 2018-06-29 中国药科大学 Heterocyclic urea compound and its pharmaceutical composition and application
RU2733950C1 (en) 2017-02-13 2020-10-08 Канпу Биофармасьютикалс, Лтд. Combination for treating prostate cancer, a pharmaceutical composition and a method of treating
CN106916101B (en) 2017-02-15 2020-05-01 聚缘（上海）生物科技有限公司 NAMPT/HDAC dual-target inhibitor and preparation method thereof
CN107011238B (en) 2017-03-14 2020-05-01 北京化工大学 Histone deacetylase inhibitor and preparation method and application thereof
JP7187486B2 (en) 2017-05-25 2022-12-12 レイドス， インコーポレイテッド PD-1 and CTLA-4 Dual Inhibitor Peptides
US20190046513A1 (en) 2017-08-10 2019-02-14 Huya Bioscience International, Llc Combination therapies of hdac inhibitors and tubulin inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015157162A1 (en) * 2014-04-06 2015-10-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Histone deacetylase as a modulator of pdl1 expression and activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Study of HBI-8000 With Nivolumab in Melanoma, Renal Cell Carcinoma and Non-Small Cell Lung Cancer - NCT02718066", CLINICALTRIALS.GOV, 24 March 2016 (2016-03-24), Internet, pages 1 - 9, XP055647346, Retrieved from the Internet <URL:https://clinicaltrials.gov/ct2/show/record/NCT02718066> [retrieved on 20191128] *
DAVID M WOODS ET AL: "Abstract 257: Class I HDAC inhibition upregulates PD-1 ligands in melanoma and increases the efficacy of PD-1 blockade", PROCEEDINGS: AACR 106TH ANNUAL MEETING, 18 April 2015 (2015-04-18), pages 1 - 2, XP055647334, Retrieved from the Internet <URL:https://cancerres.aacrjournals.org/content/75/15_Supplement/257> [retrieved on 20191128], DOI: 10.1158/1538-7445.AM2015-257 *
REID P BISSONNETTE ET AL: "Abstract B108: The HDAC inhibitor HBI-8000 enhances immunotherapy with either PD-1 or PD-L1 blockade in the MC38 model of colon cancer", vol. 4, no. 11 Suppl, 25 September 2016 (2016-09-25), XP002795767, Retrieved from the Internet <URL:https://cancerimmunolres.aacrjournals.org/content/4/11_Supplement/B108> [retrieved on 20191031], DOI: 10.1158/2326-6066.IMM2016-B108 *
ZHI-QIANG NING ET AL: "Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 69, no. 4, 12 November 2011 (2011-11-12), pages 901 - 909, XP035035155, ISSN: 1432-0843, DOI: 10.1007/S00280-011-1766-X *

Also Published As

Publication number Publication date
EP4450085A2 (en) 2024-10-23
JP7190549B2 (en) 2022-12-15
JP2019519498A (en) 2019-07-11
US12122833B2 (en) 2024-10-22
CN109562177A (en) 2019-04-02
EP3454844A1 (en) 2019-03-20
AU2017263478B2 (en) 2022-04-21
US20180355042A1 (en) 2018-12-13
US20200172621A1 (en) 2020-06-04
JP2022017296A (en) 2022-01-25
EP4450085A3 (en) 2024-12-25
US20170327582A1 (en) 2017-11-16
KR20190022521A (en) 2019-03-06
DK3454844T3 (en) 2024-10-07
WO2017197153A8 (en) 2018-11-01
US10287353B2 (en) 2019-05-14
IL262814A (en) 2018-12-31
MX2018013591A (en) 2019-11-07
MA44991A (en) 2019-03-20
AU2017263478A1 (en) 2018-11-29
PT3454844T (en) 2024-10-02
IL262814B1 (en) 2023-09-01
WO2017197153A1 (en) 2017-11-16
MX2022001834A (en) 2022-03-17
KR20220123743A (en) 2022-09-08
IL262814B2 (en) 2024-01-01
EP3454844B1 (en) 2024-07-03
CA3023549A1 (en) 2017-11-16
TWI808055B (en) 2023-07-11
KR102469268B1 (en) 2022-11-22
JP7013387B2 (en) 2022-01-31
AU2022202392A1 (en) 2022-05-05
ES2988149T3 (en) 2024-11-19
US10385130B2 (en) 2019-08-20
TW201740943A (en) 2017-12-01
BR112018073329A2 (en) 2019-02-26
US20250026832A1 (en) 2025-01-23

Similar Documents

Publication Publication Date Title
EP3454844A4 (en) COMBINATION THERAPIES OF HDAC INHIBITORS AND PD-1 INHIBITORS
IL262808A (en) Combination therapies of hdac inhibitors and pd-l1 inhibitors
EP3541932A4 (en) INHIBITORS OF CRISPR-CAS9
EP3442420C0 (en) PREDICTION AND MONITORING OF VITAMINATION
HK1258058A1 (en) Anti-TIGIT antibodies and methods of use
IL264486A (en) Combination therapies of chimeric antigen receptors and pd-1 inhibitors
DK3368069T3 (en) USE OF MYOSTATINI INHIBITORS AND COMBINATION THERAPIES
EP3634430A4 (en) MULTIBIOTICS AND METHOD OF USING THEREFORE
EP3600273A4 (en) CD73 INHIBITORS AND USES THEREOF
EP4212536C0 (en) Benzoxazepine-oxazolidinone compounds and methods of use
EP3746075A4 (en) GCN2 INHIBITORS AND USES THEREOF
RS62568B1 (en) PD-1-BINDING MOLECULES AND METHODS OF THEIR USE
PT3548033T (en) COMPOUNDS AND THEIR METHODS OF USE
PT3319612T (en) OXISTEROLS AND METHODS OF USE THEREOF
PT3250610T (en) FCRN ANTIBODIES AND METHODS OF USE THEREOF
HK1254129A1 (en) Methods of administering glutaminase inhibitors
EP3125952C0 (en) STABLE COMPOSITIONS OF NON-COMPLEXED IODINE AND METHODS OF USE
EP3592731A4 (en) INHIBITORS OF MALT1 AND USES THEREOF
EP3572400A4 (en) EZH2 INHIBITOR AND USE OF IT
EP3548497A4 (en) POLYMORPHES OF SEPIAPTERIN AND SALT THEREOF
DE102016116153A8 (en) EFFECTIVE TRACKING OF PLACES OF PERSONAL DEVICES
EP3551625A4 (en) HETEROCYCLIC INHIBITORS OF MCT4
EP3543240A4 (en) URAT1 INHIBITOR AND USE THEREOF
EP3728267A4 (en) TRICYCLIC INHIBITORS OF BCL6-BTB DOMAIN-PROTEIN-PROTEIN INTERACTION AND USES THEREOF
EP3405477C0 (en) INHIBITORS OF TRANSGLUTAMINASE

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20181107

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

A4 Supplementary search report drawn up and despatched

Effective date: 20191216

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 39/395 20060101ALI20191210BHEP

Ipc: C12Q 1/70 20060101ALI20191210BHEP

Ipc: A61K 38/15 20060101ALI20191210BHEP

Ipc: A61K 31/395 20060101ALI20191210BHEP

Ipc: A61K 45/06 20060101ALI20191210BHEP

Ipc: C12Q 1/68 20180101ALI20191210BHEP

Ipc: A61K 31/4184 20060101ALI20191210BHEP

Ipc: C07K 14/16 20060101ALI20191210BHEP

Ipc: A61K 31/4045 20060101ALI20191210BHEP

Ipc: A61K 31/136 20060101ALI20191210BHEP

Ipc: A61K 31/18 20060101ALI20191210BHEP

Ipc: A61K 31/13 20060101AFI20191210BHEP

Ipc: C07K 16/28 20060101ALI20191210BHEP

Ipc: A61K 31/4406 20060101ALI20191210BHEP

Ipc: A61K 31/167 20060101ALI20191210BHEP

Ipc: A61K 31/506 20060101ALI20191210BHEP

Ipc: A61P 35/00 20060101ALI20191210BHEP

Ipc: A61K 31/343 20060101ALI20191210BHEP

Ipc: A61K 39/21 20060101ALI20191210BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40008034

Country of ref document: HK

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20210519

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: HUYABIO INTERNATIONAL, LLC

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20231222

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602017083021

Country of ref document: DE

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Ref document number: 3454844

Country of ref document: PT

Date of ref document: 20241002

Kind code of ref document: T

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20240920

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20240930

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20240703

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2988149

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20241119

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1699085

Country of ref document: AT

Kind code of ref document: T

Effective date: 20240703

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20241003

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20241004

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20241103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20241003

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20241003

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20241003

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20241103

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20241004

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240703