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EP3143379A4 - Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation - Google Patents

Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation Download PDF

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Publication number
EP3143379A4
EP3143379A4 EP15792752.6A EP15792752A EP3143379A4 EP 3143379 A4 EP3143379 A4 EP 3143379A4 EP 15792752 A EP15792752 A EP 15792752A EP 3143379 A4 EP3143379 A4 EP 3143379A4
Authority
EP
European Patent Office
Prior art keywords
imaging
flow cell
cell assemblies
microfluidic flow
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15792752.6A
Other languages
German (de)
English (en)
Other versions
EP3143379A1 (fr
Inventor
Kashan Ali Shaikh
Mengli Wang
Adriana Ines Larriera Moreno
Jessica Godin Karp
Christine Lynne Pitner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/277,503 external-priority patent/US9080941B2/en
Application filed by General Electric Co filed Critical General Electric Co
Publication of EP3143379A1 publication Critical patent/EP3143379A1/fr
Publication of EP3143379A4 publication Critical patent/EP3143379A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/05Flow-through cuvettes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/30Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
    • B01F31/31Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/025Align devices or objects to ensure defined positions relative to each other
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/028Modular arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874Three dimensional network
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/12Specific details about materials
    • B01L2300/123Flexible; Elastomeric
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0346Capillary cells; Microcells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP15792752.6A 2014-05-14 2015-04-24 Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation Ceased EP3143379A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/277,503 US9080941B2 (en) 2012-04-27 2014-05-14 Microfluidic flow cell assemblies for imaging and method of use
PCT/US2015/027549 WO2015175188A1 (fr) 2014-05-14 2015-04-24 Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation

Publications (2)

Publication Number Publication Date
EP3143379A1 EP3143379A1 (fr) 2017-03-22
EP3143379A4 true EP3143379A4 (fr) 2017-05-31

Family

ID=54480428

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15792752.6A Ceased EP3143379A4 (fr) 2014-05-14 2015-04-24 Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation

Country Status (3)

Country Link
EP (1) EP3143379A4 (fr)
JP (1) JP6723541B2 (fr)
WO (1) WO2015175188A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150166956A1 (en) * 2013-12-16 2015-06-18 General Electric Company Devices for separation of particulates, associated methods and systems
FR3063990A1 (fr) * 2017-03-17 2018-09-21 Commissariat A L'energie Atomique Et Aux Energies Alternatives Dispositif micro-fluidique
ES2992887T3 (en) 2017-04-27 2024-12-19 Mochida Pharm Co Ltd Novel tetrahydronaphthyl urea derivatives as inhibitors of tropomyosin receptor kinase a for the treatment of pain
US11326989B2 (en) * 2017-10-26 2022-05-10 Essenlix Corporation Devices and methods for tissue and cell staining
CA3134919C (fr) 2019-03-26 2022-11-15 Siemens Healthcare Diagnostics Inc. Procedes et et appareil pour effectuer des mesures d'echantillons en utilisant la lumiere visible sur des echantillons manipules avec des ondes acoustiques
CA3155289A1 (fr) * 2019-09-23 2021-04-01 Element Biosciences, Inc. Procedes de sequencage d'acide nucleique adressable cellulairement

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020185184A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic synthesis devices and methods
WO2003015922A1 (fr) * 2001-08-20 2003-02-27 Biomicro Systems, Inc. Dispositif d'interface a microreseaux stratifie
US20050019898A1 (en) * 2001-03-09 2005-01-27 Nils Adey Fluid mixing in low aspect ratio chambers
US20090081464A1 (en) * 2005-12-06 2009-03-26 Philip Summersgill Fine Line Bonding and/or Sealing System and Method
US20100179068A1 (en) * 2007-05-03 2010-07-15 Clondiag Gmbh Assays
EP2388500A1 (fr) * 2010-05-18 2011-11-23 Samsung Electronics Co., Ltd. Microvanne et procédé destiné à sa fabrication
US20120128548A1 (en) * 2007-08-14 2012-05-24 Arcxis Biotechnologies Polymer microfluidic biochip fabrication
WO2013106458A2 (fr) * 2012-01-09 2013-07-18 Micronics, Inc. Filière de réacteur microfluidique
US20130287645A1 (en) * 2012-04-27 2013-10-31 General Electric Company Microfluidic chamber device and fabrication

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147606A (en) * 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5872582A (en) * 1996-07-02 1999-02-16 Hewlett-Packard Company Microfluid valve for modulating fluid flow within an ink-jet printer
JP3777112B2 (ja) * 2001-11-02 2006-05-24 財団法人川村理化学研究所 マイクロ流体デバイス及びその製造方法
WO2004103563A2 (fr) * 2003-05-20 2004-12-02 Fluidigm Corporation Procede et systeme pour dispositif microfluidique et son imagerie
JP2007322284A (ja) * 2006-06-01 2007-12-13 Konica Minolta Medical & Graphic Inc マイクロチップおよびマイクロチップへの試薬の充填方法
US9494500B2 (en) * 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019898A1 (en) * 2001-03-09 2005-01-27 Nils Adey Fluid mixing in low aspect ratio chambers
US20020185184A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic synthesis devices and methods
WO2003015922A1 (fr) * 2001-08-20 2003-02-27 Biomicro Systems, Inc. Dispositif d'interface a microreseaux stratifie
US20090081464A1 (en) * 2005-12-06 2009-03-26 Philip Summersgill Fine Line Bonding and/or Sealing System and Method
US20100179068A1 (en) * 2007-05-03 2010-07-15 Clondiag Gmbh Assays
US20120128548A1 (en) * 2007-08-14 2012-05-24 Arcxis Biotechnologies Polymer microfluidic biochip fabrication
EP2388500A1 (fr) * 2010-05-18 2011-11-23 Samsung Electronics Co., Ltd. Microvanne et procédé destiné à sa fabrication
WO2013106458A2 (fr) * 2012-01-09 2013-07-18 Micronics, Inc. Filière de réacteur microfluidique
US20130287645A1 (en) * 2012-04-27 2013-10-31 General Electric Company Microfluidic chamber device and fabrication

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2015175188A1 *

Also Published As

Publication number Publication date
EP3143379A1 (fr) 2017-03-22
WO2015175188A1 (fr) 2015-11-19
JP6723541B2 (ja) 2020-07-15
JP2017516099A (ja) 2017-06-15

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