EP2566484A4 - Compositions contenant des nucléosides puriques et pyrimidiniques, des peptides, et du manganèse, et utilisations associées - Google Patents

Compositions contenant des nucléosides puriques et pyrimidiniques, des peptides, et du manganèse, et utilisations associées

Info

Publication number: EP2566484A4
Authority: EP; European Patent Office
Prior art keywords: pyrimidinic; puric; nucleosides; peptides; manganese
Prior art date: 2010-04-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP11778041.1A

Other languages

German (de)

English (en)

Other versions

EP2566484B1 (fr

EP2566484A2 (fr

Inventor

Michael J Daly

Elena K Gaidamakova

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Henry M Jackson Foundation for Advancedment of Military Medicine Inc

Original Assignee

Henry M Jackson Foundation for Advancedment of Military Medicine Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-04-29

Filing date

2011-04-29

Publication date

2014-03-05

2011-04-29 Application filed by Henry M Jackson Foundation for Advancedment of Military Medicine Inc filed Critical Henry M Jackson Foundation for Advancedment of Military Medicine Inc

2013-03-13 Publication of EP2566484A2 publication Critical patent/EP2566484A2/fr

2014-03-05 Publication of EP2566484A4 publication Critical patent/EP2566484A4/fr

2017-09-13 Application granted granted Critical

2017-09-13 Publication of EP2566484B1 publication Critical patent/EP2566484B1/fr

Status Active legal-status Critical Current

2031-04-29 Anticipated expiration legal-status Critical

Links

WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/00061—Methods of inactivation or attenuation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10311—Siphoviridae
- C12N2795/10334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Virology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)

EP11778041.1A 2010-04-29 2011-04-29 Procédure pour le production des vaccines comprenant l'irradiation des microorganismes dans une composition comprenant des acides aminés et d'orthophosphate de manganèse Active EP2566484B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32938110P	2010-04-29	2010-04-29
PCT/US2011/034484 WO2011139881A2 (fr)	2010-04-29	2011-04-29	Compositions contenant des nucléosides puriques et pyrimidiniques, des peptides, et du manganèse, et utilisations associées

Publications (3)

Publication Number	Publication Date
EP2566484A2 EP2566484A2 (fr)	2013-03-13
EP2566484A4 true EP2566484A4 (fr)	2014-03-05
EP2566484B1 EP2566484B1 (fr)	2017-09-13

Family

ID=44904396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP11778041.1A Active EP2566484B1 (fr)	2010-04-29	2011-04-29	Procédure pour le production des vaccines comprenant l'irradiation des microorganismes dans une composition comprenant des acides aminés et d'orthophosphate de manganèse

Country Status (9)

Country	Link
US (2)	US9234168B2 (fr)
EP (1)	EP2566484B1 (fr)
JP (3)	JP5916147B2 (fr)
CN (1)	CN102946888B (fr)
AU (2)	AU2011248517B2 (fr)
BR (1)	BR112012027740B1 (fr)
CA (2)	CA2797716C (fr)
ES (1)	ES2647584T3 (fr)
WO (1)	WO2011139881A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2011248517B2 (en) *	2010-04-29	2016-02-25	The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.	Compositions containing purine and pyrimidine nucleosides, peptides, and manganese and their uses
ITMI20112390A1 (it)	2011-12-27	2013-06-28	Biodue S P A	Composizione per un dispositivo medico o per un preparato cosmetico o farmaceutico
WO2019194862A2 (fr) *	2017-09-29	2019-10-10	The Henry M. Jackson Foundation For The Advancement Of Military Medicine	Radioprotecteurs et résonance paramagnétique électronique pour la détermination de la résistance cellulaire à un rayonnement ionisant sans exposition au rayonnement
CA3095478A1 (fr) *	2018-03-30	2019-10-03	Biological Mimetics, Inc.	Poliovirus inactive par irradiation, compositions les comprenant, et procedes de preparation
EP3919022A4 (fr)	2019-01-31	2022-03-16	Cell-Medicine, Inc.	Instrument médical composite à base de sel inorganique-protéine
EP4267175A4 (fr) *	2020-12-22	2024-12-11	Biological Mimetics, Inc.	Immunogènes à cellules entières irradiés d'acinetobacter baumannii

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4959211A (en) *	1987-04-28	1990-09-25	Lombardo Jorge H	Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine
US20030143707A1 (en) *	2001-08-14	2003-07-31	Japan Atomic Energy Research Institute	Proteins having DNA repair promoting activity
WO2009045655A2 (fr) *	2007-08-16	2009-04-09	The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.	Compositions contenant des nucléosides de purine et du manganèse et utilisations de celles-ci

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4897346A (en)	1986-07-15	1990-01-30	Beckman Instruments, Inc.	Stabilized liquid enzyme composition for glucose determination
JPH01124395A (ja)	1986-10-06	1989-05-17	Univ Calgary	脂質基材による放射線の防護
ES2007350A6 (es)	1987-05-29	1989-06-16	Ganadera Union Ind Agro	Productos alimenticios enriquecidos con nucleosidos yno nucleotidos para la nutricion infantil y de adultos, y procedimiento para su preparacion.
EP0355131B1 (fr)	1987-10-28	1996-09-04	Pro-Neuron, Inc.	Derives de desoxyribonucleosides d'acyle et leurs utilisations
CA2041828A1 (fr)	1990-03-05	1992-11-04	Richard L. Lindstrom	Solution viscoelastique
US6187572B1 (en) *	1990-04-16	2001-02-13	Baxter International Inc.	Method of inactivation of viral and bacterial blood contaminants
ATE179615T1 (de)	1991-02-08	1999-05-15	Pro Neuron Inc	Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese
FR2713240B1 (fr)	1993-12-02	1996-03-01	Bio Merieux	Milieu nutritif pour la culture de microorganismes.
WO1996004923A1 (fr)	1994-08-12	1996-02-22	Pro-Neuron, Inc.	Procedes permettant de traiter la sepsie ou des maladies inflammatoires avec des nucleosides a base d'oxypurine
US20060264357A1 (en)	1997-04-22	2006-11-23	Zikria Bashir A	Capillary membrane stabilization and reduction of tissue injury through use of biodegradable macromolecules with antioxidants and/or other chemicals
WO2002053138A2 (fr)	2001-01-02	2002-07-11	Elisabeth Shanahan-Prendergast	Traitement pour inhiber des lesions neoplasiques
US20040029129A1 (en) *	2001-10-25	2004-02-12	Liangsu Wang	Identification of essential genes in microorganisms
US7597879B2 (en)	2002-11-29	2009-10-06	Bioderm Research	Sunscreen safety and efficacy enhancement
AU2003300351A1 (en)	2002-12-19	2004-07-14	Praecis Pharmaceuticals, Inc.	Methods of enhancing immune system function in a subject
JP2007176879A (ja)	2005-12-28	2007-07-12	Natl Inst Of Radiological Sciences	酵母を有効成分とする放射線防護剤
US8414899B2 (en)	2006-04-11	2013-04-09	Yeda Research And Development Co. Ltd.	Vaccines comprising multimeric HSP60 peptide carriers
WO2009020480A2 (fr) *	2007-04-26	2009-02-12	The Scripps Research Institute	Inhibiteurs de mutation génomique qui inhibent des adn polymérases de la famille y
EP2344189B1 (fr)	2008-09-30	2018-05-30	University of Maryland, Baltimore	Vaccin protecteur contre des biofilms de staphylococcus aureus renfermant des immunogènes associés à la paroi cellulaire
AU2011248517B2 (en) *	2010-04-29	2016-02-25	The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.	Compositions containing purine and pyrimidine nucleosides, peptides, and manganese and their uses

2011
- 2011-04-29 AU AU2011248517A patent/AU2011248517B2/en active Active
- 2011-04-29 US US13/643,794 patent/US9234168B2/en active Active
- 2011-04-29 JP JP2013508274A patent/JP5916147B2/ja active Active
- 2011-04-29 WO PCT/US2011/034484 patent/WO2011139881A2/fr active Application Filing
- 2011-04-29 CA CA2797716A patent/CA2797716C/fr active Active
- 2011-04-29 CN CN201180021507.XA patent/CN102946888B/zh active Active
- 2011-04-29 ES ES11778041.1T patent/ES2647584T3/es active Active
- 2011-04-29 EP EP11778041.1A patent/EP2566484B1/fr active Active
- 2011-04-29 CA CA3012801A patent/CA3012801A1/fr not_active Abandoned
- 2011-04-29 BR BR112012027740-5A patent/BR112012027740B1/pt active IP Right Grant
2015
- 2015-12-08 US US14/962,596 patent/US9758760B2/en active Active
2016
- 2016-01-08 JP JP2016002815A patent/JP6422898B2/ja active Active
- 2016-05-25 AU AU2016203411A patent/AU2016203411B2/en active Active
2017
- 2017-07-13 JP JP2017137261A patent/JP2017222687A/ja active Pending

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4959211A (en) *	1987-04-28	1990-09-25	Lombardo Jorge H	Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine
US20030143707A1 (en) *	2001-08-14	2003-07-31	Japan Atomic Energy Research Institute	Proteins having DNA repair promoting activity
WO2009045655A2 (fr) *	2007-08-16	2009-04-09	The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.	Compositions contenant des nucléosides de purine et du manganèse et utilisations de celles-ci

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Polyvalent vaccine production by radiation inactivation of microorganisms ED - Hanekom Professor Willem; Kollmann Assist Prof Tobias R; Levy Assist Prof Ofer", VACCINE, ELSEVIER LTD, GB, vol. 4, no. 4, December 1986 (1986-12-01), pages 272 - 273, XP023711894, ISSN: 0264-410X, [retrieved on 19861201], DOI: 10.1016/0264-410X(86)90149-0 *
A. KRISKO ET AL: "Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 107, no. 32, 10 August 2010 (2010-08-10), pages 14373 - 14377, XP055073635, ISSN: 0027-8424, DOI: 10.1073/pnas.1009312107 *
ELENAK GAIDAMAKOVA ET AL: "Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn-Peptide Complex from", CELL HOST & MICROBE, ELSEVIER, NL, vol. 12, no. 1, 14 May 2012 (2012-05-14), pages 117 - 124, XP028432329, ISSN: 1931-3128, [retrieved on 20120625], DOI: 10.1016/J.CHOM.2012.05.011 *
M. J. DALY ET AL: "Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance", SCIENCE, vol. 306, no. 5698, 5 November 2004 (2004-11-05), pages 1025 - 1028, XP055097476, ISSN: 0036-8075, DOI: 10.1126/science.1103185 *
MICHAEL J. DALY ET AL: "Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans", PLOS ONE, vol. 5, no. 9, 3 September 2010 (2010-09-03), pages e12570, XP055073879, DOI: 10.1371/journal.pone.0012570 *

Also Published As

Publication number	Publication date
WO2011139881A3 (fr)	2012-03-08
BR112012027740B1 (pt)	2021-02-17
AU2016203411A1 (en)	2016-06-16
ES2647584T3 (es)	2017-12-22
CA2797716A1 (fr)	2011-11-10
JP5916147B2 (ja)	2016-05-11
CN102946888B (zh)	2018-07-31
JP6422898B2 (ja)	2018-11-14
JP2017222687A (ja)	2017-12-21
US9758760B2 (en)	2017-09-12
AU2011248517B2 (en)	2016-02-25
CA3012801A1 (fr)	2011-11-10
JP2013525456A (ja)	2013-06-20
EP2566484B1 (fr)	2017-09-13
US20130209508A1 (en)	2013-08-15
CN102946888A (zh)	2013-02-27
AU2016203411B2 (en)	2017-08-31
WO2011139881A2 (fr)	2011-11-10
CA2797716C (fr)	2018-09-11
US9234168B2 (en)	2016-01-12
EP2566484A2 (fr)	2013-03-13
US20160222343A1 (en)	2016-08-04
AU2011248517A1 (en)	2012-11-15
JP2016106104A (ja)	2016-06-16

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