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EP1945307B1 - Tensidfreie dispersionen, zusammensetzungen und verwendung in topischen formulierungen - Google Patents

Tensidfreie dispersionen, zusammensetzungen und verwendung in topischen formulierungen Download PDF

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Publication number
EP1945307B1
EP1945307B1 EP06816354A EP06816354A EP1945307B1 EP 1945307 B1 EP1945307 B1 EP 1945307B1 EP 06816354 A EP06816354 A EP 06816354A EP 06816354 A EP06816354 A EP 06816354A EP 1945307 B1 EP1945307 B1 EP 1945307B1
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EP
European Patent Office
Prior art keywords
dispersion
cps
oil
fluid
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
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EP06816354A
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English (en)
French (fr)
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EP1945307A1 (de
Inventor
David P. Jones
Duncan T. Aust
Vitthal Kulkarni
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DPT Laboratories Ltd
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DPT Laboratories Ltd
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Publication of EP1945307A1 publication Critical patent/EP1945307A1/de
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/33—Free of surfactant

Definitions

  • the present invention relates generally to the preparation of surfactant-free dispersions comprising a low viscosity hydrophilic continuous phase and the use of such dispersions in topical formulations.
  • the present invention is directed to stable surfactant-free dispersions of hydrophobic substances in low viscosity hydrophilic glyceryl polyacrylate or glyceryl polymethacrylate fluids, and topical vehicles formulated with such ingredients.
  • Topical formulations generally have to combine multiple, and sometimes competing, attributes, such as those relating to aesthetics, stability, delivery and compatibility.
  • aesthetics topical formulations are generally required to display appropriate tactile and visual properties when applied to the skin.
  • Such formulations should also maintain functionality in regard to the delivery of various active agents onto or into the skin.
  • Stability requirements apply both to individual ingredients (e.g ., active agents) as well as to more gross aspects of the product form, such as precipitation or potential separation of phases.
  • Compatibility constraints generally require that a formulation can be applied to the skin without eliciting a significant adverse reaction, such as an allergic or irritant response.
  • Formulations range from aqueous based solutions and gels to anhydrous vehicles.
  • Simple aqueous based vehicles have limitations in regard to both solubility and stability of active agents, and can have poor tactile properties.
  • Anhydrous vehicles have limitations in regard to desirable aesthetic properties.
  • Emulsions are often employed in skin formulations to obviate such problems.
  • An emulsion is a dispersion comprising two immiscible liquid phases, wherein one phase, a non-continuous phase, is dispersed into the continuous phase.
  • the two basic types of such dispersions usually comprise either a hydrophilic, e.g. aqueous, dispersed phase in a hydrophobic continuous phase (water-in-oil) or a hydrophobic dispersed phase in a hydrophilic continuous phase (oil-in-water).
  • Emulsions are generally made by preparing separate hydrophobic and hydrophilic phases and mixing the two together. This is generally accomplished with the use of one or more emulsifying agents which reduce the surface tension between the immiscible phases creating micelles, i.e ., a surfactant effect, thereby making the dispersion physically stable.
  • surfactants have long been known to be associated with skin irritation and comprise the majority of adverse skin reaction to personal care products (e.g ., Barany et al ., 1999; Bodin et al ., 2000; Effendy & Maibach, 1995).
  • Low viscosity dispersions are advantageous in that they can be readily processed through various mixers, mills and homogenizing equipment in order to produce a stable dispersion without the build up of excessive heat, which can occur when processing high viscosity "gel-like" dispersions due to friction.
  • Low viscosity dispersions can spread and absorb easily into the skin and impart a characteristic "light" feel.
  • the omission of surfactants from low viscosity dispersions would be expected to result in physical instability of the dispersed phase, i.e. phase separation, in contrast to high viscosity dispersions wherein the gel-like consistency physically stabilizes the dispersed particles.
  • US 5,928,632 discloses a surfactant free skin conditioning composition comprising a high moleculor weight emulsion stabilizer.
  • the present invention overcomes the deficiencies in the art by providing dispersions as defined in defined in claims 1 to 5 suitable for formulating topical preparations.
  • the removal of surfactants will generally enhance cutaneous compatibility of topical preparations. For instance, skin irritation can be reduced or prevented.
  • An additional benefit of the dispersions and compositions of the present invention is the reduction in manufacturing costs by excluding surfactants and detergents from the dispersions and compositions of the present invention.
  • a dispersion comprising a hydrophobic dispersed phase in a hydrophilic fluid continuous phase.
  • the hydropilic continuous phase can include glyceryl polyacrylate fluid or glyceryl polymethacrylate fluid. or mixtures of the two.
  • a unique aspect of the dispersion is that it is surfactant free and stable. Stated another way, no surfactants are needed to obtain a stable dispersion of the present invention.
  • the dispersion comprises from 30, 35, 40, 45, 50, 55, 60, 63, 70, 75, 80, 85, 90, 95 to 99%, or any range or integer derivable therein, by weight of the glyceryl polyacrylate fluid.
  • the dispersion can include from 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 to 99% or any range or integer derivable therein, by weight of the glycerol polymethacrylate fluid.
  • the viscosity of the hydrophilic fluid can range from 20 to 1600 cps. In certain aspects, the viscosity of the hydrophilic fluid is 20, 50,100,150,200,250,300,350,400, 450,500, 550.
  • the dispersion can include from about 15, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 63, 70, 75, 80, 85, 90, 95 to about 99%, or any range or integer derivable therein, by weight of the hydropbobic dispersed phase.
  • the hydrophobie phase can include a plant, animal, paraffinic, or synthetic derived fat, butter, grease, solvent, wax, or oil, or mixtures thereof.
  • the hydrophobic phase can include a non-volatile silicene, a mineral oil, a vegetable oil, a water insoluble organic ester, a water insoluble triglyceride, or a fluorinated compound or mixtures thereof.
  • the hydrophobic dispersed phase can be a liquid and/or can have a melting point below 25°C.
  • the malting point can be below 24°C, 23°C, 22°C, 21°C, 20°C, 19°C, 18°C, 17°C, 16°C, 15°C, 14°C, 13°C, 12°C, 11°C, 10°C, 9°C, 8°C. 7°C, 6°C, 5°C, 4°C, 3°C, 2°C, or 1°C.
  • the hydrophobic dispersed phase does not include a wax.
  • the dispersion of the present invention includes water, a polyol, or mixtures thereof.
  • polyols include glycerin, propylene glycol, butylene glycol, or pentylene glycol, or mixtures thereof.
  • the dispersion can be incorporated into a vehicle.
  • the vehicle can be a cosmetic or pharmaceutical vehicle.
  • the vehicle can be formulated for topical application to skin.
  • the vehicle can be a lotion, a cream, a gel, an ointment, a serum, a liquid, a fluid, a non-aerosol spray, an aerosol spray, a non-aerosol foam, or an aerosol foam:
  • the dispersion is formulated into a cosmetic skin care product.
  • the inventors disclose a formulation of a surfactant free topical vehicle that includes a dispersion of the present invention.
  • the topical vehicle can include a cosmetic ingredient, or a pharmaceutical active agent, or mixtures thereof.
  • Cosmetic ingredient includes, but is not limited to, "rheology modifiers” and "cosmetic active agents.”
  • Non-limiting examples of cosmetic ingredients include preservatives, colorants, fragrances, pH adjusters, antioxidants, chelating agents, absorbents, exfoliants, humectants, skin lightening agents, waterproofing agents, skin conditioning agents, or mixtures thereof.
  • the topical vehicle can include a rheology modifier.
  • Non-limiting examples of rheology modifiers include sodium polyacrylate, carbomer, natural gum, natural gum derivative, clay, modified clay, cellulose, cellulose derivative, magnesium aluminum silicate, gellan gum, xanthan gum, starch, and modified starch, or mixtures thereof.
  • the topical vehicle can be a lotion, cream, gel, ointment, serum, liquid, fluid, non-aerosol spray, aerosol spray, non-aerosol foam, or aerosol foam.
  • the topical vehicle can have a pH of from about 3, 4, 5, 6, 7, 8, 9, 10 to about 11, or any range or integer derivable therein.
  • a method of typically delivering a pharmaceutical or cosmetic ingredient to skin comprising contacting the skin of a subject (e.g. , animals and humans or persons) with a topical vehicle formulated according to the present invention.
  • the method can include applying the topical vehicle or compositions of the present invention to skin at least once, twice, three, four, five, six, seven, eight, nine, or more times a day as needed.
  • the topical vehicle or compositions can be incorporated into clothes, wound dressings, bandages, gauzes and the like.
  • Another aspect of the present invention includes a method of preparing a surfactant free topical vehicle.
  • the method can include admixing a hydrophobic phase with a low viscosity hydrophilic phase comprising a glyceryl polyacrylate or glyceryl polymethacrylate fluid to obtain a stable dispersion.
  • the stable dispersion can then be combined with an additional non-surfactant ingredient such as a cosmetic or pharmaceutical ingredient.
  • the admixing can be performed by methods and apparatuses known to those of ordinary skill in the art including, but not limited to, mechanical mixers, mills, dispersers, and homogenizers.
  • suspension refers to a suspension of liquid, semi-solid, or solid particles of colloidal size or larger in a liquid medium.
  • the particle size can range from about 50 nanometers to about 1000 microns.
  • the suspended particles contain one or more hydrophobic materials.
  • stable dispersion means a dispersion that is physically stable by visual examination for at least about 5 days.
  • fluid means a low viscosity liquid.
  • Low viscosity means a viscosity of from 20 to 1600 cps as measured by a BROOKFIELD RV model viscometer using a #3 spindle at 50 rpm at 25 °C.
  • One aspect of the present invention provides for stable dispersions of hydrophobic substances in low viscosity hydrophilic glyceryl polyacrylate or glyceryl polymethacrylate fluids. Further aspects provide for the use of the stable dispersions of the invention in topical vehicles and methods of delivering pharmaceutical and cosmetic active agents in such topical vehicles. These and other aspects of the present invention are described in further detail below.
  • surfactants means those compounds or mixture of compounds recognized by one of ordinary skill in the art as surfactants and emulsifiers useful in formulating topical preparations such as emulsions.
  • surfactants can be found in McCutcheon's Emulsifiers and Detergents (2001) under “Surfactants” and examples include, but are not limited to, the following (the CTFA/INCI name is denoted in parentheses for reference): block polymers, e.g ., PLURONIC L44 (Poloxamer 124); ethoxylated alcohols e.g., BRIJ 52 (Ceteth-2), EUMULGIN B-2 (Ceteareth-20), GENAPOL 26-L3 (Laureth-3); ethoxylated fatty esters and oils, e.g ., CREMOPHOR RH-40 (PEG-40 Hydrogenated Castor Oil), EMULSOGEN EL (P
  • EMEREST 2452 Polyglyceryl-3 Diisostearate
  • CREMOPHOR GS-11 Glyceryl Stearate
  • glycol esters ALKAMULS 600-DO (PEG-12 Dioleate), LEXEMUL P (Propylene Glycol Stearate SE)
  • phosphate esters e.g ., HOSTAPHAT CC 100 (Cetyl Phosphate)
  • polymeric surfactants e.g ., GANTREZ AN-119 (PVM/MA Copolymer), GANTREZ S-95 (PVM/MA Copolymer)
  • PEMULIN TR-1 Acrylates/C10-30 Alkyl Acrylate Crosspolymer
  • PEMULIN TR-2 Acrylates/C10-30 Alkyl Acrylate Crosspolymer
  • quaternary surfactants e.g ., DEHYQUART A (Cetrimonium Chloride); Silicone Based Surfactants, e.g ., ABIL
  • surfactants can be classified by their ionic type such as anionic, cationic, nonionic, or amphoteric. They can also be classified by their chemical structures, such as block polymers, ethoxylated alcohols, ethoxylated fatty esters and oils, glycerol esters, glycol esters, phosphate esters, polymeric surfactants, quaternary surfactants, silicone-based surfactants, sorbitan derivatives, sucrose and glucose esters and derivatives, and sulfates of alcohols. In that a formulation is "surfactant free," such surfactants are not included as ingredients.
  • the stable dispersion of the present invention comprises a hydrophobic dispersed phase and a low viscosity hydrophilic glyceryl polyacrylate or glyceryl polymethacrylate continuous phase.
  • a low viscosity glyceryl polyacrylate or glyceryl polymethacrylate fluid provides the hydrophilic continuous phase of the stable dispersions of the present invention.
  • the hydrophilic fluid further comprises water, a polyol, or mixtures thereof.
  • the polyol is glycerin, propylene glycol, butylene glycol, or pentylene glycol; or mixtures thereof.
  • low viscosity means a viscosity of from 20 to 1600 cps as measured by a BROOKFIELD RV model viscometer using a #3 spindle at 50 rpm at 25 ° C.
  • the viscosity of the hydrophilic fluid is from about 400 cps to 1600 cps, or is from about 500 cps to about 1200 cps, or is about 400 cps, or is about 500 cps, or is about 600 cps, or about 700 cps, or about 800 cps, or about 900 cps, or about 1000 cps, or about 1100 cps, or about 1200 cps, or about 1300 cps, or about 1400 cps, or about 1500 cps, or is from 20 cps to about 400 cps, or is from about 20 cps to about 500 cps, or is from 20 cps to about 600 cps, or is from 20 cps to about 700 cps, or is from 20 cps to about 800 cps, or is from 20 cps to about 900 cps, or is from 20
  • HISPAGEL Oil LV manufactured by Cognis Iberia S.L., Spain and distributed by Centerchem, Inc., Norwalk, CT), which is a mixture of glyceryl polyacrylate, glycerin and water, and is supplied with a viscosity in the range of 500-1200 cps.
  • HISPAGEL Oil LV does not contain surfactants.
  • Suitable glyceryl polyacrylate and glyceryl polymethacrylate preparations can be prepared by use of methods known in the art to esterify polyols to polyacids. Such methods include conventional chemical synthesis (e.g ., U.S. Patent 2,680,735 ; U.S. Patent 2,877,215 ; U.S. Patent 2,967,173 , U.S. Patent 2,979,514; Bovin, 1998 , all incorporated herein by reference) and use of enzymes (e.g ., Sahoo & Gross, 2004; U.S. Patent 6,924,129 , all incorporated herein by reference).
  • conventional chemical synthesis e.g ., U.S. Patent 2,680,735 ; U.S. Patent 2,877,215 ; U.S. Patent 2,967,173 , U.S. Patent 2,979,514; Bovin, 1998 , all incorporated herein by reference
  • enzymes e.g .,
  • Example 6 Preparation of a suitable glyceryl polyacrylate fluid by use of NOVOZYME 435 (Lipase B from Candida antartica) is exemplified in Example 6 below.
  • NOVOZYME 435 Lipase B from Candida antartica
  • Example 8 Preparation of a suitable glyceryl polymethacrylate fluid is exemplified in Example 8 below.
  • Suitable components of the hydrophobic dispersed phase include, but are not limited to plant, animal, paraffinic, and synthetic derived fats, butters, greases, waxes, solvents, and oils; mineral oils, vegetable oils, water insoluble organic esters, water insoluble triglycerides, non-volatile silicones, and fluorinated compounds; and mixtures thereof.
  • Plant derived materials include, but are not limited to, arachis (peanut) oil, balsam Peru oil, carnauba wax, candellila wax, castor oil, hydrogenated castor oil, cocoa butter, coconut oil, corn oil, cotton seed oil, jojoba oil, macadamia seed oil, olive oil, orange oil, orange wax, palm kernel oil, rapeseed oil, safflower oil, sesame seed oil, shea butter, soybean oil, sunflower seed oil, tea tree oil, vegetable oil, and hydrogenated vegetable oil.
  • animal derived materials include beeswax, cod liver oil, emu oil, lard, mink oil, shark liver oil, squalane, squalene, and tallow.
  • paraffinic materials include isoparaffin, microcrystalline wax, heavy mineral oil, light mineral oil, ozokerite, petrolatum, and paraffin.
  • a non-limiting example of a non- volatile silicone is dimethicone.
  • Suitable hydrophobic materials also include C12-15 alkyl benzoate, isopropyl myristate, isopropyl palmitate, trilaurin, trihydroxystearin, and polytetrafluoroethylene (PTFE).
  • the hydrophobic dispersed phase can be a liquid and/or can have a melting point below 25°C. In certain aspects the hydrophobic dispersed phase does not include a wax.
  • the topical formulations comprise the low viscosity surfactant free dispersion of the present invention and other suitable ingredients such as cosmetic ingredients and pharmaceutical active agents, including those known to persons of ordinary skill in the art and/or described throughout the specification.
  • Topical formulations may be made by first preparing the low viscosity dispersion and subsequently adding the other ingredients of the topical formulations. Alternatively, one or more, or all the other ingredients of a topical formulation, may be added at the time the surfactant free dispersion of the present invention is made by admixing the appropriate phases.
  • the topical formulations can be applied to the skin without undue toxicity, incompatibility, instability, allergic response, and the like.
  • Cosmetic ingredients includes “rheology modifiers” and “cosmetic active agents”, i.e ., agents directed to enhancing, modifying or maintaining a biological or physiological functionality other than those such agents required for prescribed or over-the-counter drugs, these being pharmaceutical active agents.
  • the CTFA International Cosmetic Ingredient Dictionary and Handbook (2004 ) describes a wide variety of non-limiting cosmetic ingredients commonly used in the skin care industry, generally suitable for use in the compositions of the present invention.
  • these ingredient classes include: fragrances (artificial and natural), dyes and color ingredients (e.g ., Blue 1, Blue 1 Lake, Red 40, and titanium dioxide, D&C blue no. 4, D&C green no. 5, D&C orange no. 4, D&C red no. 17, D&C red no. 33, D&C violet no. 2, D&C yellow no. 10, and D&C yellow no.
  • adsorbents include, e.g ., emollients, humectants, film formers, occlusive agents, and agents that affect the natural moisturization mechanisms of the skin), water-repellants, UV absorbers (physical and chemical absorbers such as paraaminobenzoic acid (“PABA”) and corresponding PABA derivatives, titanium dioxide, zinc oxide, etc .), essential oils, vitamins (e.g. A, B, C, D, E, and K), trace metals (e.g . zinc, calcium and selenium), anti-irritants (e.g . steroids and non-steroidal anti-inflammatories), and botanical extracts (e.g .
  • absorbents e.g ., aluminum starch octenylsuccinate, kaolin, corn starch, oat starch, cyclodextrin, talc, and zeolite
  • skin bleaching and lightening agents e.g ., hydroquinone and niacinamide lactate
  • humectants e.g ., glycerin, propylene glycol, butylene glycol, pentylene glycol, sorbitol, urea, and manitol
  • exfoliants e.g.
  • alpha-hydroxyacids, and beta-hydroxyacids such as lactic acid, glycolic acid, and salicylic acid; and salts thereof) waterproofing agents (e.g ., magnesium/aluminum hydroxide stearate), skin conditioning agents (e.g. , aloe extracts, allantoin, bisabolol, ceramides, dimethicone, hyaluronic acid, and dipotassium glycyrrhizate).
  • waterproofing agents e.g ., magnesium/aluminum hydroxide stearate
  • skin conditioning agents e.g. , aloe extracts, allantoin, bisabolol, ceramides, dimethicone, hyaluronic acid, and dipotassium glycyrrhizate.
  • Non-limiting examples of preservatives that can be used in the context of the present invention include parabens (e.g ., methylparabens and propylparabens), benzyl alcohol, chlorobutanol, phenol, sorbic acid, thimerosal or combinations thereof.
  • parabens e.g ., methylparabens and propylparabens
  • benzyl alcohol e.g methylparabens and propylparabens
  • chlorobutanol phenol
  • sorbic acid thimerosal or combinations thereof.
  • Non-limiting examples of moisturizing agents that can be used with the compositions of the present invention can be found in the International Cosmetic Ingredient Dictionary, 10th Ed., 2004 , which is incorporated by reference.
  • moisturizing agents include amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, polyglyceryl sorbitol, salts of pyrollidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • emollients include, but are not limited to, vegetable oils, mineral oils, silicone oils, synthetic and natural waxes, medium chain triglycerides, petrolatum, lanolin, aluminum magnesium hydroxide stearate (which can also function as a water repellent), and fatty acid esters.
  • vegetable oils include safflower oil, corn oil, sunflower seed oil, and olive oil.
  • antioxidants include, but are not limited to, acetyl cysteine, ascorbic acid, ascorbic acid polypeptide, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl palmitate, ascorbyl stearate, BHA, BHT, t-butyl hydroquinone, cysteine, cysteine HCI, diamylhydroquinone, di-t-butylhydroquinone, dicetyl thiodipropionate, dioleyl tocopheryl methylsilanol, disodium ascorbyl sulfate, distearyl thiodipropionate, ditridecyl thiodipropionate, dodecyl gallate, erythorbic acid, esters of ascorbic acid, ethyl ferulate, ferulic acid, gallic acid esters, hydroquinone, isooctyl thiog
  • Pharmaceutical active agents may include, but are not limited to, anti-acne agents including those for the treatment of rosacea, analgesics, anesthetics, anorectals, antihistamines, anti-inflammatory agents including non-steroidal anti-inflammatory drugs, antibiotics, antifungals, antivirals, antimicrobials, anti-cancer actives, scabicides, pediculicides, antineoplastics, antiperspirants, antipruritics, antipsoriatic agents, antiseborrheic agents, biologically active proteins and peptides, burn treatment agents, cauterizing agents, depigmenting agents, depilatories, diaper rash treatment agents, enzymes, hair growth stimulants, hair growth retardants including DFMO and its salts and analogs, hemostatics, kerotolytics, canker sore treatment agents, cold sore treatment agents, dental and periodontal treatment agents, photosensitizing actives, skin protectant/barrier agents, steroids including hormones and corticosteroids
  • Topical formulations may include rheology modifiers (also known as thickeners). Such agents used in topical formulations are known to those of skill in the art and serve to impart certain desirable physical attributes such as product consistency, texture, and viscosity to a formulation.
  • rheology modifiers may be selected from sodium polyacrylates, carbomers, natural gums, natural gum derivatives, clays, modified clays, cellulose, cellulose derivatives, magnesium aluminum silicates, gellan gums, xanthan gums, starches and modified starches.
  • the formulator can achieve the desired physical characteristics of a topical formulation. Examples of rheology modifiers can be found in McCutcheon's Functional Materials (2001 ) under "Thickeners" and include the following (the CTFA/INCI name is denoted in parentheses for reference):
  • rheology modifiers and any additional topical vehicle ingredients should not include those materials that are also surfactants, as in the surfactant examples listed in McCutcheon's Emulsifiers and Detergents (2001) under "Surfactants.”
  • compositions of the present invention can include any number of combinations of ingredients (components of the dispersions (e.g. , the hydrophobic and hydrophilic phases), cosmetic ingredients, pharmaceutical active ingredients, etc .) of the present invention. It is also contemplated that the concentrations of these ingredients within the compositions can vary.
  • the compositions may include in their final form, for example, at least about 0.0001% to about 0.001%, 0.001% to about 0.01%, 0.01% to about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 5.0%, 5.1%, 5.2%
  • the dispersions of the present invention can be incorporated into several different vehicles.
  • suitable vehicles include emulsions (e.g. , water-in-oil, water-in-oil-in-water, oil-in-water, oil-in-water-in-oil, oil-in-water-in-silicone emulsions), creams, lotions, solutions (both aqueous and hydro-alcoholic), anhydrous bases (such as lipsticks and powders), gels, ointments, serums, liquids, fluids, non-aerosol sprays, aerosol sprays, non-aerosol foams, aerosol foams or by other method or any combination of the forgoing as would be known to one of ordinary skill in the art (Remington's, 1990).
  • emulsions e.g. , water-in-oil, water-in-oil-in-water, oil-in-water, oil-in-water-in-silicone emulsions
  • creams lotions
  • the dispersions of the present invention can also be used in many cosmetic and pharmaceutical products.
  • cosmetic products include sunscreen products, sunless skin tanning products, hair products, finger nail products, moisturizing creams, skin benefit creams and lotions, softeners, day lotions, foundations, night creams, lipsticks, cleansers, toners, masks, and other known cosmetic products and applications.
  • Non-limiting examples of pharmaceutical products include anti-acne products, analgesic products, anesthetic products, anorectal products, antihistamine products, anti-inflammatory products, antibiotic products, antifungal products, antiviral prodcuts, antimicrobial products, anti-cancer products, scabicidal products, pediculicidal products, antineoplastic products, antiperspirants, antipruritic products, antipsoriatic products, antiseborrheic products, burn treatment products, cauterizing products, depigmenting products, depilatory products, diaper rash treatment products, hair growth products, hair growth retardant products, hemostatic products, keratolytic products, canker sore treatment products, cold sore treatment products, dental and periodontal treatment products, skin protectant/barrier products, steroidal products including hormonal and corticosteroidal products, sunburn treatment products, sunscreen products, transdermal products, nasal products, vaginal products, wart treatment products, wound debriding products, wound treatment products, wound healing products.
  • Kits are also contemplated as being used in certain aspects of the present invention.
  • the dispersions of the present invention can be included in a kit.
  • Containers can be included in the kit.
  • Containers can include a bottle, a metal tube, a laminate tube, a plastic tube, a dispenser, a pressurized container, a barrier container, a package, a compartment, or other types of containers such as injection or blow-molded plastic containers into which the dispersions or compositions or desired bottles, dispensers, or packages are retained.
  • the kit and/or container can include indicia on its surface.
  • the indicia for example, can be a word, a phrase, an abbreviation, a picture, or a symbol.
  • the containers can dispense a pre-determined amount of the dispersion or composition.
  • the container can be squeezed (e.g. , metal, laminate, or plastic tube) to dispense a desired amount of the dispersion or composition.
  • the dispersion or composition can be dispensed as a spray, an aerosol, a liquid, a fluid, or a semi-solid.
  • the containers can have spray, pump, or squeeze mechanisms.
  • a kit can also include instructions for employing the kit components as well the use of any other dispersions or compositions included in the container. Instructions can include an explanation of how to apply, use, and maintain the products, dispersions, or compositions.
  • Non-limiting embodiments of dispersions of the present invention are described in the following Tables 1-6.
  • Table 3 (dispersion)* Ingredient % w/w HISPAGEL Oil LV 50.0 Mineral Oil USP 50.0 *The dispersion was prepared as follows: The mineral oil was added to the HISPAGEL Oil while mixing with a COWLES disperser and mixed until uniform.
  • Table 4 (dispersion)* Ingredient % w/w HISPAGEL Oil LV 68.0 Mineral Oil USP 32.0 *The dispersion was prepared as follows: The mineral oil was added to the HISPAGEL Oil while mixing with a COWLES disperser and mixed until uniform.
  • Table 5 (dispersion)* Ingredient % w/w HISPAGEL Oil LV 62.6 Safflower Oil USP 37.4 *The dispersion was prepared as follows: The safflower oil was added to the HISPAGEL Oil while mixing with a COWLES disperser and mixed until uniform. The dispersion was passed through a GREECO Colloid Mill. Table 6 (dispersion)* Ingredient % w/w HISPAGEL Oil LV 62.5 Caprylic/Capric Triglycerides 37.5 *The dispersion was prepared as follows: The caprylic/capric triglycerides were added to the HISPAGEL Oil while mixing with a COWLES disperser and mixed until uniform.
  • a non-limiting example of a surfactant free cream with mineral oil was prepared as described in the following two steps:
  • Step 1 A mineral oil dispersion was prepared as described in Table 7 below: Table 7 (mineral oil dispersion)* Ingredient % w/w (of total surfactant free cream) HISPAGEL OiI LV 30.0 Mineral Oil USP 10.0 *The mineral oil was added to the HISPAGEL Oil while mixing with a COWLES disperser and mixed until uniform The dispersion was passed through a GREECO Colloid Mill.
  • Step 2 The mineral oil dispersion was incorporated into an aqueous based topical vehicle as described in Table 8: Table 8 (aqueous based topical vehicle)* Ingredient % w/w Xanthan Gum 0.10 Hydroxyethylcellulose 0.10 CARBOPOL 974P 0.30 Sodium Polyacrylate 0.75 Aluminum Starch Octenylsuccinate 2.50 Methylparaben 0.25 Propylparaben 0.02 Purified Water q.s. ad 100 % Sodium Hydroxide q.s. pH to 5 - 6 *The aqueous based topical vehicle was prepared by first dissolving the methylparaben and propylparaben in hot water then cooling the solution.
  • the xanthan gum, hydroxytheylcellulose, CARBOPOL 974P, and sodium polyacrylate were then added and mixed with a COWLES disperser until hydrated.
  • the aluminum starch octenylsuccinate was then added and mixed with a COWLES disperser.
  • the Mineral Oil Dispersion was then blended with the vehicle using a mixer with a high lift impeller, and the pH was adjusted to 5 - 6 using sodium hydroxide.
  • Step 1 A mineral oil dispersion was prepared as described in Table 9 below: Table 9 (mineral oil dispersion)* Ingredient % w/w (of total surfactant free cream) HISPAGEL Oil LV 6.80 Mineral Oil USP 3.20 *The mineral oil was added to the HISPAGEL Oil while mixing with a COWLES disperser and mixed until uniform.
  • Step 2 The mineral oil dispersion was incorporated into an aqueous based topical vehicle as described in Table 10: Table 10 (aqueous based topical vehicle)* Ingredient % w/w Xanthan Gum 0.08 Hydroxyethylcellulose 0.16 Sodium Polyacrylate 1.33 Methylparaben 0.20 Propylparaben 0.03 Purified Water q.s. ad 100 % *The aqueous based topical vehicle was prepared by first dissolving the methylparaben and propylparaben in hot water then cooling the solution. The sodium polyacrylate, hydroxytheylcellulose, and xanthan gum were then added and mixed with a COWLES disperser until hydrated. The mineral oil dispersion was then blended with the vehicle using a mixer with a 3-prong paddle blade and mixed until uniform
  • a non-limiting example of a surfactant free lotion with mineral oil was prepared as described in the following two steps:
  • Step 1 A mineral oil dispersion was prepared as described in Table 11 below: Table 11 (mineral oil dispersion)* Ingredient % w/w (of total surfactant free lotion) HISPAGEL Oil LV 27.2 Mineral Oil USP 12.8 *The mineral oil was added to the HISPAGEL Oil while mixing with a COWLES disperser and mixed until uniform The dispersion was passed through a GREECO Colloid Mill.
  • Step 2 The mineral oil dispersion was incorporated into an aqueous based topical vehicle as described in Table 12: Table 12 (aqueous based topical vehicle)* Ingredient % w/w Xanthan Gum 0.10 Hydroxyethylcellulose 0.10 Sorbitol Solution 5.00 Glycerin 6.00 Sodium Polyacrylate 0.30 Aluminum Starch Octenylsuccinate 2.50 Methylparaben 0.20 Propylparaben 0.03 Purified Water q.s. ad 100% * The aqueous based topical vehicle was prepared by first dissolving the sorbitol solution in the water, then adding sodium polyacrylate and mixing until hydrated using a COWLES disperser.
  • a solution of methylparaben and propylparaben in hot glyceryin was prepared, cooled, and then xanthan gum and hydroxyethyl cellulose were dispersed in the paraben solution.
  • the paraben solution/xanthan gum/hydroxyethyl cellulose dispersion was then added to the batch and mixed with a COWLES disperser until uniform.
  • the mineral oil dispersion was added to the vehicle while mixing with a paddle mixer and mixed until uniform.
  • the aluminum starch octenylsuccinate was then added and mixed until uniform.
  • Step 1 A mineral oil dispersion was prepared as described in Table 13 below: Table 13 (mineral oil dispersion)* Ingredient % w/w (of total surfactant free lotion) HISPAGEL Oil LV 6.80 Mineral Oil USP 3.20 *The mineral oil was added to the HISPAGEL Oil while mixing with a COWLES disperser and mixed until uniform.
  • Step 2 The mineral oil dispersion was incorporated into an aqueous based topical vehicle as described in Table 14: Table 14 (aqueous based topical vehicle)* Ingredient % w/w Xanthan Gum 0.08 Hydroxyethylcellulose 0.10 Sodium Polyacrylate 0.40 Methylparaben 0.20 Propylparaben 0.03 Purified Water q.s. ad 100% *The aqueous based topical vehicle was prepared by first dissolving the methylparaben and propylparaben in hot water then cooling the solution. The sodium polyacrylate, hydroxytheylcellulose, and xanthan gum were then added and mixed with a COWLES disperser until hydrated. The mineral oil dispersion was then blended with the vehicle using a mixer with a 3-prong paddle blade and mixed until uniform.
  • the reaction was mixed for 6 consecutive days using a COWLES disperser at approximately 75°C (the mixture was stored each night at room temperature without mixing). At the end of the reaction-mixing period, the enzyme beads were removed by centrifugation (the beads accumulate at the surface upon centrifugation).
  • the fluid was completed by mixing 50% w/w of the reaction mixture with 50% w/w of 50:50 solution of water and glycerin using a COWLES disperser until a uniform fluid was formed.
  • the viscosity of the fluid was 826 cps as measured by a BROOKFIELD RV model viscometer using a #3 spindle at 50 rpm at 25°C.
  • a non-limiting example of a mineral oil dispersion having glyceryl polyacrylate fluid as the hydrophilic phase and mineral oil USP as the hydrophobic phase is described in Table 16 below.
  • the glyceryl polyacrylate fluid was prepared as described in Example 6 and a dispersion was prepared as follows: Table 16 (dispersion)* Ingredient % w/w (of total surfactant free cream) Glyceryl polyacrylate fluid (hydrophilic phase) 76.7 Mineral Oil USP (hydrophobic phase) 23.3 *The hydrophobic phase was added to the hydrophilic phase and mixed with a COWLES disperser until homogeneous. The dispersion was physically stable by visual examination for at least 5 days.
  • a non-limiting example of synthesizing glyceryl polymethacrylate fluid is described.
  • remove the enzyme beads by centrifugation the beads accumulate at the surface upon centrifugation).
  • Complete the preparation of the fluid by mixing a portion of the reaction mixture with a portion of a solution of water and glycerin using a COWLES disperser until a uniform fluid is formed.
  • Confirm the viscosity of the fluid is between 20 and 1600 cps as measured by a BROOKFIELD RV model viscometer using a #3 spindle at 50 rpm at 25°C.
  • a non-limiting example of a mineral oil dispersion having glyceryl polymethacrylate fluid as the hydrophilic phase and mineral oil USP as the hydrophobic phase is described in Table 17 below.
  • the glyceryl polymethacrylate fluid is prepared as described in Example 8 and a dispersion is prepared as follows: Table 17 (dispersion)* Ingredient % w/w (of total surfactant free cream) Glyceryl polymethacrylate fluid (hydrophilic phase) 76.7 Mineral Oil USP (hydrophobic phase) 23.3 *The hydrophobic phase was added to the hydrophilic phase and mixed with a COWLES disperser until homogeneous. The dispersion was physically stable by visual examination for at least 5 days.

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Claims (17)

  1. Stabile Dispersion, umfassend:
    - eine hydrophile fluide kontinuierliche Phase, umfassend 30 bis 99 Gew.-% Glycerylpolyacrylatfluid oder 30 bis 99 Gew.-% Glycerylpolymethacrylatfluid, Wasser und einen Polyol, wobei die hydrophile fluide kontinuierliche Phase eine mit einem BROOKFIELD-RV-Viskosimeter unter Verwendung einer Spindel Nr. 3 bei 50 U/min und 25°C gemessene Viskosität im Bereich von 20 cps bis 1600 cps aufweist, und
    - eine hydrophobe dispergierte Phase, und wobei die Dispersion frei ist von jeglichen Tensiden und Emulgatoren.
  2. Dispersion nach Anspruch 1, wobei die Viskosität der hydrophilen fluiden kontinuierlichen Phase 400 cps bis 1600 cps beträgt.
  3. Dispersion nach Anspruch 1, wobei die Viskosität der hydrophilen fluiden kontinuierlichen Phase 500 cps bis 1200 cps beträgt.
  4. Dispersion nach einem der Ansprüche 1 bis 3, wobei die hydrophobe Phase ein nichtflüchtiges Silikon, ein Mineralöl, ein Pflanzenöl, einen wasserunlöslichen organischen Ester, ein wasserunlösliches Triglycerid, eine fluorierte Verbindung oder eine Mischung davon umfasst.
  5. Dispersion nach einem der Ansprüche 1 bis 4, wobei es sich bei dem Polyol um Glycerin, Propylenglycol, Butylenglycol oder Pentylenglycol oder eine Mischung davon handelt.
  6. Verwendung einer Dispersion nach einem der Ansprüche 1 bis 5 bei der Formulierung einer kosmetischen Zusammensetzung.
  7. Verwendung nach Anspruch 6, wobei die kosmetische Zusammensetzung zu einer Lotion, einer Creme, einem Gel, einer Salbe, einem Serum, einer Flüssigkeit, einem Fluid, einem Nicht-Aerosol-Spray, einem Aerosolspray, einem Nicht-Aerosol-Schaum oder einem Aerosolschaum formuliert wird.
  8. Dispersion nach einem der Ansprüche 1 bis 5, wobei die hydrophobe dispergierte Phase 1 Gew.-% bis 70 Gew.-% der stabilen Dispersion ausmacht.
  9. Verwendung einer Dispersion nach einem der Ansprüche 1 bis 5 bei der Formulierung eines tensidfreien topischen Vehikels.
  10. Verwendung nach Anspruch 9, wobei das Vehikel weiterhin einen kosmetischen Inhaltsstoff oder ein pharmazeutisch wirksames Mittel oder eine Mischung davon umfasst.
  11. Verwendung nach Anspruch 9, wobei das Vehikel einen kosmetischen Inhaltsstoff umfasst.
  12. Verwendung nach Anspruch 11, wobei es sich bei dem kosmetischen Inhaltsstoff um einen Konservierungsstoff, ein Farbmittel, einen Duftstoff, eine Substanz zum Einstellen des pH-Wertes, ein Antioxidationsmittel, einen Chelator, ein Absorptionsmittel, einen Exfolianten, ein Feuchthaltemittel, ein die Haut aufhellendes Mitte-, ein gegen Wasser schützendes Mittel oder ein Mittel zum Konditionieren der Haut oder eine Mischung davon handelt.
  13. Verwendung nach einem der Ansprüche 10 bis 12, wobei das topische Vehikel weiterhin eine Substanz zum Modifizieren der Fließfähigkeit umfasst.
  14. Verwendung nach Anspruch 13, wobei die Substanz zum Modifizieren der Fließfähigkeit aus der aus Natriumpolyacrylat, Carbomer, natürlichem Gummi, natürlichen Gummiderivaten, Ton, modifiziertem Ton, Cellulose, Cellulosederivaten, Magnesiumaluminiumsilikat, Gellan, Xanthan, Stärke und modifizierter Stärke oder Mischungen davon bestehenden Gruppe ausgewählt ist.
  15. Verwendung nach einem der Ansprüche 10 bis 14, wobei es sich bei dem topischen Vehikel um eine Lotion, eine Creme, ein Gel, eine Salbe, ein Serum, eine Flüssigkeit, ein Fluid, ein Nicht-Aerosol-Spray, ein Aerosol-spray, einen Nicht-Aerosol-Schaum oder einen Aerosol-schaum handelt.
  16. Verfahren zur Herstellung eines tensidfreien topischen Vehikels, umfassend:
    die Herstellung einer stabilen Dispersion nach einem der Ansprüche 1 bis 5 durch Mischen der hydrophoben Phase mit der hydrophilen fluiden kontinuierlichen Phase und die Kombination der Dispersion mit einem zusätzlichen Nicht-Tensid-Inhaltsstoff.
  17. Verfahren nach Anspruch 16, wobei das Mischen mit einem mechanischen Mischer, einer Mühle, einem Dispergiergerät oder einem Homogenisator erfolgt.
EP06816354A 2005-10-11 2006-10-11 Tensidfreie dispersionen, zusammensetzungen und verwendung in topischen formulierungen Not-in-force EP1945307B1 (de)

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