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EP1799557B1 - Doppelkammerampulle - Google Patents

Doppelkammerampulle Download PDF

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Publication number
EP1799557B1
EP1799557B1 EP05771027A EP05771027A EP1799557B1 EP 1799557 B1 EP1799557 B1 EP 1799557B1 EP 05771027 A EP05771027 A EP 05771027A EP 05771027 A EP05771027 A EP 05771027A EP 1799557 B1 EP1799557 B1 EP 1799557B1
Authority
EP
European Patent Office
Prior art keywords
receptacle
dosing chamber
medium
container
constriction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP05771027A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1799557A1 (de
Inventor
Bernd Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PL05771027T priority Critical patent/PL1799557T3/pl
Publication of EP1799557A1 publication Critical patent/EP1799557A1/de
Application granted granted Critical
Publication of EP1799557B1 publication Critical patent/EP1799557B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/09—Ampoules
    • B65D1/095—Ampoules made of flexible material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/09—Ampoules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents

Definitions

  • the invention relates to a container consisting of a resilient plastic material, with a metering chamber in which a dispensing medium is located, wherein the one end of the metering chamber has a discharge opening and the opposite end is connected via a connection point with a compressible container part, in which a particular gaseous Austreibmedium is located, wherein the compression medium at least partially displaces the discharge medium from the metering chamber via the discharge opening upon compression of the container part.
  • DE-PS 32 44 403 is a generic container made of a resilient plastic material known with a tubular metering chamber in which a material medium is, and which is designed such that the material medium remains independent of the position of the container in the metering chamber and with a squeezable, a gaseous medium containing container part, which has a larger volume than the metering chamber, wherein upon compression of the container part located in the metering material material medium from this metering chamber can be driven by a dispensing opening attachable thereto.
  • the known container solution is used to deliver a material medium of ointment-like consistency at ambient temperature, which is filled in the preparation of the container exclusively in the metering chamber.
  • the ointment-like consistency of the material medium at ambient temperature prevents it from escaping from the tubular metering chamber, which may also be tapered towards the free end of the metering chamber.
  • the gaseous medium is as Ausreibmedium, so that when squeezing the container which is located solely in the dosing chamber material medium is removed substantially from this dosing without practically leaving a residue in the container.
  • the known solution finds its limitation insofar as for dispensing media in the metering chamber with low viscosity compared to the ointment-like consistency, the discharge medium from the metering chamber via the extension as a junction enters the container part, there mixed with the Austreibmedium and thus the container solution can be unusable.
  • a container made of plastic for a dispensable dispensing of flowable substances has been proposed, with a provided at one end discharge opening and an adjoining the other open end, and only to the interior of the container open chamber whose volume is reduced by a manual deformation, and which is formed integrally with the container, wherein the container is formed as a cylinder and wherein the flowable substance receiving interior of the cylinder is separated from the interior of the chamber by a longitudinally displaceable in the cylinder by hand separating piston, wherein in the chamber air is stored, the hand displaces the separating piston against the discharge opening of the container suppressed.
  • the material separation of the discharge medium in the metering chamber to Austreibmedium in the container part is achieved in the known solution, so that it does not unintentionally come to mixtures insofar as the container solution could be unusable.
  • the known container solution it is also possible to dispense very thin-bodied dispensing media, but with the disadvantage that, due to the separating piston, the known solution is expensive to produce and in particular builds up axially large in dispensing direction.
  • the present invention seeks to provide a container that is inexpensive to produce, constructively small and can build, it allows, without much design effort as delivery media such thin consistency and / or in the manner of an aerosol deploy.
  • This object is achieved by a container having the features of claim 1 in its entirety.
  • connection point between metering chamber and container part is formed from a constriction, which is designed such that a capillary effect is formed, regardless of the spatial position of the container, a transfer of the delivery medium from the metering chamber into the container part prevented with the Austreibmedium, it is ensured that even without Trennkolbenanowski the discharge medium can not accidentally flow from the metering chamber in the direction of the container part with the Austreibmedium.
  • the reliability is ensured in any case and it is surprising for a person of ordinary skill in the field of manufacturing pertinent container that he thus also sprayable as a release medium Aerosols od.
  • Can deploy The latter substances are becoming increasingly important in pharmacy, because there is the possibility of bringing sprayable active ingredients into contact with the nasal mucous membrane, in order to ensure a rapid absorption of active substance, which is not guaranteed in the case of intake of a different kind.
  • the constriction is formed from a capillary tube. Furthermore, it is preferably provided that the vulnerable bottleneck is stiffened by means of a support device. With the pertinent support device ensures that the bottleneck can not be accidentally damaged or compressed, which could damage their function.
  • the support means comprises at least two web-like support arms, which comprise both at least parts of the container part, the bottleneck and the metering chamber.
  • the two support arms extend along a parting plane and at least partially cover it, along which the parts of the container abut in half. In addition to the already mentioned stiffening of the overall container, this also allows an improved sealing of the container contents relative to the environment, so that the sterility of the container interior is ensured even over a long period of time.
  • the container according to the invention go in extension of the container part on its side facing away from the dosing chamber, the two support arms in a provided with a coding terminal lug on.
  • coding can be a container identification obtained in particular based on its contents.
  • the dosing chamber tapers toward the discharge opening, at least in stages, conically.
  • the degree of the selected conical taper results in such a way when expressing the container, an increase in speed for the stored medium, which positively affects its output.
  • an increased beam effect can be achieved.
  • the container shown in the figures consists of a transparent, elastically yielding plastic material which alone (see. Fig.1 and 2 ) or together with other containers (cf. Figure 3 ) Can be produced by means of a blow molding machine, filled and sterile closable.
  • the container has a tubular metering chamber 10, which is closed at its lower end in the drawing by a toggle closure 12 having a constricted predetermined breaking point 14 and a handle 16 for twisting the toggle closure 12 so as to release the discharge port 18 at the lower end of the metering chamber 10.
  • the dosing chamber 10 is a release medium, for example, such an ointment-like consistency, such as an eye ointment;
  • the delivery medium consists of such a low viscosity, also in the form of an aerosol, which can be dispensed from the dosing chamber 10 via the discharge opening 18 from the container in the manner of a spray or spray process.
  • the tubular structure of the metering chamber 10 would allow such good insertion into a body opening, such as a nostril od. Like., Allow.
  • the opposite end of the metering chamber 10 is connected via a connection point 20 with a compressible container part 22, in which a particular gaseous Austreibmedium, for example in the form of air, is located.
  • a compressible container part 22 in which a particular gaseous Austreibmedium, for example in the form of air, is located.
  • the expelling medium at least partially displaces the dispensing medium out of the dosing chamber 10 via the dispensing opening 18 for an application process outwards into the environment.
  • connection point 20 between the dosing chamber 10 and the container part 22 is formed from a constriction according to the figurative representation, wherein the constriction is formed such that a capillary effect is formed, regardless of the spatial position of the container, a transfer of the discharge medium from the metering chamber into the container part 22nd prevented with the Austreibmedium.
  • the Austreibmedium not squeeze unintentionally through the junction 20 in the direction of the dosing chamber 10 without squeezing the container part.
  • the bottleneck formed from a capillary tube, which is arranged in the manner of a constriction in the transition region between metering chamber 10 and container part 22.
  • the axial extent of the capillary tube along the parting plane 24 of the container is smaller than its free passage cross section for the delivery medium.
  • the vulnerable bottleneck is stiffened by means of a support device designated as a whole by 26.
  • the support means 26 has two web-like support arms 28,30, which include both the container part 22, the junction 20 and at least the lower third of the metering chamber 10.
  • the particular Fig. 2 shows extend the two support arms 28,30 along said parting plane 24 and cover them in the frame described above, at least partially, so that at the point along which the parts of the container manufacturing technology in half abut each other, achieved an additional seal on the support means 26 is.
  • At her in the direction of the Fig.1 seen lower end go the two support arms 28,30 via a conical inlet section in one piece into the dosing chamber 10 via.
  • the two support arms 28,30 open in a flat, square terminal lug 32.
  • the terminal lug 32 also allows to attach a coding 34 so as to identify the container and its contents .
  • the height of the terminal lug 32 is chosen such that it according to the illustration of the Fig.2 projecting beyond the dividing plane 24 with the support device 26 with a marginal projection.
  • the terminal lug 32 via another Predetermined breaking point 36 are separated from the container part 22.
  • the container part 22 is configured substantially cuboid and has, according to the illustration of the Fig.2 on opposite sides of two contact surfaces 38, which allow the compression of the container part 22 by hand, for example with the thumb and forefinger of an operator.
  • the abutment surfaces 38 in turn extend parallel to the parting plane 24.
  • the abutment surfaces 38 are clearly projected in both directions over the upper side of the metering chamber 10.
  • the volume ratios of container part 22 to dosing chamber 10 are about 2: 1, in order to be able to ensure a complete media discharge via the discharge opening 18 in this way.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
  • Packaging Frangible Articles (AREA)
EP05771027A 2004-09-21 2005-07-26 Doppelkammerampulle Not-in-force EP1799557B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL05771027T PL1799557T3 (pl) 2004-09-21 2005-07-26 Ampułka dwukomorowa

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004046536A DE102004046536A1 (de) 2004-09-21 2004-09-21 Behälter
PCT/EP2005/008093 WO2006032320A1 (de) 2004-09-21 2005-07-26 Doppelkammerampulle

Publications (2)

Publication Number Publication Date
EP1799557A1 EP1799557A1 (de) 2007-06-27
EP1799557B1 true EP1799557B1 (de) 2011-07-06

Family

ID=34993349

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05771027A Not-in-force EP1799557B1 (de) 2004-09-21 2005-07-26 Doppelkammerampulle

Country Status (17)

Country Link
US (1) US8551053B2 (pt)
EP (1) EP1799557B1 (pt)
JP (1) JP4922171B2 (pt)
KR (1) KR101182691B1 (pt)
CN (1) CN101001784B (pt)
AT (1) ATE515446T1 (pt)
AU (1) AU2005287690B2 (pt)
BR (1) BRPI0515481B1 (pt)
CA (1) CA2573402C (pt)
DE (1) DE102004046536A1 (pt)
DK (1) DK1799557T3 (pt)
ES (1) ES2365718T3 (pt)
HK (1) HK1105140A1 (pt)
MX (1) MX2007003346A (pt)
PL (1) PL1799557T3 (pt)
PT (1) PT1799557E (pt)
WO (1) WO2006032320A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015007690A1 (de) 2015-06-11 2016-12-15 Kocher-Plastik Maschinenbau Gmbh Verfahren zum Herstellen eines befüllten und geschlossenen Behälters sowie Vorrichtung zum Durchführen des Verfahrens und ein danach hergestellter Behälter

Families Citing this family (18)

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DE102005038619A1 (de) 2005-08-16 2007-02-22 Pari GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments
DE102005050403A1 (de) * 2005-10-19 2007-05-03 Bayer Cropscience Ag Tuben- oder flaschenartiger Behälter
DE102007009457A1 (de) * 2007-02-27 2008-08-28 Bernd Hansen Behälter, insbesondere hermetisch verschlossene Ampulle
DE102007056462B4 (de) 2007-11-23 2011-10-27 Pari Pharma Gmbh Einwegampulle für eine Vorrichtung zur Erzeugung von Aerosolen
WO2011077147A1 (en) * 2009-12-22 2011-06-30 Special Products Limited Containers
FR2967136B1 (fr) * 2010-11-08 2013-11-01 Unither Dev Procede de fabrication de fioles marquees, chaine de fabrication de fioles marquees et fioles marquees
FR2974755B1 (fr) * 2011-05-04 2014-03-21 Unither Pharmaceuticals Procede de marquage d'un contenant unidose de faible volume, contenant ainsi marque
US20130018329A1 (en) * 2011-07-14 2013-01-17 Mehta Ketan C Portable ampoule with a specialized tip and sealer
BR102015020878B1 (pt) * 2015-08-28 2019-08-27 F B M Ind Farmaceutica Ltda formulação farmacêutica nasal de testosterona e “kit” em forma de cartela de dispositivos nasais unitários para aplicação de monodose de testosterona.
CA2999419A1 (en) * 2015-09-24 2017-03-30 Mystic Pharmaceuticals, Inc. Devices and systems for air assisted dry powder administration
TW201733558A (zh) 2016-01-06 2017-10-01 賽諾菲阿凡提斯德意志有限公司 藥劑容器及其製造方法
CA3021989A1 (en) 2016-04-25 2017-11-02 Marc Andrew Koska Medical delivery system
US10494157B2 (en) 2016-06-15 2019-12-03 Robert T. Chang Single use vials for administering eye drops
WO2019099954A1 (en) 2017-11-17 2019-05-23 Koska Family Limited Systems and methods for fluid delivery manifolds
US11320295B2 (en) * 2019-04-26 2022-05-03 Festo Se & Co. Kg Dosing unit and method for dosing a liquid
USD1052082S1 (en) 2020-06-01 2024-11-19 Koska Family Limited Sealed fluid container
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container
CN115158898B (zh) * 2022-09-05 2022-11-22 烟台凯博机械自动化设备有限公司 一种针剂瓶用贮存运输装置及方法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015007690A1 (de) 2015-06-11 2016-12-15 Kocher-Plastik Maschinenbau Gmbh Verfahren zum Herstellen eines befüllten und geschlossenen Behälters sowie Vorrichtung zum Durchführen des Verfahrens und ein danach hergestellter Behälter
WO2016198135A1 (de) 2015-06-11 2016-12-15 Kocher-Plastik Maschinenbau Gmbh Verfahren zum herstellen eines befüllten und geschlossenen behälters sowie vorrichtung zum durchführen des verfahrens und ein danach hergestellter behälter

Also Published As

Publication number Publication date
AU2005287690A1 (en) 2006-03-30
US20080275404A1 (en) 2008-11-06
HK1105140A1 (en) 2008-02-01
BRPI0515481A (pt) 2008-07-22
AU2005287690B2 (en) 2011-08-11
PL1799557T3 (pl) 2011-11-30
CN101001784B (zh) 2012-10-17
KR101182691B1 (ko) 2012-09-17
CA2573402A1 (en) 2006-03-30
ATE515446T1 (de) 2011-07-15
EP1799557A1 (de) 2007-06-27
CN101001784A (zh) 2007-07-18
US8551053B2 (en) 2013-10-08
KR20070057774A (ko) 2007-06-07
DK1799557T3 (da) 2011-09-26
CA2573402C (en) 2012-07-03
WO2006032320A1 (de) 2006-03-30
DE102004046536A1 (de) 2006-03-30
JP2008513303A (ja) 2008-05-01
JP4922171B2 (ja) 2012-04-25
MX2007003346A (es) 2007-06-05
BRPI0515481B1 (pt) 2017-02-07
ES2365718T3 (es) 2011-10-10
PT1799557E (pt) 2011-07-25

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